Details of the Target

General Information of Target

Target ID LDTP02179
Target Name L-lactate dehydrogenase B chain (LDHB)
Gene Name LDHB
Gene ID 3945
Synonyms
L-lactate dehydrogenase B chain; LDH-B; EC 1.1.1.27; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
Target Bioclass
Enzyme
Family
LDH/MDH superfamily, LDH family
Subcellular location
Cytoplasm
Function Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
Uniprot ID
P07195
Ensemble ID
ENST00000350669.5
HGNC ID
HGNC:6541
ChEMBL ID
CHEMBL4940

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 54 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.79  LDD0402  [1]
P2
 Probe Info  		1.76  LDD0449  [2]
P3
 Probe Info  		1.56  LDD0450  [2]
P8
 Probe Info  		1.79  LDD0451  [2]
A-EBA
 Probe Info  		3.40  LDD0215  [3]
8RK64
 Probe Info  		N.A.  LDD0039  [4]
CHEMBL5175495
 Probe Info  		7.61  LDD0196  [5]
CY4
 Probe Info  		4.02  LDD0244  [6]
N1
 Probe Info  		3.15  LDD0242  [6]
TH211
 Probe Info  		Y173(14.56); Y84(12.42); Y282(12.29); Y240(11.70)  LDD0257  [7]
TH214
 Probe Info  		Y173(20.00); Y84(20.00); Y240(8.30)  LDD0258  [7]
TH216
 Probe Info  		Y84(17.01); Y173(7.74)  LDD0259  [7]
AZ-9
 Probe Info  		D326(0.98); E237(1.05); E14(1.28); E241(0.98)  LDD2208  [8]
ONAyne
 Probe Info  		K310(0.00); K318(0.00); K308(0.00); K7(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K156(6.77)  LDD3494  [10]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [11]
THZ1-DTB
 Probe Info  		C294(1.03)  LDD0460  [11]
AHL-Pu-1
 Probe Info  		C294(5.16)  LDD0168  [12]
DBIA
 Probe Info  		C164(5.01)  LDD0209  [13]
HHS-482
 Probe Info  		Y173(0.91); Y240(1.01); Y282(1.01); Y84(0.76)  LDD0285  [14]
HHS-475
 Probe Info  		Y84(0.73); Y240(0.92); Y248(3.21)  LDD0264  [15]
HHS-465
 Probe Info  		Y173(10.00); Y240(9.62); Y248(10.00); Y282(2.96)  LDD2237  [16]
5E-2FA
 Probe Info  		H232(0.00); H68(0.00)  LDD2235  [17]
AMP probe
 Probe Info  		K82(0.00); K244(0.00); K246(0.00); K329(0.00)  LDD0200  [18]
ATP probe
 Probe Info  		K82(0.00); K244(0.00); K246(0.00); K329(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C294(0.00); C164(0.00); C36(0.00); C132(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C164(0.00); C294(0.00); C36(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [21]
IPIAA_L
 Probe Info  		C186(0.00); C164(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C294(0.00); C36(0.00); C164(0.00); C132(0.00)  LDD0037  [19]
ATP probe
 Probe Info  		K77(0.00); K319(0.00); K58(0.00)  LDD0035  [22]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [23]
NAIA_4
 Probe Info  		N.A.  LDD2226  [24]
TFBX
 Probe Info  		N.A.  LDD0027  [23]
WYneC
 Probe Info  		N.A.  LDD0014  [25]
