Details of the Target

General Information of Target

Target ID LDTP02087
Target Name ADP/ATP translocase 2 (SLC25A5)
Gene Name SLC25A5
Gene ID 292
Synonyms
AAC2; ANT2; ADP/ATP translocase 2; ADP,ATP carrier protein 2; ADP,ATP carrier protein, fibroblast isoform; Adenine nucleotide translocator 2; ANT 2; Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVR
IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASG
GAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVS
VQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMM
QSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Probably mediates mitochondrial uncoupling in tissues that do not express UCP1. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it. Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
Uniprot ID
P05141
Ensemble ID
ENST00000317881.9
HGNC ID
HGNC:10991
ChEMBL ID
CHEMBL3709670

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 62 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.12  LDD0402  [2]
P1
 Probe Info  		1.63  LDD0452  [3]
P2
 Probe Info  		1.98  LDD0449  [3]
P3
 Probe Info  		1.77  LDD0450  [3]
11RK72
 Probe Info  		4.09  LDD0327  [4]
11RK73
 Probe Info  		3.54  LDD0328  [4]
8RK64
 Probe Info  		N.A.  LDD0039  [4]
CHEMBL5175495
 Probe Info  		9.16  LDD0196  [5]
CY4
 Probe Info  		3.17  LDD0244  [6]
N1
 Probe Info  		10.04  LDD0242  [6]
W1
 Probe Info  		14.81  LDD0235  [7]
TH211
 Probe Info  		Y81(5.37)  LDD0257  [8]
TH214
 Probe Info  		Y81(13.85); Y95(5.69)  LDD0258  [8]
TH216
 Probe Info  		Y81(20.00); Y165(13.33)  LDD0259  [8]
YN-1
 Probe Info  		100.00  LDD0444  [9]
YN-4
 Probe Info  		100.00  LDD0445  [9]
BTD
 Probe Info  		C160(2.79)  LDD1699  [10]
AZ-9
 Probe Info  		D11(0.96); D3(1.01)  LDD2208  [11]
ONAyne
 Probe Info  		K147(0.00); K245(0.00)  LDD0273  [12]
OPA-S-S-alkyne
 Probe Info  		K272(1.13); K245(2.26); K63(3.19); K23(3.58)  LDD3494  [13]
JZ128-DTB
 Probe Info  		C160(0.00); C257(0.00)  LDD0462  [14]
THZ1-DTB
 Probe Info  		C129(1.11)  LDD0460  [14]
AHL-Pu-1
 Probe Info  		C257(3.41)  LDD0168  [15]
EA-probe
 Probe Info  		N.A.  LDD0440  [16]
DBIA
 Probe Info  		C129(0.89)  LDD0078  [17]
5E-2FA
 Probe Info  		N.A.  LDD2235  [18]
AMP probe
 Probe Info  		K23(0.00); K147(0.00); K163(0.00); K63(0.00)  LDD0200  [19]
ATP probe
 Probe Info  		K23(0.00); K147(0.00); K163(0.00); K63(0.00)  LDD0199  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		C57(0.00); C160(0.00); C257(0.00); C129(0.00)  LDD0038  [20]
IA-alkyne
 Probe Info  		C160(0.00); C257(0.00)  LDD0032  [21]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [22]
IPIAA_L
 Probe Info  		C160(0.00); C257(0.00)  LDD0031  [22]
Lodoacetamide azide
 Probe Info  		C57(0.00); C257(0.00); C129(0.00); C160(0.00)  LDD0037  [20]
ATP probe
 Probe Info  		K94(0.00); K23(0.00); K163(0.00); K92(0.00)  LDD0035  [23]
JW-RF-010
 Probe Info  		C57(0.00); C257(0.00)  LDD0026  [24]
NAIA_4
 Probe Info  		C129(0.00); C257(0.00)  LDD2226  [25]
TFBX
 Probe Info  		C57(0.00); C257(0.00)  LDD0027  [24]
WYneN
 Probe Info  		C257(0.00); C160(0.00)  LDD0021  [26]
WYneO
 Probe Info  		C160(0.00); C257(0.00)  LDD0022  [26]
Compound 10
 Probe Info  		N.A.  LDD2216  [27]
Compound 11
 Probe Info  		N.A.  LDD2213  [27]
ENE
 Probe Info  		C160(0.00); C257(0.00); C57(0.00)  LDD0006  [26]
IPM
 Probe Info  		N.A.  LDD0005  [26]
NHS
 Probe Info  		K23(0.00); K272(0.00); K199(0.00); K92(0.00)  LDD0010  [26]
OSF
 Probe Info  		Y81(0.00); H40(0.00)  LDD0029  [28]
PF-06672131
 Probe Info  		C160(0.00); C257(0.00)  LDD0017  [29]
SF
 Probe Info  		K43(0.00); K10(0.00); K147(0.00); K23(0.00)  LDD0028  [28]
STPyne
 Probe Info  		K33(0.00); K245(0.00); K96(0.00); K23(0.00)  LDD0009  [26]
VSF
 Probe Info  		C160(0.00); C257(0.00)  LDD0007  [26]
Phosphinate-6
 Probe Info  		C160(0.00); C257(0.00); C57(0.00)  LDD0018  [30]
Ox-W18
 Probe Info  		W71(0.00); W214(0.00); W258(0.00); W275(0.00)  LDD2175  [31]
1c-yne
 Probe Info  		K245(0.00); K33(0.00); K10(0.00)  LDD0228  [32]
1d-yne
 Probe Info  		N.A.  LDD0357  [32]
Acrolein
 Probe Info  		C257(0.00); H40(0.00); K52(0.00); C160(0.00)  LDD0217  [33]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [33]
Crotonaldehyde
 Probe Info  		H40(0.00); C257(0.00); C160(0.00)  LDD0219  [33]
Methacrolein
 Probe Info  		C257(0.00); H40(0.00); C160(0.00)  LDD0218  [33]
AOyne
 Probe Info  		15.00  LDD0443  [34]
MPP-AC
 Probe Info  		N.A.  LDD0428  [35]
NAIA_5
 Probe Info  		C160(0.00); C57(0.00); C257(0.00); C129(0.00)  LDD2223  [25]
TER-AC
 Probe Info  		N.A.  LDD0426  [35]
TPP-AC
 Probe Info  		N.A.  LDD0427  [35]
PAL-AfBPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		7.67  LDD1728  [36]
C040
