Details of the Target

General Information of Target

Target ID LDTP01184
Target Name Tubulin-specific chaperone A (TBCA)
Gene Name TBCA
Gene ID 6902
Synonyms
Tubulin-specific chaperone A; TCP1-chaperonin cofactor A; Tubulin-folding cofactor A; CFA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADPRVRQIKIKTGVVKRLVKEKVMYEKEAKQQEEKIEKMRAEDGENYDIKKQAEILQES
RMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA
Target Bioclass
Other
Family
TBCA family
Subcellular location
Cytoplasm, cytoskeleton
Function Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
Uniprot ID
O75347
Ensemble ID
ENST00000306388.10
HGNC ID
HGNC:11579

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE410 SNV: p.L99Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.87  LDD0402  [1]
P2
 Probe Info  		10.00  LDD0449  [2]
P3
 Probe Info  		10.00  LDD0450  [2]
P8
 Probe Info  		10.00  LDD0451  [2]
A-EBA
 Probe Info  		3.89  LDD0215  [3]
TG42
 Probe Info  		4.82  LDD0326  [4]
TH211
 Probe Info  		Y48(7.36)  LDD0260  [5]
TH214
 Probe Info  		Y94(11.22)  LDD0258  [5]
TH216
 Probe Info  		Y94(5.78)  LDD0259  [5]
STPyne
 Probe Info  		K12(7.05); K17(8.75); K28(7.42); K31(10.00)  LDD0277  [6]
AZ-9
 Probe Info  		E46(0.74); E72(1.03); E59(1.38); Y75(1.03)  LDD2208  [7]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
Probe 1
 Probe Info  		Y48(53.15); Y75(14.78); Y94(25.47)  LDD3495  [8]
BTD
 Probe Info  		C67(1.04)  LDD2090  [9]
HHS-475
 Probe Info  		Y48(0.87)  LDD0264  [10]
HHS-465
 Probe Info  		Y48(10.00); Y75(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C67(1.17)  LDD0080  [12]
ATP probe
 Probe Info  		K28(0.00); K51(0.00); K52(0.00); K95(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
NHS
 Probe Info  		N.A.  LDD0010  [17]
SF
 Probe Info  		Y75(0.00); Y48(0.00); K28(0.00); K52(0.00)  LDD0028  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
1d-yne
 Probe Info  		N.A.  LDD0357  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
W1
 Probe Info  		N.A.  LDD0236  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C67(1.29)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C67(1.05)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C67(0.99)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C67(0.95)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C67(1.00)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C67(1.10)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C67(1.01)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C67(1.02)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C67(0.92)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C67(1.13)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C67(0.79)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C67(0.72)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C67(1.28)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C67(0.87)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C67(0.90)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C67(0.87)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C67(0.77)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C67(1.28)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C67(0.68)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C67(0.80)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C67(0.49)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C67(0.38)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C67(0.45)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C67(1.26)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C67(0.52)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C67(0.74)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C67(0.52)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C67(0.48)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C67(0.81)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C67(0.83)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C67(0.52)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C67(0.62)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C67(0.63)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C67(0.70)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C67(0.81)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C67(0.75)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C67(0.95)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C67(0.84)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C67(0.81)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C67(0.79)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C67(0.93)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C67(0.79)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C67(0.87)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C67(0.86)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C67(1.24)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C67(1.11)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C67(1.00)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C67(1.00)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C67(1.32)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C67(1.12)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C67(1.24)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C67(1.42)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C67(1.12)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C67(1.47)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C67(1.53)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C67(1.31)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C67(1.21)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C67(1.27)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C67(1.42)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C67(1.50)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C67(1.20)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C67(1.53)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C67(1.54)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C67(1.34)  LDD2161  [12]
 LDCM0276  AC17 HEK-293T C67(1.26)  LDD0874  [12]
 LDCM0277  AC18 HEK-293T C67(1.23)  LDD0875  [12]
 LDCM0278  AC19 HEK-293T C67(1.20)  LDD0876  [12]
 LDCM0279  AC2 HCT 116 C67(1.34)  LDD0596  [12]
 LDCM0280  AC20 HEK-293T C67(1.33)  LDD0878  [12]
 LDCM0281  AC21 HEK-293T C67(1.13)  LDD0879  [12]
 LDCM0282  AC22 HEK-293T C67(1.19)  LDD0880  [12]
 LDCM0283  AC23 HEK-293T C67(1.00)  LDD0881  [12]
 LDCM0284  AC24 HEK-293T C67(1.03)  LDD0882  [12]
