General Information of Target

Target ID LDTP11518
Target Name Histone-lysine N-methyltransferase NSD3 (NSD3)
Gene Name NSD3
Gene ID 54904
Synonyms
WHSC1L1; Histone-lysine N-methyltransferase NSD3; EC 2.1.1.370; EC 2.1.1.371; Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like protein 1; WHSC1-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTH
KVYHVGMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAG
ENPDVFNLSPVEKNQLTIDFIDIVKDPVPHNEYKTEEDPKLFQSTKTQRGPLSENWIEEY
KKQVFPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSME
NIRELEKEAQLMLSRKMAQFNEDGEEATELVKHEAVSDQTSGEPPEPSSSNGEPLVGRGL
KKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDTEEMFP
KDITKWSSNDLMDKIESPEPEDTQDGLYRQGAPEFRVASSVEQLNIIEDEVSQPLAAPPS
KIHVLLLVLHGGTILDTGAGDPSSKKGDANTIANVFDTVMRVHYPSALGRLAIRLVPCPP
VCSDAFALVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYG
DFIKSQEGMTFNGQVCLIGDCVGGILAFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLS
PGILMNAAHCCGGGGGGGGGGGSSGGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQ
LPRKRSDSSTYELDTIQQHQAFLSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEIT
DLFLFGCPLGLVLALRKTVIPALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHAL
PPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIAS
QVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERA
PGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQ
VMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVL
TGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGV
YPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHW
QDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISEL
HLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHR
ARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQR
GQRSMSVAAGCWGRAMTGRLEPGAAAGPK
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily
Subcellular location
Nucleus
Function
Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
Uniprot ID
Q9BZ95
Ensemble ID
ENST00000316985.7
HGNC ID
HGNC:12767
ChEMBL ID
CHEMBL3108646

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.V1243L DBIA    Probe Info 
DOTC24510 SNV: p.Q705Ter .
GAMG Deletion: p.D32LfsTer2; p.F34LfsTer110 .
HEC1B SNV: p.K196R .
HT115 SNV: p.N511D DBIA    Probe Info 
IPC298 SNV: p.A1277G DBIA    Probe Info 
KYSE410 SNV: p.S626P .
MDAMB453 Deletion: p.V604FfsTer6 .
MOLT4 SNV: p.R635C IA-alkyne    Probe Info 
NALM6 SNV: p.R898H DBIA    Probe Info 
NCIH1944 SNV: p.S1384Ter .
NCIH196 SNV: p.E1183K DBIA    Probe Info 
OCUG1 SNV: p.R1309T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info 
C627(4.94)  LDD0168  [1]
DBIA
 Probe Info 
C1273(2.80); C798(3.51); C802(3.51); C799(3.51)  LDD0080  [2]
4-Iodoacetamidophenylacetylene
 Probe Info 
C173(0.00); C286(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info 
N.A.  LDD0032  [4]
Lodoacetamide azide
 Probe Info 
C778(0.00); C286(0.00)  LDD0037  [3]
NAIA_5
 Probe Info 
N.A.  LDD2224  [5]
IPM
 Probe Info 
C173(0.00); C495(0.00); C627(0.00)  LDD0005  [6]
TFBX
 Probe Info 
C1292(0.00); C495(0.00)  LDD0148  [7]
VSF
 Probe Info 
N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info 
N.A.  LDD0018  [8]
Acrolein
 Probe Info 
N.A.  LDD0217  [9]
Crotonaldehyde
 Probe Info 
N.A.  LDD0219  [9]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info 
20.97  LDD1793  [10]
C108
 Probe Info 
8.75  LDD1795  [10]
C139
 Probe Info 
15.14  LDD1821  [10]
C420
 Probe Info 
10.85  LDD2075  [10]
Diazir
 Probe Info 
N.A.  LDD0011  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C627(4.94)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C627(12.82); C173(2.16)  LDD0169  [1]
 LDCM0214  AC1 HCT 116 C1134(1.11); C1138(1.11); C1273(1.07); C1275(1.03)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C1123(1.04); C1128(0.75); C1226(0.74); C1273(1.03)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C1123(0.54); C1128(0.47); C1134(0.54); C1138(0.55)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C1123(0.51); C1128(0.40); C1134(0.74); C1138(0.68)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C1123(0.52); C1128(0.54); C1134(0.52); C1138(0.53)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C1123(0.50); C1128(0.52); C1134(0.56); C1138(0.57)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C1123(0.47); C1128(0.47); C1134(0.65); C1138(0.69)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C1123(0.64); C1128(0.54); C1134(0.61); C1138(0.56)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C1123(0.58); C1128(0.52); C1134(0.53); C1138(0.53)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C1123(0.51); C1128(0.49); C1134(0.58); C1138(0.61)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C1123(0.57); C1128(0.44); C1134(0.57); C1138(0.52)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C1123(0.51); C1128(0.40); C1134(0.68); C1138(0.73)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C1123(0.95); C1128(0.69); C1226(1.13); C1273(1.10)