Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Diazir  Probe Info 
Probe concentration 100 uM
Criteria Qualitation: Labeling site identification
Quantitative Method
Isotope tag
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 107 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP04963  26S proteasome regulatory subunit 8 (PSMC5) E381
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) E416
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) E492
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) E107
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C17
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E253
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E99
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E107
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E100
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E361
 LDTP04876  Actin, cytoplasmic 1 (ACTB) Y240
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E241
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E364
 LDTP04876  Actin, cytoplasmic 1 (ACTB) Y362
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E205
 LDTP04876  Actin, cytoplasmic 1 (ACTB) E57
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) Y240
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E99
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E241
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E364
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E253
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E100
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E107
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E205
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) Y362
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E57
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) E361
 LDTP05060  Actin, gamma-enteric smooth muscle (ACTG2) E242
 LDTP05060  Actin, gamma-enteric smooth muscle (ACTG2) E254
 LDTP05060  Actin, gamma-enteric smooth muscle (ACTG2) E84
 LDTP05060  Actin, gamma-enteric smooth muscle (ACTG2) Y241
 LDTP05060  Actin, gamma-enteric smooth muscle (ACTG2) E58
 LDTP02220  Adenine phosphoribosyltransferase (APRT) E10
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) E552
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) E553
 LDTP05550  ATP-dependent RNA helicase A (DHX9) E831
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) C856
 LDTP02616  Creatine kinase B-type (CKB) E94
 LDTP03753  Cystathionine beta-synthase (CBS) C15
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) E197
 LDTP02672  Elongation factor 2 (EEF2) E585
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) E51
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) Y70
 LDTP13751  Exonuclease 1 (EXO1) Y149
 LDTP04243  Fatty acid synthase (FASN) C2202
 LDTP04243  Fatty acid synthase (FASN) E1115
 LDTP02718  Glucosidase 2 subunit beta (PRKCSH) E212
 LDTP02718  Glucosidase 2 subunit beta (PRKCSH) E210
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) E231
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) Y371
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) E27
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) Y465
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) E353
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) E451
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) E199
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) E557
 LDTP01759  Histone-lysine N-methyltransferase NSD2 (NSD2) E272
 LDTP11518  Histone-lysine N-methyltransferase NSD3 (NSD3) E318
 LDTP14854  Inorganic pyrophosphatase (PPA1) C274
 LDTP14854  Inorganic pyrophosphatase (PPA1) E271
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) Y110
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) E313
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) C163
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) E240
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) Y239
 LDTP02179  L-lactate dehydrogenase B chain (LDHB) C164
 LDTP02179  L-lactate dehydrogenase B chain (LDHB) E14
 LDTP03697  Mannose-6-phosphate isomerase (MPI) C289