WYneO
 Probe Info  		N.A.  LDD0022  [25]
1d-yne
 Probe Info  		K60(0.00); K7(0.00)  LDD0356  [26]
ENE
 Probe Info  		N.A.  LDD0006  [25]
IPM
 Probe Info  		N.A.  LDD0005  [25]
NHS
 Probe Info  		K318(0.00); K244(0.00); K308(0.00); K310(0.00)  LDD0010  [25]
OSF
 Probe Info  		N.A.  LDD0029  [27]
PF-06672131
 Probe Info  		N.A.  LDD0152  [28]
PPMS
 Probe Info  		N.A.  LDD0008  [25]
SF
 Probe Info  		Y240(0.00); K318(0.00); Y84(0.00); K7(0.00)  LDD0028  [27]
STPyne
 Probe Info  		K244(0.00); K82(0.00); K308(0.00); K7(0.00)  LDD0009  [25]
VSF
 Probe Info  		N.A.  LDD0007  [25]
Phosphinate-6
 Probe Info  		C164(0.00); C294(0.00)  LDD0018  [29]
Ox-W18
 Probe Info  		W149(0.00); W251(0.00); W325(0.00)  LDD2175  [30]
1c-yne
 Probe Info  		K7(0.00); K91(0.00); K60(0.00); K308(0.00)  LDD0228  [26]
Acrolein
 Probe Info  		H272(0.00); C36(0.00)  LDD0217  [31]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [31]
Methacrolein
 Probe Info  		H272(0.00); C36(0.00)  LDD0218  [31]
MPP-AC
 Probe Info  		N.A.  LDD0428  [32]
TER-AC
 Probe Info  		N.A.  LDD0426  [32]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe4
 Probe Info  		12.30  LDD0466  [33]
VE-P
 Probe Info  		N.A.  LDD0396  [34]
Diazir
 Probe Info  		C164(0.00); E14(0.00)  LDD0011  [25]
KIRA6 AfBP
 Probe Info  		N.A.  LDD0378  [35]
STS-1
 Probe Info  		N.A.  LDD0069  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C294(5.16)  LDD0168  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C294(4.26); C164(4.33)  LDD0169  [12]
 LDCM0214  AC1 HCT 116 C294(1.05)  LDD0531  [37]
 LDCM0215  AC10 HCT 116 C294(0.72)  LDD0532  [37]
 LDCM0226  AC11 HCT 116 C294(0.86)  LDD0543  [37]
 LDCM0237  AC12 HCT 116 C294(0.99)  LDD0554  [37]
 LDCM0259  AC14 HCT 116 C294(0.91)  LDD0576  [37]
 LDCM0270  AC15 HCT 116 C294(1.10)  LDD0587  [37]
 LDCM0276  AC17 HEK-293T C36(0.97); C294(1.04); C164(1.04)  LDD1515  [38]
 LDCM0277  AC18 HEK-293T C36(0.99); C294(1.00); C164(1.01); C186(1.14)  LDD1516  [38]
 LDCM0278  AC19 HEK-293T C36(0.85); C294(0.98); C164(1.14)  LDD1517  [38]
 LDCM0279  AC2 HCT 116 C294(1.32)  LDD0596  [37]
 LDCM0280  AC20 HEK-293T C36(0.98); C294(1.07); C164(1.17)  LDD1519  [38]
 LDCM0281  AC21 HEK-293T C36(1.03); C294(1.04); C164(1.01); C132(0.98)  LDD1520  [38]
 LDCM0282  AC22 HEK-293T C36(1.14); C294(1.10); C164(1.02)  LDD1521  [38]
 LDCM0283  AC23 HEK-293T C36(0.99); C294(1.11); C164(1.02); C132(1.19)  LDD1522  [38]
 LDCM0284  AC24 HEK-293T C36(1.03); C294(1.04); C164(1.03)  LDD1523  [38]
 LDCM0285  AC25 HEK-293T C36(0.94); C294(1.03); C164(1.02)  LDD1524  [38]
 LDCM0286  AC26 HEK-293T C36(1.00); C294(1.13); C164(0.97); C186(0.93)  LDD1525  [38]