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C1123(0.60); C1128(0.68); C1134(0.54); C1138(0.57)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C1123(0.47); C1128(0.55); C1134(0.75); C1138(0.51)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C1123(0.49); C1128(0.51); C1134(0.59); C1138(0.63)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C1123(0.55); C1128(0.55); C1138(1.14); C1226(0.90)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C1123(0.50); C1128(0.50); C1138(1.17); C1226(0.80)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C1123(0.76); C1128(0.76); C1138(1.07); C1226(0.92)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C1123(0.48); C1128(0.48); C1138(0.99); C1226(0.81)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C1123(0.58); C1128(0.58); C1138(1.10); C1226(1.03)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C1123(0.78); C1128(0.78); C1138(0.97); C1226(0.92)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C1123(0.64); C1128(0.64); C1138(1.01); C1226(1.02)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C1123(1.02); C1128(0.81); C1226(0.80); C1273(1.01)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C1123(0.64); C1128(0.64); C1138(0.97); C1226(1.02)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C1123(0.63); C1128(0.63); C1138(1.01); C1226(0.96)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C1123(0.90); C1128(0.90); C1138(1.08); C1226(1.18)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C1123(0.64); C1128(0.64); C1138(1.03); C1226(0.95)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C1123(0.71); C1128(0.71); C1138(0.97); C1226(1.06)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C1123(0.63); C1128(0.63); C1138(0.95); C1226(0.86)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C1123(0.52); C1128(0.52); C1138(1.08); C1226(0.97)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C1123(0.51); C1128(0.51); C1138(1.08); C1226(0.72)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C1108(0.87); C1114(0.87); C1123(0.93); C1128(0.93)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C1108(0.92); C1114(0.92); C1123(1.10); C1128(1.10)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C1108(1.04); C1114(1.04); C1123(1.01); C1128(1.01)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C1108(0.78); C1114(0.78); C1123(0.84); C1128(0.84)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C1108(0.82); C1114(0.82); C1123(0.98); C1128(0.98)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C1108(0.79); C1114(0.79); C1123(0.80); C1128(0.80)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C1108(0.54); C1114(0.54); C1123(0.89); C1128(0.89)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C1108(1.19); C1114(1.19); C1123(0.94); C1128(0.94)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C1108(0.80); C1114(0.80); C1123(1.10); C1128(1.10)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C1108(0.80); C1114(0.80); C1123(0.98); C1128(0.98)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C1108(0.46); C1114(0.46); C1123(0.84); C1128(0.84)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C1108(0.64); C1114(0.64); C1123(0.71); C1128(0.71)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C1123(1.02); C1128(0.77); C1226(1.08); C1273(1.20)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C1108(0.53); C1114(0.53); C1123(0.88); C1128(0.88)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C1108(0.54); C1114(0.54); C1123(0.85); C1128(0.85)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C1108(0.68); C1114(0.68); C1123(1.42); C1128(1.42)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C1226(0.98); C1230(0.98); C1134(0.98); C1138(0.98)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C1138(0.78); C1134(0.79); C1226(0.84); C1230(0.84)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C1226(0.84); C1230(0.84); C1273(0.98); C1138(1.00)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C1138(1.02); C1134(1.07); C495(1.08); C286(1.11)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C1134(0.77); C1138(0.80); C1226(0.85); C1230(0.85)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C495(1.00); C1226(1.16); C1230(1.16); C1138(1.22)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C1226(0.81); C1230(0.81); C1134(0.90); C1138(0.91)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C1128(0.71); C1226(0.76); C495(0.96); C1273(1.04)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C1226(0.73); C1230(0.73); C1138(0.88); C286(0.89)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C286(0.97); C1226(1.00); C1230(1.00); C752(1.01)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C1226(0.80); C1230(0.80); C495(0.88); C1138(0.90)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C1226(0.85); C1230(0.85); C1134(0.94); C495(1.02)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