Details of the Target

General Information of Target

Target ID LDTP11233
Target Name Tubulin beta-6 chain (TUBB6)
Gene Name TUBB6
Gene ID 84617
Synonyms
Tubulin beta-6 chain; Tubulin beta class V
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSASLVRATVRAVSKRKLQPTRAALTLTPSAVNKIKQLLKDKPEHVGVKVGVRTRGCNGL
SYTLEYTKTKGDSDEEVIQDGVRVFIEKKAQLTLLGTEMDYVEDKLSSEFVFNNPNIKGT
CGCGESFNI
Target Bioclass
Other
Family
Tubulin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Uniprot ID
Q9BUF5
Ensemble ID
ENST00000317702.10
HGNC ID
HGNC:20776
ChEMBL ID
CHEMBL2095182

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		4.20  LDD0215  [2]
TH211
 Probe Info  		Y36(20.00); Y50(20.00); Y59(9.26)  LDD0257  [3]
TH214
 Probe Info  		Y50(19.90); Y51(16.14)  LDD0258  [3]
TH216
 Probe Info  		Y50(20.00); Y59(20.00)  LDD0259  [3]
STPyne
 Probe Info  		K362(6.25); K379(0.76); K58(6.97)  LDD0277  [4]
BTD
 Probe Info  		C12(5.74)  LDD1699  [5]
Probe 1
 Probe Info  		Y50(9,886.60)  LDD3495  [6]
SAHA-CA-4PAP
 Probe Info  		N.A.  LDD0360  [7]
AHL-Pu-1
 Probe Info  		C303(2.15)  LDD0168  [8]
HPAP
 Probe Info  		5.86  LDD0062  [9]
HHS-482
 Probe Info  		Y222(0.91); Y310(0.92); Y50(0.93)  LDD0285  [10]
HHS-475
 Probe Info  		Y281(0.79); Y340(0.90)  LDD0264  [11]
HHS-465
 Probe Info  		Y106(9.01); Y183(10.00); Y200(3.29); Y208(10.00)  LDD2237  [12]
DBIA
 Probe Info  		C124(1.10); C127(1.10); C129(1.10); C303(1.08)  LDD0078  [13]
5E-2FA
 Probe Info  		N.A.  LDD2235  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C127(0.00); C129(0.00); C124(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C303(0.00); C201(0.00)  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		C124(0.00); C127(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		K252(0.00); K362(0.00)  LDD0035  [17]
IPM
 Probe Info  		C303(0.00); C12(0.00)  LDD0025  [18]
JW-RF-010
 Probe Info  		C303(0.00); C211(0.00); C12(0.00); C354(0.00)  LDD0026  [18]
NAIA_4
 Probe Info  		C354(0.00); C12(0.00); C129(0.00); C127(0.00)  LDD2226  [19]
TFBX
 Probe Info  		C12(0.00); C303(0.00)  LDD0027  [18]
WYneN
 Probe Info  		C303(0.00); C12(0.00)  LDD0021  [20]
1d-yne
 Probe Info  		K252(0.00); K362(0.00)  LDD0356  [21]
VSF
 Probe Info  		N.A.  LDD0007  [20]
Phosphinate-6
 Probe Info  		C303(0.00); C211(0.00); C12(0.00); C201(0.00)  LDD0018  [22]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1c-yne
 Probe Info  		K350(0.00); K216(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C12(0.00); H105(0.00); H6(0.00); C124(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [24]
Methacrolein
 Probe Info  		N.A.  LDD0218  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
NAIA_5
 Probe Info  		C12(0.00); C124(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C049
 Probe Info  		5.28  LDD1747  [26]
C159
 Probe Info  		16.22  LDD1839  [26]
C160
 Probe Info  		6.87  LDD1840  [26]
C198
 Probe Info  		28.05  LDD1874  [26]
C213
 Probe Info  		15.03  LDD1887  [26]
C264
 Probe Info  		85.63  LDD1935  [26]
C270
 Probe Info  		9.32  LDD1940  [26]
C287
 Probe Info  		16.00  LDD1957  [26]
C382
 Probe Info  		14.72  LDD2041  [26]
C390
 Probe Info  		21.56  LDD2049  [26]
C413
 Probe Info  		13.45  LDD2069  [26]
C424
 Probe Info  		11.08  LDD2079  [26]
FFF probe11
 Probe Info  		17.46  LDD0472  [27]
FFF probe13
 Probe Info  		9.77  LDD0475  [27]
FFF probe2
 Probe Info  		5.10  LDD0463  [27]
FFF probe3
 Probe Info  		11.22  LDD0464  [27]
FFF probe4
 Probe Info  		10.39  LDD0466  [27]
FFF probe6
 Probe Info  		8.07  LDD0467  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [28]
A-DA
 Probe Info  		2.24  LDD0143  [29]
Kambe_55
 Probe Info  		3.09  LDD0129  [30]
Photoindomethacin
 Probe Info  		N.A.  LDD0155  [31]
DA-2
 Probe Info  		N.A.  LDD0071  [32]
OEA-DA
 Probe Info  		5.66  LDD0046  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C12(1.14)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C12(1.50)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C12(0.63)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C12(0.46)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C12(0.71)  LDD2131  [5]
 LDCM0025  4SU-RNA HEK-293T C303(2.15)  LDD0168  [8]
 LDCM0214  AC1 HCT 116 C12(1.34); C124(0.62); C129(0.62); C303(1.23)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C12(1.12); C124(0.54); C127(0.53); C129(0.49)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C12(1.04); C124(0.96); C127(0.96); C303(0.83)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C12(0.96); C124(1.44); C127(1.44); C303(0.81)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C12(1.12); C124(1.42); C127(1.42); C303(0.89)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C12(1.21); C124(2.16); C127(2.16); C303(0.98)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C12(1.11); C124(1.20); C127(1.20); C303(0.82)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C12(1.18); C124(1.51); C127(1.51); C303(1.17)