 Probe Info  		7.73  LDD1740  [36]
C094
 Probe Info  		26.54  LDD1785  [36]
C106
 Probe Info  		16.68  LDD1793  [36]
C112
 Probe Info  		17.15  LDD1799  [36]
C143
 Probe Info  		13.45  LDD1825  [36]
C161
 Probe Info  		10.85  LDD1841  [36]
C220
 Probe Info  		15.89  LDD1894  [36]
C228
 Probe Info  		18.51  LDD1901  [36]
C231
 Probe Info  		11.39  LDD1904  [36]
C289
 Probe Info  		31.34  LDD1959  [36]
C293
 Probe Info  		15.89  LDD1963  [36]
C310
 Probe Info  		7.73  LDD1977  [36]
C349
 Probe Info  		10.70  LDD2010  [36]
C350
 Probe Info  		37.53  LDD2011  [36]
C362
 Probe Info  		25.81  LDD2023  [36]
C388
 Probe Info  		36.25  LDD2047  [36]
FFF probe11
 Probe Info  		14.12  LDD0471  [37]
FFF probe13
 Probe Info  		16.38  LDD0475  [37]
FFF probe14
 Probe Info  		13.77  LDD0477  [37]
FFF probe2
 Probe Info  		15.71  LDD0463  [37]
FFF probe3
 Probe Info  		11.79  LDD0464  [37]
FFF probe4
 Probe Info  		8.99  LDD0466  [37]
JN0003
 Probe Info  		14.99  LDD0469  [37]
STS-2
 Probe Info  		1.83  LDD0139  [38]
VE-P
 Probe Info  		N.A.  LDD0396  [39]
BD-F
 Probe Info  		L13(0.00); D292(0.00); F12(0.00); E293(0.00)  LDD0024  [40]
DA-2
 Probe Info  		N.A.  LDD0073  [41]
OEA-DA
 Probe Info  		3.81  LDD0046  [42]
STS-1
 Probe Info  		N.A.  LDD0068  [43]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C160(0.95)  LDD2117  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C160(0.99)  LDD2103  [10]
 LDCM0025  4SU-RNA HEK-293T C257(3.41)  LDD0168  [15]
 LDCM0214  AC1 HCT 116 C257(0.96)  LDD0531  [17]
 LDCM0215  AC10 HCT 116 C257(0.91)  LDD0532  [17]
 LDCM0216  AC100 HCT 116 C160(1.22); C257(0.71)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C160(0.98); C257(0.65)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C160(1.07); C257(0.65)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C160(0.99); C257(0.64)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C160(1.06); C257(0.64)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C160(1.02); C257(0.63)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C160(1.01); C257(0.64)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C160(1.05); C257(0.86)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C160(1.22); C257(0.80)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C160(1.00); C257(0.82)  LDD0542  [17]
 LDCM0226  AC11 HCT 116 C257(0.92)  LDD0543  [17]
 LDCM0227  AC110 HCT 116 C160(1.00); C257(0.75)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C160(0.95); C257(0.80)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C160(1.14); C257(0.80)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C160(1.14); C257(1.01)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C160(1.21); C257(0.92)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C160(1.13); C257(0.85)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C160(1.19); C257(0.85)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C160(1.41); C257(0.93)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C160(1.38); C257(0.92)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C160(1.06); C257(0.83)  LDD0553  [17]
 LDCM0237  AC12 HCT 116 C257(0.96)  LDD0554  [17]
 LDCM0238  AC120 HCT 116 C160(1.67); C257(0.88)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C160(1.21); C257(0.98)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C160(1.28); C257(0.85)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C160(1.08); C257(0.94)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C160(1.31); C257(0.90)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C160(1.11); C257(0.93)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C160(1.50); C257(0.90)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C160(1.48); C257(0.87)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C160(1.19); C257(1.25)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C160(0.80); C257(1.33)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C160(0.89); C257(1.20)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C160(0.93); C257(1.41)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C160(1.07); C257(1.15)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C160(0.95); C257(1.24)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C160(1.15); C257(1.34)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C160(1.01); C257(1.28)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C160(0.99); C257(1.18)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C160(1.09); C257(1.16)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C160(0.94); C257(1.28)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C160(1.22); C257(1.34)  LDD0575  [17]
 LDCM0259  AC14 HCT 116 C257(0.83)  LDD0576  [17]