C1134(1.04); C1138(0.98); C1226(0.87); C1230(0.87)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C1134(0.84); C1138(0.85); C1226(0.94); C1230(0.94)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C1134(0.99); C1138(0.96); C1226(1.09); C1230(1.09)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C1134(1.26); C1138(1.07); C1226(1.09); C1230(1.09)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C1275(0.86); C1273(0.86); C1280(0.86); C765(0.98)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C1275(0.87); C1273(0.89); C1280(0.89); C495(1.06)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C1275(0.92); C1273(0.94); C1280(0.94); C765(1.03)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C1134(0.87); C1138(0.87); C286(0.93); C1275(1.02)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C1275(0.83); C1273(0.84); C1280(0.84); C495(0.86)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C1275(0.94); C1273(0.95); C1280(0.95); C495(1.00)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C1275(0.92); C1273(0.94); C1280(0.94); C495(0.98)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C495(0.83); C1275(0.89); C1273(0.91); C1280(0.91)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C495(0.79); C1275(0.92); C1273(0.93); C1280(0.93)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C1226(0.81); C1230(0.81); C1275(0.81); C1273(0.86)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C286(0.69); C1226(0.74); C1230(0.74); C1275(0.87)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C286(0.76); C1226(0.78); C1230(0.78); C1275(0.95)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C286(0.74); C1226(0.76); C1230(0.76); C1275(0.81)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C286(0.62); C1226(0.82); C1230(0.82); C1123(0.90)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C1134(0.86); C1138(0.86); C1275(0.96); C286(1.01)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C286(0.67); C1226(0.76); C1230(0.76); C1123(0.95)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C286(0.70); C1226(0.80); C1230(0.80); C1275(1.01)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C286(0.69); C1226(0.73); C1230(0.73); C1275(0.93)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C1226(0.77); C1230(0.77); C286(0.88); C1275(0.97)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C1226(0.72); C1230(0.72); C1123(0.81); C1275(0.89)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C979(0.77); C765(0.85); C770(0.85); C495(0.86)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C1123(0.65); C1128(0.84); C979(0.84); C1226(0.96)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C1123(0.54); C1128(0.62); C495(0.69); C979(0.82)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C1123(0.78); C1226(0.78); C1230(0.78); C1128(0.79)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C1123(0.84); C979(0.92); C495(0.93); C1128(0.95)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C1134(0.88); C1138(0.88); C495(0.93); C1273(1.03)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C1123(0.67); C1128(0.85); C1226(0.92); C1230(0.92)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C1123(0.77); C1226(0.83); C1230(0.83); C1128(0.85)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C1123(0.70); C1128(0.77); C1226(0.82); C1230(0.82)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C1123(0.61); C1128(0.74); C765(0.97); C770(0.97)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C1123(0.61); C1128(0.71); C1226(0.84); C1230(0.84)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C1123(0.67); C1128(0.79); C495(0.79); C979(0.85)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C1123(0.69); C1230(0.79); C1226(0.94); C1273(1.02)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C1123(0.52); C1230(0.74); C1273(0.93); C1275(0.93)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C1226(0.84); C1230(0.93); C1123(0.95); C286(0.98)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C1123(0.70); C1273(0.86); C1275(0.86); C1280(0.86)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C1134(0.82); C1138(0.82); C495(0.93); C1275(1.02)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C798(0.80); C802(0.80); C1123(0.87); C1230(0.88)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C1123(0.70); C1273(0.93); C1275(0.93); C1280(0.93)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C1123(0.66); C1230(0.84); C1273(0.85); C1275(0.85)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C1123(0.58); C1226(0.77); C1273(0.82); C1275(0.82)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C1123(0.65); C1226(0.84); C1273(0.85); C1275(0.85)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C1123(0.74); C1273(0.91); C1275(0.91); C1280(0.91)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C1123(0.43); C1273(0.93); C1275(0.93); C1280(0.93)