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C12(1.17); C124(1.24); C127(1.24); C303(1.11)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C12(1.11); C124(1.36); C127(1.36); C303(1.24)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C12(0.97); C124(0.90); C127(0.90); C303(0.90)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C12(0.82); C124(0.94); C127(0.94); C303(0.81)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C12(1.33); C124(0.46); C127(0.43); C129(0.42)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C12(0.89); C124(1.25); C127(1.25); C303(0.82)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C12(0.91); C124(1.11); C127(1.11); C303(0.88)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C12(1.01); C124(1.21); C127(1.21); C303(1.03)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C12(0.98); C124(0.91); C127(0.90); C129(0.90)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C12(1.12); C124(1.17); C127(0.94); C129(1.14)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C12(1.16); C124(1.47); C127(0.99); C129(1.26)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C12(1.16); C124(1.06); C127(0.86); C129(1.33)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C12(1.02); C124(0.81); C127(1.08); C129(0.87)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C12(1.06); C124(0.67); C127(1.03); C129(0.81)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C12(1.10); C124(0.77); C127(0.91); C129(0.98)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C12(1.18); C124(0.58); C127(0.52); C129(0.49)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C12(1.23); C124(1.16); C127(0.98); C129(1.16)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C12(0.95); C124(0.59); C127(1.11); C129(0.67)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C12(1.19); C124(0.87); C127(0.86); C129(1.02)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C12(0.90); C124(1.06); C127(0.67); C129(0.90)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C12(0.99); C124(1.39); C127(1.15); C129(1.18)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C12(1.11); C124(0.62); C127(0.84); C129(0.92)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C12(1.09); C124(0.83); C127(0.94); C129(0.95)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C12(1.06); C124(0.83); C127(1.22); C129(0.92)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C12(1.09); C124(1.27); C127(1.83); C129(1.55)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C12(1.04); C124(1.05); C127(2.09); C129(1.57)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C12(1.16); C124(0.99); C127(1.21); C129(1.10)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C12(0.92); C124(1.55); C127(2.29); C129(1.92)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C12(1.12); C124(0.99); C127(1.03); C129(1.01)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C12(1.14); C124(1.26); C127(1.53); C129(1.39)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C12(1.28); C124(1.74); C127(2.25); C129(2.00)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C12(1.13); C124(1.27); C127(1.28); C129(1.27)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C12(1.14); C124(1.49); C127(2.03); C129(1.76)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C12(1.21); C124(1.33); C127(2.19); C129(1.76)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C12(1.48); C124(2.23); C127(2.87); C129(2.55)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C12(1.32); C124(1.55); C127(1.64); C129(1.60)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C12(1.20); C124(0.80); C127(0.79); C129(0.80)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C12(1.46); C124(1.45); C127(2.52); C129(1.98)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C12(1.43); C124(1.71); C127(2.01); C129(1.86)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C12(1.12); C124(1.39); C127(1.60); C129(1.49)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C124(0.56); C129(0.56); C303(0.78); C12(1.08)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C124(1.01); C129(1.01); C303(1.17); C12(1.26)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C124(0.98); C129(0.98); C303(1.04); C12(1.10)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C303(1.14); C12(1.17); C124(1.21); C129(1.21)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C12(1.37); C303(1.43); C124(1.76); C129(1.76)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C124(1.05); C129(1.05); C303(1.50); C12(1.54)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C124(0.96); C129(0.96); C303(1.29); C12(1.36)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C129(0.77); C127(0.80); C124(0.86); C12(1.22)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C303(0.89); C124(0.96); C129(0.96); C12(1.13)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C124(0.71); C129(0.71); C303(0.92); C12(1.03)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