Details of the Target

General Information of Target

Target ID LDTP05904
Target Name Tubulin beta-3 chain (TUBB3)
Gene Name TUBB3
Gene ID 10381
Synonyms
TUBB4; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPK
Target Bioclass
Other
Family
Tubulin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord.
Uniprot ID
Q13509
Ensemble ID
ENST00000315491.12
HGNC ID
HGNC:20772
ChEMBL ID
CHEMBL2597

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.L273SfsTer12 DBIA    Probe Info 
MOLT4 SNV: p.A18S .
RKO SNV: p.R156H DBIA    Probe Info 
SKMEL5 SNV: p.F341L DBIA    Probe Info 
SNGM SNV: p.R156C DBIA    Probe Info 
SW1783 SNV: p.R62Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y51(20.00); Y106(15.26); Y36(14.00); Y50(7.14)  LDD0257  [2]
TH214
 Probe Info  		Y310(20.00); Y106(15.12); Y51(10.13)  LDD0258  [2]
TH216
 Probe Info  		Y106(20.00); Y310(20.00); Y51(17.48); Y50(15.06)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
ONAyne
 Probe Info  		K58(1.14)  LDD0274  [4]
STPyne
 Probe Info  		K58(4.34)  LDD0277  [4]
AZ-9
 Probe Info  		D74(0.84); E383(0.90)  LDD2208  [5]
Probe 1
 Probe Info  		Y36(10.77); Y50(24.07); Y159(52.68)  LDD3495  [6]
JZ128-DTB
 Probe Info  		C211(0.00); C201(0.00)  LDD0462  [7]
THZ1-DTB
 Probe Info  		C211(1.03); C201(1.04)  LDD0460  [7]
AHL-Pu-1
 Probe Info  		C303(2.15)  LDD0168  [8]
HHS-482
 Probe Info  		Y106(0.87); Y159(0.81); Y222(0.85); Y310(0.92)  LDD0285  [9]
HHS-475
 Probe Info  		Y106(0.78); Y281(0.79); Y340(0.90); Y51(0.99)  LDD0264  [10]
HHS-465
 Probe Info  		Y106(10.00); Y159(6.54); Y281(7.61); Y340(9.74)  LDD2237  [11]
DBIA
 Probe Info  		C303(1.14); C354(1.09)  LDD0078  [12]
5E-2FA
 Probe Info  		H227(0.00); H83(0.00)  LDD2235  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C354(0.00); C124(0.00); C127(0.00); C129(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C303(0.00); C12(0.00); C354(0.00)  LDD0162  [15]
IPIAA_H
 Probe Info  		C12(0.00); C303(0.00)  LDD0030  [16]
IPIAA_L
 Probe Info  		C303(0.00); C12(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [14]
ATP probe
 Probe Info  		K252(0.00); K122(0.00); K297(0.00)  LDD0035  [17]
JW-RF-010
 Probe Info  		C354(0.00); C12(0.00); C303(0.00)  LDD0026  [18]
NAIA_4
 Probe Info  		C211(0.00); C201(0.00); C12(0.00); C129(0.00)  LDD2226  [19]
WYneC
 Probe Info  		N.A.  LDD0014  [20]
IPM
 Probe Info  		C354(0.00); C129(0.00); C124(0.00); C201(0.00)  LDD2156  [21]
Phosphinate-6
 Probe Info  		C12(0.00); C303(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		C127(0.00); K362(0.00); K216(0.00); K103(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		H6(0.00); H105(0.00); C12(0.00); C354(0.00)  LDD0217  [24]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [24]
Crotonaldehyde
 Probe Info  		C12(0.00); H6(0.00); C354(0.00); H105(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C12(0.00); H105(0.00); H6(0.00); C354(0.00)  LDD0218  [24]
W1
 Probe Info  		N.A.  LDD0236  [25]
AOyne
 Probe Info  		15.00  LDD0443  [26]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C213
 Probe Info  		14.72  LDD1887  [27]
C287
 Probe Info  		14.42  LDD1957  [27]
C288
 Probe Info  		9.19  LDD1958  [27]
FFF probe11
 Probe Info  		17.99  LDD0472  [28]
FFF probe13
 Probe Info  		16.44  LDD0476  [28]
FFF probe3
 Probe Info  		10.54  LDD0464  [28]
FFF probe4
 Probe Info  		6.57  LDD0466  [28]
FFF probe6
 Probe Info  		8.75  LDD0467  [28]
STS-2
 Probe Info  		4.63  LDD0138  [29]
A-DA
 Probe Info  		2.30  LDD0143  [30]
Kambe_55
 Probe Info  		3.05  LDD0129  [31]
KIRA6 AfBP
 Probe Info  		N.A.  LDD0378  [32]
OEA-DA
 Probe Info  		5.75  LDD0046  [33]
STS-1
 Probe Info  		N.A.  LDD0068  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C303(2.15)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C201(20.00)  LDD0171  [8]
 LDCM0214  AC1 HCT 116 C12(0.95); C303(0.88)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C12(0.91); C303(1.04)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C12(1.51); C303(1.38)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C12(1.17); C303(1.23)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C12(1.27); C303(1.13)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C12(1.41); C303(1.32)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C12(1.05); C303(1.03)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C12(1.42); C303(1.24)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C12(1.41); C303(1.40)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C12(1.47); C303(1.22)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C12(1.52); C303(1.35)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C12(0.92); C303(0.94)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C12(0.83); C303(0.78)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C12(1.36); C303(1.28)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C12(1.34); C303(1.24)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C12(1.30); C303(1.28)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C12(1.04); C303(0.98)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C12(0.84); C303(0.82)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C12(0.86); C303(0.75)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C12(1.06); C303(0.81)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C12(0.79); C303(0.88)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C12(0.82); C303(1.01)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C12(1.03); C303(0.91)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C12(0.91); C303(0.92)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C12(0.78); C303(1.02)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C12(0.87); C303(0.74)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C12(0.99); C303(0.86)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C12(1.06); C303(0.63)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C12(0.94); C303(1.18)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C12(1.05); C303(1.00)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C12(