Details of the Target
General Information of Target
Target ID | LDTP03189 | |||||
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Target Name | Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) | |||||
Gene Name | UQCRC2 | |||||
Gene ID | 7385 | |||||
Synonyms |
Cytochrome b-c1 complex subunit 2, mitochondrial; Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2 |
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3D Structure | ||||||
Sequence |
MKLLTRAGSFSRFYSLKVAPKVKATAAPAGAPPQPQDLEFTKLPNGLVIASLENYSPVSR
IGLFIKAGSRYEDFSNLGTTHLLRLTSSLTTKGASSFKITRGIEAVGGKLSVTATRENMA YTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQPQLKIDKAVAFQNPQTHVIENLHAA AYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNM RGGLGLSGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVK RGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLFGIYTISQATAAGDVIKAAYNQVKT IAQGNLSNTDVQAAKNKLKAGYLMSVESSECFLEEVGSQALVAGSYMPPSTVLQQIDSVA NADIINAAKKFVSGQKSMAASGNLGHTPFVDEL |
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Target Bioclass |
Enzyme
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Family |
Peptidase M16 family, UQCRC2/QCR2 subfamily
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Subcellular location |
Mitochondrion inner membrane
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Function |
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable).
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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CY-1 Probe Info |
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100.00 | LDD0243 | [1] | |
N1 Probe Info |
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100.00 | LDD0242 | [1] | |
TH211 Probe Info |
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Y182(20.00) | LDD0257 | [2] | |
TH216 Probe Info |
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Y355(8.96) | LDD0259 | [2] | |
YN-1 Probe Info |
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100.00 | LDD0444 | [3] | |
YN-4 Probe Info |
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100.00 | LDD0445 | [3] | |
Probe 1 Probe Info |
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Y55(8.08); Y355(62.63) | LDD3495 | [4] | |
m-APA Probe Info |
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9.47 | LDD0403 | [5] | |
BTD Probe Info |
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C192(1.07) | LDD2089 | [6] | |
DBIA Probe Info |
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C125(0.94) | LDD0078 | [7] | |
5E-2FA Probe Info |
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H172(0.00); H308(0.00); H446(0.00); H206(0.00) | LDD2235 | [8] | |
4-Iodoacetamidophenylacetylene Probe Info |
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C125(0.00); C192(0.00) | LDD0038 | [9] | |
IA-alkyne Probe Info |
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N.A. | LDD0032 | [10] | |
IPIAA_L Probe Info |
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C125(0.00); C192(0.00) | LDD0031 | [11] | |
Lodoacetamide azide Probe Info |
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C192(0.00); C125(0.00) | LDD0037 | [9] | |
ATP probe Probe Info |
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K375(0.00); K250(0.00) | LDD0035 | [12] | |
JW-RF-010 Probe Info |
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N.A. | LDD0026 | [13] | |
NAIA_4 Probe Info |
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C125(0.00); C192(0.00) | LDD2226 | [14] | |
TFBX Probe Info |
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N.A. | LDD0027 | [13] | |
WYneN Probe Info |
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N.A. | LDD0021 | [15] | |
WYneO Probe Info |
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N.A. | LDD0022 | [15] | |
1d-yne Probe Info |
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N.A. | LDD0356 | [16] | |
Compound 10 Probe Info |