C303(1.05); C12(1.50); C124(1.68); C129(1.68)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C124(0.78); C129(0.78); C303(1.37); C12(1.45)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C12(1.33); C124(1.08); C129(1.08); C303(1.28)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C12(1.18); C124(1.16); C129(1.16); C303(1.08)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C12(0.96); C124(0.81); C129(0.81); C303(0.97)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C12(0.87); C124(1.06); C129(1.06); C303(1.02)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C303(0.81); C124(0.95); C127(0.95); C129(0.95)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C303(0.94); C124(1.17); C127(1.17); C129(1.17)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C303(0.95); C12(0.99); C124(1.29); C127(1.29)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C124(0.85); C129(0.85); C12(1.22); C303(1.39)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C303(0.75); C12(0.95); C124(1.02); C127(1.02)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C303(0.73); C124(0.96); C127(0.96); C129(0.96)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C303(0.76); C124(0.81); C127(0.81); C129(0.81)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C303(0.77); C124(0.93); C127(0.93); C129(0.93)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C12(0.95); C303(1.00); C124(1.13); C127(1.13)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C127(0.81); C129(0.81); C124(0.86); C12(0.92)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C124(0.65); C127(0.69); C129(0.69); C12(1.11)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C124(0.80); C127(0.82); C129(0.82); C12(0.90)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C127(0.64); C129(0.64); C124(0.68); C12(0.94)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C12(1.14); C127(1.25); C129(1.25); C124(1.29)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C124(0.82); C129(0.82); C12(1.21); C303(1.51)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C12(1.23); C303(1.28); C127(1.28); C129(1.28)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C12(1.04); C127(1.04); C129(1.04); C124(1.25)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C127(0.81); C129(0.81); C124(0.86); C12(1.24)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C12(0.97); C127(1.26); C129(1.26); C303(1.37)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C12(1.09); C303(1.50); C127(1.84); C129(1.84)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C303(0.85); C12(0.94)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C12(0.97); C303(1.01)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C12(0.99); C303(1.03)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C12(0.93); C303(0.95)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C303(0.97); C12(1.02)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C124(0.71); C129(0.71); C12(1.34); C303(1.69)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C303(0.95); C12(1.01)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C12(1.15); C303(1.16)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C12(1.02); C303(1.06)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C303(1.02); C12(1.06)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C12(0.99); C303(1.13)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C12(1.03); C303(1.07)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C12(1.03); C303(1.07); C124(1.23); C127(1.23)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C124(0.81); C127(0.81); C12(1.05); C303(1.12)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C12(1.11); C124(1.14); C127(1.14); C303(1.39)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C124(1.10); C127(1.10); C303(1.24); C12(1.36)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C124(0.63); C129(0.63); C12(1.36); C303(1.71)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C124(1.11); C127(1.11); C12(1.25); C303(1.34)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C303(0.71); C12(0.98); C124(1.29); C127(1.29)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C303(0.95); C12(1.07); C124(1.22); C127(1.22)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C124(0.82); C127(0.82); C303(0.92); C12(1.11)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C303(0.84); C12(1.13); C124(1.37); C127(1.37)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C124(0.72); C127(0.72); C303(0.91); C12(1.18)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C124(0.96); C127(0.96); C303(0.97); C12(1.38)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C127(0.89); C129(0.96); C124(1.04); C303(1.27)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C127(1.07); C129(1.10); C124(1.14); C12(1.41)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C124(0.95); C129(0.98); C127(1.00); C303(1.31)