Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name P8  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Skin
Disease Model Skin squamous cell carcinoma [ICD-11:2C31]
Model Name Human skin squamous cell carcinoma cells (A431)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) 10.0
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 10.0
 LDTP05550  ATP-dependent RNA helicase A (DHX9) 10.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 10.0
 LDTP03669  Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) 10.0
 LDTP02567  DNA topoisomerase 1 (TOP1) 10.0
 LDTP12922  EH domain-containing protein 3 (EHD3) 10.0
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) 10.0
 LDTP03907  Malate dehydrogenase, cytoplasmic (MDH1) 10.0
 LDTP03908  Malate dehydrogenase, mitochondrial (MDH2) 10.0
 LDTP04898  NEDD8-conjugating enzyme Ubc12 (UBE2M) 10.0
 LDTP12469  Nucleolar RNA helicase 2 (DDX21) 10.0
 LDTP13831  Phenylalanine--tRNA ligase alpha subunit (FARSA) 10.0
 LDTP09899  Probable ATP-dependent RNA helicase DDX17 (DDX17) 10.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) 10.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) 10.0
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 10.0
 LDTP02502  Thioredoxin (TXN) 10.0
 LDTP04665  Transitional endoplasmic reticulum ATPase (VCP) 10.0
 LDTP06067  Tubulin--tyrosine ligase-like protein 12 (TTLL12) 10.0
 LDTP02188  Protein disulfide-isomerase (P4HB) 8.2
 LDTP04375  Methionine aminopeptidase 2 (METAP2) 5.5
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 4.5
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) 4.4
 LDTP02001  Catalase (CAT) 4.4
 LDTP13029  Serine/threonine-protein kinase PAK 5 (PAK5) 3.5
 LDTP03847  Transaldolase (TALDO1) 3.4
 LDTP04399  Ras-related protein Rab-7a (RAB7A) 3.0
 LDTP02162  Glucose-6-phosphate isomerase (GPI) 2.9
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) 2.7
 LDTP02924  Probable ATP-dependent RNA helicase DDX5 (DDX5) 2.6
 LDTP05073  Actin, alpha skeletal muscle (ACTA1) 2.5
 LDTP02159  Alpha-enolase (ENO1) 2.3
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) 2.2
 LDTP05812  Ras GTPase-activating protein-binding protein 1 (G3BP1) 2.1
 LDTP01785  Epidermal growth factor receptor (EGFR) 1.9
 LDTP03764  Myosin-9 (MYH9) 1.8
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) 1.8
 LDTP02179  L-lactate dehydrogenase B chain (LDHB) 1.8
 LDTP05503  Peroxiredoxin-1 (PRDX1) 1.8
 LDTP07932  Probable ATP-dependent RNA helicase DDX46 (DDX46) 1.7
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) 1.7
 LDTP01768  Glutamate dehydrogenase 1, mitochondrial (GLUD1) 1.7
 LDTP04851  Triosephosphate isomerase (TPI1) 1.7
 LDTP03216  Peptidyl-prolyl cis-trans isomerase B (PPIB) 1.6
 LDTP15029  Putative elongation factor 1-alpha-like 3 (EEF1A1P5) 1.6
 LDTP03487  Transketolase (TKT) 1.6
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) 1.5
Transporter and channel
Click to Show/Hide to Show 27 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04969  14-3-3 protein epsilon (YWHAE) 10.0
 LDTP04393  Annexin A11 (ANXA11) 10.0
 LDTP03405  Calnexin (CANX) 10.0
 LDTP01037  Catenin delta-1 (CTNND1) 10.0
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 10.0
 LDTP05292  Fatty acid-binding protein 5 (FABP5) 10.0
 LDTP00328  Importin subunit alpha-3 (KPNA4) 10.0
 LDTP05273  Spectrin beta chain, non-erythrocytic 1 (SPTBN1) 10.0
 LDTP04391  T-complex protein 1 subunit delta (CCT4) 10.0
 LDTP08274  THO complex subunit 4 (ALYREF) 10.0
 LDTP04885  Protein S100-A10 (S100A10) 7.4