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N.A. | LDD2216 | [17] | |
IPM Probe Info |
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N.A. | LDD0005 | [15] | |
NHS Probe Info |
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N.A. | LDD0010 | [15] | |
PF-06672131 Probe Info |
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N.A. | LDD0017 | [18] | |
SF Probe Info |
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Y55(0.00); Y207(0.00) | LDD0028 | [19] | |
STPyne Probe Info |
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N.A. | LDD0009 | [15] | |
Phosphinate-6 Probe Info |
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N.A. | LDD0018 | [20] | |
1c-yne Probe Info |
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K359(0.00); K162(0.00); K199(0.00); K436(0.00) | LDD0228 | [16] | |
Acrolein Probe Info |
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H308(0.00); H310(0.00); C125(0.00); C192(0.00) | LDD0217 | [21] | |
Cinnamaldehyde Probe Info |
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N.A. | LDD0220 | [21] | |
Crotonaldehyde Probe Info |
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C192(0.00); C125(0.00); H81(0.00); H308(0.00) | LDD0219 | [21] | |
Methacrolein Probe Info |
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C192(0.00); C125(0.00) | LDD0218 | [21] | |
W1 Probe Info |
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N.A. | LDD0236 | [22] | |
AOyne Probe Info |
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6.70 | LDD0443 | [23] | |
NAIA_5 Probe Info |
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C125(0.00); C192(0.00) | LDD2223 | [14] | |
TER-AC Probe Info |
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N.A. | LDD0426 | [24] | |
TPP-AC Probe Info |
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N.A. | LDD0427 | [24] |
PAL-AfBPP Probe
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0548 | 1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one | MDA-MB-231 | C192(0.91); C125(0.73) | LDD2142 | [6] |
LDCM0519 | 1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one | MDA-MB-231 | C192(0.83); C125(0.88) | LDD2112 | [6] |
LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C125(0.94) | LDD2117 | [6] |
LDCM0561 | Abegg_cp(-)-10 | HeLa | C192(2.06) | LDD0312 | [13] |
LDCM0214 | AC1 | HCT 116 | C125(1.14); C192(1.06) | LDD0531 | [7] |
LDCM0215 | AC10 | HCT 116 | C125(1.21); C192(1.29) | LDD0532 | [7] |
LDCM0216 | AC100 | HCT 116 | C125(1.51); C192(1.03) | LDD0533 | [7] |
LDCM0217 | AC101 | HCT 116 | C125(1.20); C192(0.97) | LDD0534 | [7] |
LDCM0218 | AC102 | HCT 116 | C125(1.54); C192(0.94) | LDD0535 | [7] |
LDCM0219 | AC103 | HCT 116 | C125(1.39); C192(0.91) | LDD0536 | [7] |
LDCM0220 | AC104 | HCT 116 | C125(1.80); C192(1.06) | LDD0537 | [7] |
LDCM0221 | AC105 | HCT 116 | C125(1.66); C192(1.01) | LDD0538 | [7] |
LDCM0222 | AC106 | HCT 116 | C125(1.59); C192(1.03) | LDD0539 | [7] |
LDCM0223 | AC107 | HCT 116 | C125(1.25); C192(1.04) | LDD0540 | [7] |
LDCM0224 | AC108 | HCT 116 | C125(1.19); C192(0.93) | LDD0541 | [7] |
LDCM0225 | AC109 | HCT 116 | C125(1.26); C192(1.04) | LDD0542 | [7] |
LDCM0226 | AC11 | HCT 116 | C125(1.06); C192(1.10) | LDD0543 | [7] |
LDCM0227 | AC110 | HCT 116 | C125(1.36); C192(1.01) | LDD0544 | [7] |
LDCM0228 | AC111 | HCT 116 | C125(1.31); C192(0.94) | LDD0545 | [7] |
LDCM0229 | AC112 | HCT 116 | C125(1.27); C192(0.95) | LDD0546 | [7] |
LDCM0230 | AC113 | HCT 116 | C125(1.16); C192(1.07) | LDD0547 | [7] |
LDCM0231 | AC114 | HCT 116 | C125(1.66); C192(1.03) | LDD0548 | [7] |
LDCM0232 | AC115 | HCT 116 | C125(1.50); C192(0.97) | LDD0549 | [7] |
LDCM0233 | AC116 | HCT 116 | C125(1.36); C192(0.91) | LDD0550 | [7] |
LDCM0234 | AC117 | HCT 116 | C125(1.57); C192(1.12) | LDD0551 | [7] |
LDCM0235 | AC118 | HCT 116 | C125(1.42); C192(1.28) | LDD0552 | [7] |
LDCM0236 | AC119 | HCT 116 | C125(1.17); C192(1.00) | LDD0553 | [7] |
