Details of the Target

General Information of Target

Target ID LDTP08224
Target Name Protein LYRIC (MTDH)
Gene Name MTDH
Gene ID 92140
Synonyms
AEG1; LYRIC; Protein LYRIC; 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALG
LLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRK
KLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSS
RHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASF
PVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAG
EEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQST
TSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIP
DDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKT
RPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPIL
QETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
TTD ID
T52547
Uniprot ID
Q86UE4
DrugMap ID
TTH6SA5
Ensemble ID
ENST00000336273.8
HGNC ID
HGNC:29608

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.99  LDD0215  [2]
FBPP2
 Probe Info  		2.02  LDD0318  [3]
TG42
 Probe Info  		23.89  LDD0326  [4]
C-Sul
 Probe Info  		2.12  LDD0066  [5]
STPyne
 Probe Info  		K107(8.45); K174(10.00); K248(10.00); K486(2.13)  LDD0277  [6]
OPA-S-S-alkyne
 Probe Info  		K195(1.36)  LDD3494  [7]
m-APA
 Probe Info  		10.90  LDD0403  [8]
Acrolein
 Probe Info  		N.A.  LDD0221  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K248(0.00); K314(0.00); K185(0.00)  LDD0199  [11]
ATP probe
 Probe Info  		N.A.  LDD0035  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
Ox-W18
 Probe Info  		N.A.  LDD2175  [14]
AOyne
 Probe Info  		4.70  LDD0443  [15]
PAL-AfBPP Probe
Click To Hide/Show 99 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.66  LDD1714  [16]
C007
 Probe Info  		5.94  LDD1716  [16]
C017
 Probe Info  		8.00  LDD1725  [16]
C022
 Probe Info  		15.78  LDD1728  [16]
C026
 Probe Info  		6.28  LDD1732  [16]
C027
 Probe Info  		11.16  LDD1733  [16]
C040
 Probe Info  		35.75  LDD1740  [16]
C041
 Probe Info  		6.15  LDD1741  [16]
C049
 Probe Info  		6.63  LDD1747  [16]
C055
 Probe Info  		15.45  LDD1752  [16]
C056
 Probe Info  		33.13  LDD1753  [16]
C063
 Probe Info  		11.00  LDD1760  [16]
C082
 Probe Info  		6.19  LDD1774  [16]
C091
 Probe Info  		25.11  LDD1782  [16]
C092
 Probe Info  		41.07  LDD1783  [16]
C094
 Probe Info  		60.55  LDD1785  [16]
C095
 Probe Info  		6.28  LDD1786  [16]
C106
 Probe Info  		48.17  LDD1793  [16]
C107
 Probe Info  		8.46  LDD1794  [16]
C108
 Probe Info  		10.63  LDD1795  [16]
C112
 Probe Info  		38.85  LDD1799  [16]
C134
 Probe Info  		39.67  LDD1816  [16]
C135
 Probe Info  		10.93  LDD1817  [16]
C139
 Probe Info  		10.85  LDD1821  [16]
C141
 Probe Info  		13.93  LDD1823  [16]
C143
 Probe Info  		16.00  LDD1825  [16]
C159
 Probe Info  		9.65  LDD1839  [16]
C160
 Probe Info  		11.39  LDD1840  [16]
C161
 Probe Info  		12.21  LDD1841  [16]
C163
 Probe Info  		6.63  LDD1843  [16]
C165
 Probe Info  		14.22  LDD1845  [16]
C169
 Probe Info  		26.54  LDD1849  [16]
C187
 Probe Info  		20.25  LDD1865  [16]
C191
 Probe Info  		14.83  LDD1868  [16]
C193
 Probe Info  		7.78  LDD1869  [16]
C196
 Probe Info  		17.27  LDD1872  [16]
C198
 Probe Info  		9.58  LDD1874  [16]
C218
 Probe Info  		44.02  LDD1892  [16]
C219
 Probe Info  		15.45  LDD1893  [16]
C220
 Probe Info  		44.94  LDD1894  [16]
C225
 Probe Info  		6.19  LDD1898  [16]
C226
 Probe Info  		8.69  LDD1899  [16]
C228