 LDCM0260  AC140 HCT 116 C160(1.05); C257(1.45)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C160(1.11); C257(1.32)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C160(1.14); C257(1.25)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C257(0.80)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C257(0.74)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C257(0.93)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C257(0.73)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C257(0.80)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C257(0.92)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C257(0.77)  LDD0586  [17]
 LDCM0270  AC15 HCT 116 C257(0.93)  LDD0587  [17]
 LDCM0271  AC150 HCT 116 C257(0.87)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C257(0.66)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C257(0.64)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C257(0.79)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C257(0.90)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C257(0.71)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C257(0.94)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C257(1.00)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C257(0.90)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C257(0.99)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C257(0.90)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C257(1.21)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C257(1.20)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C257(1.04)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C257(1.27)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C257(1.31)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C257(1.67)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C257(0.94); C160(1.34)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C257(0.81); C160(1.44)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C257(0.91); C160(1.07)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C257(0.77); C160(1.28)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C257(0.83); C160(1.09)  LDD0606  [17]
 LDCM0290  AC3 HCT 116 C257(1.12)  LDD0607  [17]
 LDCM0291  AC30 HCT 116 C257(0.81); C160(1.09)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C257(0.88); C160(1.27)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C257(0.84); C160(1.23)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C257(0.81); C160(1.02)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C257(0.80); C160(1.15)  LDD0612  [17]
 LDCM0296  AC35 HCT 116 C160(1.02); C257(1.15)  LDD0613  [17]
 LDCM0297  AC36 HCT 116 C160(1.11); C257(1.19)  LDD0614  [17]
 LDCM0298  AC37 HCT 116 C257(0.92); C160(1.36)  LDD0615  [17]
 LDCM0299  AC38 HCT 116 C257(0.90); C160(0.91)  LDD0616  [17]
 LDCM0300  AC39 HCT 116 C257(1.06); C160(1.10)  LDD0617  [17]
 LDCM0301  AC4 HCT 116 C257(1.07)  LDD0618  [17]
 LDCM0302  AC40 HCT 116 C257(0.89); C160(1.09)  LDD0619  [17]
 LDCM0303  AC41 HCT 116 C257(1.05); C160(1.21)  LDD0620  [17]
 LDCM0304  AC42 HCT 116 C257(1.03); C160(1.11)  LDD0621  [17]
 LDCM0305  AC43 HCT 116 C257(0.98); C160(1.23)  LDD0622  [17]
 LDCM0306  AC44 HCT 116 C257(1.09); C160(1.14)  LDD0623  [17]
 LDCM0307  AC45 HCT 116 C257(1.02); C160(1.22)  LDD0624  [17]
 LDCM0308  AC46 HCT 116 C257(0.88); C160(1.02)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C257(0.93); C160(1.10)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C257(0.95); C160(1.09)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C160(1.00); C257(1.00)  LDD0628  [17]
 LDCM0312  AC5 HCT 116 C257(1.05)  LDD0629  [17]
 LDCM0313  AC50 HCT 116 C257(0.95); C160(1.07)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C257(0.99); C160(1.02)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C257(0.91); C160(1.12)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C160(1.00); C257(1.01)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C257(1.02); C160(1.06)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C257(1.06); C160(1.23)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C160(1.05); C257(1.06)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C257(0.95); C160(0.98)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C257(1.02); C160(1.10)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C257(0.98); C160(1.07)  LDD0639  [17]
 LDCM0323  AC6 HCT 116 C257(0.89)  LDD0640  [17]