LDCM0237 | AC12 | HCT 116 | C125(1.16); C192(1.20) | LDD0554 | [7] |
LDCM0238 | AC120 | HCT 116 | C125(1.67); C192(0.66) | LDD0555 | [7] |
LDCM0239 | AC121 | HCT 116 | C125(2.04); C192(1.10) | LDD0556 | [7] |
LDCM0240 | AC122 | HCT 116 | C125(1.67); C192(1.10) | LDD0557 | [7] |
LDCM0241 | AC123 | HCT 116 | C125(1.32); C192(0.99) | LDD0558 | [7] |
LDCM0242 | AC124 | HCT 116 | C125(1.81); C192(1.01) | LDD0559 | [7] |
LDCM0243 | AC125 | HCT 116 | C125(1.68); C192(1.13) | LDD0560 | [7] |
LDCM0244 | AC126 | HCT 116 | C125(1.47); C192(1.03) | LDD0561 | [7] |
LDCM0245 | AC127 | HCT 116 | C125(2.35); C192(1.21) | LDD0562 | [7] |
LDCM0246 | AC128 | HCT 116 | C192(1.14) | LDD0563 | [7] |
LDCM0247 | AC129 | HCT 116 | C192(1.62) | LDD0564 | [7] |
LDCM0249 | AC130 | HCT 116 | C192(1.50) | LDD0566 | [7] |
LDCM0250 | AC131 | HCT 116 | C192(1.10) | LDD0567 | [7] |
LDCM0251 | AC132 | HCT 116 | C192(1.25) | LDD0568 | [7] |
LDCM0252 | AC133 | HCT 116 | C192(1.37) | LDD0569 | [7] |
LDCM0253 | AC134 | HCT 116 | C192(1.24) | LDD0570 | [7] |
LDCM0254 | AC135 | HCT 116 | C192(1.29) | LDD0571 | [7] |
LDCM0255 | AC136 | HCT 116 | C192(1.12) | LDD0572 | [7] |
LDCM0256 | AC137 | HCT 116 | C192(1.20) | LDD0573 | [7] |
LDCM0257 | AC138 | HCT 116 | C192(1.15) | LDD0574 | [7] |
LDCM0258 | AC139 | HCT 116 | C192(1.33) | LDD0575 | [7] |
LDCM0259 | AC14 | HCT 116 | C125(1.10); C192(1.22) | LDD0576 | [7] |
LDCM0260 | AC140 | HCT 116 | C192(1.25) | LDD0577 | [7] |
LDCM0261 | AC141 | HCT 116 | C192(1.35) | LDD0578 | [7] |
LDCM0262 | AC142 | HCT 116 | C192(1.39) | LDD0579 | [7] |
LDCM0263 | AC143 | HCT 116 | C192(1.00) | LDD0580 | [7] |
LDCM0264 | AC144 | HCT 116 | C192(1.20) | LDD0581 | [7] |
LDCM0265 | AC145 | HCT 116 | C192(1.10) | LDD0582 | [7] |
LDCM0266 | AC146 | HCT 116 | C192(1.31) | LDD0583 | [7] |
LDCM0267 | AC147 | HCT 116 | C192(1.18) | LDD0584 | [7] |
LDCM0268 | AC148 | HCT 116 | C192(2.08) | LDD0585 | [7] |
LDCM0269 | AC149 | HCT 116 | C192(1.62) | LDD0586 | [7] |
LDCM0270 | AC15 | HCT 116 | C125(1.01); C192(1.07) | LDD0587 | [7] |
LDCM0271 | AC150 | HCT 116 | C192(1.15) | LDD0588 | [7] |
LDCM0272 | AC151 | HCT 116 | C192(1.14) | LDD0589 | [7] |
LDCM0273 | AC152 | HCT 116 | C192(1.26) | LDD0590 | [7] |
LDCM0274 | AC153 | HCT 116 | C192(2.06) | LDD0591 | [7] |
LDCM0621 | AC154 | HCT 116 | C192(1.23) | LDD2158 | [7] |
LDCM0622 | AC155 | HCT 116 | C192(1.32) | LDD2159 | [7] |
LDCM0623 | AC156 | HCT 116 | C192(1.26) | LDD2160 | [7] |
LDCM0624 | AC157 | HCT 116 | C192(1.24) | LDD2161 | [7] |
LDCM0276 | AC17 | HCT 116 | C192(1.15); C125(1.24) | LDD0593 | [7] |
LDCM0277 | AC18 | HCT 116 | C192(1.01); C125(1.03) | LDD0594 | [7] |
LDCM0278 | AC19 | HCT 116 | C125(0.95); C192(1.02) | LDD0595 | [7] |
LDCM0279 | AC2 | HCT 116 | C125(0.97); C192(1.10) | LDD0596 | [7] |
LDCM0280 | AC20 | HCT 116 | C192(0.99); C125(1.03) | LDD0597 | [7] |
LDCM0281 | AC21 | HCT 116 | C125(0.90); C192(0.93) | LDD0598 | [7] |
LDCM0282 | AC22 | HCT 116 | C125(1.01); C192(1.04) | LDD0599 | [7] |
LDCM0283 | AC23 | HCT 116 | C192(0.94); C125(1.09) | LDD0600 | [7] |
LDCM0284 | AC24 | HCT 116 | C125(0.95); C192(0.95) | LDD0601 | [7] |
LDCM0285 | AC25 | HCT 116 | C125(1.00); C192(1.14) | LDD0602 | [7] |
LDCM0286 | AC26 | HCT 116 | C125(1.03); C192(1.34) | LDD0603 | [7] |
LDCM0287 | AC27 | HCT 116 | C192(1.07); C125(1.09) | LDD0604 | [7] |
LDCM0288 | AC28 | HCT 116 | C192(1.06); C125(1.07) | LDD0605 | [7] |
LDCM0289 | AC29 | HCT 116 | C125(0.87); C192(0.89) | LDD0606 | [7] |
LDCM0290 | AC3 | HCT 116 | C125(1.03); C192(1.14) | LDD0607 | [7] |
LDCM0291 | AC30 | HCT 116 | C192(0.83); C125(1.07) | LDD0608 | [7] |
LDCM0292 | AC31 | HCT 116 | C125(0.92); C192(1.24) | LDD0609 | [7] |
LDCM0293 | AC32 | HCT 116 | C125(1.04); C192(1.09) | LDD0610 | [7] |
LDCM0294 | AC33 | HCT 116 | C192(0.85); C125(1.19) | LDD0611 | [7] |
LDCM0295 | AC34 | HCT 116 | C192(0.75); C125(1.15) | LDD0612 | [7] |
