Details of the Target

General Information of Target

Target ID LDTP02057
Target Name Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1)
Gene Name RPN1
Gene ID 6184
Synonyms
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit; Ribophorin I; RPN-I; Ribophorin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAPAAGLFLLLLLGTWAPAPGSASSEAPPLINEDVKRTVDLSSHLAKVTAEVVLAHLGG
GSTSRATSFLLALEPELEARLAHLGVQVKGEDEEENNLEVRETKIKGKSGRFFTVKLPVA
LDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASR
NVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWG
NIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNV
STSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVF
DEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQH
IQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITE
QVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTE
GSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKI
DHILDAL
Target Bioclass
Transporter and channel
Family
OST1 family
Subcellular location
Endoplasmic reticulum
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Uniprot ID
P04843
Ensemble ID
ENST00000296255.8
HGNC ID
HGNC:10381
ChEMBL ID
CHEMBL4295697

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P8
 Probe Info  		10.00  LDD0451  [2]
11RK72
 Probe Info  		5.79  LDD0327  [3]
11RK73
 Probe Info  		5.36  LDD0328  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
W1
 Probe Info  		20.09  LDD0235  [5]
TH211
 Probe Info  		Y387(20.00)  LDD0260  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
BTD
 Probe Info  		C545(2.62)  LDD1699  [8]
ONAyne
 Probe Info  		N.A.  LDD0273  [9]
Probe 1
 Probe Info  		Y582(15.58)  LDD3495  [10]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [11]
AHL-Pu-1
 Probe Info  		C477(2.86)  LDD0170  [12]
HPAP
 Probe Info  		3.83  LDD0062  [13]
EA-probe
 Probe Info  		N.A.  LDD0440  [14]
DBIA
 Probe Info  		C545(1.13); C477(0.99)  LDD0078  [15]
5E-2FA
 Probe Info  		H397(0.00); H83(0.00); H160(0.00)  LDD2235  [16]
ATP probe
 Probe Info  		K187(0.00); K538(0.00); K414(0.00); K579(0.00)  LDD0199  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C545(0.00); C477(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C477(0.00); C545(0.00)  LDD0032  [19]
IPIAA_H
 Probe Info  		C477(0.00); C545(0.00)  LDD0030  [20]
IPIAA_L
 Probe Info  		C477(0.00); C545(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C545(0.00); C477(0.00)  LDD0037  [18]
ATP probe
 Probe Info  		K559(0.00); K116(0.00)  LDD0035  [21]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [22]
NAIA_4
 Probe Info  		N.A.  LDD2226  [23]
TFBX
 Probe Info  		N.A.  LDD0027  [22]
WYneN
 Probe Info  		N.A.  LDD0021  [24]
aHNE
 Probe Info  		N.A.  LDD0001  [24]
Compound 10
 Probe Info  		N.A.  LDD2216  [25]
Compound 11
 Probe Info  		N.A.  LDD2213  [25]
ENE
 Probe Info  		N.A.  LDD0006  [24]
IPM
 Probe Info  		C477(0.00); C545(0.00)  LDD0005  [24]
NHS
 Probe Info  		K379(0.00); K559(0.00); K187(0.00); K579(0.00)  LDD0010  [24]
PF-06672131
 Probe Info  		N.A.  LDD0152  [26]
SF
 Probe Info  		K517(0.00); Y185(0.00)  LDD0028  [27]
STPyne
 Probe Info  		K538(0.00); K579(0.00); K187(0.00); K379(0.00)  LDD0009  [24]
VSF
 Probe Info  		C477(0.00); C545(0.00)  LDD0007  [24]
Phosphinate-6
 Probe Info  		C545(0.00); C477(0.00)  LDD0018  [28]
Ox-W18
 Probe Info  		N.A.  LDD2175  [29]
1c-yne
 Probe Info  		K524(0.00); K215(0.00); K379(0.00); K352(0.00)  LDD0228  [30]
1d-yne
 Probe Info  		N.A.  LDD0357  [30]
Acrolein
 Probe Info  		C477(0.00); H495(0.00); H83(0.00); H57(0.00)  LDD0217  [31]
Cinnamaldehyde
 Probe Info  		C545(0.00); K538(0.00)  LDD0220  [31]
Crotonaldehyde
 Probe Info  		C545(0.00); H495(0.00); H252(0.00); H602(0.00)  LDD0219  [31]
Methacrolein
 Probe Info  		C545(0.00); H602(0.00); H495(0.00)  LDD0218  [31]
AOyne
 Probe Info  		14.90  LDD0443  [32]
NAIA_5
 Probe Info  		C545(0.00); C477(0.00)  LDD2223  [23]
TER-AC
 Probe Info  		N.A.  LDD0426  [33]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C218
 Probe Info  		12.04  LDD1892  [34]
C355
 Probe Info  		23.26  LDD2016  [34]
FFF probe11
 Probe Info  		14.72  LDD0471  [35]
FFF probe12
 Probe Info  		5.50  LDD0487  [35]
FFF probe13
 Probe Info  		20.00  LDD0475  [35]
FFF probe14
 Probe Info  		15.17  LDD0477  [35]
FFF probe2
 Probe Info  		9.20  LDD0463  [35]
FFF probe3
 Probe Info  		20.00  LDD0464  [35]
FFF probe4
 Probe Info  		7.26  LDD0466  [35]
FFF probe6
 Probe Info  		7.15  LDD0467  [35]
FFF probe9
 Probe Info  		6.29  LDD0470  [35]
JN0003
 Probe Info  		20.00  LDD0469  [35]
VE-P
 Probe Info  		N.A.  LDD0396  [36]
DA-2
 Probe Info  		N.A.  LDD0071  [37]
OEA-DA
 Probe Info  		15.13  LDD0046  [38]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C545(0.62)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C545(0.63)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C545(0.65)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C545(0.87)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C545(1.04)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C545(1.66)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C545(1.05)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C545(0.49)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C545(0.88)  LDD2131  [8]
 LDCM0025  4SU-RNA DM93 C477(2.86)  LDD0170  [12]
 LDCM0026  4SU-RNA+native RNA DM93 C477(2.01)  LDD0171  [12]
 LDCM0214  AC1 HCT 116 C477(1.09); C545(1.27)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C477(1.12); C545(1.66)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C477(1.06); C545(1.31)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C477(1.04); C545(1.16)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C477(0.78); C545(0.95)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C477(1.15); C545(1.06)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C477(1.14); C545(1.10)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C477(1.00); C545(1.25)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C477(1.07); C545(1.23)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C477(0.82); C545(0.99)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C477(1.05); C545(1.02)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C477(0.85); C545(0.97)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C477(1.21); C545(1.41)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C477(0.87); C545(1.05)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C477(1.15); C545(1.03)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C477(0.95); C545(1.23)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C477(1.05); C545(1.15)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C477(1.30); C545(1.39)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C477(1.63); C545(1.24)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C477(1.49); C545(0.99)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C477(1.16); C545(1.75)