 LDCM0287  AC27 HEK-293T C36(0.98); C294(1.00); C164(1.09)  LDD1526  [38]
 LDCM0288  AC28 HEK-293T C36(0.99); C294(1.05); C164(1.10)  LDD1527  [38]
 LDCM0289  AC29 HEK-293T C36(0.99); C294(0.96); C164(1.05); C132(1.06)  LDD1528  [38]
 LDCM0290  AC3 HCT 116 C294(0.83)  LDD0607  [37]
 LDCM0291  AC30 HEK-293T C36(1.06); C294(1.11); C164(1.09)  LDD1530  [38]
 LDCM0292  AC31 HEK-293T C36(1.05); C294(1.03); C164(1.11); C132(1.12)  LDD1531  [38]
 LDCM0293  AC32 HEK-293T C36(0.99); C294(1.02); C164(0.96)  LDD1532  [38]
 LDCM0294  AC33 HEK-293T C36(1.00); C294(1.01); C164(1.12)  LDD1533  [38]
 LDCM0295  AC34 HEK-293T C36(1.00); C294(1.12); C164(1.05); C186(1.20)  LDD1534  [38]
 LDCM0296  AC35 HEK-293T C36(0.93); C294(1.05); C164(1.09)  LDD1535  [38]
 LDCM0297  AC36 HEK-293T C36(1.00); C294(1.07); C164(1.24)  LDD1536  [38]
 LDCM0298  AC37 HEK-293T C36(1.04); C294(1.09); C164(0.98); C132(1.07)  LDD1537  [38]
 LDCM0299  AC38 HEK-293T C36(1.07); C294(1.16); C164(1.17)  LDD1538  [38]
 LDCM0300  AC39 HEK-293T C36(1.05); C294(1.07); C164(1.03); C132(1.07)  LDD1539  [38]
 LDCM0301  AC4 HCT 116 C294(1.16)  LDD0618  [37]
 LDCM0302  AC40 HEK-293T C36(0.99); C294(1.09); C164(0.99)  LDD1541  [38]
 LDCM0303  AC41 HEK-293T C36(0.95); C294(1.06); C164(1.01)  LDD1542  [38]
 LDCM0304  AC42 HEK-293T C36(0.98); C294(1.04); C164(0.99); C186(1.23)  LDD1543  [38]
 LDCM0305  AC43 HEK-293T C36(0.98); C294(1.06); C164(1.29)  LDD1544  [38]
 LDCM0306  AC44 HEK-293T C36(0.99); C294(1.08); C164(1.22)  LDD1545  [38]
 LDCM0307  AC45 HEK-293T C36(1.04); C294(1.03); C164(1.01); C132(1.00)  LDD1546  [38]
 LDCM0308  AC46 HEK-293T C36(1.06); C294(1.12); C164(1.17)  LDD1547  [38]
 LDCM0309  AC47 HEK-293T C36(1.04); C294(1.05); C164(0.99); C132(1.29)  LDD1548  [38]
 LDCM0310  AC48 HEK-293T C36(1.02); C294(1.15); C164(0.97)  LDD1549  [38]
 LDCM0311  AC49 HEK-293T C36(0.96); C294(1.06); C164(1.05)  LDD1550  [38]
 LDCM0312  AC5 HCT 116 C294(0.78)  LDD0629  [37]
 LDCM0313  AC50 HEK-293T C36(0.96); C294(1.08); C164(1.02); C186(1.04)  LDD1552  [38]
 LDCM0314  AC51 HEK-293T C36(0.99); C294(1.08); C164(1.22)  LDD1553  [38]
 LDCM0315  AC52 HEK-293T C36(0.98); C294(1.05); C164(1.25)  LDD1554  [38]
 LDCM0316  AC53 HEK-293T C36(1.01); C294(1.05); C164(1.14); C132(1.02)  LDD1555  [38]
 LDCM0317  AC54 HEK-293T C36(1.04); C294(1.14); C164(1.04)  LDD1556  [38]
 LDCM0318  AC55 HEK-293T C36(1.05); C294(1.00); C164(0.99); C132(0.98)  LDD1557  [38]
 LDCM0319  AC56 HEK-293T C36(1.00); C294(1.09); C164(0.99)  LDD1558  [38]
 LDCM0320  AC57 HEK-293T C36(0.98); C294(1.01); C164(1.04)  LDD1559  [38]
 LDCM0321  AC58 HEK-293T C36(1.12); C294(1.16); C164(1.00); C186(0.94)  LDD1560  [38]
 LDCM0322  AC59 HEK-293T C36(1.02); C294(1.07); C164(1.24)  LDD1561  [38]