 LDCM0285  AC25 HCT 116 C67(1.16)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C67(1.49)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C67(1.58)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C67(1.47)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C67(1.35)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C67(1.10)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C67(1.51)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C67(1.47)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C67(1.75)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C67(1.55)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C67(1.62)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C67(0.72)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C67(0.81)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C67(0.85)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C67(0.88)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C67(0.71)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C67(1.34)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C67(0.73)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C67(1.14)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C67(1.05)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C67(1.07)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C67(0.93)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C67(0.80)  LDD0624  [12]
 LDCM0308  AC46 HEK-293T C67(1.16)  LDD0906  [12]
 LDCM0309  AC47 HEK-293T C67(1.11)  LDD0907  [12]
 LDCM0310  AC48 HEK-293T C67(1.08)  LDD0908  [12]
 LDCM0311  AC49 HEK-293T C67(1.03)  LDD0909  [12]
 LDCM0312  AC5 HCT 116 C67(1.38)  LDD0629  [12]
 LDCM0313  AC50 HEK-293T C67(1.03)  LDD0911  [12]
 LDCM0314  AC51 HEK-293T C67(1.72)  LDD0912  [12]
 LDCM0315  AC52 HEK-293T C67(1.15)  LDD0913  [12]
 LDCM0316  AC53 HEK-293T C67(1.42)  LDD0914  [12]
 LDCM0317  AC54 HEK-293T C67(1.37)  LDD0915  [12]
 LDCM0318  AC55 HEK-293T C67(1.31)  LDD0916  [12]
 LDCM0319  AC56 HEK-293T C67(1.16)  LDD0917  [12]
 LDCM0320  AC57 HCT 116 C67(0.87)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C67(0.93)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C67(0.96)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C67(0.95)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C67(1.03)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C67(1.07)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C67(0.98)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C67(0.85)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C67(0.98)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C67(1.05)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C67(0.90)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C67(1.12)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C67(0.97)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C67(1.08)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C67(1.01)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C67(1.27)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C67(1.13)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C67(1.12)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C67(1.09)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C67(0.99)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C67(1.30)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C67(1.00)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C67(1.24)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C67(1.15)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C67(1.32)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C67(1.37)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C67(1.18)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C67(1.31)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C67(1.15)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C67(0.96)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C67(0.94)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C67(0.95)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C67(1.05)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C67(1.05)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C67(1.02)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C67(1.12)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C67(1.04)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C67(1.08)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C67(1.01)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C67(1.01)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C67(1.08)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C67(1.00)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C67(0.92)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C67(1.19)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C67(0.86)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C67(0.83)  LDD0683  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C67(1.06)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C67(1.19)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C67(1.13)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C67(1.36)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 10.69  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [21]
 LDCM0367  CL1 HCT 116 C67(0.73)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C67(1.04)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C67(1.26)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C67(1.08)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C67(0.99)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C67(1.30)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C67(1.26)  LDD0690  [12]
 LDCM0374  CL105 HEK-293T C67(0.98)  LDD0972  [12]
 LDCM0375  CL106 HEK-293T C67(1.25)  LDD0973  [12]
 LDCM0376  CL107 HEK-293T C67(1.18)  LDD0974  [12]
 LDCM0377  CL108 HEK-293T C67(1.07)  LDD0975  [12]
 LDCM0378  CL109 HEK-293T C67(1.19)  LDD0976  [12]
 LDCM0379  CL11 HCT 116 C67(1.10)  LDD0696  [12]
 LDCM0380  CL110 HEK-293T C67(1.21)  LDD0978  [12]
 LDCM0381  CL111 HEK-293T C67(1.10)  LDD0979  [12]
 LDCM0382  CL112 HCT 116 C67(1.16)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C67(1.34)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C67(1.20)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C67(1.37)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C67(1.61)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C67(0.74)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C67(0.98)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C67(0.95)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C67(1.13)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C67(0.94)  LDD0708  [12]
 LDCM0392  CL121 HEK-293T C67(1.17)  LDD0990  [12]
 LDCM0393  CL122 HEK-293T C67(1.20)  LDD0991  [12]
 LDCM0394  CL123 HEK-293T C67(0.95)  LDD0992  [12]
 LDCM0395  CL124 HEK-293T C67(1.14)  LDD0993  [12]