 LDTP03445  Mitogen-activated protein kinase 1 (MAPK1) Y64
 LDTP03764  Myosin-9 (MYH9) E772
 LDTP03764  Myosin-9 (MYH9) E773
 LDTP03764  Myosin-9 (MYH9) E1013
 LDTP03764  Myosin-9 (MYH9) E1147
 LDTP04898  NEDD8-conjugating enzyme Ubc12 (UBE2M) Y172
 LDTP12469  Nucleolar RNA helicase 2 (DDX21) E553
 LDTP05028  Peptidyl-prolyl cis-trans isomerase A (PPIA) E140
 LDTP05773  Peroxiredoxin-4 (PRDX4) E193
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) E404
 LDTP02375  Poly [ADP-ribose] polymerase 1 (PARP1) E491
 LDTP09899  Probable ATP-dependent RNA helicase DDX17 (DDX17) E538
 LDTP13750  Proliferation-associated protein 2G4 (PA2G4) E4
 LDTP04284  Proteasome subunit beta type-3 (PSMB3) E106
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) E176
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) Y224
 LDTP02733  Pyruvate kinase PKM (PKM) Y175
 LDTP02733  Pyruvate kinase PKM (PKM) E418
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) C432
 LDTP06513  Septin-7 (SEPTIN7) C204
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97
 LDTP02502  Thioredoxin (TXN) E13
 LDTP03156  Trifunctional purine biosynthetic protein adenosine-3 (GART) E43
 LDTP03156  Trifunctional purine biosynthetic protein adenosine-3 (GART) C41
 LDTP04851  Triosephosphate isomerase (TPI1) E184
 LDTP04851  Triosephosphate isomerase (TPI1) E187
 LDTP05074  Tubulin alpha-1B chain (TUBA1B) E55
 LDTP05074  Tubulin alpha-1B chain (TUBA1B) E77
 LDTP05074  Tubulin alpha-1B chain (TUBA1B) Y357
 LDTP05074  Tubulin alpha-1B chain (TUBA1B) E71
 LDTP05074  Tubulin alpha-1B chain (TUBA1B) C347
 LDTP11074  Tubulin alpha-1C chain (TUBA1C) E77
 LDTP11074  Tubulin alpha-1C chain (TUBA1C) E71
 LDTP11074  Tubulin alpha-1C chain (TUBA1C) Y357
 LDTP11074  Tubulin alpha-1C chain (TUBA1C) E55
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) E491
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) E479
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) Y103
Transporter and channel
Click to Show/Hide to Show 23 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP04969  14-3-3 protein epsilon (YWHAE) Y131
 LDTP04969  14-3-3 protein epsilon (YWHAE) C98
 LDTP04969  14-3-3 protein epsilon (YWHAE) E212
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) E171
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) E159
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) E161
 LDTP02009  Cystatin-B (CSTB) C3
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) E324
 LDTP02058  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) E452
 LDTP00810  Exportin-T (XPOT) E326
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) E300
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) E549
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) E194
 LDTP14066  Hypoxia up-regulated protein 1 (HYOU1) E184
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) E19
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) E365
 LDTP09203  Nucleoporin Nup37 (NUP37) E136
 LDTP09203  Nucleoporin Nup37 (NUP37) E139
 LDTP04707  Protein SEC13 homolog (SEC13) C187
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) E73
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C210
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) E84
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C47
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP08006  PHD finger-like domain-containing protein 5A (PHF5A) Y54
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP03772  Basigin (BSG) E288
Other
Click to Show/Hide to Show 87 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP03617  14-3-3 protein beta/alpha (YWHAB) Y130
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) Y327
 LDTP14951  Beta-actin-like protein 2 (ACTBL2) E254
 LDTP14951  Beta-actin-like protein 2 (ACTBL2) E242
 LDTP14951  Beta-actin-like protein 2 (ACTBL2) Y241
 LDTP14951  Beta-actin-like protein 2 (ACTBL2) E101
 LDTP14486  Clustered mitochondria protein homolog (CLUH) C1196
 LDTP03767  Coatomer subunit beta' (COPB2) Y824
 LDTP03367  Elongation factor 1-gamma (EEF1G) E262
 LDTP03367  Elongation factor 1-gamma (EEF1G) E267