 LDCM0324  AC60 HCT 116 C257(0.90); C160(0.92)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C257(0.87); C160(0.93)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C257(0.77); C160(1.07)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C257(0.90); C160(1.29)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C257(1.02); C160(1.32)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C160(1.09); C257(1.09)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C160(1.04); C257(1.05)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C257(0.97); C160(1.08)  LDD0648  [17]
 LDCM0332  AC68 HCT 116 C257(1.13)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C257(1.01)  LDD0650  [17]
 LDCM0334  AC7 HCT 116 C257(1.05)  LDD0651  [17]
 LDCM0335  AC70 HCT 116 C257(1.05)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C257(1.10)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C257(1.15)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C257(1.31)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C257(1.34)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C257(1.34)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C257(1.15)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C257(1.18)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C257(0.92)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C257(1.10)  LDD0661  [17]
 LDCM0345  AC8 HCT 116 C257(0.96)  LDD0662  [17]
 LDCM0346  AC80 HCT 116 C257(1.13)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C257(0.93)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C257(1.32)  LDD0665  [17]
 LDCM0349  AC83 HCT 116 C160(0.75); C257(0.81)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C160(0.68); C257(0.80)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C160(0.51); C257(0.81)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C160(0.84); C257(0.94)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C160(0.66); C257(0.90)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C160(0.66); C257(0.92)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C160(0.61); C257(0.81)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C160(0.81); C257(1.14)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C160(0.69); C257(0.89)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C160(0.69); C257(0.86)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C160(0.62); C257(0.84)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C160(0.58); C257(0.80)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C160(0.56); C257(0.77)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C160(0.62); C257(0.77)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C160(0.69); C257(0.77)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C257(0.55); C160(1.06)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C257(0.71); C160(1.08)  LDD0683  [17]
 LDCM0545  Acetamide MDA-MB-231 C160(0.64)  LDD2138  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C160(0.91)  LDD2113  [10]
 LDCM0248  AKOS034007472 HCT 116 C257(1.07)  LDD0565  [17]
 LDCM0356  AKOS034007680 HCT 116 C257(0.96)  LDD0673  [17]
 LDCM0275  AKOS034007705 HCT 116 C257(0.95)  LDD0592  [17]
 LDCM0156  Aniline NCI-H1299 12.22  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C129(0.89)  LDD0078  [17]
 LDCM0108  Chloroacetamide HeLa C257(0.00); H40(0.00); C160(0.00); C57(0.00)  LDD0222  [33]
 LDCM0632  CL-Sc Hep-G2 C257(0.87); C257(0.81); C257(0.11)  LDD2227  [25]
 LDCM0367  CL1 HCT 116 C160(0.91); C257(1.12)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C257(0.97); C160(1.10)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C257(1.03)  LDD0686  [17]
 LDCM0370  CL101 HCT 116 C257(0.91)  LDD0687  [17]
 LDCM0371  CL102 HCT 116 C257(0.99)  LDD0688  [17]
 LDCM0372  CL103 HCT 116 C257(0.94)  LDD0689  [17]
 LDCM0373  CL104 HCT 116 C257(0.97)  LDD0690  [17]
 LDCM0374  CL105 HCT 116 C257(0.90)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C257(0.90)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C257(1.05)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C257(1.00)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C257(0.87)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C160(1.03); C257(1.21)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C257(0.89)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C257(0.85)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C257(0.99); C160(1.18)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C257(0.90); C160(1.07)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C257(0.89); C160(1.21)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C257(0.89); C160(0.99)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C257(0.91); C160(1.11)  LDD0703  [17]
 LDCM0387  CL117 HCT 116 C160(1.10); C257(1.12)  LDD0704  [17]
 LDCM0388  CL118 HCT 116 C160(1.01); C257(1.05)  LDD0705  [17]
 LDCM0389  CL119 HCT 116 C257(1.04); C160(1.16)  LDD0706  [17]