LDCM0296 | AC35 | HCT 116 | C192(1.10) | LDD0613 | [7] |
LDCM0297 | AC36 | HCT 116 | C192(1.14) | LDD0614 | [7] |
LDCM0298 | AC37 | HCT 116 | C192(1.14) | LDD0615 | [7] |
LDCM0299 | AC38 | HCT 116 | C192(1.07) | LDD0616 | [7] |
LDCM0300 | AC39 | HCT 116 | C192(1.09) | LDD0617 | [7] |
LDCM0301 | AC4 | HCT 116 | C192(1.18); C125(1.23) | LDD0618 | [7] |
LDCM0302 | AC40 | HCT 116 | C192(0.97) | LDD0619 | [7] |
LDCM0303 | AC41 | HCT 116 | C192(0.96) | LDD0620 | [7] |
LDCM0304 | AC42 | HCT 116 | C192(1.07) | LDD0621 | [7] |
LDCM0305 | AC43 | HCT 116 | C192(1.01) | LDD0622 | [7] |
LDCM0306 | AC44 | HCT 116 | C192(0.97) | LDD0623 | [7] |
LDCM0307 | AC45 | HCT 116 | C192(1.00) | LDD0624 | [7] |
LDCM0308 | AC46 | HCT 116 | C125(0.78); C192(0.87) | LDD0625 | [7] |
LDCM0309 | AC47 | HCT 116 | C125(1.05); C192(1.08) | LDD0626 | [7] |
LDCM0310 | AC48 | HCT 116 | C125(0.81); C192(0.90) | LDD0627 | [7] |
LDCM0311 | AC49 | HCT 116 | C125(0.93); C192(0.97) | LDD0628 | [7] |
LDCM0312 | AC5 | HCT 116 | C192(1.14); C125(1.20) | LDD0629 | [7] |
LDCM0313 | AC50 | HCT 116 | C125(0.82); C192(0.88) | LDD0630 | [7] |
LDCM0314 | AC51 | HCT 116 | C125(0.66); C192(0.95) | LDD0631 | [7] |
LDCM0315 | AC52 | HCT 116 | C125(0.81); C192(0.92) | LDD0632 | [7] |
LDCM0316 | AC53 | HCT 116 | C125(0.76); C192(1.09) | LDD0633 | [7] |
LDCM0317 | AC54 | HCT 116 | C192(0.93); C125(0.95) | LDD0634 | [7] |
LDCM0318 | AC55 | HCT 116 | C192(1.23); C125(1.37) | LDD0635 | [7] |
LDCM0319 | AC56 | HCT 116 | C125(0.88); C192(1.14) | LDD0636 | [7] |
LDCM0320 | AC57 | HCT 116 | C125(1.10); C192(1.11) | LDD0637 | [7] |
LDCM0321 | AC58 | HCT 116 | C125(1.03); C192(1.11) | LDD0638 | [7] |
LDCM0322 | AC59 | HCT 116 | C192(1.00); C125(1.05) | LDD0639 | [7] |
LDCM0323 | AC6 | HCT 116 | C125(1.06); C192(1.10) | LDD0640 | [7] |
LDCM0324 | AC60 | HCT 116 | C192(1.02); C125(1.03) | LDD0641 | [7] |
LDCM0325 | AC61 | HCT 116 | C192(1.18); C125(1.19) | LDD0642 | [7] |
LDCM0326 | AC62 | HCT 116 | C192(1.05); C125(1.07) | LDD0643 | [7] |
LDCM0327 | AC63 | HCT 116 | C125(0.97); C192(1.21) | LDD0644 | [7] |
LDCM0328 | AC64 | HCT 116 | C125(1.13); C192(1.32) | LDD0645 | [7] |
LDCM0329 | AC65 | HCT 116 | C125(1.07); C192(1.39) | LDD0646 | [7] |
LDCM0330 | AC66 | HCT 116 | C125(1.12); C192(1.20) | LDD0647 | [7] |
LDCM0331 | AC67 | HCT 116 | C192(0.94); C125(0.99) | LDD0648 | [7] |
LDCM0332 | AC68 | HCT 116 | C192(0.78) | LDD0649 | [7] |
LDCM0333 | AC69 | HCT 116 | C192(0.96) | LDD0650 | [7] |
LDCM0334 | AC7 | HCT 116 | C192(1.21); C125(1.31) | LDD0651 | [7] |
LDCM0335 | AC70 | HCT 116 | C192(1.19) | LDD0652 | [7] |
LDCM0336 | AC71 | HCT 116 | C192(1.03) | LDD0653 | [7] |
LDCM0337 | AC72 | HCT 116 | C192(1.15) | LDD0654 | [7] |
LDCM0338 | AC73 | HCT 116 | C192(1.12) | LDD0655 | [7] |
LDCM0339 | AC74 | HCT 116 | C192(1.15) | LDD0656 | [7] |
LDCM0340 | AC75 | HCT 116 | C192(1.09) | LDD0657 | [7] |
LDCM0341 | AC76 | HCT 116 | C192(1.22) | LDD0658 | [7] |
LDCM0342 | AC77 | HCT 116 | C192(0.78) | LDD0659 | [7] |
LDCM0343 | AC78 | HCT 116 | C192(0.91) | LDD0660 | [7] |
LDCM0344 | AC79 | HCT 116 | C192(1.07) | LDD0661 | [7] |
LDCM0345 | AC8 | HCT 116 | C192(0.89); C125(1.15) | LDD0662 | [7] |
LDCM0346 | AC80 | HCT 116 | C192(1.23) | LDD0663 | [7] |
LDCM0347 | AC81 | HCT 116 | C192(1.07) | LDD0664 | [7] |
LDCM0348 | AC82 | HCT 116 | C192(1.07) | LDD0665 | [7] |
LDCM0349 | AC83 | HCT 116 | C192(1.16); C125(1.17) | LDD0666 | [7] |
LDCM0350 | AC84 | HCT 116 | C192(1.02); C125(1.27) | LDD0667 | [7] |
LDCM0351 | AC85 | HCT 116 | C192(1.06); C125(1.91) | LDD0668 | [7] |
LDCM0352 | AC86 | HCT 116 | C125(0.96); C192(1.01) | LDD0669 | [7] |
LDCM0353 | AC87 | HCT 116 | C192(0.99); C125(1.46) | LDD0670 | [7] |
LDCM0354 | AC88 | HCT 116 | C192(0.90); C125(1.82) | LDD0671 | [7] |
LDCM0355 | AC89 | HCT 116 | C192(0.94); C125(1.20) | LDD0672 | [7] |
LDCM0357 | AC90 | HCT 116 | C192(1.00); C125(1.08) | LDD0674 | [7] |