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C1134(0.36); C1138(0.36); C1273(0.97); C1275(0.97)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C1134(0.52); C1138(0.52); C1123(0.64); C495(1.03)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C1134(0.43); C1138(0.43); C1123(0.86); C1273(1.06)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C1128(0.48); C1226(0.79); C1123(0.82); C495(0.99)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C1134(0.83); C1138(0.83); C1123(0.90); C1273(1.01)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C1123(0.79); C1134(0.85); C1138(0.85); C865(1.00)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C1134(0.41); C1138(0.41); C1123(1.00); C1273(1.13)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C1134(0.46); C1138(0.46); C1123(0.63); C1273(0.97)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C1134(0.41); C1138(0.41); C1123(0.65); C1273(0.99)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C1134(0.38); C1138(0.38); C798(0.88); C799(0.88)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C1134(0.34); C1138(0.34); C1123(0.69); C1273(0.97)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C1134(0.44); C1138(0.44); C1123(0.68); C1273(1.09)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C799(0.79); C1134(0.96); C1138(0.96); C1226(0.99)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C286(0.98); C1226(0.99); C1134(1.03); C1138(1.03)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C1273(0.97); C1275(0.97); C1280(0.97); C1226(1.01)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C1108(0.69); C1114(0.69); C865(1.10); C868(1.10)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C1108(0.89); C1114(0.89); C1273(0.90); C1275(0.90)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C1273(0.86); C1275(0.86); C1280(0.86); C752(0.95)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C752(1.06); C755(1.06); C1273(1.15); C1275(1.15)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C752(1.11); C755(1.11); C1128(1.11); C1226(1.18)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C752(1.10); C755(1.10); C1134(1.25); C1138(1.25)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C752(0.93); C755(0.93); C1128(1.00); C1226(1.06)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C1226(0.96); C286(0.97); C1128(0.98); C979(0.99)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C752(0.87); C755(0.87); C1128(0.90); C1226(0.94)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C752(0.73); C755(0.73); C1108(0.86); C1114(0.86)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C1128(0.82); C495(1.00); C1226(1.00); C1273(1.01)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C1108(0.87); C1114(0.87); C752(0.91); C755(0.91)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C1134(0.72); C1138(0.72); C865(0.85); C868(0.85)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C1108(0.88); C1114(0.88); C752(0.97); C755(0.97)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C286(0.78); C1134(0.79); C1138(0.79); C979(0.82)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C1134(0.76); C1138(0.76); C979(0.82); C1123(0.90)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C1230(0.73); C1273(0.74); C1275(0.74); C1280(0.74)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C1134(0.63); C1138(0.63); C1230(0.66); C1226(0.76)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C1273(0.79); C1275(0.79); C1280(0.79); C1230(0.79)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C1230(0.62); C1134(0.69); C1138(0.69); C1226(0.71)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C1230(0.68); C1134(0.73); C1138(0.73); C1226(0.77)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C798(0.55); C799(0.65); C802(0.69); C1226(0.74)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C1134(0.75); C1138(0.75); C1123(0.77); C979(0.78)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C979(0.66); C1134(0.71); C1138(0.71); C1230(0.73)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C1134(0.68); C1138(0.68); C1230(0.75); C286(0.80)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C1230(0.67); C1134(0.73); C1138(0.73); C1273(0.80)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C1230(0.78); C1226(0.82); C1273(0.86); C1275(0.86)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C979(0.70); C1230(0.77); C1134(0.82); C1138(0.82)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C1134(0.71); C1138(0.71); C1230(0.72); C979(0.75)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C1138(0.54); C1123(0.54); C1128(0.54); C979(0.61)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C1128(0.45); C1123(0.52); C865(0.59); C868(0.59)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C1123(1.03); C1128(0.83); C1226(0.96); C1273(1.08)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C1128(0.95); C1226(1.00); C1273(1.06); C1275(1.06)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C1128(0.65); C1123(0.96); C1226(1.05); C495(1.13)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C1273(1.03); C1280(1.03); C1134(1.49); C1138(1.49)  LDD2171  [2]
