Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe3  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 34  Competitor Info 
Competitor Concentration 160 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 43.5
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 37.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 36.4
 LDTP02837  Beta-galactosidase (GLB1) 32.0
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 19.4
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 19.2
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 18.5
 LDTP02198  Cathepsin D (CTSD) 18.5
 LDTP00697  Cytochrome b5 type B (CYB5B) 18.3
 LDTP13751  Exonuclease 1 (EXO1) 17.1
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 17.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 16.9
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 16.9
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 16.8
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 16.7
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 16.7
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 16.4
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 16.1
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 15.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 15.5
 LDTP03842  Squalene synthase (FDFT1) 15.5
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 15.4
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 15.0
 LDTP04689  Adenosine kinase (ADK) 14.9
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 14.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 14.3
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 13.9
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 13.6
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 13.5
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 13.4
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 13.2
 LDTP04183  Lanosterol synthase (LSS) 12.8
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 12.3
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 12.3
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2) 11.7
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 11.5
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 10.0
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 9.2
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 8.5
 LDTP03540  Heme oxygenase 2 (HMOX2) 8.4
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 8.3
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 7.5
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 6.7
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 5.9
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 5.7
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 4.9
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 4.7
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 32.8
 LDTP11213  Nucleoporin NDC1 (NDC1) 21.3
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 18.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 18.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 17.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 17.5
 LDTP02215  Prosaposin (PSAP) 17.1
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 14.8
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 11.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 11.3
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 10.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.1
Other
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02756  Junction plakoglobin (JUP) 125.0
 LDTP12412  Reticulon-4 (RTN4) 37.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 30.3
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 22.8
 LDTP05922  Dynactin subunit 2 (DCTN2) 19.6
 LDTP13630  Neudesin (NENF) 16.7
 LDTP08224  Protein LYRIC (MTDH) 16.5
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 15.6
 LDTP11233  Tubulin beta-6 chain (TUBB6) 13.0
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) 12.9
 LDTP09920  Golgi apparatus protein 1 (GLG1) 12.7
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 12.4
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 12.3
 LDTP05904  Tubulin beta-3 chain (TUBB3) 12.0
 LDTP02205  Tubulin beta chain (TUBB) 12.0
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 11.9
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 11.6
 LDTP15705  BTB/POZ domain-containing protein KCTD12 (KCTD12) 6.9

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.