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C129(1.01); C124(1.03); C127(1.07); C12(1.19)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C124(0.88); C129(0.92); C127(0.95); C12(1.37)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C124(0.82); C129(0.85); C127(0.88); C303(1.34)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C127(0.73); C129(0.78); C124(0.83); C303(1.50)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C124(0.77); C129(0.78); C127(0.78); C303(1.23)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C127(0.76); C129(0.78); C124(0.81); C303(1.42)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C127(0.87); C129(0.95); C124(1.03); C12(1.61)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C127(0.69); C129(0.75); C124(0.80); C303(1.18)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C127(1.07); C129(1.19); C124(1.32); C303(1.59)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C12(1.09); C303(1.15); C124(1.22); C127(1.29)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C129(0.88); C127(0.93); C124(0.93); C303(1.11)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C129(0.65); C127(0.70); C124(0.76); C12(1.09)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C129(0.90); C124(0.94); C127(1.04); C12(1.23)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C124(0.86); C127(0.93); C12(0.99); C129(1.02)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C124(0.91); C129(1.02); C12(1.09); C127(1.11)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C124(0.91); C129(0.94); C127(0.96); C12(1.21)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C124(1.05); C12(1.13); C127(1.20); C303(1.22)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C124(0.91); C127(0.92); C129(0.99); C12(1.08)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C127(0.74); C124(0.81); C129(0.87); C12(1.12)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C127(0.80); C124(0.94); C129(0.95); C12(1.08)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C127(0.72); C124(0.88); C129(0.91); C12(0.94)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C124(0.84); C129(0.99); C127(1.04); C12(1.07)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C129(0.84); C127(0.86); C124(0.88); C303(1.20)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C127(0.65); C124(0.82); C129(0.89); C12(1.04)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C124(0.93); C129(0.95); C303(0.95); C12(1.00)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C124(0.83); C129(0.97); C303(1.03); C127(1.13)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C127(0.62); C124(0.91); C129(0.91); C303(1.51)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C127(0.75); C124(0.98); C129(0.98); C303(1.58)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C127(0.73); C124(1.21); C129(1.21); C303(1.32)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C127(0.68); C124(1.10); C129(1.10); C12(1.25)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C127(0.67); C124(0.85); C129(0.85); C12(1.13)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C127(0.79); C124(0.99); C129(0.99); C12(1.24)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C127(0.75); C124(1.00); C129(1.00); C12(1.32)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C127(0.69); C124(0.74); C129(0.74); C12(1.03)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C127(0.65); C124(0.81); C129(0.81); C12(1.50)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C127(0.57); C124(0.71); C129(0.71); C12(1.56)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C127(0.76); C124(0.87); C129(0.87); C303(1.19)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C127(0.63); C124(0.78); C129(0.78); C12(1.13)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C127(0.72); C124(0.80); C129(0.80); C12(1.16)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C127(0.71); C124(0.73); C129(0.73); C12(1.21)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C127(0.82); C124(0.87); C129(0.87); C12(1.39)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C303(0.78); C12(1.18); C124(1.32); C127(1.32)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C303(0.82); C12(1.06); C124(1.07); C127(1.07)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C12(1.13); C124(0.64); C127(0.57); C129(0.55)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C129(0.53); C127(0.58); C124(0.59); C303(1.02)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C129(0.84); C124(0.85); C127(1.12); C303(1.36)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 11.71  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C124(1.10); C127(1.10); C129(1.10); C303(1.08)  LDD0078  [13]
 LDCM0083  Avasimibe A-549 2.24  LDD0143  [29]
 LDCM0498  BS-3668 MDA-MB-231 C12(0.41)  LDD2091  [5]
 LDCM0630  CCW28-3 231MFP C12(1.86)  LDD2214  [34]