 LDCM0323  AC6 HCT 116 C294(0.85)  LDD0640  [37]
 LDCM0324  AC60 HEK-293T C36(1.04); C294(1.05); C164(1.12)  LDD1563  [38]
 LDCM0325  AC61 HEK-293T C36(1.02); C294(1.06); C164(1.06); C132(0.97)  LDD1564  [38]
 LDCM0326  AC62 HEK-293T C36(1.12); C294(1.13); C164(1.20)  LDD1565  [38]
 LDCM0327  AC63 HEK-293T C36(1.04); C294(1.09); C164(1.06); C132(1.14)  LDD1566  [38]
 LDCM0328  AC64 HEK-293T C36(1.06); C294(1.14); C164(0.96)  LDD1567  [38]
 LDCM0334  AC7 HCT 116 C294(0.91)  LDD0651  [37]
 LDCM0345  AC8 HCT 116 C294(0.98)  LDD0662  [37]
 LDCM0248  AKOS034007472 HCT 116 C294(1.02)  LDD0565  [37]
 LDCM0356  AKOS034007680 HCT 116 C294(1.23)  LDD0673  [37]
 LDCM0275  AKOS034007705 HCT 116 C294(1.05)  LDD0592  [37]
 LDCM0020  ARS-1620 HCC44 C164(1.16); C294(0.87)  LDD2171  [37]
 LDCM0630  CCW28-3 231MFP C294(2.91)  LDD2214  [39]
 LDCM0108  Chloroacetamide HeLa C164(0.00); C36(0.00); H272(0.00)  LDD0222  [31]
 LDCM0367  CL1 HCT 116 C294(0.85)  LDD0684  [37]
 LDCM0368  CL10 HCT 116 C294(0.87)  LDD0685  [37]
 LDCM0369  CL100 HCT 116 C294(1.05)  LDD0686  [37]
 LDCM0370  CL101 HCT 116 C294(1.19)  LDD0687  [37]
 LDCM0371  CL102 HCT 116 C294(0.81)  LDD0688  [37]
 LDCM0372  CL103 HCT 116 C294(0.92)  LDD0689  [37]
 LDCM0373  CL104 HCT 116 C294(1.09)  LDD0690  [37]
 LDCM0374  CL105 HEK-293T C36(0.88); C294(0.98); C164(0.93); C186(1.20)  LDD1578  [38]
 LDCM0375  CL106 HEK-293T C36(0.98); C294(0.96); C164(1.04); C186(0.91)  LDD1579  [38]
 LDCM0376  CL107 HEK-293T C36(1.05); C294(1.04); C164(1.04); C132(1.14)  LDD1580  [38]
 LDCM0377  CL108 HEK-293T C36(0.96); C294(1.08); C164(1.03)  LDD1581  [38]
 LDCM0378  CL109 HEK-293T C36(0.94); C294(1.04); C164(0.96); C186(1.15)  LDD1582  [38]
 LDCM0379  CL11 HCT 116 C294(0.94)  LDD0696  [37]
 LDCM0380  CL110 HEK-293T C36(0.87); C294(0.99); C164(1.05); C186(1.11)  LDD1584  [38]
 LDCM0381  CL111 HEK-293T C36(0.91); C294(0.98); C164(1.02); C132(0.91)  LDD1585  [38]
 LDCM0382  CL112 HEK-293T C36(0.98); C294(1.08); C164(0.95)  LDD1586  [38]
 LDCM0383  CL113 HEK-293T C36(0.97); C294(1.04); C164(0.92); C186(1.16)  LDD1587  [38]
 LDCM0384  CL114 HEK-293T C36(0.87); C294(0.99); C164(1.00); C186(0.91)  LDD1588  [38]
 LDCM0385  CL115 HEK-293T C36(0.98); C294(1.06); C164(0.95); C132(0.97)  LDD1589  [38]
 LDCM0386  CL116 HEK-293T C36(1.01); C294(1.06); C164(0.94)  LDD1590  [38]
 LDCM0387  CL117 HEK-293T C36(0.95); C294(1.06); C164(0.93); C186(1.17)  LDD1591  [38]
 LDCM0388  CL118 HEK-293T C36(1.03); C294(1.08); C164(0.94); C186(0.99)  LDD1592  [38]
 LDCM0389  CL119 HEK-293T C36(1.01); C294(1.02); C164(0.94); C132(1.05)  LDD1593  [38]
 LDCM0390  CL12 HCT 116 C294(1.12)  LDD0707  [37]