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C477(1.11); C545(1.23)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C477(1.35); C545(1.33)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C477(1.05); C545(1.40)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C477(1.44); C545(1.05)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C477(1.17); C545(1.25)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C477(1.05); C545(1.36)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C477(0.93); C545(1.59)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C477(1.07); C545(1.28)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C477(1.03); C545(1.36)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C477(1.32); C545(1.41)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C477(1.37); C545(1.43)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C477(1.26); C545(1.17)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C477(0.88); C545(1.28)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C477(1.01); C545(1.62)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C477(0.95); C545(1.30)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C477(0.82); C545(1.46)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C477(0.90); C545(1.41)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C477(1.02); C545(1.41)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C477(1.08); C545(1.47)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C477(1.05); C545(1.21)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C477(0.83); C545(1.56)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C477(0.92); C545(1.34)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C477(1.01); C545(1.30)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C477(1.16); C545(1.60)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C477(1.05); C545(1.55)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C477(0.94); C545(1.43)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C477(0.70); C545(1.33)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C477(1.50); C545(1.07)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C545(0.98); C477(2.30)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C477(1.47); C545(2.35)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C545(1.02); C477(1.75)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C545(1.03); C477(2.08)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C545(0.84); C477(3.77)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C545(1.06); C477(2.14)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C477(1.15); C545(1.38)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C545(0.94); C477(1.45)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C545(1.41); C477(1.44)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C545(1.16); C477(1.84)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C545(1.13); C477(4.64)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C477(2.08); C545(1.22)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C477(1.65); C545(1.13)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C477(1.45); C545(1.52)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C477(1.66); C545(1.01)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C545(1.19); C477(1.21)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C545(0.85); C477(1.40)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C477(1.09); C545(1.23)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C545(1.14); C477(1.26)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C545(1.03); C477(1.10)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C545(1.01); C477(1.13)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C545(0.91); C477(1.02)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C545(1.05); C477(1.17)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C477(1.04); C545(1.08)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C477(0.94); C545(1.07)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C477(0.91); C545(1.15)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C477(1.09); C545(1.39)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C477(1.03); C545(1.24)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C477(1.09); C545(1.13)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C477(1.12); C545(1.33)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C477(1.11); C545(1.16)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C477(1.11); C545(1.33)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C477(1.17); C545(1.30)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C477(1.12); C545(1.56)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C545(1.26); C477(1.27)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C545(0.84); C477(0.95)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C477(0.84); C545(1.15)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C477(0.88); C545(1.32)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C477(0.95); C545(0.98)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C545(0.99); C477(1.05)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C477(1.34); C545(1.55)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C545(1.02); C477(1.18)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C477(0.93); C545(1.18)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C477(0.97); C545(0.98)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C477(0.96); C545(1.09)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C545(0.93); C477(0.97)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C545(1.06); C477(1.17)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C477(1.02); C545(1.23)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C545(1.08); C477(1.15)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C477(1.14); C545(1.52)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C545(1.01); C477(1.83)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C545(1.28); C477(1.40)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C545(1.26); C477(1.56)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C477(0.83); C545(1.15)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C477(1.02); C545(1.23)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C545(1.01); C477(1.42)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C545(1.01); C477(1.24)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C545(1.08); C477(1.74)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C545(1.18); C477(2.48)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C477(1.47); C545(1.53)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C477(1.70); C545(1.93)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C545(1.27); C477(1.78)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C477(1.20); C545(1.55)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