 LDCM0108  Chloroacetamide HeLa C12(0.00); H105(0.00); H28(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C12(1.39); C12(0.63)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C303(0.75); C12(0.76); C124(0.79); C129(0.79)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C124(0.62); C129(0.62); C303(1.13); C12(1.36)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C124(0.64); C129(0.64); C12(1.28); C303(1.37)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C129(0.76); C127(0.79); C124(0.84); C12(1.09)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C129(0.54); C124(0.56); C127(0.60); C12(1.00)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C129(0.42); C127(0.46); C124(0.49); C12(1.00)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C129(0.67); C127(0.69); C124(0.78); C303(0.95)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C303(0.82); C124(0.91); C127(0.91); C129(0.91)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C124(0.87); C127(0.87); C129(0.87); C303(0.98)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C124(0.84); C127(0.84); C129(0.84); C303(1.15)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C124(0.66); C127(0.66); C129(0.66); C303(1.09)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C124(0.96); C127(0.96); C129(0.96); C303(0.96)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C124(0.55); C129(0.55); C303(1.07); C12(1.41)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C303(0.99); C124(1.03); C127(1.03); C129(1.03)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C303(0.96); C12(1.12); C124(1.52); C127(1.52)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C12(0.88); C303(1.07); C127(1.09); C129(1.09)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C303(1.30); C12(1.31); C127(1.47); C129(1.47)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C303(1.15); C12(1.38); C127(2.10); C129(2.10)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C303(1.03); C12(1.16); C127(1.54); C129(1.54)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C12(1.12); C303(1.29); C127(1.37); C129(1.37)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C303(0.98); C12(1.15)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C12(1.03); C303(1.09)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C303(0.99); C12(1.13)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C124(0.67); C129(0.67); C303(1.25); C12(1.27)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C303(0.97); C12(1.03)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C12(1.01); C303(1.02); C124(1.26); C127(1.26)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C303(1.05); C12(1.12); C124(1.38); C127(1.38)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C303(1.02); C12(1.04); C124(1.19); C127(1.19)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C303(1.09); C12(1.18); C124(1.55); C127(1.55)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C303(0.98); C127(0.99); C12(1.03); C129(1.14)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C127(0.90); C129(0.90); C124(0.90); C12(0.92)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C127(0.95); C129(0.98); C124(1.01); C12(1.26)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C127(1.11); C129(1.16); C124(1.21); C12(1.29)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C124(0.97); C129(0.97); C303(1.07); C12(1.21)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C124(1.03); C129(1.03); C303(1.10); C12(1.10)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C124(1.05); C129(1.05); C303(1.08); C12(1.19)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C303(1.03); C12(1.09); C127(1.40); C129(1.40)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C12(0.96); C303(0.98); C124(1.05); C127(1.06)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C303(1.01); C124(1.06); C127(1.09); C129(1.09)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C303(0.99); C12(1.04); C124(1.08); C127(1.08)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C124(0.86); C129(0.86); C303(0.99); C12(1.04)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C12(1.15); C303(1.17); C124(1.21); C127(1.24)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C303(1.07); C124(1.11); C12(1.12); C127(1.13)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C303(1.25); C12(1.29); C127(1.31); C129(1.31)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C12(1.13); C303(1.13); C127(1.31); C129(1.31)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C12(1.17); C124(1.25); C127(1.29); C129(1.29)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C12(1.19); C124(1.12); C127(1.13); C129(1.13)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C12(1.27); C124(1.33); C127(1.34); C129(1.34)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C12(1.06); C124(1.03); C127(1.06); C129(1.06)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C12(1.10); C124(1.20); C127(1.27); C129(1.27)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C12(1.15); C124(1.23); C127(1.29); C129(1.29)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C12(1.02); C124(0.95); C129(0.95); C303(1.15)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C12(1.16); C124(0.97); C127(1.02); C129(1.02)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C12(1.14); C124(0.87); C127(0.91); C129(0.87)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C12(1.29); C124(0.77); C127(0.75); C129(0.77)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C12(1.22); C124(0.70); C127(0.74); C129(0.70)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C12(1.42); C124(0.80); C127(0.91); C129(0.80)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C12(1.39); C124(1.13); C127(1.06); C129(1.13)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C12(1.40); C124(0.97); C127(1.05); C129(0.97)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C12(1.41); C124(1.26); C127(1.44); C129(1.26)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C12(1.29); C124(0.73); C127(0.74); C129(0.73)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C12(0.89); C124(1.28); C129(1.28); C303(0.97)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C12(1.33); C124(0.77); C127(0.73); C129(0.77)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C12(1.29); C124(0.98); C127(1.03); C129(0.98)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C12(1.75); C124(1.17); C127(1.25); C129(1.17)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C12(1.51); C124(0.62); C127(0.62); C129(0.62)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C12(1.41); C124(0.76); C127(0.78); C129(0.76)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C12(1.53); C124(0.69); C127(0.75); C129(0.69)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C12(0.78); C124(0.51); C127(0.50); C129(0.56)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C12(0.84); C124(0.95); C127(0.85); C129(0.95)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C12(0.89); C124(0.70); C127(0.66); C129(0.71)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C12(0.81); C124(0.52); C127(0.47); C129(0.57)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C12(1.04); C124(1.23); C129(1.23); C303(1.11)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C12(0.87); C124(0.70); C127(0.66); C129(0.76)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C12(0.84); C124(0.47); C127(0.47); C129(0.53)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C12(0.81); C124(0.54); C127(0.53); C129(0.61)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C12(0.86); C124(1.56); C127(1.82); C129(1.80)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C12(0.80); C124(0.62); C127(0.55); C129(0.62)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C12(0.86); C124(0.73); C127(0.71); C129(0.75)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C12(1.06); C124(0.91); C127(0.99); C129(1.02)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C12(0.81); C124(1.32); C127(1.23); C129(1.35)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C12(0.80); C124(0.61); C127(0.60); C129(0.69)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C12(0.96); C124(0.78); C127(0.77); C129(0.82)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C12(1.06); C124(1.08); C129(1.08); C303(1.17)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C12(0.97); C124(0.49); C127(0.47); C129(0.51)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C12(1.05); C124(0.67); C127(0.67); C129(0.74)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C12(1.13); C124(0.66); C127(0.66); C129(0.71)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C12(1.25); C124(1.09); C127(1.09); C129(1.05)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C12(1.15); C124(0.78); C127(0.78); C129(0.84)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C12(1.11); C124(0.95); C127(0.95); C129(1.00)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C12(1.45); C124(0.75); C127(0.75); C129(0.86)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C12(1.28); C124(1.20); C127(1.20); C129(1.35)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C12(1.20); C124(2.33); C127(2.33); C129(2.57)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C12(1.05); C124(0.92); C127(0.92); C129(1.04)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C12(1.22); C124(0.75); C129(0.75); C303(1.36)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C12(1.27); C124(0.97); C127(0.97); C129(1.18)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C12(1.28); C124(0.97); C127(0.97); C129(1.04)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C12(1.09); C124(1.12); C127(1.12); C129(1.22)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C12(1.18); C124(1.13); C127(1.13); C129(1.18)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C12(1.23); C124(1.15); C127(1.15); C129(1.35)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C12(1.10); C124(2.04); C127(2.11); C129(1.98)