LDCM0358 | AC91 | HCT 116 | C125(0.94); C192(1.06) | LDD0675 | [7] |
LDCM0359 | AC92 | HCT 116 | C125(0.95); C192(1.03) | LDD0676 | [7] |
LDCM0360 | AC93 | HCT 116 | C192(1.03); C125(1.05) | LDD0677 | [7] |
LDCM0361 | AC94 | HCT 116 | C192(1.12); C125(1.48) | LDD0678 | [7] |
LDCM0362 | AC95 | HCT 116 | C192(0.82); C125(2.40) | LDD0679 | [7] |
LDCM0363 | AC96 | HCT 116 | C192(1.10); C125(1.21) | LDD0680 | [7] |
LDCM0364 | AC97 | HCT 116 | C192(0.81); C125(0.92) | LDD0681 | [7] |
LDCM0365 | AC98 | HCT 116 | C192(0.98); C125(1.40) | LDD0682 | [7] |
LDCM0366 | AC99 | HCT 116 | C192(0.93); C125(1.46) | LDD0683 | [7] |
LDCM0248 | AKOS034007472 | HCT 116 | C125(1.16); C192(1.47) | LDD0565 | [7] |
LDCM0356 | AKOS034007680 | HCT 116 | C125(1.08); C192(1.10) | LDD0673 | [7] |
LDCM0275 | AKOS034007705 | HCT 116 | C125(0.91); C192(1.15) | LDD0592 | [7] |
LDCM0156 | Aniline | NCI-H1299 | 9.47 | LDD0403 | [5] |
LDCM0020 | ARS-1620 | HCC44 | C125(0.94) | LDD0078 | [7] |
LDCM0498 | BS-3668 | MDA-MB-231 | C192(1.27) | LDD2091 | [6] |
LDCM0108 | Chloroacetamide | HeLa | C192(0.00); C125(0.00); H308(0.00); H81(0.00) | LDD0222 | [21] |
LDCM0632 | CL-Sc | Hep-G2 | C125(0.95) | LDD2227 | [14] |
LDCM0367 | CL1 | HCT 116 | C192(0.97) | LDD0684 | [7] |
LDCM0368 | CL10 | HCT 116 | C192(1.13) | LDD0685 | [7] |
LDCM0369 | CL100 | HCT 116 | C192(1.13); C125(1.15) | LDD0686 | [7] |
LDCM0370 | CL101 | HCT 116 | C125(1.01); C192(1.04) | LDD0687 | [7] |
LDCM0371 | CL102 | HCT 116 | C125(1.20); C192(1.34) | LDD0688 | [7] |
LDCM0372 | CL103 | HCT 116 | C192(1.12); C125(1.15) | LDD0689 | [7] |
LDCM0373 | CL104 | HCT 116 | C192(1.23); C125(1.30) | LDD0690 | [7] |
LDCM0374 | CL105 | HCT 116 | C192(0.77); C125(1.21) | LDD0691 | [7] |
LDCM0375 | CL106 | HCT 116 | C192(0.89); C125(1.26) | LDD0692 | [7] |
LDCM0376 | CL107 | HCT 116 | C192(1.06); C125(1.19) | LDD0693 | [7] |
LDCM0377 | CL108 | HCT 116 | C192(0.88); C125(1.19) | LDD0694 | [7] |
LDCM0378 | CL109 | HCT 116 | C192(0.93); C125(1.13) | LDD0695 | [7] |
LDCM0379 | CL11 | HCT 116 | C192(1.16) | LDD0696 | [7] |
LDCM0380 | CL110 | HCT 116 | C192(0.90); C125(0.95) | LDD0697 | [7] |
LDCM0381 | CL111 | HCT 116 | C125(0.40); C192(0.81) | LDD0698 | [7] |
LDCM0382 | CL112 | HCT 116 | C192(0.90); C125(1.04) | LDD0699 | [7] |
LDCM0383 | CL113 | HCT 116 | C192(1.01); C125(1.05) | LDD0700 | [7] |
LDCM0384 | CL114 | HCT 116 | C192(0.80); C125(1.10) | LDD0701 | [7] |
LDCM0385 | CL115 | HCT 116 | C192(0.87); C125(1.05) | LDD0702 | [7] |
LDCM0386 | CL116 | HCT 116 | C192(0.93); C125(1.23) | LDD0703 | [7] |
LDCM0387 | CL117 | HCT 116 | C192(0.89) | LDD0704 | [7] |
LDCM0388 | CL118 | HCT 116 | C192(1.26) | LDD0705 | [7] |
LDCM0389 | CL119 | HCT 116 | C192(1.10) | LDD0706 | [7] |
LDCM0390 | CL12 | HCT 116 | C192(1.29) | LDD0707 | [7] |
LDCM0391 | CL120 | HCT 116 | C192(1.11) | LDD0708 | [7] |
LDCM0392 | CL121 | HCT 116 | C125(0.73); C192(0.94) | LDD0709 | [7] |
LDCM0393 | CL122 | HCT 116 | C192(0.98); C125(1.16) | LDD0710 | [7] |
LDCM0394 | CL123 | HCT 116 | C192(0.89); C125(1.14) | LDD0711 | [7] |
LDCM0395 | CL124 | HCT 116 | C192(0.79); C125(0.93) | LDD0712 | [7] |
LDCM0396 | CL125 | HCT 116 | C125(1.03); C192(1.33) | LDD0713 | [7] |
LDCM0397 | CL126 | HCT 116 | C125(1.07); C192(1.19) | LDD0714 | [7] |
LDCM0398 | CL127 | HCT 116 | C192(0.99); C125(1.06) | LDD0715 | [7] |
LDCM0399 | CL128 | HCT 116 | C125(1.05); C192(1.05) | LDD0716 | [7] |
LDCM0400 | CL13 | HCT 116 | C192(1.11) | LDD0717 | [7] |
LDCM0401 | CL14 | HCT 116 | C192(1.15) | LDD0718 | [7] |
LDCM0402 | CL15 | HCT 116 | C192(1.14) | LDD0719 | [7] |
LDCM0403 | CL16 | HCT 116 | C192(0.69) | LDD0720 | [7] |
LDCM0404 | CL17 | HCT 116 | C192(0.70); C125(0.77) | LDD0721 | [7] |
LDCM0405 | CL18 | HCT 116 | C192(0.84); C125(0.96) | LDD0722 | [7] |
LDCM0406 | CL19 | HCT 116 | C192(0.86); C125(1.06) | LDD0723 | [7] |
LDCM0407 | CL2 | HCT 116 | C192(0.88) | LDD0724 | [7] |