 LDCM0391  CL120 HEK-293T C36(0.97); C294(1.09); C164(0.91)  LDD1595  [38]
 LDCM0392  CL121 HEK-293T C36(0.92); C294(1.02); C164(0.91); C186(1.02)  LDD1596  [38]
 LDCM0393  CL122 HEK-293T C36(1.02); C294(1.05); C164(1.21); C186(0.86)  LDD1597  [38]
 LDCM0394  CL123 HEK-293T C36(0.90); C294(1.00); C164(1.05); C132(0.88)  LDD1598  [38]
 LDCM0395  CL124 HEK-293T C36(0.94); C294(1.06); C164(0.90)  LDD1599  [38]
 LDCM0396  CL125 HEK-293T C36(1.59); C294(1.19); C164(0.95); C186(0.65)  LDD1600  [38]
 LDCM0397  CL126 HEK-293T C36(1.09); C294(1.04); C164(1.08); C186(0.65)  LDD1601  [38]
 LDCM0398  CL127 HEK-293T C36(1.09); C294(1.03); C164(1.06); C132(1.05)  LDD1602  [38]
 LDCM0399  CL128 HEK-293T C36(1.07); C294(1.03); C164(1.01)  LDD1603  [38]
 LDCM0400  CL13 HCT 116 C294(1.08)  LDD0717  [37]
 LDCM0401  CL14 HCT 116 C294(0.83)  LDD0718  [37]
 LDCM0402  CL15 HCT 116 C294(0.32)  LDD0719  [37]
 LDCM0403  CL16 HCT 116 C294(1.09)  LDD0720  [37]
 LDCM0404  CL17 HCT 116 C294(0.78)  LDD0721  [37]
 LDCM0405  CL18 HCT 116 C294(0.93)  LDD0722  [37]
 LDCM0406  CL19 HCT 116 C294(0.93)  LDD0723  [37]
 LDCM0407  CL2 HCT 116 C294(0.80)  LDD0724  [37]
 LDCM0408  CL20 HCT 116 C294(1.44)  LDD0725  [37]
 LDCM0409  CL21 HCT 116 C294(0.90)  LDD0726  [37]
 LDCM0410  CL22 HCT 116 C294(0.65)  LDD0727  [37]
 LDCM0411  CL23 HCT 116 C294(1.48)  LDD0728  [37]
 LDCM0412  CL24 HCT 116 C294(1.10)  LDD0729  [37]
 LDCM0413  CL25 HCT 116 C294(0.92)  LDD0730  [37]
 LDCM0414  CL26 HCT 116 C294(1.29)  LDD0731  [37]
 LDCM0415  CL27 HCT 116 C294(0.98)  LDD0732  [37]
 LDCM0416  CL28 HCT 116 C294(0.83)  LDD0733  [37]
 LDCM0417  CL29 HCT 116 C294(1.43)  LDD0734  [37]
 LDCM0418  CL3 HCT 116 C294(0.74)  LDD0735  [37]
 LDCM0419  CL30 HCT 116 C294(1.46)  LDD0736  [37]
 LDCM0420  CL31 HCT 116 C294(1.12)  LDD0737  [37]
 LDCM0421  CL32 HCT 116 C294(0.82)  LDD0738  [37]
 LDCM0422  CL33 HCT 116 C294(0.86)  LDD0739  [37]
 LDCM0423  CL34 HCT 116 C294(0.89)  LDD0740  [37]
 LDCM0424  CL35 HCT 116 C294(1.16)  LDD0741  [37]
 LDCM0425  CL36 HCT 116 C294(1.30)  LDD0742  [37]
 LDCM0426  CL37 HCT 116 C294(1.04)  LDD0743  [37]
 LDCM0428  CL39 HCT 116 C294(0.95)  LDD0745  [37]
 LDCM0429  CL4 HCT 116 C294(0.81)  LDD0746  [37]
 LDCM0430  CL40 HCT 116 C294(1.02)  LDD0747  [37]
 LDCM0431  CL41 HCT 116 C294(1.33)  LDD0748  [37]
 LDCM0432  CL42 HCT 116 C294(0.77)  LDD0749  [37]
 LDCM0433  CL43 HCT 116 C294(1.14)  LDD0750  [37]
 LDCM0434  CL44 HCT 116 C294(1.09)  LDD0751  [37]
 LDCM0435  CL45 HCT 116 C294(1.04)  LDD0752  [37]
 LDCM0436  CL46 HEK-293T C36(1.08); C294(0.96); C164(1.37)  LDD1640  [38]
 LDCM0437  CL47 HEK-293T C36(1.08); C294(1.03); C164(1.07); C132(1.15)  LDD1641  [38]
 LDCM0438  CL48 HEK-293T C36(1.09); C294(0.98); C164(1.02)  LDD1642  [38]