 LDCM0632  CL-Sc Hep-G2 C173(2.27)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C495(0.85); C1275(1.01); C1273(1.02); C1280(1.02)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C495(0.85); C286(0.91); C1134(1.25); C1138(1.25)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C1134(0.80); C1138(0.80); C286(0.84); C1275(0.97)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C1128(0.71); C1123(0.86); C495(1.14); C1273(1.26)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C1128(0.54); C1123(0.84); C1273(1.01); C1275(1.01)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C1128(0.97); C1273(1.11); C1275(1.11); C1280(1.11)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C1128(0.99); C1273(1.03); C1275(1.03); C1280(1.03)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C495(0.93); C286(0.96); C1275(1.07); C765(1.08)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C495(0.91); C1275(1.06); C1273(1.08); C1280(1.08)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C1275(0.93); C1273(0.95); C1280(0.95); C765(1.05)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C1275(1.05); C1273(1.06); C1280(1.06); C495(1.14)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C286(0.94); C495(0.96); C1275(0.97); C1273(1.01)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C495(0.94); C1275(1.13); C1134(1.15); C1138(1.15)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C495(0.94); C286(1.03); C765(1.08); C770(1.08)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C1275(0.80); C1273(0.84); C1280(0.84); C495(0.88)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C1226(0.86); C1230(0.86); C286(0.90); C1275(0.90)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C1226(0.73); C1230(0.73); C286(0.77); C1128(0.80)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C765(0.81); C770(0.81); C1226(0.82); C1230(0.82)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C286(0.76); C1226(0.80); C1230(0.80); C1275(0.87)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C1226(0.80); C1230(0.80); C286(0.94); C1275(0.94)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C1123(0.66); C1128(0.81); C1226(0.88); C1230(0.88)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C979(0.90); C765(0.96); C770(0.96); C1128(0.97)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C1123(0.82); C1128(0.91); C979(0.94); C495(1.05)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C495(1.01); C1134(1.09); C1138(1.09); C1275(1.17)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C1123(0.79); C1128(0.88); C979(0.96); C1273(0.97)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C798(0.50); C802(0.50); C979(0.76); C286(0.77)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C1123(0.60); C1273(0.91); C1275(0.91); C1280(0.91)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C1123(0.54); C1273(0.88); C1275(0.88); C1280(0.88)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C1123(0.55); C1273(0.87); C1275(0.87); C1280(0.87)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C1134(0.50); C1138(0.50); C865(0.75); C868(0.75)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C1134(0.63); C1138(0.63); C1123(0.65); C865(0.91)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C1134(0.70); C1138(0.70); C798(0.78); C799(0.78)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C1134(0.49); C1138(0.49); C495(0.94); C1273(1.04)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C495(0.99); C1275(1.11); C286(1.12); C1273(1.13)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C495(0.90); C1275(0.96); C286(0.96); C1273(0.98)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C1275(1.10); C1273(1.14); C1280(1.14); C495(1.19)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C1273(0.88); C1280(0.88); C1275(0.88); C1108(0.93)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C286(0.78); C1226(0.96); C1230(0.96); C1273(1.04)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C286(0.83); C1226(1.01); C1230(1.02); C1123(1.08)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C286(0.84); C1226(0.92); C1230(1.03); C1134(1.06)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C495(0.98); C1273(1.07); C1280(1.07); C1275(1.09)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C286(0.71); C1123(0.75); C1128(0.75); C1226(0.87)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C1123(0.84); C1128(0.84); C286(0.86); C1226(0.94)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C286(0.82); C495(0.90); C1134(1.26); C1138(1.26)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C286(0.67); C1123(0.84); C1128(0.84); C495(0.87)