LDCM0408 | CL20 | HCT 116 | C192(0.89); C125(1.06) | LDD0725 | [7] |
LDCM0409 | CL21 | HCT 116 | C192(0.86); C125(1.42) | LDD0726 | [7] |
LDCM0410 | CL22 | HCT 116 | C192(0.69); C125(1.08) | LDD0727 | [7] |
LDCM0411 | CL23 | HCT 116 | C125(0.82); C192(0.83) | LDD0728 | [7] |
LDCM0412 | CL24 | HCT 116 | C125(1.23); C192(0.78) | LDD0729 | [7] |
LDCM0413 | CL25 | HCT 116 | C125(0.63); C192(0.66) | LDD0730 | [7] |
LDCM0414 | CL26 | HCT 116 | C125(0.93); C192(0.74) | LDD0731 | [7] |
LDCM0415 | CL27 | HCT 116 | C125(0.94); C192(1.01) | LDD0732 | [7] |
LDCM0416 | CL28 | HCT 116 | C125(1.07); C192(0.80) | LDD0733 | [7] |
LDCM0417 | CL29 | HCT 116 | C125(1.19); C192(1.05) | LDD0734 | [7] |
LDCM0418 | CL3 | HCT 116 | C192(1.17) | LDD0735 | [7] |
LDCM0419 | CL30 | HCT 116 | C125(1.18); C192(0.84) | LDD0736 | [7] |
LDCM0420 | CL31 | HCT 116 | C125(0.90); C192(1.53) | LDD0737 | [7] |
LDCM0421 | CL32 | HCT 116 | C125(0.84); C192(0.89) | LDD0738 | [7] |
LDCM0422 | CL33 | HCT 116 | C125(0.81); C192(0.99) | LDD0739 | [7] |
LDCM0423 | CL34 | HCT 116 | C125(0.74); C192(0.78) | LDD0740 | [7] |
LDCM0424 | CL35 | HCT 116 | C125(0.78); C192(0.95) | LDD0741 | [7] |
LDCM0425 | CL36 | HCT 116 | C125(0.86); C192(1.21) | LDD0742 | [7] |
LDCM0426 | CL37 | HCT 116 | C125(0.79); C192(0.97) | LDD0743 | [7] |
LDCM0428 | CL39 | HCT 116 | C125(0.81); C192(1.01) | LDD0745 | [7] |
LDCM0429 | CL4 | HCT 116 | C192(1.03) | LDD0746 | [7] |
LDCM0430 | CL40 | HCT 116 | C125(0.90); C192(0.91) | LDD0747 | [7] |
LDCM0431 | CL41 | HCT 116 | C125(0.81); C192(0.93) | LDD0748 | [7] |
LDCM0432 | CL42 | HCT 116 | C125(0.64); C192(0.72) | LDD0749 | [7] |
LDCM0433 | CL43 | HCT 116 | C125(0.82); C192(0.98) | LDD0750 | [7] |
LDCM0434 | CL44 | HCT 116 | C125(0.84); C192(0.87) | LDD0751 | [7] |
LDCM0435 | CL45 | HCT 116 | C125(0.79); C192(0.89) | LDD0752 | [7] |
LDCM0436 | CL46 | HCT 116 | C125(1.12); C192(0.99) | LDD0753 | [7] |
LDCM0437 | CL47 | HCT 116 | C125(1.11); C192(0.93) | LDD0754 | [7] |
LDCM0438 | CL48 | HCT 116 | C125(1.04); C192(1.04) | LDD0755 | [7] |
LDCM0439 | CL49 | HCT 116 | C125(1.07); C192(0.96) | LDD0756 | [7] |
LDCM0440 | CL5 | HCT 116 | C192(1.19) | LDD0757 | [7] |
LDCM0441 | CL50 | HCT 116 | C125(1.04); C192(1.04) | LDD0758 | [7] |
LDCM0442 | CL51 | HCT 116 | C125(1.03); C192(1.38) | LDD0759 | [7] |
LDCM0443 | CL52 | HCT 116 | C125(1.04); C192(1.28) | LDD0760 | [7] |
LDCM0444 | CL53 | HCT 116 | C125(1.19); C192(1.03) | LDD0761 | [7] |
LDCM0445 | CL54 | HCT 116 | C125(1.27); C192(1.11) | LDD0762 | [7] |
LDCM0446 | CL55 | HCT 116 | C125(1.01); C192(1.02) | LDD0763 | [7] |
LDCM0447 | CL56 | HCT 116 | C125(0.95); C192(0.98) | LDD0764 | [7] |
LDCM0448 | CL57 | HCT 116 | C125(1.11); C192(1.19) | LDD0765 | [7] |
LDCM0449 | CL58 | HCT 116 | C125(1.17); C192(1.07) | LDD0766 | [7] |
LDCM0450 | CL59 | HCT 116 | C125(1.10); C192(1.05) | LDD0767 | [7] |
LDCM0451 | CL6 | HCT 116 | C192(0.98) | LDD0768 | [7] |
LDCM0452 | CL60 | HCT 116 | C125(1.14); C192(0.98) | LDD0769 | [7] |
LDCM0453 | CL61 | HCT 116 | C125(1.58); C192(1.16) | LDD0770 | [7] |
LDCM0454 | CL62 | HCT 116 | C125(1.41); C192(0.92) | LDD0771 | [7] |
LDCM0455 | CL63 | HCT 116 | C125(1.25); C192(0.93) | LDD0772 | [7] |
LDCM0456 | CL64 | HCT 116 | C125(1.50); C192(0.96) | LDD0773 | [7] |
LDCM0457 | CL65 | HCT 116 | C125(1.80); C192(0.97) | LDD0774 | [7] |
LDCM0458 | CL66 | HCT 116 | C125(1.32); C192(0.87) | LDD0775 | [7] |
LDCM0459 | CL67 | HCT 116 | C125(1.37); C192(1.00) | LDD0776 | [7] |
LDCM0460 | CL68 | HCT 116 | C125(1.28); C192(0.93) | LDD0777 | [7] |
LDCM0461 | CL69 | HCT 116 | C125(1.45); C192(1.01) | LDD0778 | [7] |
LDCM0462 | CL7 | HCT 116 | C192(1.32) | LDD0779 | [7] |
LDCM0463 | CL70 | HCT 116 | C125(1.38); C192(0.90) | LDD0780 | [7] |
LDCM0464 | CL71 | HCT 116 | C125(1.30); C192(0.90) | LDD0781 | [7] |
LDCM0465 | CL72 | HCT 116 | C125(1.46); C192(1.00) | LDD0782 | [7] |
