Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C106  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 179 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 99.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 99.7
 LDTP02359  Heme oxygenase 1 (HMOX1) 99.7
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 86.8
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 84.4
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 81.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 78.2
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 76.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 67.2
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 67.2
 LDTP12790  Glutaminyl-peptide cyclotransferase-like protein (QPCTL) 66.3
 LDTP01769  Dihydrofolate reductase (DHFR) 64.4
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 63.6
 LDTP04114  E3 ubiquitin-protein ligase NEDD4 (NEDD4) 59.3
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 58.9
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 58.1
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) 53.8
 LDTP05905  Acid ceramidase (ASAH1) 52.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 52.0
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 50.6
 LDTP06511  Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) 49.5
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 49.2
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 47.8
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 46.9
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 45.9
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 45.6
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 44.9
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 44.6
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 43.4
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 43.1
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 42.8
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 42.8
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 42.2
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 41.6
 LDTP03374  Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2) 41.4
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 38.6
 LDTP10780  Trimethylguanosine synthase (TGS1) 38.6
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 38.3
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 37.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 37.3
 LDTP02505  Lysosomal protective protein (CTSA) 37.3
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 35.5
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 34.8
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 34.8
 LDTP11127  ADP-dependent glucokinase (ADPGK) 34.3
 LDTP07931  Heme A synthase COX15 (COX15) 33.8
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 33.6
 LDTP03671  Multidrug resistance-associated protein 1 (ABCC1) 33.1
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 32.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 31.6
 LDTP03676  ATP-binding cassette sub-family D member 1 (ABCD1) 31.3
 LDTP10329  Ceramide synthase 2 (CERS2) 31.1
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 30.9
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 30.5
 LDTP11199  DCN1-like protein 5 (DCUN1D5) 30.3
 LDTP06657  2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) 30.1
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 30.1
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 29.7
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 29.7
 LDTP12197  Ethanolamine kinase 1 (ETNK1) 29.2
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 28.8
 LDTP10249  Metalloendopeptidase OMA1, mitochondrial (OMA1) 28.8
 LDTP02837  Beta-galactosidase (GLB1) 28.6
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 28.2
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 28.1
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 28.1
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 27.9
 LDTP13367  Glutathione hydrolase 7 (GGT7) 27.5
 LDTP03523  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) 27.5
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 26.7
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 26.7
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 26.7
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 26.4
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 26.2
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 26.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 25.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 25.5
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 25.5
 LDTP03145  Catechol O-methyltransferase (COMT) 25.3
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 25.3
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) 25.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 25.1
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 25.1
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 25.1
 LDTP00975  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) 25.1
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 24.9
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 24.9
 LDTP10020  Ras-related protein Rab-24 (RAB24) 24.9
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 24.9
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 24.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 24.8
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 24.3
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 24.3
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 24.1
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 24.1
 LDTP00316  Ribonuclease T2 (RNASET2) 24.1
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 23.6
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 23.3
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 22.5
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 22.3
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 22.2
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 22.0
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 21.9
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 21.9
 LDTP12886  Glycerophosphodiester phosphodiesterase 1 (GDE1) 21.7
 LDTP07762  Hydroxysteroid dehydrogenase-like protein 2 (HSDL2) 21.7
 LDTP02141  Alpha-galactosidase A (GLA) 21.6
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 21.4
 LDTP01502  NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) 21.4
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 21.4
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 21.1
 LDTP11518  Histone-lysine N-methyltransferase NSD3 (NSD3) 21.0
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 20.7
 LDTP06142  Squalene monooxygenase (SQLE) 20.5
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) 20.5
 LDTP05408  Antigen peptide transporter 1 (TAP1) 20.3
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 20.3
 LDTP08203  E3 ubiquitin-protein ligase synoviolin (SYVN1) 20.1
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 19.8
 LDTP03394  Ceramide synthase 1 (CERS1) 19.7
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 19.7
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) 19.7
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 19.3
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 19.3
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 19.2
 LDTP11852  Presenilin-associated rhomboid-like protein, mitochondrial (PARL) 19.2
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 18.9
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 18.9
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 18.8
 LDTP06988  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) 18.5
 LDTP06977  GPI ethanolamine phosphate transferase 2 (PIGG) 18.5
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 18.5
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 18.4
