Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe6  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 18  Competitor Info 
Competitor Concentration 160 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 31 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13751  Exonuclease 1 (EXO1) 13.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 12.0
 LDTP02198  Cathepsin D (CTSD) 11.9
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 11.5
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 10.6
 LDTP13702  E3 ubiquitin-protein ligase TRIM33 (TRIM33) 10.2
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 10.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 10.0
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 9.6
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 9.5
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 9.4
 LDTP04689  Adenosine kinase (ADK) 9.2
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 7.9
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 7.7
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 7.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 7.3
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 6.4
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 6.3
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 6.1
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 5.8
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 5.3
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 5.3
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 5.3
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 5.1
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 4.7
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 4.5
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 4.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 4.4
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 4.2
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 3.5
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2) 3.0
Transporter and channel
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 11.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 9.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.4
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 3.8
Other
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 18.0
 LDTP06809  Tubulin beta-8 chain (TUBB8) 10.0
 LDTP05904  Tubulin beta-3 chain (TUBB3) 7.9
 LDTP02205  Tubulin beta chain (TUBB) 7.2
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 7.1
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 7.1
 LDTP13630  Neudesin (NENF) 7.0
 LDTP11233  Tubulin beta-6 chain (TUBB6) 6.9
 LDTP03322  Bromodomain-containing protein 2 (BRD2) 6.7
 LDTP05922  Dynactin subunit 2 (DCTN2) 6.0
 LDTP02756  Junction plakoglobin (JUP) 4.0
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 4.0

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.