LDCM0466 | CL73 | HCT 116 | C125(1.42); C192(0.85) | LDD0783 | [7] |
LDCM0467 | CL74 | HCT 116 | C125(1.28); C192(0.94) | LDD0784 | [7] |
LDCM0469 | CL76 | HCT 116 | C125(0.81); C192(0.97) | LDD0786 | [7] |
LDCM0470 | CL77 | HCT 116 | C125(0.62); C192(0.83) | LDD0787 | [7] |
LDCM0471 | CL78 | HCT 116 | C125(0.82); C192(0.95) | LDD0788 | [7] |
LDCM0472 | CL79 | HCT 116 | C125(0.84); C192(0.96) | LDD0789 | [7] |
LDCM0473 | CL8 | HCT 116 | C192(0.98) | LDD0790 | [7] |
LDCM0474 | CL80 | HCT 116 | C125(0.88); C192(0.99) | LDD0791 | [7] |
LDCM0475 | CL81 | HCT 116 | C125(0.95); C192(0.98) | LDD0792 | [7] |
LDCM0476 | CL82 | HCT 116 | C125(1.03); C192(0.91) | LDD0793 | [7] |
LDCM0477 | CL83 | HCT 116 | C125(0.77); C192(0.88) | LDD0794 | [7] |
LDCM0478 | CL84 | HCT 116 | C125(0.77); C192(0.79) | LDD0795 | [7] |
LDCM0479 | CL85 | HCT 116 | C125(0.64); C192(0.97) | LDD0796 | [7] |
LDCM0480 | CL86 | HCT 116 | C125(0.76); C192(0.94) | LDD0797 | [7] |
LDCM0481 | CL87 | HCT 116 | C125(0.87); C192(1.02) | LDD0798 | [7] |
LDCM0482 | CL88 | HCT 116 | C125(0.83); C192(0.93) | LDD0799 | [7] |
LDCM0483 | CL89 | HCT 116 | C125(0.87); C192(0.65) | LDD0800 | [7] |
LDCM0484 | CL9 | HCT 116 | C192(0.98) | LDD0801 | [7] |
LDCM0485 | CL90 | HCT 116 | C125(0.69); C192(0.92) | LDD0802 | [7] |
LDCM0486 | CL91 | HCT 116 | C125(0.97); C192(0.86) | LDD0803 | [7] |
LDCM0487 | CL92 | HCT 116 | C125(0.67); C192(0.91) | LDD0804 | [7] |
LDCM0488 | CL93 | HCT 116 | C125(0.93); C192(1.12) | LDD0805 | [7] |
LDCM0489 | CL94 | HCT 116 | C125(0.92); C192(0.96) | LDD0806 | [7] |
LDCM0490 | CL95 | HCT 116 | C125(0.95); C192(0.93) | LDD0807 | [7] |
LDCM0491 | CL96 | HCT 116 | C125(0.85); C192(0.87) | LDD0808 | [7] |
LDCM0492 | CL97 | HCT 116 | C125(1.01); C192(0.94) | LDD0809 | [7] |
LDCM0493 | CL98 | HCT 116 | C125(1.24); C192(0.98) | LDD0810 | [7] |
LDCM0494 | CL99 | HCT 116 | C125(0.86); C192(1.03) | LDD0811 | [7] |
LDCM0189 | Compound 16 | HEK-293T | 15.67 | LDD0492 | [26] |
LDCM0185 | Compound 17 | HEK-293T | 24.06 | LDD0504 | [26] |
LDCM0182 | Compound 18 | HEK-293T | 3.49 | LDD0501 | [26] |
LDCM0184 | Compound 20 | HEK-293T | 9.27 | LDD0503 | [26] |
LDCM0191 | Compound 21 | HEK-293T | 9.65 | LDD0493 | [26] |
LDCM0186 | Compound 31 | HEK-293T | 15.26 | LDD0506 | [26] |
LDCM0187 | Compound 32 | HEK-293T | 28.43 | LDD0507 | [26] |
LDCM0188 | Compound 33 | HEK-293T | 10.51 | LDD0505 | [26] |
LDCM0190 | Compound 34 | HEK-293T | 15.02 | LDD0497 | [26] |
LDCM0192 | Compound 35 | HEK-293T | 12.56 | LDD0491 | [26] |
LDCM0193 | Compound 36 | HEK-293T | 6.94 | LDD0494 | [26] |
LDCM0194 | Compound 37 | HEK-293T | 13.75 | LDD0498 | [26] |
LDCM0195 | Compound 38 | HEK-293T | 19.17 | LDD0499 | [26] |
LDCM0196 | Compound 39 | HEK-293T | 7.40 | LDD0496 | [26] |
LDCM0197 | Compound 40 | HEK-293T | 10.41 | LDD0495 | [26] |
LDCM0181 | Compound 41 | HEK-293T | 3.29 | LDD0502 | [26] |
LDCM0495 | E2913 | HEK-293T | C125(0.89); C192(1.07) | LDD1698 | [30] |
LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C192(5.07); C125(3.05) | LDD1702 | [6] |
LDCM0625 | F8 | Ramos | C125(0.55); C192(0.53) | LDD2187 | [31] |
LDCM0572 | Fragment10 | Ramos | C125(1.28); C192(0.81) | LDD2189 | [31] |
LDCM0573 | Fragment11 | Ramos | C125(0.04); C192(0.06) | LDD2190 | [31] |
LDCM0574 | Fragment12 | Ramos | C125(1.01); C192(1.04) | LDD2191 | [31] |
LDCM0575 | Fragment13 | Ramos | C125(0.99); C192(0.88) | LDD2192 | [31] |
LDCM0576 | Fragment14 | Ramos | C125(0.34); C192(0.33) | LDD2193 | [31] |
LDCM0579 | Fragment20 | Ramos | C125(1.03); C192(1.09) | LDD2194 | [31] |
LDCM0580 | Fragment21 | Ramos | C125(0.77); C192(0.64) | LDD2195 | [31] |
LDCM0582 | Fragment23 | Ramos | C125(1.40); C192(1.12) | LDD2196 | [31] |
LDCM0578 | Fragment27 | Ramos | C125(0.92); C192(0.72) | LDD2197 | [31] |
LDCM0586 | Fragment28 | Ramos | C125(1.18); C192(1.73) | LDD2198 | [31] |
LDCM0588 | Fragment30 | Ramos | C125(1.00); C192(1.05) | LDD2199 | [31] |