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C12(1.06); C124(2.04); C127(2.59); C129(1.48)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C12(1.15); C124(1.14); C127(1.23); C129(1.04)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C12(1.18); C124(1.45); C127(1.54); C129(1.36)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C12(1.38); C124(0.81); C129(0.81); C303(1.08)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C12(1.05); C124(1.37); C127(1.23); C129(1.51)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C12(1.13); C124(1.06); C127(1.11); C129(1.01)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C12(1.31); C124(1.21); C127(1.13); C129(1.30)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C12(1.33); C124(0.85); C127(0.82); C129(0.89)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C12(1.29); C124(0.99); C127(0.89); C129(1.09)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C12(1.16); C124(1.40); C127(1.45); C129(1.35)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C12(1.12); C124(1.83); C127(1.74); C129(1.92)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C12(1.05); C124(1.35); C127(1.26); C129(1.43)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C12(1.34); C124(1.64); C127(1.93); C129(1.35)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C12(1.39); C124(1.18); C127(1.16); C129(1.20)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C12(1.18); C124(1.02); C129(1.02); C303(1.08)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C12(0.92); C124(1.24); C127(1.43); C129(1.04)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C12(1.24); C124(1.15); C129(1.15); C303(1.27)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C12(1.19); C124(1.02); C129(1.02); C303(0.99)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C12(1.07); C124(1.18); C129(1.18); C303(1.00)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C12(1.24); C124(0.96); C129(0.96); C303(1.31)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C12(1.25); C124(1.21); C129(1.21); C303(1.12)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C12(1.14); C124(0.93); C129(0.93); C303(1.06)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C12(1.18); C124(1.10); C129(1.10); C303(1.29)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C12(1.27); C124(0.67); C129(0.67); C303(1.45)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C12(1.26); C124(0.60); C129(0.60); C303(1.31)  LDD0811  [13]
 LDCM0189  Compound 16 HEK-293T 11.79  LDD0492  [27]
 LDCM0182  Compound 18 HEK-293T 6.87  LDD0501  [27]
 LDCM0191  Compound 21 HEK-293T 7.67  LDD0493  [27]
 LDCM0190  Compound 34 HEK-293T 12.97  LDD0497  [27]
 LDCM0192  Compound 35 HEK-293T 6.69  LDD0491  [27]
 LDCM0193  Compound 36 HEK-293T 5.25  LDD0494  [27]
 LDCM0194  Compound 37 HEK-293T 9.98  LDD0498  [27]
 LDCM0195  Compound 38 HEK-293T 7.21  LDD0499  [27]
 LDCM0196  Compound 39 HEK-293T 6.62  LDD0496  [27]
 LDCM0197  Compound 40 HEK-293T 6.49  LDD0495  [27]
 LDCM0181  Compound 41 HEK-293T 7.47  LDD0502  [27]
 LDCM0183  Compound 42 HEK-293T 5.14  LDD0500  [27]
 LDCM0634  CY-0357 Hep-G2 C12(1.42); C124(1.15)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C12(0.93); C201(1.05); C129(1.14)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C12(2.80)  LDD1702  [5]
 LDCM0625  F8 Ramos C12(0.43)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C12(0.80)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C12(0.01)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C12(0.98)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C12(0.23)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C12(0.71)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C12(0.95)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C12(0.82)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C12(1.14)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C12(0.32)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C12(0.16)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C12(0.94)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C12(0.65)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C12(0.87)  LDD2201  [36]
 LDCM0468  Fragment33 HCT 116 C12(1.26); C124(0.90); C127(0.90); C129(1.03)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C12(0.62)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C12(0.74)  LDD2184  [36]
 LDCM0427  Fragment51 HCT 116 C12(1.51); C124(1.12); C127(0.94); C129(1.12)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C12(0.23)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C12(0.29)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C12(1.11)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C12(1.17)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y281(0.79); Y340(0.90)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y281(0.80); Y340(0.92)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y281(0.85); Y340(0.89)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y281(0.91); Y340(1.26)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y281(0.76); Y340(1.21)  LDD0268  [11]
