Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe3  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 16  Competitor Info 
Competitor Concentration 160 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 46 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 45.5
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 44.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 40.0
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 38.1
 LDTP03842  Squalene synthase (FDFT1) 37.7
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 36.4
 LDTP02837  Beta-galactosidase (GLB1) 34.4
 LDTP13751  Exonuclease 1 (EXO1) 30.3
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 29.6
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 29.6
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 27.4
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 26.0
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 24.5
 LDTP02198  Cathepsin D (CTSD) 24.1
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 24.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 21.5
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 20.7
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 18.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 17.5
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 17.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 16.9
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 16.6
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 16.4
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 16.3
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 16.2
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 15.9
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 15.7
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 15.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 15.2
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 15.2
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 14.7
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 13.8
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 13.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 13.1
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 12.8
 LDTP13702  E3 ubiquitin-protein ligase TRIM33 (TRIM33) 12.6
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 12.5
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 11.8
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 11.6
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 11.6
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 11.3
 LDTP04183  Lanosterol synthase (LSS) 11.3
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2) 10.4
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 7.4
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 6.3
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 4.5
Transporter and channel
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 37.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 23.8
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 21.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.8
 LDTP02215  Prosaposin (PSAP) 18.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 15.5
 LDTP11213  Nucleoporin NDC1 (NDC1) 15.4
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 13.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 10.7
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 10.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 9.3
 LDTP11916  Tubulin beta-1 chain (TUBB1) 5.7
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 5.5
Other
Click to Show/Hide to Show 19 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 74.1
 LDTP02756  Junction plakoglobin (JUP) 71.4
 LDTP12412  Reticulon-4 (RTN4) 58.8
 LDTP13630  Neudesin (NENF) 40.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 34.3
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 33.3
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 30.8
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 26.5
 LDTP00105  Protein unc-119 homolog B (UNC119B) 25.3
 LDTP08224  Protein LYRIC (MTDH) 18.7
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 17.0
 LDTP11233  Tubulin beta-6 chain (TUBB6) 11.8
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 11.5
 LDTP15705  BTB/POZ domain-containing protein KCTD12 (KCTD12) 11.4
 LDTP05904  Tubulin beta-3 chain (TUBB3) 10.9
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 10.7
 LDTP02205  Tubulin beta chain (TUBB) 10.4
 LDTP09920  Golgi apparatus protein 1 (GLG1) 6.6
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 3.8

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.