Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name TG42  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Liver
Disease Model Hepatocellular carcinoma [ICD-11:2C12]
Model Name Human hepatocellular carcinoma cells (Huh-7)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02798  NAD(P)H dehydrogenase [quinone] 1 (NQO1) 89.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 51.5
 LDTP00697  Cytochrome b5 type B (CYB5B) 20.8
 LDTP06104  Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) 13.3
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 10.4
 LDTP12734  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (OXSM) 9.1
 LDTP03145  Catechol O-methyltransferase (COMT) 7.7
 LDTP02383  Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) 6.7
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) 6.6
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 5.9
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 5.8
 LDTP00616  Protein phosphatase 1G (PPM1G) 5.1
 LDTP12046  Ubiquitin-conjugating enzyme E2 Z (UBE2Z) 5.0
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 5.0
 LDTP02386  Fructose-bisphosphate aldolase C (ALDOC) 4.6
 LDTP02406  DNA-directed RNA polymerase II subunit GRINL1A (POLR2M) 4.5
 LDTP08858  Probable hydrolase PNKD (PNKD) 4.3
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 4.2
Transporter and channel
Click to Show/Hide to Show 27 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10148  Store-operated calcium entry-associated regulatory factor (SARAF) 63.6
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 24.5
 LDTP00777  Prominin-1 (PROM1) 16.3
 LDTP10065  Transmembrane protein 230 (TMEM230) 13.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 13.0
 LDTP12191  Vezatin (VEZT) 10.7
 LDTP15838  Translocation protein SEC62 (SEC62) 10.7
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 10.6
 LDTP00127  Nuclear envelope pore membrane protein POM 121C (POM121C) 9.0
 LDTP12938  Leucine-rich repeat transmembrane protein FLRT3 (FLRT3) 8.8
 LDTP02352  Clathrin light chain A (CLTA) 8.5
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 8.4
 LDTP04393  Annexin A11 (ANXA11) 8.2
 LDTP01185  V-type proton ATPase subunit G 1 (ATP6V1G1) 7.7
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 7.4
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 6.3
 LDTP04866  Protein transport protein Sec61 subunit beta (SEC61B) 5.5
 LDTP04512  Cationic amino acid transporter 2 (SLC7A2) 5.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 5.0
 LDTP07002  Transport and Golgi organization protein 1 homolog (MIA3) 4.9
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 4.4
 LDTP02122  Integrin beta-1 (ITGB1) 4.4
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 4.3
 LDTP00014  Extended synaptotagmin-2 (ESYT2) 4.3
 LDTP01936  Apolipoprotein E (APOE) 4.2
 LDTP11615  Protein tweety homolog 3 (TTYH3) 4.2
 LDTP06549  Hsp90 co-chaperone Cdc37 (CDC37) 4.1
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06748  Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) 9.0
 LDTP05644  Sterol regulatory element-binding protein 2 (SREBF2) 5.6
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04387  Basal cell adhesion molecule (BCAM) 26.7
Other
Click to Show/Hide to Show 33 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01959  Protein AMBP (AMBP) 51.9
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 40.4
 LDTP12412  Reticulon-4 (RTN4) 34.1
 LDTP08224  Protein LYRIC (MTDH) 23.9
 LDTP15599  UPF0729 protein C18orf32 (C18orf32) 23.0
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 13.8
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 12.5
 LDTP01210  Transforming acidic coiled-coil-containing protein 1 (TACC1) 8.4
 LDTP01522  Reticulon-3 (RTN3) 8.0
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 8.0
 LDTP03503  Myristoylated alanine-rich C-kinase substrate (MARCKS) 7.2
 LDTP04224  MARCKS-related protein (MARCKSL1) 7.1
 LDTP10091  Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) 6.0
 LDTP14421  Ladinin-1 (LAD1) 5.8
 LDTP11076  Apolipoprotein L2 (APOL2) 5.8
 LDTP10889  Perilipin-2 (PLIN2) 5.4
 LDTP10753  Sperm-associated antigen 5 (SPAG5) 5.3
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 4.9
 LDTP01184  Tubulin-specific chaperone A (TBCA) 4.8
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) 4.7
 LDTP04722  BH3-interacting domain death agonist (BID) 4.7
 LDTP04880  Small ribosomal subunit protein uS10 (RPS20) 4.6
 LDTP01964  Alpha-fetoprotein (AFP) 4.6
 LDTP12544  Serine incorporator 1 (SERINC1) 4.6
 LDTP19963  TraB domain-containing protein (TRABD) 4.6
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 4.6
 LDTP11737  Nonsense-mediated mRNA decay factor SMG9 (SMG9) 4.5
 LDTP11737  Nonsense-mediated mRNA decay factor SMG9 (SMG9) 4.5
 LDTP05179  SAP domain-containing ribonucleoprotein (SARNP) 4.4
 LDTP11695  Kinesin light chain 2 (KLC2) 4.4
 LDTP11019  Endophilin-A2 (SH3GL1) 4.3
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 4.2
 LDTP01296  Protein XRP2 (RP2) 4.1

References

1 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277