 LDCM0439  CL49 HEK-293T C36(0.89); C294(0.93); C164(1.15); C186(0.79)  LDD1643  [38]
 LDCM0440  CL5 HCT 116 C294(0.88)  LDD0757  [37]
 LDCM0441  CL50 HEK-293T C36(0.93); C294(1.09); C164(1.10); C186(0.78)  LDD1645  [38]
 LDCM0443  CL52 HEK-293T C36(0.99); C294(1.05); C164(0.88)  LDD1646  [38]
 LDCM0444  CL53 HEK-293T C36(0.92); C294(0.93); C164(1.07)  LDD1647  [38]
 LDCM0445  CL54 HEK-293T C36(0.84); C294(1.06); C164(1.09); C186(0.97)  LDD1648  [38]
 LDCM0446  CL55 HEK-293T C36(0.98); C294(1.04); C164(1.15)  LDD1649  [38]
 LDCM0447  CL56 HEK-293T C36(1.02); C294(1.05); C164(1.26)  LDD1650  [38]
 LDCM0448  CL57 HEK-293T C36(0.99); C294(0.90); C164(0.91); C132(0.93)  LDD1651  [38]
 LDCM0449  CL58 HEK-293T C36(1.00); C294(1.06); C164(1.13)  LDD1652  [38]
 LDCM0450  CL59 HEK-293T C36(1.04); C294(1.00); C164(1.01); C132(1.18)  LDD1653  [38]
 LDCM0451  CL6 HCT 116 C294(1.56)  LDD0768  [37]
 LDCM0452  CL60 HEK-293T C36(1.11); C294(1.04); C164(1.05)  LDD1655  [38]
 LDCM0453  CL61 HCT 116 C294(1.18)  LDD0770  [37]
 LDCM0454  CL62 HCT 116 C294(1.16)  LDD0771  [37]
 LDCM0455  CL63 HCT 116 C294(1.13)  LDD0772  [37]
 LDCM0456  CL64 HCT 116 C294(1.08)  LDD0773  [37]
 LDCM0457  CL65 HCT 116 C294(0.84)  LDD0774  [37]
 LDCM0458  CL66 HCT 116 C294(1.12)  LDD0775  [37]
 LDCM0459  CL67 HCT 116 C294(1.57)  LDD0776  [37]
 LDCM0460  CL68 HCT 116 C294(0.95)  LDD0777  [37]
 LDCM0461  CL69 HCT 116 C294(0.91)  LDD0778  [37]
 LDCM0462  CL7 HCT 116 C294(1.20)  LDD0779  [37]
 LDCM0463  CL70 HCT 116 C294(1.06)  LDD0780  [37]
 LDCM0464  CL71 HCT 116 C294(0.92)  LDD0781  [37]
 LDCM0465  CL72 HCT 116 C294(1.26)  LDD0782  [37]
 LDCM0466  CL73 HCT 116 C294(1.12)  LDD0783  [37]
 LDCM0467  CL74 HCT 116 C294(1.13)  LDD0784  [37]
 LDCM0469  CL76 HCT 116 C294(0.76)  LDD0786  [37]
 LDCM0470  CL77 HCT 116 C294(0.79)  LDD0787  [37]
 LDCM0471  CL78 HCT 116 C294(0.96)  LDD0788  [37]
 LDCM0472  CL79 HCT 116 C294(1.03)  LDD0789  [37]
 LDCM0473  CL8 HCT 116 C294(0.88)  LDD0790  [37]
 LDCM0474  CL80 HCT 116 C294(0.96)  LDD0791  [37]
 LDCM0475  CL81 HCT 116 C294(0.99)  LDD0792  [37]
 LDCM0476  CL82 HCT 116 C294(1.03)  LDD0793  [37]
 LDCM0477  CL83 HCT 116 C294(1.17)  LDD0794  [37]
 LDCM0478  CL84 HCT 116 C294(0.82)  LDD0795  [37]
 LDCM0479  CL85 HCT 116 C294(0.93)  LDD0796  [37]
 LDCM0480  CL86 HCT 116 C294(1.15)  LDD0797  [37]
 LDCM0481  CL87 HCT 116 C294(0.99)  LDD0798  [37]
 LDCM0482  CL88 HCT 116 C294(0.93)  LDD0799  [37]
 LDCM0483  CL89 HCT 116 C294(0.68)  LDD0800  [37]
 LDCM0484  CL9 HCT 116 C294(0.76)  LDD0801  [37]
 LDCM0485  CL90 HCT 116 C294(0.80)  LDD0802  [37]
 LDCM0486  CL91 HCT 116 C294(0.89)  LDD0803  [37]
 LDCM0487  CL92 HCT 116 C294(0.70)  LDD0804  [37]