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C1108(1.31); C1114(1.31); C1123(0.98); C1128(0.98)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C1108(1.21); C1114(1.21); C1123(1.05); C1128(1.05)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C1108(1.02); C1114(1.02); C1123(0.87); C1128(0.87)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C1108(1.32); C1114(1.32); C1123(1.01); C1128(1.01)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C1108(1.24); C1114(1.24); C1123(0.97); C1128(0.97)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C1108(1.38); C1114(1.38); C1123(0.98); C1128(0.98)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C1134(1.06); C1138(1.06); C1273(0.96); C1275(0.99)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C1108(1.27); C1114(1.27); C1123(1.15); C1128(1.15)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C1226(1.15); C1273(0.99); C1275(1.08); C1280(1.04)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C1108(0.96); C1114(0.96); C1273(0.88); C1275(0.86)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C1108(0.78); C1114(0.78); C1273(0.71); C1275(0.66)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C1108(0.99); C1114(0.99); C1273(0.86); C1275(0.90)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C1108(1.61); C1114(1.61); C1273(1.09); C1275(1.13)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C1108(1.05); C1114(1.05); C1273(0.90); C1275(0.95)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C1108(1.32); C1114(1.32); C1273(0.83); C1275(0.90)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C1108(1.07); C1114(1.07); C1273(0.79); C1275(0.87)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C1134(1.03); C1138(1.03); C1273(1.15); C1275(1.16)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C1108(0.85); C1114(0.85); C1273(0.88); C1275(0.93)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C1108(1.22); C1114(1.22); C1273(0.79); C1275(0.92)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C1108(1.05); C1114(1.05); C1273(0.79); C1275(0.87)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C1108(1.60); C1114(1.60); C1273(0.80); C1275(0.88)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C1108(1.45); C1114(1.45); C1273(0.88); C1275(0.88)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C1108(1.71); C1114(1.71); C1273(0.78); C1275(0.89)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C1108(0.86); C1114(0.86); C1123(1.20); C1134(0.87)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C1108(0.90); C1114(0.90); C1123(2.14); C1134(0.83)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C1108(0.84); C1114(0.84); C1123(1.28); C1134(0.80)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C1108(1.02); C1114(1.02); C1123(1.76); C1134(0.77)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C1134(0.99); C1138(0.99); C1273(1.03); C1275(1.04)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C1108(0.91); C1114(0.91); C1123(1.21); C1134(0.91)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C1108(0.95); C1114(0.95); C1123(1.77); C1134(0.88)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C1108(0.79); C1114(0.79); C1123(1.20); C1134(1.04)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C1108(0.76); C1114(0.76); C1123(0.73); C1134(0.92)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C1108(0.99); C1114(0.99); C1123(0.84); C1134(1.04)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C1108(0.93); C1114(0.93); C1123(0.94); C1134(0.86)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C1108(1.06); C1114(1.06); C1123(1.03); C1134(0.92)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C1108(1.07); C1114(1.07); C1123(1.18); C1134(0.83)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C1108(0.93); C1114(0.93); C1123(1.01); C1134(0.89)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C1108(0.91); C1114(0.91); C1123(1.03); C1134(0.83)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C1134(1.39); C1138(1.39); C1273(1.18); C1275(1.19)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C1108(1.00); C1114(1.00); C1123(1.67); C1134(0.75)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C1123(0.77); C1128(0.77); C1134(1.00); C1138(1.00)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C1123(0.73); C1128(0.73); C1134(0.89); C1138(0.89)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C1123(0.63); C1128(0.63); C1134(0.88); C1138(0.88)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C1123(0.77); C1128(0.77); C1134(0.93); C1138(0.93)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C1123(0.88); C1128(0.88); C1134(0.92); C1138(0.92)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C1123(0.76); C1128(0.76); C1134(0.86); C1138(0.86)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C1123(0.95); C1128(0.95); C1134(0.85); C1138(0.85)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