Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name 11RK73  Probe Info 
Probe concentration 5 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10878  Parkinson disease protein 7 (PARK7) 14.7
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 6.5
 LDTP02672  Elongation factor 2 (EEF2) 6.0
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) 5.3
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) 2.6
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) 2.5
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) 2.5
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 3.5
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09938  Far upstream element-binding protein 2 (KHSRP) 6.7
 LDTP05034  Ubiquitin-ribosomal protein eL40 fusion protein (UBA52) 4.0
 LDTP02435  Heat shock 70 kDa protein 1B (HSPA1B) 3.1

References

1 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828