0.99); C303(0.78)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C12(1.04); C303(0.90)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C12(0.82); C303(0.86)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C12(0.98); C303(1.05)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C12(1.17); C303(1.18)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C12(0.96); C303(1.01)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C12(1.10); C303(1.30)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C12(1.05); C303(1.16)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C12(1.17); C303(1.17)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C12(1.12); C303(1.06)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C12(1.19); C303(1.21)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C12(1.20); C303(1.03)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C12(1.62); C303(1.30)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C12(1.17); C303(1.23)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C12(0.86); C303(0.88)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C12(1.52); C303(1.34)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C12(1.41); C303(1.32)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C12(1.04); C303(1.15)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C12(1.11); C303(1.23)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C303(0.80); C12(1.50)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C303(0.78); C12(1.66)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C303(0.71); C12(0.98)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C303(0.91); C12(1.16)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C303(0.74); C12(1.20)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C303(0.70); C12(0.93)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C303(0.89); C12(0.91)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C12(0.77); C303(0.78)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C303(0.88); C12(1.00)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C303(0.78); C12(0.95)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C303(0.70); C12(1.30)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C12(0.95); C303(0.82)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C12(0.87); C303(0.76)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C12(0.83); C303(0.88)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C12(1.02); C303(0.74)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C12(0.94); C303(0.96)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C12(0.78); C303(0.82)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C12(0.77); C303(0.82)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C303(0.95); C12(0.95)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C303(0.93); C12(1.00)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C12(0.82); C303(0.85)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C303(0.91); C12(0.97)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C303(0.84); C12(0.85)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C303(0.93); C12(1.00)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C303(1.06); C12(1.07)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C12(1.29); C303(1.31)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C12(0.97); C303(1.27)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C12(1.10); C303(1.32)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C12(1.52); C303(1.58)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C12(0.88); C303(0.96)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C12(1.52); C303(1.59)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C12(1.11); C303(1.38)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C12(1.45); C303(1.59)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C303(1.12); C12(1.14)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C303(1.11); C12(1.27)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C303(0.75); C12(0.89)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C303(0.84); C12(0.94)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C303(0.75); C12(0.77)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C303(0.92); C12(1.03)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C303(0.89); C12(0.98)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C12(0.82); C303(0.84)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C303(0.84); C12(0.93)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C303(0.85); C12(0.96)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C303(0.86); C12(0.99)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C303(0.92); C12(1.04)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C303(0.71); C12(0.78)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C303(0.69); C12(0.77)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C12(1.24); C303(1.27)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C303(1.14); C12(1.19)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C303(1.27); C12(1.52)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C303(1.28); C12(1.54)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C12(0.81); C303(0.85)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C303(1.37); C12(1.38)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C303(1.22); C12(1.50)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C303(1.22); C12(1.47)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C12(0.95); C303(1.00)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C303(1.23); C12(1.37)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C12(1.02); C303(1.05)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C303(1.16); C12(1.25)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C12(0.94); C303(1.11)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C12(1.06); C303(1.20)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C12(0.96); C303(1.05)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C12(1.11); C303(1.11)