C1123(0.79); C1128(0.79); C1134(0.98); C1138(0.98)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C1123(1.45); C1128(1.45); C1134(1.34); C1138(1.34)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C1134(1.19); C1138(1.19); C1273(1.08); C1275(1.10)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C1123(0.93); C1128(0.93); C1134(1.08); C1138(1.08)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C1123(0.76); C1128(0.76); C1134(0.85); C1138(0.85)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C1123(0.85); C1128(0.85); C1134(0.89); C1138(0.89)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C1123(0.75); C1128(0.75); C1134(0.74); C1138(0.74)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C1123(0.80); C1128(0.80); C1134(0.86); C1138(0.86)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C1123(1.25); C1134(1.36); C1138(1.36); C1273(1.05)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C1123(2.52); C1134(0.97); C1138(0.97); C1273(1.03)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C1123(1.15); C1134(0.95); C1138(0.95); C1273(0.95)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C1123(1.40); C1134(0.88); C1138(0.88); C1273(1.09)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C1134(0.99); C1138(0.99); C1273(1.09); C1275(1.08)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C1123(1.71); C1134(1.29); C1138(1.29); C1273(0.77)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C1123(3.29); C1134(0.87); C1138(0.87); C1273(0.91)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C1123(2.81); C1134(1.02); C1138(1.02); C1273(1.09)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C1123(0.75); C1134(0.93); C1138(0.93); C1273(1.01)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C1123(0.82); C1134(1.07); C1138(1.07); C1273(1.02)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C1123(0.77); C1134(0.84); C1138(0.84); C1273(0.99)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C1123(1.06); C1134(0.94); C1138(0.94); C1273(0.94)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C1123(1.40); C1134(0.84); C1138(0.84); C1273(0.88)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C1123(1.03); C1134(0.96); C1138(0.96); C1273(1.08)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C1123(1.66); C1134(1.20); C1138(1.20); C1273(1.18)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C1134(1.02); C1138(1.02); C1273(1.04); C1275(1.04)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C1123(0.97); C1134(0.99); C1138(0.99); C1273(0.89)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C1134(0.96); C1138(0.96); C1273(1.11); C1275(1.11)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C1134(1.04); C1138(1.04); C1273(1.06); C1275(1.03)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C1134(1.09); C1138(1.09); C1273(0.89); C1275(0.88)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C1134(0.91); C1138(0.91); C1273(1.21); C1275(1.10)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C1134(0.90); C1138(0.90); C1273(1.08); C1275(1.00)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C1134(1.03); C1138(1.03); C1273(1.01); C1275(1.04)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C1134(0.91); C1138(0.91); C1273(1.08); C1275(1.00)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C1134(0.87); C1138(0.87); C1273(0.97); C1275(0.96)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C1134(0.94); C1138(0.94); C1273(1.09); C1275(1.08)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C173(0.88); C1292(1.02); C745(0.94)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C495(1.35)  LDD1702  [12]
 LDCM0625  F8 Ramos C173(0.92)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C173(0.43)  LDD2190  [13]
 LDCM0468  Fragment33 HCT 116 C1123(0.85); C1128(0.85); C1134(0.87); C1138(0.87)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C1108(0.97); C1114(0.97); C1273(0.83); C1275(1.01)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C1273(2.80); C798(3.51); C802(3.51); C799(3.51)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C1273(2.34); C798(3.84); C802(3.84); C799(3.84)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C1273(2.92); C798(2.15); C802(2.15); C799(2.15)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C1273(1.03); C1280(1.03); C1134(1.49); C1138(1.49)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine-protein kinase ATM (ATM) PI3/PI4-kinase family Q13315
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Myeloid cell nuclear differentiation antigen (MNDA) . P41218
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Prelamin-A/C (LMNA) Intermediate filament family P02545
DNA repair protein RAD51 homolog 1 (RAD51) RecA family Q06609
Pre-mRNA-splicing factor SLU7 (SLU7) SLU7 family O95391
Chromobox protein homolog 5 (CBX5) . P45973
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578