 LDTP03402  Calreticulin (CALR) 7.3
 LDTP06203  Major vault protein (MVP) 6.0
 LDTP02010  Annexin A1 (ANXA1) 4.9
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 4.3
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) 4.0
 LDTP06350  RNA-binding protein with serine-rich domain 1 (RNPS1) 3.3
 LDTP02199  Annexin A2 (ANXA2) 3.2
 LDTP05043  14-3-3 protein zeta/delta (YWHAZ) 3.1
 LDTP02959  Protein SON (SON) 2.4
 LDTP03107  Filamin-A (FLNA) 2.3
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) 2.3
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) 1.9
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 1.9
 LDTP08637  Serine/arginine repetitive matrix protein 1 (SRRM1) 1.7
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 1.7
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 1.6
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05194  Enhancer of rudimentary homolog (ERH) 10.0
 LDTP02886  High mobility group protein HMG-I/HMG-Y (HMGA1) 10.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) 2.3
 LDTP03212  Splicing factor, proline- and glutamine-rich (SFPQ) 1.5
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 10.0
Other
Click to Show/Hide to Show 107 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04931  10 kDa heat shock protein, mitochondrial (HSPE1) 10.0
 LDTP14866  Adipogenesis regulatory factor (ADIRF) 10.0
 LDTP02699  Annexin A8 (ANXA8) 10.0
 LDTP12937  Calmodulin-like protein 5 (CALML5) 10.0
 LDTP06121  Caprin-1 (CAPRIN1) 10.0
 LDTP07495  Caveolae-associated protein 1 (CAVIN1) 10.0
 LDTP03499  Elongation factor 1-delta (EEF1D) 10.0
 LDTP03953  Eukaryotic translation initiation factor 1 (EIF1) 10.0
 LDTP05421  Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) 10.0
 LDTP04743  Eukaryotic translation initiation factor 6 (EIF6) 10.0
 LDTP04544  F-actin-capping protein subunit alpha-1 (CAPZA1) 10.0
 LDTP02974  Keratin, type I cytoskeletal 15 (KRT15) 10.0
 LDTP02308  Keratin, type I cytoskeletal 16 (KRT16) 10.0
 LDTP02125  Keratin, type II cytoskeletal 8 (KRT8) 10.0
 LDTP05974  Laminin subunit beta-3 (LAMB3) 10.0
 LDTP05975  Laminin subunit gamma-2 (LAMC2) 10.0
 LDTP02108  Large ribosomal subunit protein P2 (RPLP2) 10.0
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) 10.0
 LDTP04027  Matrin-3 (MATR3) 10.0
 LDTP04041  Melanoma-associated antigen 4 (MAGEA4) 10.0
 LDTP03346  Moesin (MSN) 10.0
 LDTP01993  Muellerian-inhibiting factor (AMH) 10.0
 LDTP13817  Nuclear migration protein nudC (NUDC) 10.0
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 10.0
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 10.0
 LDTP02691  Plastin-2 (LCP1) 10.0
 LDTP17266  Pre-mRNA-splicing factor 38B (PRPF38B) 10.0
 LDTP01932  Prelamin-A/C (LMNA) 10.0
 LDTP10924  Prohibitin-2 (PHB2) 10.0
 LDTP03336  Protein S100-P (S100P) 10.0
 LDTP09851  Protein TFG (TFG) 10.0
 LDTP01914  Putative HLA class I histocompatibility antigen, alpha chain H (HLA-H) 10.0
 LDTP09145  Regulator of G-protein signaling 22 (RGS22) 10.0
 LDTP12412  Reticulon-4 (RTN4) 10.0
 LDTP03825  Serpin B5 (SERPINB5) 10.0
 LDTP04981  Small nuclear ribonucleoprotein Sm D1 (SNRPD1) 10.0
 LDTP03864  Small ribosomal subunit protein eS19 (RPS19) 10.0
 LDTP05012  Small ribosomal subunit protein eS24 (RPS24) 10.0
 LDTP14323  Small ribosomal subunit protein uS2B (RPSA2) 10.0
 LDTP04966  Small ribosomal subunit protein uS9 (RPS16) 10.0
 LDTP16102  SPATS2-like protein (SPATS2L) 10.0
 LDTP03619  Stress-induced-phosphoprotein 1 (STIP1) 10.0
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) 10.0