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C12(0.96); C303(1.02)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C12(0.98); C303(1.17)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C303(0.98); C12(0.99)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C303(0.95); C12(0.95)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C12(0.83); C303(0.91)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C12(1.24); C303(1.28)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C12(1.02); C303(1.22)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C303(1.05); C12(1.20)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C12(1.02); C303(1.08)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C12(0.94); C303(1.06)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C12(0.94); C303(1.00)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C12(1.26); C303(1.29)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C12(0.89); C303(0.92)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C12(1.12); C303(1.25)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C12(1.12); C303(1.20)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C12(0.89); C303(0.95)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C12(1.12); C303(1.22)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C12(0.85); C303(0.92)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C12(1.02); C303(1.02)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C12(0.96); C303(1.01)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C12(1.09); C303(1.18)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C303(1.06); C12(1.07)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C12(0.75); C303(0.82)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C12(0.93); C303(1.01)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C12(0.86); C303(0.91)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C303(1.35); C12(1.58)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C303(1.38); C12(1.52)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C303(1.39); C12(1.55)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C303(1.34); C12(1.56)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C303(1.38); C12(1.55)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C303(1.44); C12(1.59)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C303(1.36); C12(1.46)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C303(1.46); C12(1.52)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C303(1.25); C12(1.27)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C303(1.21); C12(1.55)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C303(1.27); C12(1.38)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C303(0.93); C12(1.22)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C303(1.31); C12(1.63)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C303(0.95); C12(1.15)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C303(1.36); C12(1.53)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C303(1.39); C12(1.42)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C303(1.35); C12(1.41)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C12(0.89); C303(0.90)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C12(0.82); C303(0.90)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C12(1.12); C303(1.14)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 11.66  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C303(1.14); C354(1.09)  LDD0078  [12]
 LDCM0083  Avasimibe A-549 2.30  LDD0143  [30]
 LDCM0108  Chloroacetamide HeLa H105(0.00); C12(0.00); H6(0.00); C354(0.00)  LDD0222  [24]
 LDCM0367  CL1 HCT 116 C303(0.91); C12(1.02)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C303(0.93); C12(0.95)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C303(0.81); C12(0.96)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C12(0.88); C303(1.02)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C12(0.78); C303(0.85)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C12(0.76); C303(0.90)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C12(0.86); C303(0.87)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C303(0.84); C12(0.90)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C303(0.74); C12(0.78)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C12(0.83); C303(0.83)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C12(0.82); C303(0.86)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C303(0.83); C12(0.90)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C303(0.93); C12(0.95)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C303(0.76); C12(0.79)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C12(0.80); C303(0.81)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C12(1.02); C303(1.07)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C303(1.08); C12(1.58)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C303(1.25); C12(1.77)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C303(1.21); C12(1.40)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C303(1.14); C12(1.28)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C303(0.95); C12(1.08)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C303(0.85); C12(0.98)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C303(0.90); C12(0.98)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C12(0.94); C303(0.99)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C303(0.85); C12(1.05)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C12(1.04); C303(1.06)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C303(1.06); C12(1.17)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C12(1.03); C303(1.04)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C303(1.18); C12(1.27)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C12(1.13); C303(1.34)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C12(0.86); C303(1.08)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C12(1.11); C303(1.22)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C12(1.04); C303(1.15)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C303(1.03); C12(1.04)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C12(0.97); C303(1.01)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C12(0.98); C303(0.98)  LDD0719  [12]