LDCM0589 | Fragment31 | Ramos | C125(0.68); C192(0.63) | LDD2200 | [31] |
LDCM0590 | Fragment32 | Ramos | C125(0.79); C192(0.93) | LDD2201 | [31] |
LDCM0468 | Fragment33 | HCT 116 | C125(1.49); C192(0.94) | LDD0785 | [7] |
LDCM0596 | Fragment38 | Ramos | C125(0.67); C192(0.86) | LDD2203 | [31] |
LDCM0566 | Fragment4 | Ramos | C125(0.92); C192(0.93) | LDD2184 | [31] |
LDCM0427 | Fragment51 | HCT 116 | C125(0.76); C192(0.94) | LDD0744 | [7] |
LDCM0610 | Fragment52 | Ramos | C125(0.90); C192(1.07) | LDD2204 | [31] |
LDCM0614 | Fragment56 | Ramos | C125(1.03); C192(1.15) | LDD2205 | [31] |
LDCM0569 | Fragment7 | Ramos | C125(0.82); C192(0.68) | LDD2186 | [31] |
LDCM0571 | Fragment9 | Ramos | C125(1.13); C192(0.94) | LDD2188 | [31] |
LDCM0107 | IAA | HeLa | H308(0.00); H81(0.00); H310(0.00); C192(0.00) | LDD0221 | [21] |
LDCM0022 | KB02 | HCT 116 | C192(3.14) | LDD0080 | [7] |
LDCM0023 | KB03 | HCT 116 | C192(6.95) | LDD0081 | [7] |
LDCM0024 | KB05 | HCT 116 | C192(3.20) | LDD0082 | [7] |
LDCM0109 | NEM | HeLa | H178(0.00); H310(0.00); H212(0.00); H81(0.00) | LDD0223 | [21] |
LDCM0496 | Nucleophilic fragment 11a | MDA-MB-231 | C192(1.07) | LDD2089 | [6] |
LDCM0499 | Nucleophilic fragment 12b | MDA-MB-231 | C192(0.95) | LDD2092 | [6] |
LDCM0505 | Nucleophilic fragment 15b | MDA-MB-231 | C192(0.87) | LDD2098 | [6] |
LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C192(2.02) | LDD2099 | [6] |
LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C192(1.60) | LDD2100 | [6] |
LDCM0511 | Nucleophilic fragment 18b | MDA-MB-231 | C192(1.69) | LDD2104 | [6] |
LDCM0513 | Nucleophilic fragment 19b | MDA-MB-231 | C192(1.40); C125(0.58) | LDD2106 | [6] |
LDCM0514 | Nucleophilic fragment 20a | MDA-MB-231 | C192(2.58) | LDD2107 | [6] |
LDCM0515 | Nucleophilic fragment 20b | MDA-MB-231 | C192(0.85) | LDD2108 | [6] |
LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C125(0.72) | LDD2109 | [6] |
LDCM0521 | Nucleophilic fragment 23b | MDA-MB-231 | C192(1.14) | LDD2114 | [6] |
LDCM0526 | Nucleophilic fragment 26a | MDA-MB-231 | C192(1.93) | LDD2119 | [6] |
LDCM0527 | Nucleophilic fragment 26b | MDA-MB-231 | C192(1.02) | LDD2120 | [6] |
LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C192(2.57) | LDD2123 | [6] |
LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C192(0.95); C125(0.93) | LDD2125 | [6] |
LDCM0534 | Nucleophilic fragment 30a | MDA-MB-231 | C192(2.70); C125(1.06) | LDD2127 | [6] |
LDCM0536 | Nucleophilic fragment 31 | MDA-MB-231 | C192(1.46) | LDD2129 | [6] |
LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C192(2.09); C125(1.30) | LDD2136 | [6] |
LDCM0544 | Nucleophilic fragment 39 | MDA-MB-231 | C192(1.84) | LDD2137 | [6] |
LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C192(1.15); C125(0.56) | LDD2141 | [6] |
LDCM0550 | Nucleophilic fragment 5a | MDA-MB-231 | C192(4.28) | LDD2144 | [6] |
LDCM0551 | Nucleophilic fragment 5b | MDA-MB-231 | C192(3.44) | LDD2145 | [6] |
LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C192(0.99) | LDD2146 | [6] |
LDCM0627 | NUDT7-COV-1 | HEK-293T | C192(0.87); C125(0.71) | LDD2206 | [32] |
LDCM0628 | OTUB2-COV-1 | HEK-293T | C192(0.89); C125(0.89) | LDD2207 | [32] |
LDCM0131 | RA190 | MM1.R | C192(1.52); C125(1.41) | LDD0304 | [33] |
LDCM0021 | THZ1 | HCT 116 | C125(1.22); C192(1.02) | LDD2173 | [7] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Transporter and channel
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) | Calcium channel alpha-1 subunit (TC 1.A.1.11) family | O00555 |
Transcription factor
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
LIM/homeobox protein Lhx5 (LHX5) | . | Q9H2C1 |
Other
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
SNW domain-containing protein 1 (SNW1) | SNW family | Q13573 | |||
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) | . | Q15027 |
The Drug(s) Related To This Target
Investigative
References