 LDCM0390  CL12 HCT 116 C160(0.93); C257(1.33)  LDD0707  [17]
 LDCM0391  CL120 HCT 116 C257(1.13); C160(1.16)  LDD0708  [17]
 LDCM0392  CL121 HCT 116 C257(0.79); C160(0.95)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C257(1.00); C160(1.03)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C257(0.88); C160(1.00)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C160(1.02); C257(1.04)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C257(1.05); C160(1.06)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C160(0.81); C257(1.10)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C160(0.93); C257(1.00)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C160(0.88); C257(1.01)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C160(0.94); C257(1.10)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C160(0.98); C257(1.13)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C257(1.03); C160(1.22)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C257(0.84)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C257(0.74)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C257(0.72)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C257(0.81)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C160(1.02); C257(1.23)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C257(0.78)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C257(0.84)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C257(0.96)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C257(0.79)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C257(0.78)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C257(0.80)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C257(0.75)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C257(0.79)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C257(0.67)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C257(0.73)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C160(1.29); C257(1.25)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C257(0.66)  LDD0736  [17]
 LDCM0420  CL31 HCT 116 C160(1.16); C257(0.76)  LDD0737  [17]
 LDCM0421  CL32 HCT 116 C160(1.18); C257(0.65)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C160(1.01); C257(0.62)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C160(0.96); C257(0.64)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C160(0.95); C257(0.71)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C160(1.05); C257(0.75)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C160(1.10); C257(0.86)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C160(1.36); C257(0.77)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C160(0.77); C257(1.13)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C160(1.33); C257(0.72)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C160(1.24); C257(0.70)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C160(1.24); C257(0.89)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C160(1.54); C257(0.73)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C160(1.29); C257(0.70)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C160(1.42); C257(0.66)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C160(0.83); C257(1.31)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C160(0.78); C257(1.36)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C160(0.84); C257(0.86)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C160(1.01); C257(1.27)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C160(1.03); C257(1.21)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C160(0.99); C257(1.29)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C160(0.98); C257(1.35)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C160(0.97); C257(1.46)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C160(0.67); C257(1.28)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C160(0.85); C257(1.53)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C160(1.00); C257(1.46)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C160(0.86); C257(1.29)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C160(0.68); C257(1.33)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C160(0.88); C257(1.23)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C160(0.85); C257(1.28)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C160(0.95); C257(1.06)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C160(0.88); C257(1.20)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C160(0.92); C257(0.87)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C160(0.89); C257(0.94)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C160(0.88); C257(0.90)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