 LDCM0396  CL125 HCT 116 C67(0.99)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C67(0.83)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C67(1.05)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C67(0.99)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C67(0.95)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C67(0.87)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C67(0.63)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C67(1.24)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C67(0.85)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C67(0.92)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C67(1.00)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C67(0.82)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C67(1.17)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C67(0.95)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C67(1.59)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C67(1.17)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C67(1.33)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C67(1.15)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C67(0.91)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C67(1.14)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C67(1.21)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C67(1.15)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C67(0.84)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C67(1.12)  LDD0736  [12]
 LDCM0420  CL31 HEK-293T C67(1.05)  LDD1018  [12]
 LDCM0421  CL32 HEK-293T C67(0.95)  LDD1019  [12]
 LDCM0422  CL33 HEK-293T C67(0.75)  LDD1020  [12]
 LDCM0423  CL34 HEK-293T C67(0.83)  LDD1021  [12]
 LDCM0424  CL35 HEK-293T C67(0.97)  LDD1022  [12]
 LDCM0425  CL36 HEK-293T C67(0.87)  LDD1023  [12]
 LDCM0426  CL37 HEK-293T C67(1.23)  LDD1024  [12]
 LDCM0428  CL39 HEK-293T C67(0.88)  LDD1026  [12]
 LDCM0429  CL4 HCT 116 C67(1.00)  LDD0746  [12]
 LDCM0430  CL40 HEK-293T C67(0.79)  LDD1028  [12]
 LDCM0431  CL41 HEK-293T C67(0.81)  LDD1029  [12]
 LDCM0432  CL42 HEK-293T C67(0.88)  LDD1030  [12]
 LDCM0433  CL43 HEK-293T C67(0.89)  LDD1031  [12]
 LDCM0434  CL44 HEK-293T C67(0.94)  LDD1032  [12]
 LDCM0435  CL45 HEK-293T C67(0.83)  LDD1033  [12]
 LDCM0436  CL46 HCT 116 C67(1.02)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C67(0.99)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C67(0.98)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C67(0.91)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C67(0.96)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C67(0.94)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C67(0.91)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C67(0.96)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C67(1.02)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C67(0.84)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C67(0.97)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C67(0.87)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C67(1.00)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C67(1.01)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C67(1.09)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C67(0.85)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C67(0.98)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C67(0.98)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C67(0.88)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C67(1.12)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C67(1.46)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C67(1.35)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C67(1.51)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C67(1.17)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C67(1.04)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C67(1.15)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C67(1.11)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C67(1.25)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C67(1.05)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C67(1.17)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C67(1.28)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C67(1.21)  LDD0784  [12]
 LDCM0469  CL76 HEK-293T C67(1.58)  LDD1067  [12]
 LDCM0470  CL77 HEK-293T C67(1.81)  LDD1068  [12]
 LDCM0471  CL78 HEK-293T C67(2.01)  LDD1069  [12]
 LDCM0472  CL79 HEK-293T C67(1.11)  LDD1070  [12]
 LDCM0473  CL8 HCT 116 C67(1.24)  LDD0790  [12]
 LDCM0474  CL80 HEK-293T C67(1.87)  LDD1072  [12]
 LDCM0475  CL81 HEK-293T C67(1.85)  LDD1073  [12]
 LDCM0476  CL82 HEK-293T C67(1.69)  LDD1074  [12]
 LDCM0477  CL83 HEK-293T C67(1.70)  LDD1075  [12]
 LDCM0478  CL84 HEK-293T C67(1.63)  LDD1076  [12]
 LDCM0479  CL85 HEK-293T C67(1.99)  LDD1077  [12]
 LDCM0480  CL86 HEK-293T C67(1.89)  LDD1078  [12]
 LDCM0481  CL87 HEK-293T C67(1.93)  LDD1079  [12]
 LDCM0482  CL88 HEK-293T C67(1.65)  LDD1080  [12]
 LDCM0483  CL89 HEK-293T C67(2.21)  LDD1081  [12]
 LDCM0484  CL9 HCT 116 C67(1.03)  LDD0801  [12]
 LDCM0485  CL90 HEK-293T C67(1.50)  LDD1083  [12]
 LDCM0486  CL91 HCT 116 C67(1.21)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C67(1.15)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C67(0.97)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C67(1.16)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C67(1.30)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C67(1.20)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C67(1.16)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C67(1.22)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C67(1.20)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C67(0.95)  LDD1698  [23]
 LDCM0468  Fragment33 HCT 116 C67(1.26)  LDD0785  [12]
 LDCM0427  Fragment51 HEK-293T C67(0.96)  LDD1025  [12]
 LDCM0116  HHS-0101 DM93 Y48(0.87)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y48(0.69)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y48(0.84)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y48(0.76)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y48(0.97)  LDD0268  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0022  KB02 HCT 116 C67(1.17)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C67(1.13)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C67(1.24)  LDD0082  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C67(1.04)  LDD2090  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C67(0.67)  LDD2097  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C67(1.01)  LDD2099  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C67(1.60)  LDD2101  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C67(0.81)  LDD2115  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C67(1.04)  LDD2120  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C67(0.97)  LDD2123  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C67(0.74)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C67(1.10)  LDD2128  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C67(1.00)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C67(0.55)  LDD2134  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C67(1.36)  LDD2136  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C67(0.98)  LDD2143  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C67(1.84)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C67(0.66)  LDD2148  [9]
 LDCM0131  RA190 MM1.R C67(1.20)  LDD0304  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.