 LDCM0107  IAA HeLa H105(0.00); H28(0.00); H6(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y222(0.91); Y310(0.92); Y50(0.93)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y222(0.75); Y310(0.54); Y36(0.19); Y50(1.10)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y222(1.08); Y310(1.27); Y36(0.34); Y50(1.17)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y222(2.84); Y310(2.67); Y36(1.78); Y50(2.61)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y222(1.56); Y310(1.75); Y36(0.71); Y50(1.71)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y222(1.20); Y310(1.23); Y50(1.06)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y222(0.60); Y310(0.41); Y36(0.08); Y50(0.70)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y222(1.24); Y310(1.03); Y36(0.29); Y50(0.93)  LDD0292  [10]
 LDCM0073  Kambe_cp3 PC-3 3.09  LDD0129  [30]
 LDCM0022  KB02 HCT 116 C124(3.06); C129(3.06); C127(3.06); C12(3.10)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C124(9.18); C129(9.18); C127(9.18); C12(3.89)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C124(5.44); C129(5.44); C127(5.44); C12(2.93)  LDD0082  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C12(0.75)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C12(0.47)  LDD2121  [5]
 LDCM0109  NEM HeLa H28(0.00); H105(0.00); H6(0.00); H227(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C12(0.46)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C12(0.96)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C12(0.85)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C12(1.01)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C12(0.98)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C12(0.62)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C12(1.08)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C12(1.04)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C12(1.01)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C12(0.98)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C12(0.98)  LDD2101  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C12(1.10)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C12(0.41)  LDD2106  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C12(0.74)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C12(1.24)  LDD2110  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C12(0.86)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C12(0.76)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C12(0.44)  LDD2115  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C12(3.24)  LDD2116  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C12(0.65)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C12(0.94)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C12(0.91)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C12(1.00)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C12(0.69)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C12(7.56)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C12(0.93)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C12(0.75)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C12(0.79)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C12(0.79)  LDD2135  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C12(0.92)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C12(1.73)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C12(0.63)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C12(0.71)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C12(0.81)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C12(1.90)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C12(0.75)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C12(3.03)  LDD2147  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C12(1.03)  LDD2149  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C12(0.31)  LDD2150  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C12(1.06)  LDD2151  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C12(1.90)  LDD2153  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C124(15.00); C12(1.60); C12(1.04); C354(0.14)  LDD2206  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C12(1.13); C12(0.74)  LDD2207  [37]
 LDCM0014  Panhematin HEK-293T 5.86  LDD0062  [9]
 LDCM0096  SAHA K562 N.A.  LDD0360  [7]
 LDCM0021  THZ1 HCT 116 C303(1.19); C124(1.18); C127(1.18); C129(1.18)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cyt997 . DB05147

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
30 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
31 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
32 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
33 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
34 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.