 LDCM0403  CL16 HEK-293T C201(1.15); C303(1.30)  LDD1001  [12]
 LDCM0404  CL17 HEK-293T C201(0.90); C303(0.97)  LDD1002  [12]
 LDCM0405  CL18 HEK-293T C201(0.88); C303(0.95)  LDD1003  [12]
 LDCM0406  CL19 HEK-293T C201(1.08); C303(0.99)  LDD1004  [12]
 LDCM0407  CL2 HCT 116 C303(0.92); C12(0.96)  LDD0724  [12]
 LDCM0408  CL20 HEK-293T C201(0.91); C303(1.14)  LDD1006  [12]
 LDCM0409  CL21 HEK-293T C201(0.74); C303(0.91)  LDD1007  [12]
 LDCM0410  CL22 HEK-293T C201(0.66); C303(1.05)  LDD1008  [12]
 LDCM0411  CL23 HEK-293T C201(1.19); C303(1.12)  LDD1009  [12]
 LDCM0412  CL24 HEK-293T C201(1.09); C303(1.12)  LDD1010  [12]
 LDCM0413  CL25 HEK-293T C201(0.78); C303(0.90)  LDD1011  [12]
 LDCM0414  CL26 HEK-293T C201(1.35); C303(1.13)  LDD1012  [12]
 LDCM0415  CL27 HEK-293T C201(0.75); C303(1.04)  LDD1013  [12]
 LDCM0416  CL28 HEK-293T C201(0.98); C303(0.97)  LDD1014  [12]
 LDCM0417  CL29 HEK-293T C201(0.93); C303(1.04)  LDD1015  [12]
 LDCM0418  CL3 HCT 116 C12(0.88); C303(0.82)  LDD0735  [12]
 LDCM0419  CL30 HEK-293T C201(0.66); C303(0.90)  LDD1017  [12]
 LDCM0420  CL31 HCT 116 C12(0.71); C303(0.72)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C12(0.94); C303(1.00)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C12(0.96); C303(1.08)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C12(1.01); C303(1.08)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C12(1.11); C303(1.06)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C12(0.99); C303(1.01)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C12(1.01); C303(0.95)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C12(0.89); C303(0.97)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C12(0.91); C303(0.90)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C12(0.86); C303(0.82)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C12(0.92); C303(0.92)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C12(0.97); C303(0.90)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C12(0.89); C303(0.96)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C12(1.00); C303(0.97)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C12(0.92); C303(0.94)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C12(1.08); C303(1.09)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C12(1.15); C303(1.10)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C12(1.11); C303(1.14)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C12(0.91); C303(1.05)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C12(0.93); C303(0.98)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C12(1.07); C303(1.10)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C12(1.14); C303(1.08)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C12(1.07); C303(1.11)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C12(1.15); C303(0.93)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C12(1.00); C303(1.03)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C12(1.12); C303(0.94)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C12(1.19); C303(1.02)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C12(1.05); C303(1.00)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C12(1.04); C303(1.05)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C12(1.11); C303(1.06)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C12(0.92); C303(0.97)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C12(1.09); C303(1.07)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C12(1.08); C303(1.03)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C12(1.01); C303(1.02)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C12(1.05); C303(1.01)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C12(1.01); C303(1.07)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C12(1.03); C303(1.09)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C12(0.98); C303(1.03)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C12(1.02); C303(1.00)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C12(1.09); C303(0.88)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C12(1.02); C303(0.99)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C12(0.91); C303(0.92)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C12(1.08); C303(0.89)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C12(1.17); C303(0.94)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C12(1.21); C303(1.06)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C12(1.03); C303(0.91)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C12(1.01); C303(0.95)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C12(1.07); C303(0.92)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C12(1.17); C303(0.91)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C12(1.10); C303(0.95)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C12(1.04); C303(0.94)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C12(0.96); C303(0.99)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C12(1.09); C303(1.03)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C12(1.05); C303(0.97)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C12(0.90); C303(0.95)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C12(0.92); C303(0.81)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C12(1.02); C303(0.86)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C12(1.21); C303(0.87)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C12(1.23); C303(0.95)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C12(1.09); C303(0.89)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C12(1.16); C303(0.89)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C12(0.94); C303(0.90)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C12(0.97); C303(1.06)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C12(0.95); C303(0.73)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C12(1.14); C303(1.20)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C12(1.19); C303(1.03)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C12(0.91); C303(0.89)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C12(0.73); C303(0.81)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C12(0.96); C303(0.99)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C12(1.02); C303(1.09)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C12(1.07); C303(1.09)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C12(0.95); C303(1.07)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C12(0.91); C303(1.01)  LDD0811  [12]