 LDCM0488  CL93 HCT 116 C294(0.85)  LDD0805  [37]
 LDCM0489  CL94 HCT 116 C294(0.83)  LDD0806  [37]
 LDCM0490  CL95 HCT 116 C294(0.71)  LDD0807  [37]
 LDCM0491  CL96 HCT 116 C294(0.71)  LDD0808  [37]
 LDCM0492  CL97 HCT 116 C294(0.94)  LDD0809  [37]
 LDCM0493  CL98 HCT 116 C294(1.05)  LDD0810  [37]
 LDCM0494  CL99 HCT 116 C294(1.07)  LDD0811  [37]
 LDCM0495  E2913 HEK-293T C36(0.98); C294(0.98); C164(0.86); C132(1.01)  LDD1698  [38]
 LDCM0625  F8 Ramos C164(1.82); C294(0.27)  LDD2187  [40]
 LDCM0572  Fragment10 Ramos C164(0.72); C294(0.60)  LDD2189  [40]
 LDCM0573  Fragment11 Ramos C164(1.59); C294(1.63)  LDD2190  [40]
 LDCM0574  Fragment12 Ramos C164(0.52); C294(0.45)  LDD2191  [40]
 LDCM0575  Fragment13 Ramos C164(0.54)  LDD2192  [40]
 LDCM0576  Fragment14 Ramos C164(1.00); C294(0.51)  LDD2193  [40]
 LDCM0579  Fragment20 Ramos C164(0.38); C294(0.62)  LDD2194  [40]
 LDCM0580  Fragment21 Ramos C164(0.76); C294(4.35)  LDD2195  [40]
 LDCM0582  Fragment23 Ramos C164(0.75)  LDD2196  [40]
 LDCM0578  Fragment27 Ramos C164(0.64)  LDD2197  [40]
 LDCM0586  Fragment28 Ramos C164(0.93); C294(0.45)  LDD2198  [40]
 LDCM0588  Fragment30 Ramos C164(0.63); C294(0.95)  LDD2199  [40]
 LDCM0589  Fragment31 Ramos C164(1.06)  LDD2200  [40]
 LDCM0590  Fragment32 Ramos C164(0.65); C294(0.76)  LDD2201  [40]
 LDCM0468  Fragment33 HCT 116 C294(0.99)  LDD0785  [37]
 LDCM0596  Fragment38 Ramos C164(0.86); C294(0.75)  LDD2203  [40]
 LDCM0566  Fragment4 Ramos C164(0.72); C294(0.50)  LDD2184  [40]
 LDCM0427  Fragment51 HCT 116 C294(0.82)  LDD0744  [37]
 LDCM0610  Fragment52 Ramos C164(0.45)  LDD2204  [40]
 LDCM0614  Fragment56 Ramos C164(0.60)  LDD2205  [40]
 LDCM0569  Fragment7 Ramos C164(0.46); C294(0.39)  LDD2186  [40]
 LDCM0571  Fragment9 Ramos C164(0.20); C294(0.58)  LDD2188  [40]
 LDCM0116  HHS-0101 DM93 Y84(0.73); Y240(0.92); Y248(3.21)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y84(0.77); Y240(0.80); Y248(3.27)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y240(0.75); Y84(0.83)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y84(0.75); Y240(0.88); Y248(2.41)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y84(1.00); Y240(1.24); Y248(3.86)  LDD0268  [15]
 LDCM0107  IAA HeLa H272(0.00); C36(0.00)  LDD0221  [31]
 LDCM0123  JWB131 DM93 Y173(0.91); Y240(1.01); Y282(1.01); Y84(0.76)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y173(0.51); Y240(0.89); Y282(0.44); Y84(0.46)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y173(0.86); Y240(1.08); Y282(0.93); Y84(0.73)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y173(3.60); Y240(2.47); Y282(5.15); Y84(1.77)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y173(1.86); Y240(1.47); Y282(2.20); Y84(1.45)  LDD0289  [14]