 LDTP03367  Elongation factor 1-gamma (EEF1G) C266
 LDTP02734  Endoplasmin (HSP90B1) Y677
 LDTP02734  Endoplasmin (HSP90B1) Y678
 LDTP05834  Eukaryotic translation initiation factor 3 subunit I (EIF3I) Y308
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) E11
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) Y58
 LDTP02435  Heat shock 70 kDa protein 1B (HSPA1B) E27
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) Y240
 LDTP02364  Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) Y366
 LDTP02750  Heterogeneous nuclear ribonucleoprotein L (HNRNPL) C472
 LDTP17065  Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) C308
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) Y347
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) E195
 LDTP02845  Histone H1.2 (H1-2) E3
 LDTP02845  Histone H1.2 (H1-2) E16
 LDTP02494  Histone H1.4 (H1-4) E16
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Y89
 LDTP05590  Histone-binding protein RBBP4 (RBBP4) Y154
 LDTP06562  Histone-binding protein RBBP7 (RBBP7) Y153
 LDTP18688  Immunoglobulin-binding protein 1 family member C (IGBP1C) Y261
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) E82
 LDTP05509  Large ribosomal subunit protein eL18 (RPL18) C134
 LDTP05378  Large ribosomal subunit protein eL6 (RPL6) Y115
 LDTP02108  Large ribosomal subunit protein P2 (RPLP2) E52
 LDTP02108  Large ribosomal subunit protein P2 (RPLP2) E93
 LDTP04105  Large ribosomal subunit protein uL15 (RPL27A) C70
 LDTP05027  Large ribosomal subunit protein uL2 (RPL8) Y133
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) E108
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) Y307
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) E146
 LDTP05026  Large ribosomal subunit protein uL5 (RPL11) E41
 LDTP06444  Microtubule-associated protein RP/EB family member 1 (MAPRE1) E225
 LDTP06444  Microtubule-associated protein RP/EB family member 1 (MAPRE1) E232
 LDTP00487  Myosin regulatory light chain 12B (MYL12B) E138
 LDTP05977  Nascent polypeptide-associated complex subunit alpha (NACA) E129
 LDTP04708  NHP2-like protein 1 (SNU13) E124
 LDTP14011  Nucleolar complex protein 2 homolog (NOC2L) C585
 LDTP02164  Nucleophosmin (NPM1) E93
 LDTP02164  Nucleophosmin (NPM1) E37
 LDTP02164  Nucleophosmin (NPM1) E39
 LDTP02692  Plastin-3 (PLS3) C104
 LDTP16896  POTE ankyrin domain family member J (POTEJ) E1027
 LDTP16896  POTE ankyrin domain family member J (POTEJ) E1024
 LDTP16896  POTE ankyrin domain family member J (POTEJ) Y1025
 LDTP02218  Profilin-1 (PFN1) Y7
 LDTP06879  Protein FAM98B (FAM98B) C216
 LDTP06879  Protein FAM98B (FAM98B) E217
 LDTP02148  Prothymosin alpha (PTMA) E11
 LDTP17159  Putative heat shock protein HSP 90-beta 4 (HSP90AB4P) E457
 LDTP17159  Putative heat shock protein HSP 90-beta 4 (HSP90AB4P) E169
 LDTP13956  Putative RNA-binding protein Luc7-like 2 (LUC7L2) E146
 LDTP04111  Small ribosomal subunit protein eS10 (RPS10) Y82
 LDTP05055  Small ribosomal subunit protein eS21 (RPS21) E64
 LDTP04964  Small ribosomal subunit protein eS8 (RPS8) E164
 LDTP04964  Small ribosomal subunit protein eS8 (RPS8) E134
 LDTP04972  Small ribosomal subunit protein uS13 (RPS18) E58
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) E77
 LDTP04390  T-complex protein 1 subunit theta (CCT8) Y426
 LDTP13919  Thyroid hormone receptor-associated protein 3 (THRAP3) Y344
 LDTP06414  Transcription elongation factor A protein 2 (TCEA2) Y271
 LDTP05516  Trichohyalin (TCHH) E851
 LDTP02165  Tropomyosin alpha-3 chain (TPM3) E85
 LDTP02165  Tropomyosin alpha-3 chain (TPM3) E97
 LDTP02165  Tropomyosin alpha-3 chain (TPM3) E98
 LDTP02205  Tubulin beta chain (TUBB) Y51
 LDTP02205  Tubulin beta chain (TUBB) E53
 LDTP02205  Tubulin beta chain (TUBB) C12
 LDTP02297  Vimentin (VIM) Y61
 LDTP02297  Vimentin (VIM) E329
 LDTP02297  Vimentin (VIM) E354
 LDTP02297  Vimentin (VIM) E134
 LDTP02297  Vimentin (VIM) C328
 LDTP02297  Vimentin (VIM) E346
 LDTP02297  Vimentin (VIM) E198
 LDTP02297  Vimentin (VIM) E197
 LDTP02297  Vimentin (VIM) E348
 LDTP02297  Vimentin (VIM) E153

References

1 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764