 LDCM0189  Compound 16 HEK-293T 10.94  LDD0492  [28]
 LDCM0182  Compound 18 HEK-293T 7.91  LDD0501  [28]
 LDCM0191  Compound 21 HEK-293T 7.59  LDD0493  [28]
 LDCM0190  Compound 34 HEK-293T 12.04  LDD0497  [28]
 LDCM0192  Compound 35 HEK-293T 6.59  LDD0491  [28]
 LDCM0193  Compound 36 HEK-293T 5.39  LDD0494  [28]
 LDCM0194  Compound 37 HEK-293T 9.24  LDD0498  [28]
 LDCM0195  Compound 38 HEK-293T 6.73  LDD0499  [28]
 LDCM0196  Compound 39 HEK-293T 6.85  LDD0496  [28]
 LDCM0197  Compound 40 HEK-293T 6.02  LDD0495  [28]
 LDCM0181  Compound 41 HEK-293T 8.39  LDD0502  [28]
 LDCM0183  Compound 42 HEK-293T 5.09  LDD0500  [28]
 LDCM0495  E2913 HEK-293T C303(0.93); C12(0.86); C129(0.82)  LDD1698  [35]
 LDCM0625  F8 Ramos C354(2.62); C124(0.88); 0.96  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C354(1.05)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C354(0.00); 0.18  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C354(0.73); 1.69  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C354(0.64); C124(1.48)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C354(0.49); C124(1.00); 2.21  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C354(0.81); 3.43  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C354(0.69); 1.49  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C354(0.70); 0.72  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C354(0.60); 1.01  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C354(0.45); 1.92  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C354(0.95); 0.42  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C354(0.52); 0.95  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C354(1.02); 3.92  LDD2201  [36]
 LDCM0468  Fragment33 HCT 116 C12(1.07); C303(1.04)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C354(0.65); C124(0.74); 0.93  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C354(1.92); C124(1.39); 0.63  LDD2184  [36]
 LDCM0427  Fragment51 HCT 116 C12(0.91); C303(0.68)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C354(0.64); 0.85  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C354(0.95); 0.77  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C354(1.57); C124(1.16); 0.55  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C354(1.41); C124(0.37); 0.75  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y106(0.78); Y281(0.79); Y340(0.90); Y51(0.99)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y106(0.68); Y281(0.80); Y340(0.92); Y51(1.23)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y106(0.66); Y281(0.85); Y340(0.89); Y51(1.05)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y106(0.63); Y281(0.91); Y51(1.16); Y340(1.26)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y106(0.62); Y281(0.76); Y51(0.90); Y340(1.21)  LDD0268  [10]
 LDCM0107  IAA HeLa H105(0.00); H6(0.00); C12(0.00); C354(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y106(0.87); Y159(0.81); Y222(0.85); Y310(0.92)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y106(0.58); Y159(0.77); Y200(1.81); Y222(0.64)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y106(1.06); Y159(0.97); Y200(1.54); Y208(1.01)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y106(2.24); Y159(3.17); Y200(8.06); Y222(2.42)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y106(1.64); Y159(1.58); Y222(1.64); Y310(1.75)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y106(0.83); Y159(1.16); Y183(0.42); Y200(1.43)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y106(0.38); Y159(0.44); Y222(0.40); Y310(0.41)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y106(0.89); Y159(0.93); Y208(1.04); Y222(0.86)  LDD0292  [9]
 LDCM0179  JZ128 PC-3 C211(0.00); C201(0.00)  LDD0462  [7]
 LDCM0073  Kambe_cp3 PC-3 3.05  LDD0129  [31]
 LDCM0022  KB02 Ramos C354(1.55); 0.85  LDD2182  [36]
 LDCM0023  KB03 Jurkat C12(16.53); C303(33.20); C303(13.08); C303(8.94)  LDD0209  [37]
 LDCM0024  KB05 G361 C354(1.84)  LDD3311  [38]
 LDCM0109  NEM HeLa H105(0.00); H6(0.00); C12(0.00)  LDD0223  [24]
 LDCM0627  NUDT7-COV-1 HEK-293T C124(15.00); C127(15.00)  LDD2206  [39]
 LDCM0628  OTUB2-COV-1 HEK-293T C124(15.00); C129(0.51); C201(0.14); C211(0.14)  LDD2207  [39]
 LDCM0021  THZ1 HeLa S3 C211(1.03); C201(1.04)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tubulin alpha-1B chain (TUBA1B) Tubulin family P68363
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Netrin receptor UNC5C (UNC5C) Unc-5 family O95185
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ixabepilone Small molecular drug DB04845
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Epothilone D Small molecular drug DB01873
Patupilone Small molecular drug DB03010
Phenethyl Isothiocyanate Small molecular drug DB12695
Cyt997 . DB05147
Zen-012 . DB06042

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
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13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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32 Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor. ACS Chem Biol. 2020 Dec 18;15(12):3106-3111. doi: 10.1021/acschembio.0c00802. Epub 2020 Dec 8.
Mass spectrometry data entry: PXD022628
33 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
34 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
38 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
39 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.