 LDTP04249  T-complex protein 1 subunit gamma (CCT3) 10.0
 LDTP03888  T-complex protein 1 subunit zeta (CCT6A) 10.0
 LDTP02683  Translationally-controlled tumor protein (TPT1) 10.0
 LDTP01184  Tubulin-specific chaperone A (TBCA) 10.0
 LDTP05294  Adenylyl cyclase-associated protein 1 (CAP1) 9.0
 LDTP05055  Small ribosomal subunit protein eS21 (RPS21) 6.2
 LDTP02435  Heat shock 70 kDa protein 1B (HSPA1B) 5.9
 LDTP04970  Small ribosomal subunit protein uS11 (RPS14) 5.7
 LDTP03618  14-3-3 protein sigma (SFN) 5.5
 LDTP02227  Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) 5.1
 LDTP03617  14-3-3 protein beta/alpha (YWHAB) 4.8
 LDTP03244  Cofilin-1 (CFL1) 4.2
 LDTP02990  Nucleolin (NCL) 4.1
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 4.0
 LDTP04875  Myosin light polypeptide 6 (MYL6) 3.9
 LDTP02053  Heat shock protein beta-1 (HSPB1) 3.8
 LDTP12277  Protein S100-A14 (S100A14) 3.7
 LDTP03620  Protein S100-A11 (S100A11) 3.7
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1) 3.6
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) 3.6
 LDTP02631  Alpha-actinin-1 (ACTN1) 3.5
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 3.3
 LDTP03899  Large ribosomal subunit protein uL13 (RPL13A) 3.2
 LDTP03463  Protein S100-A2 (S100A2) 3.1
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 3.0
 LDTP08578  SURP and G-patch domain-containing protein 2 (SUGP2) 3.0
 LDTP05024  Large ribosomal subunit protein uL1 (RPL10A) 2.7
 LDTP02756  Junction plakoglobin (JUP) 2.7
 LDTP06094  Src substrate cortactin (CTTN) 2.7
 LDTP02843  Histone H1.5 (H1-5) 2.6
 LDTP02675  Keratin, type I cytoskeletal 13 (KRT13) 2.5
 LDTP04972  Small ribosomal subunit protein uS13 (RPS18) 2.4
 LDTP02845  Histone H1.2 (H1-2) 2.4
 LDTP06301  Eukaryotic translation initiation factor 4H (EIF4H) 2.4
 LDTP03846  Transgelin-2 (TAGLN2) 2.4
 LDTP02364  Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) 2.3
 LDTP02884  Heat shock 70 kDa protein 6 (HSPA6) 2.3
 LDTP05689  Interleukin enhancer-binding factor 3 (ILF3) 2.1
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2) 2.0
 LDTP10999  Histone H2A type 1-J (H2AC14) 2.0
 LDTP05424  Keratin, type I cytoskeletal 17 (KRT17) 2.0
 LDTP03364  Polypyrimidine tract-binding protein 1 (PTBP1) 2.0
 LDTP02164  Nucleophosmin (NPM1) 2.0
 LDTP02961  Large ribosomal subunit protein uL22 (RPL17) 1.9
 LDTP02975  Keratin, type II cytoskeletal 4 (KRT4) 1.9
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) 1.9
 LDTP00619  Eukaryotic translation initiation factor 3 subunit D (EIF3D) 1.9
 LDTP03728  Large ribosomal subunit protein eL22 (RPL22) 1.9
 LDTP00193  PDZ and LIM domain protein 1 (PDLIM1) 1.9
 LDTP06330  Plectin (PLEC) 1.8
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 1.8
 LDTP06220  LIM and SH3 domain protein 1 (LASP1) 1.8
 LDTP03027  Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) 1.8
 LDTP04510  Rho GDP-dissociation inhibitor 1 (ARHGDIA) 1.8
 LDTP02779  Ezrin (EZR) 1.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) 1.7
 LDTP04355  Rab GDP dissociation inhibitor beta (GDI2) 1.7
 LDTP05280  Serine/arginine-rich splicing factor 2 (SRSF2) 1.6
 LDTP02205  Tubulin beta chain (TUBB) 1.6
 LDTP05001  Large ribosomal subunit protein uL23 (RPL23A) 1.6
 LDTP02676  Keratin, type II cytoskeletal 5 (KRT5) 1.5
 LDTP05525  KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) 1.5
 LDTP07954  Arginine/serine-rich coiled-coil protein 2 (RSRC2) 1.5
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14) 1.5

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.