 LDCM0128  JWB198 DM93 Y173(1.21); Y240(0.76); Y282(1.22); Y84(0.41)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y173(0.58); Y240(0.69); Y282(0.52); Y84(0.46)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y173(0.83); Y240(0.88); Y282(0.97); Y84(0.51)  LDD0292  [14]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [11]
 LDCM0022  KB02 HEK-293T C164(0.86); C36(1.07); C294(1.09)  LDD1492  [38]
 LDCM0023  KB03 Jurkat C164(5.01)  LDD0209  [13]
 LDCM0024  KB05 COLO792 C36(0.97)  LDD3310  [41]
 LDCM0109  NEM HeLa H272(0.00); C36(0.00)  LDD0223  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C294(0.89); C164(0.81)  LDD2207  [42]
 LDCM0131  RA190 MM1.R C36(1.33)  LDD0304  [43]
 LDCM0021  THZ1 HeLa S3 C294(1.03)  LDD0460  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
L-lactate dehydrogenase A chain (LDHA) LDH family P00338
L-lactate dehydrogenase B chain (LDHB) LDH family P07195
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal targeting signal 1 receptor (PEX5) Peroxisomal targeting signal receptor family P50542
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Stiripentol Small molecular drug DB09118
Artenimol . DB11638
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4-hydroxy-125-oxadiazole-3-carboxylic Acid Small molecular drug DB02401
Oxamic Acid Small molecular drug DB03940

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
5 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
14 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
15 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
16 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
29 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
30 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
31 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
32 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
33 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
34 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
35 Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor. ACS Chem Biol. 2020 Dec 18;15(12):3106-3111. doi: 10.1021/acschembio.0c00802. Epub 2020 Dec 8.
Mass spectrometry data entry: PXD022628
36 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
37 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
38 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
39 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
40 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
41 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
42 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
43 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.