C545(1.31); C477(1.73)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C477(1.45); C545(1.83)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C545(1.83); C477(1.87)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C477(1.48); C545(1.53)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C545(1.30); C477(2.01)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C545(1.85); C477(1.97)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C545(1.67); C477(2.09)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C545(1.09); C477(2.85)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C545(0.99); C477(1.23)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C545(1.01); C477(1.47)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C477(1.19); C545(1.36)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C545(0.82); C477(1.48)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C545(0.94); C477(1.36)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C545(1.14); C477(1.42)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C545(0.77); C477(2.41)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C545(0.84); C477(2.30)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C545(0.74); C477(3.06)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C545(1.39); C477(1.62)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C545(1.13); C477(1.47)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C545(1.14); C477(1.19)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C545(1.05); C477(1.47)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C477(1.23); C545(1.36)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C545(0.86); C477(1.49)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C545(0.82); C477(0.92)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C545(0.89); C477(3.15)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C545(0.89)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C545(0.90)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C545(1.03)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C545(1.18)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C545(0.99)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C545(0.94)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C545(1.17)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C545(1.25)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C545(1.02)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C545(1.06)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C545(1.01)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C545(0.96)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C545(1.14)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C545(1.08)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C545(1.02)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C545(0.93); C477(0.94)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C477(0.83); C545(1.07)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C545(0.52)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C545(0.57)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C477(0.95); C545(1.44)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C477(1.22); C545(1.53)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C545(1.69); C477(1.72)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 11.35  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C545(1.13); C477(0.99)  LDD0078  [15]
 LDCM0498  BS-3668 MDA-MB-231 C545(0.54)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C477(2.08)  LDD2214  [39]
 LDCM0108  Chloroacetamide HeLa H83(0.00); H140(0.00); H57(0.00); C545(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C477(0.86); C477(0.79); C477(0.60)  LDD2227  [23]
 LDCM0367  CL1 HCT 116 C545(0.90); C477(0.97)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C545(1.15); C477(1.33)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C477(1.45); C545(1.55)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C477(1.32); C545(1.62)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C477(1.03); C545(1.63)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C477(1.11); C545(1.21)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C477(1.17); C545(1.40)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C545(1.22); C477(1.36)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C545(1.10); C477(1.78)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C545(1.35); C477(1.55)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C545(1.11); C477(1.81)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C545(1.14); C477(1.31)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C545(1.12); C477(1.63)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C545(1.14); C477(1.69)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C545(1.20); C477(1.40)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C477(1.05); C545(1.20)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C545(1.03); C477(1.27)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C545(1.17); C477(1.26)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C545(0.93); C477(1.00)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C477(0.97); C545(1.59)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C545(0.92); C477(1.61)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C477(1.06); C545(1.07)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C477(1.05); C545(1.22)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C545(1.25); C477(1.53)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C477(0.93); C545(1.23)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C477(0.68); C545(0.95)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C545(1.13); C477(1.29)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C545(0.98); C477(1.60)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C545(1.17); C477(1.85)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C477(1.18); C545(1.64)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C477(1.05); C545(1.43)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C477(1.49); C545(1.81)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C545(1.39); C477(2.54)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C545(1.08); C477(1.33)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C545(1.05); C477(1.08)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C545(1.20); C477(1.32)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C477(0.94); C545(1.02)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C545(1.07); C477(1.36)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C477(1.09); C545(1.37)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C477(1.06); C545(1.16)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C545(1.01); C477(1.06)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C477(1.24); C545(1.34)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