C160(1.15); C257(0.89)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C160(1.07); C257(0.97)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C160(1.03); C257(0.90)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C160(0.98); C257(0.93)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C160(1.05); C257(0.92)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C160(0.95); C257(0.79)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C160(0.91); C257(1.22)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C160(1.00); C257(0.79)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C160(1.11); C257(0.93)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C160(1.09); C257(1.01)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C160(1.05); C257(0.93)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C160(1.10); C257(0.89)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C160(0.68); C257(0.98)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C160(0.78); C257(0.93)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C160(0.86); C257(1.10)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C160(0.84); C257(1.09)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C160(1.04); C257(1.27)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C160(0.86); C257(0.74)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C160(0.96); C257(1.19)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C160(1.01); C257(1.19)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C160(0.88); C257(1.21)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C160(0.93); C257(0.88)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C160(0.86); C257(1.08)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C160(0.84); C257(1.02)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C160(0.94); C257(1.16)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C160(1.02); C257(1.19)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C160(1.33); C257(1.35)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C160(0.90); C257(1.06)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C160(0.97); C257(1.25)  LDD0802  [17]
 LDCM0486  CL91 HCT 116 C257(1.09)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C257(1.16)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C257(1.13)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C257(1.05)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C257(1.10)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C257(0.96)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C257(0.91)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C257(1.06)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C257(1.11)  LDD0811  [17]
 LDCM0495  E2913 HEK-293T C257(1.03); C160(0.97); C57(0.92); C129(1.10)  LDD1698  [44]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C257(9.10)  LDD1702  [10]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [16]
 LDCM0625  F8 Ramos C160(1.05); C257(1.87); C57(0.59)  LDD2187  [45]
 LDCM0572  Fragment10 Ramos C160(2.04); C257(2.77); C57(1.00)  LDD2189  [45]
 LDCM0573  Fragment11 Ramos C160(0.05); C257(0.02); C57(0.21)  LDD2190  [45]
 LDCM0574  Fragment12 Ramos C160(3.31); C257(3.37); C57(1.44)  LDD2191  [45]
 LDCM0575  Fragment13 Ramos C160(1.07); C257(1.13); C57(1.07)  LDD2192  [45]
 LDCM0576  Fragment14 Ramos C160(6.16); C257(7.34); C57(5.17)  LDD2193  [45]
 LDCM0579  Fragment20 Ramos C160(2.37); C257(3.16); C57(1.50)  LDD2194  [45]
 LDCM0580  Fragment21 Ramos C160(2.32); C257(1.40); C57(1.14)  LDD2195  [45]
 LDCM0582  Fragment23 Ramos C160(0.61); C257(0.77); C57(1.04)  LDD2196  [45]
 LDCM0578  Fragment27 Ramos C160(0.90); C257(1.18); C57(0.74)  LDD2197  [45]
 LDCM0586  Fragment28 Ramos C160(1.12); C257(2.05); C57(0.93)  LDD2198  [45]
 LDCM0588  Fragment30 Ramos C160(1.18); C257(1.23); C57(0.89)  LDD2199  [45]
 LDCM0589  Fragment31 Ramos C160(1.05); C257(1.32); C57(0.95)  LDD2200  [45]
 LDCM0590  Fragment32 Ramos C160(2.07); C257(2.39); C57(1.06)  LDD2201  [45]
 LDCM0468  Fragment33 HCT 116 C160(1.07); C257(0.85)  LDD0785  [17]
 LDCM0596  Fragment38 Ramos C160(1.18); C257(1.31); C57(1.03)  LDD2203  [45]
 LDCM0566  Fragment4 Ramos C160(4.02); C257(3.47); C57(3.26)  LDD2184  [45]
 LDCM0427  Fragment51 HCT 116 C160(1.13); C257(0.75)  LDD0744  [17]
 LDCM0610  Fragment52 Ramos C160(1.35); C257(1.18); C57(1.12)  LDD2204  [45]
 LDCM0614  Fragment56 Ramos C160(1.00); C257(0.67); C57(1.00)  LDD2205  [45]
 LDCM0569  Fragment7 Ramos C160(3.32); C257(3.07); C57(1.20)  LDD2186  [45]
 LDCM0571  Fragment9 Ramos C160(3.61); C257(3.33)  LDD2188  [45]
 LDCM0015  HNE MDA-MB-231 C257(1.09); C160(1.07)  LDD0346  [45]
