General Information of Experiment

Probe Name 8RK64  Probe Info 
Probe concentration 5 uM
Criteria Quantification: Probe vs DMSO
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 19 Protein Related to This Bioclass
Target ID Target Name
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1)
 LDTP05059  Actin, cytoplasmic 2 (ACTG1)
 LDTP02159  Alpha-enolase (ENO1)
 LDTP04561  ATP-citrate synthase (ACLY)
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)
 LDTP02616  Creatine kinase B-type (CKB)
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC)
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1)
 LDTP02672  Elongation factor 2 (EEF2)
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA)
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
 LDTP01766  L-lactate dehydrogenase A chain (LDHA)
 LDTP02179  L-lactate dehydrogenase B chain (LDHB)
 LDTP10878  Parkinson disease protein 7 (PARK7)
 LDTP05503  Peroxiredoxin-1 (PRDX1)
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC)
 LDTP05074  Tubulin alpha-1B chain (TUBA1B)
 LDTP02383  Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1)
 LDTP03166  Ubiquitin-like modifier-activating enzyme 1 (UBA1)
Transporter and channel
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name
 LDTP05043  14-3-3 protein zeta/delta (YWHAZ)
 LDTP02087  ADP/ATP translocase 2 (SLC25A5)
 LDTP05292  Fatty acid-binding protein 5 (FABP5)
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1)
 LDTP04391  T-complex protein 1 subunit delta (CCT4)
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A)
Other
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name
 LDTP03244  Cofilin-1 (CFL1)
 LDTP03367  Elongation factor 1-gamma (EEF1G)
 LDTP08425  Hornerin (HRNR)
 LDTP02308  Keratin, type I cytoskeletal 16 (KRT16)
 LDTP01931  Keratin, type II cytoskeletal 6A (KRT6A)
 LDTP04205  Keratin, type II cytoskeletal 6C (KRT6C)

References

1 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828