C545(1.23); C477(1.51)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C545(1.21); C477(1.72)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C477(1.03); C545(1.22)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C477(1.31); C545(1.32)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C477(1.26); C545(1.21)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C477(1.05); C545(1.07)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C477(0.98); C545(1.35)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C477(1.12); C545(1.20)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C477(1.20); C545(1.25)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C477(1.03); C545(1.06)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C477(0.95); C545(1.23)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C477(1.21); C545(1.03)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C477(1.20); C545(1.13)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C477(1.39); C545(1.14)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C477(1.61); C545(1.05)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C477(1.63); C545(1.16)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C477(1.46); C545(1.34)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C477(1.80); C545(1.34)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C477(1.74); C545(1.10)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C477(1.08); C545(0.94)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C477(1.54); C545(1.13)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C477(1.43); C545(1.12)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C477(5.90); C545(1.35)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C477(1.91); C545(1.07)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C477(1.56); C545(1.27)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C477(1.96); C545(1.19)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C477(0.86); C545(0.93)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C477(0.84); C545(0.96)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C477(0.90); C545(1.31)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C477(1.10); C545(1.07)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C477(1.04); C545(1.21)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C477(0.94); C545(1.03)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C477(0.90); C545(1.22)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C477(0.80); C545(1.21)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C477(1.36); C545(1.14)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C477(0.86); C545(1.21)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C477(0.86); C545(1.16)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C477(0.90); C545(1.19)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C477(0.87); C545(1.13)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C477(0.86); C545(1.11)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C477(0.97); C545(1.01)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C477(1.22); C545(1.13)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C477(0.96); C545(0.97)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C477(1.16); C545(0.99)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C477(1.28); C545(1.15)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C477(1.29); C545(1.40)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C477(1.67); C545(1.10)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C477(1.16); C545(1.11)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C477(1.81); C545(1.20)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C477(1.47); C545(0.96)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C477(1.29); C545(1.29)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C477(1.13); C545(1.08)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C477(1.24); C545(1.17)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C477(1.30); C545(1.15)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C477(1.65); C545(1.14)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C477(1.07); C545(0.96)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C477(1.52); C545(1.04)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C477(1.46); C545(1.07)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C477(1.11); C545(0.93)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C477(1.42); C545(1.07)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C477(1.06); C545(1.49)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C477(1.57); C545(1.37)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C477(1.93); C545(0.97)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C477(1.27); C545(1.28)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C477(1.37); C545(1.07)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C477(2.12); C545(1.34)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C477(1.89); C545(1.46)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C477(2.76); C545(1.43)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C477(1.33); C545(1.14)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C477(1.29); C545(1.07)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C477(1.49); C545(1.21)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C477(1.62); C545(1.15)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C477(3.07); C545(1.30)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C477(1.23); C545(1.09)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C477(1.12); C545(0.84)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C477(1.27); C545(1.32)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C477(1.05); C545(1.40)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C477(0.97); C545(1.51)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C477(1.66); C545(1.06)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C477(1.63); C545(0.94)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C477(1.26); C545(1.19)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C477(1.39); C545(1.27)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C477(1.27); C545(1.45)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C477(1.33); C545(1.45)  LDD0811  [15]
 LDCM0495  E2913 HEK-293T C477(0.93); C545(0.93)  LDD1698  [40]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C477(1.89); C545(0.74)  LDD1702  [8]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [14]
 LDCM0625  F8 Ramos C477(0.38); C545(1.95)  LDD2187  [41]
 LDCM0572  Fragment10 Ramos C545(6.65)  LDD2189  [41]
 LDCM0573  Fragment11 Ramos C477(0.37); C545(2.25)  LDD2190  [41]
 LDCM0574  Fragment12 Ramos C477(1.73); C545(6.57)  LDD2191  [41]
 LDCM0575  Fragment13 Ramos C477(0.61); C545(1.01)  LDD2192  [41]
 LDCM0576  Fragment14 Ramos C477(1.25); C545(0.75)  LDD2193  [41]