 LDCM0107  IAA HeLa H40(0.00); C160(0.00); C57(0.00); C257(0.00)  LDD0221  [33]
 LDCM0179  JZ128 PC-3 C160(0.00); C257(0.00)  LDD0462  [14]
 LDCM0022  KB02 HCT 116 C257(2.39)  LDD0080  [17]
 LDCM0023  KB03 HCT 116 C257(0.89)  LDD0081  [17]
 LDCM0024  KB05 HCT 116 C257(1.38)  LDD0082  [17]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C160(1.30)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C160(0.78)  LDD2121  [10]
 LDCM0109  NEM HeLa H40(0.00); C160(0.00)  LDD0223  [33]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C160(0.99)  LDD2092  [10]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C160(1.16)  LDD2094  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C160(0.26)  LDD2096  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C160(1.44)  LDD2098  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C160(1.22)  LDD2099  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C160(1.43); C257(1.16)  LDD2105  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C160(1.05)  LDD2107  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C160(0.78); C257(1.31)  LDD2109  [10]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C160(1.63)  LDD2110  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C160(0.73)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C160(0.40); C257(1.72)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C160(0.97)  LDD2123  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C257(1.30)  LDD2125  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C160(1.62)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C160(0.83)  LDD2137  [10]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C160(0.48)  LDD2149  [10]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C160(2.97)  LDD2153  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C257(1.58); C257(1.07); C257(1.00)  LDD2206  [46]
 LDCM0628  OTUB2-COV-1 HEK-293T C257(1.09); C257(1.07); C160(0.82); C257(0.81)  LDD2207  [46]
 LDCM0131  RA190 MM1.R C257(1.45)  LDD0304  [47]
 LDCM0021  THZ1 HeLa S3 C129(1.11)  LDD0460  [14]
 LDCM0110  W12 Hep-G2 R106(0.53)  LDD0237  [7]
 LDCM0112  W16 Hep-G2 R106(1.13)  LDD0239  [7]
 LDCM0113  W17 Hep-G2 K105(0.64)  LDD0240  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Uncharacterized aarF domain-containing protein kinase 2 (ADCK2) ADCK protein kinase family Q7Z695
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (SIRT4) Sirtuin family Q9Y6E7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 35 member F6 (SLC35F6) SLC35F solute transporter family Q8N357

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Clodronic Acid Small molecular drug DB00720
Etidronic Acid Small molecular drug DB01077

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
4 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
5 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
12 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
13 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
14 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
15 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
16 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
19 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
20 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
21 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
22 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
23 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
24 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
27 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
28 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
29 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
30 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
31 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
32 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
33 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
34 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
35 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
36 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
37 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
38 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
39 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
40 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
41 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
42 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
43 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
44 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
45 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
46 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
47 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.