 Probe Info  		39.12  LDD1901  [16]
C229
 Probe Info  		10.13  LDD1902  [16]
C231
 Probe Info  		90.51  LDD1904  [16]
C232
 Probe Info  		57.68  LDD1905  [16]
C233
 Probe Info  		21.41  LDD1906  [16]
C234
 Probe Info  		9.19  LDD1907  [16]
C235
 Probe Info  		65.80  LDD1908  [16]
C238
 Probe Info  		27.10  LDD1911  [16]
C240
 Probe Info  		9.58  LDD1913  [16]
C243
 Probe Info  		15.24  LDD1916  [16]
C246
 Probe Info  		31.34  LDD1919  [16]
C252
 Probe Info  		9.00  LDD1925  [16]
C264
 Probe Info  		32.67  LDD1935  [16]
C265
 Probe Info  		19.16  LDD1936  [16]
C270
 Probe Info  		8.00  LDD1940  [16]
C273
 Probe Info  		5.06  LDD1943  [16]
C277
 Probe Info  		14.12  LDD1947  [16]
C282
 Probe Info  		15.89  LDD1952  [16]
C285
 Probe Info  		58.08  LDD1955  [16]
C287
 Probe Info  		19.16  LDD1957  [16]
C288
 Probe Info  		7.16  LDD1958  [16]
C289
 Probe Info  		77.71  LDD1959  [16]
C293
 Probe Info  		27.47  LDD1963  [16]
C296
 Probe Info  		15.78  LDD1966  [16]
C299
 Probe Info  		6.63  LDD1968  [16]
C310
 Probe Info  		30.70  LDD1977  [16]
C339
 Probe Info  		6.06  LDD2002  [16]
C343
 Probe Info  		15.56  LDD2005  [16]
C348
 Probe Info  		13.09  LDD2009  [16]
C349
 Probe Info  		51.98  LDD2010  [16]
C350
 Probe Info  		65.80  LDD2011  [16]
C356
 Probe Info  		10.34  LDD2017  [16]
C357
 Probe Info  		7.73  LDD2018  [16]
C362
 Probe Info  		67.18  LDD2023  [16]
C364
 Probe Info  		16.34  LDD2025  [16]
C366
 Probe Info  		15.67  LDD2027  [16]
C376
 Probe Info  		8.34  LDD2036  [16]
C382
 Probe Info  		15.14  LDD2041  [16]
C388
 Probe Info  		71.01  LDD2047  [16]
C390
 Probe Info  		32.45  LDD2049  [16]
C403
 Probe Info  		18.64  LDD2061  [16]
C407
 Probe Info  		19.29  LDD2064  [16]
C413
 Probe Info  		11.16  LDD2069  [16]
C429
 Probe Info  		14.72  LDD2084  [16]
C431
 Probe Info  		13.93  LDD2086  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
FFF probe2
 Probe Info  		20.00  LDD0463  [17]
FFF probe3
 Probe Info  		20.00  LDD0464  [17]
FFF probe4
 Probe Info  		16.47  LDD0466  [17]
JN0003
 Probe Info  		20.00  LDD0469  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]
A-DA
 Probe Info  		2.06  LDD0145  [19]
TM-F
 Probe Info  		T34(0.00); E35(0.00)  LDD0020  [20]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [21]
OEA-DA
 Probe Info  		20.00  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 10.90  LDD0403  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0189  Compound 16 HEK-293T 18.69  LDD0492  [17]
 LDCM0185  Compound 17 HEK-293T 9.52  LDD0512  [17]
 LDCM0191  Compound 21 HEK-293T 7.63  LDD0493  [17]
 LDCM0190  Compound 34 HEK-293T 16.53  LDD0497  [17]
 LDCM0192  Compound 35 HEK-293T 10.00  LDD0491  [17]
 LDCM0193  Compound 36 HEK-293T 6.56  LDD0494  [17]
 LDCM0195  Compound 38 HEK-293T 10.93  LDD0499  [17]
 LDCM0196  Compound 39 HEK-293T 4.15  LDD0496  [17]
 LDCM0197  Compound 40 HEK-293T 8.20  LDD0495  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0109  NEM HeLa N.A.  LDD0227  [9]
 LDCM0084  Ro 48-8071 A-549 2.06  LDD0145  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
CREB-binding protein (CREBBP) . Q92793
Staphylococcal nuclease domain-containing protein 1 (SND1) . Q7KZF4

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
20 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
21 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570