 LDCM0579  Fragment20 Ramos C545(5.26)  LDD2194  [41]
 LDCM0580  Fragment21 Ramos C477(0.97); C545(6.13)  LDD2195  [41]
 LDCM0582  Fragment23 Ramos C477(1.11); C545(9.83)  LDD2196  [41]
 LDCM0578  Fragment27 Ramos C477(0.61); C545(0.77)  LDD2197  [41]
 LDCM0586  Fragment28 Ramos C477(2.09); C545(0.72)  LDD2198  [41]
 LDCM0588  Fragment30 Ramos C477(0.23); C545(6.84)  LDD2199  [41]
 LDCM0589  Fragment31 Ramos C477(1.17); C545(9.37)  LDD2200  [41]
 LDCM0590  Fragment32 Ramos C477(2.30); C545(9.51)  LDD2201  [41]
 LDCM0468  Fragment33 HCT 116 C477(1.15); C545(1.26)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C477(0.37); C545(1.38)  LDD2203  [41]
 LDCM0566  Fragment4 Ramos C477(2.46); C545(0.72)  LDD2184  [41]
 LDCM0427  Fragment51 HCT 116 C477(2.28); C545(1.27)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C477(0.25); C545(1.12)  LDD2204  [41]
 LDCM0614  Fragment56 Ramos C477(0.27); C545(0.91)  LDD2205  [41]
 LDCM0569  Fragment7 Ramos C477(7.07); C545(0.39)  LDD2186  [41]
 LDCM0571  Fragment9 Ramos C545(5.74)  LDD2188  [41]
 LDCM0015  HNE MDA-MB-231 C477(1.05)  LDD0346  [41]
 LDCM0107  IAA HeLa H397(0.00); H358(0.00); H57(0.00); H83(0.00)  LDD0221  [31]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C477(4.43)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C477(1.04)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C477(1.71)  LDD0082  [15]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C545(0.89)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C545(0.64)  LDD2121  [8]
 LDCM0109  NEM HeLa H57(0.00); H397(0.00); H495(0.00); H83(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C545(0.78)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C545(1.07)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C545(0.87)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C545(1.10)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C545(1.56)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C545(0.73)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C545(0.83)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C545(0.62)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C545(1.07)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C545(0.44)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C545(0.65)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C545(0.54)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C545(1.97)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C545(0.99)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C545(0.62)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C545(0.69)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C545(0.84)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C545(1.12)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C545(0.68)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C545(0.38)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C545(0.73)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C545(0.52)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C545(2.95)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C545(0.91)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C545(0.67)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C545(0.86)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C545(0.41)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C545(0.88)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C545(0.43)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C545(0.99)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C545(0.68)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C545(1.23)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C545(0.36)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C545(0.43)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C545(1.00)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C545(1.28)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C545(0.83)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C545(3.08)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C545(0.84)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C545(0.89)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C545(0.80)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C545(2.96)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C545(3.36)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C545(0.93)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C545(0.58)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C545(0.89)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C545(0.44)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C545(0.71)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C545(1.81)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C477(0.85); C477(0.70)  LDD2206  [42]
 LDCM0628  OTUB2-COV-1 HEK-293T C477(0.63); C477(0.62)  LDD2207  [42]
 LDCM0014  Panhematin HEK-293T 3.83  LDD0062  [13]
 LDCM0131  RA190 MM1.R C477(1.37); C545(1.11)  LDD0304  [43]
 LDCM0170  Structure8 Ramos 5.26  LDD0433  [44]
 LDCM0021  THZ1 HCT 116 C545(1.18)  LDD2173  [15]
 LDCM0111  W14 Hep-G2 C545(2.04)  LDD0238  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein O-mannose kinase (POMK) Ser/Thr protein kinase family Q9H5K3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) STT3 family Q8TCJ2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) . P49069
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Malectin (MLEC) Malectin family Q14165
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

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3 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
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5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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Mass spectrometry data entry: PXD039908 , PXD029761
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD044625
13 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
14 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
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16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
26 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
29 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
30 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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32 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
33 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
34 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
35 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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37 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
38 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
39 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD044402
41 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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