 LDTP10101  Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) 18.3
 LDTP01759  Histone-lysine N-methyltransferase NSD2 (NSD2) 18.1
 LDTP04080  Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (PHKA1) 18.1
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 18.1
 LDTP07417  Serine/threonine-protein phosphatase 4 regulatory subunit 3A (PPP4R3A) 18.1
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 18.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 17.8
 LDTP07989  Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) 17.8
 LDTP05372  Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) 17.6
 LDTP08891  Ceramide synthase 5 (CERS5) 17.5
 LDTP07154  ATPase family AAA domain-containing protein 3B (ATAD3B) 17.4
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 17.4
 LDTP03249  Plasma membrane calcium-transporting ATPase 4 (ATP2B4) 17.3
 LDTP12109  Ribitol 5-phosphate transferase FKRP (FKRP) 17.3
 LDTP02188  Protein disulfide-isomerase (P4HB) 17.1
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 17.1
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 17.1
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 17.0
 LDTP13675  COP9 signalosome complex subunit 3 (COPS3) 17.0
 LDTP14427  Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L) 17.0
 LDTP06617  Ceramide glucosyltransferase (UGCG) 16.9
 LDTP03024  Plasma membrane calcium-transporting ATPase 1 (ATP2B1) 16.9
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 16.8
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 16.8
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 16.7
 LDTP15154  Dehydrogenase/reductase SDR family member 13 (DHRS13) 16.7
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 16.7
 LDTP11318  ADP-ribose pyrophosphatase, mitochondrial (NUDT9) 16.6
 LDTP06645  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) 16.6
 LDTP01329  Lathosterol oxidase (SC5D) 16.6
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 16.6
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 16.6
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 16.6
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 16.4
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 16.3
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 16.3
 LDTP11209  Phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) 16.3
 LDTP08530  Mitofusin-1 (MFN1) 16.2
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 16.2
 LDTP12318  Calcium-independent phospholipase A2-gamma (PNPLA8) 16.1
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 16.1
 LDTP03980  Serine/threonine-protein kinase mTOR (MTOR) 16.1
 LDTP02260  Beta-glucuronidase (GUSB) 16.0
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 16.0
 LDTP09355  Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) 16.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 16.0
Transporter and channel
Click to Show/Hide to Show 146 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15648  BRI3-binding protein (BRI3BP) 99.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 99.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 99.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 79.3
 LDTP01804  ATP synthase subunit a (MT-ATP6) 73.0
 LDTP11615  Protein tweety homolog 3 (TTYH3) 66.7
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 65.3
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 63.6
 LDTP08881  Transmembrane protein 199 (TMEM199) 62.7
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 56.5
 LDTP20002  Transmembrane protein 160 (TMEM160) 56.5
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 55.7
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 52.3
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 50.6
 LDTP15967  Tetraspanin-10 (TSPAN10) 49.2
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 47.8
 LDTP02215  Prosaposin (PSAP) 47.5
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 44.9
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 43.7
 LDTP07236  Protein GPR107 (GPR107) 43.1
 LDTP16813  Tetraspanin-3 (TSPAN3) 42.5
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 39.9
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 39.7
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 39.4
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 38.6
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 38.3
 LDTP11844  Protein spinster homolog 1 (SPNS1) 38.3
 LDTP15948  Transmembrane protein 126A (TMEM126A) 38.3
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 36.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 36.5
 LDTP05871  Protein OS-9 (OS9) 35.5
 LDTP00857  Syntaxin-6 (STX6) 35.5
 LDTP11116  45 kDa calcium-binding protein (SDF4) 35.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 35.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 33.8
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 33.6
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 33.4
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 31.8
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 31.8
 LDTP15979  Transmembrane protein 245 (TMEM245) 31.8
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 31.6
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 31.1
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 30.7
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 30.3
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 30.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 30.3
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 30.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 30.1
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 29.2
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 29.0
 LDTP04501  Importin subunit alpha-1 (KPNA2) 28.6
 LDTP11812  Protein ARV1 (ARV1) 28.6
 LDTP05900  Metaxin-1 (MTX1) 28.4
 LDTP07156  Protein wntless homolog (WLS) 28.4
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 28.2
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 28.2
 LDTP11245  Derlin-1 (DERL1) 27.9
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 27.5
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 27.5
 LDTP03380  Stomatin (STOM) 27.5
 LDTP12451  Integral membrane protein 2C (ITM2C) 26.9
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 26.9
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 26.7
 LDTP01301  Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) 25.3
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 25.3
 LDTP17682  Zinc transporter ZIP11 (SLC39A11) 25.3
 LDTP00405  Etoposide-induced protein 2.4 homolog (EI24) 25.1
 LDTP10769  Intermembrane lipid transfer protein VPS13A (VPS13A) 25.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 24.9
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 24.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 24.6
 LDTP11634  Derlin-2 (DERL2) 24.3
 LDTP05934  Stromal interaction molecule 1 (STIM1) 24.1
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 23.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 23.9
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 23.6
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 23.4
 LDTP09949  Transportin-1 (TNPO1) 23.3
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 23.1
 LDTP04462  H(+)/Cl(-) exchange transporter 6 (CLCN6) 22.9
 LDTP09144  Metal transporter CNNM3 (CNNM3) 22.9
 LDTP11250  MICOS complex subunit MIC26 (APOO) 22.9
 LDTP13833  Integral membrane protein 2B (ITM2B) 22.5
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 22.2
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 22.0
 LDTP14275  Sodium bicarbonate cotransporter 3 (SLC4A7) 21.9
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 21.7
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 21.7
 LDTP02071  Amyloid-beta precursor protein (APP) 21.6
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 21.6
 LDTP00630  Importin-8 (IPO8) 21.6
 LDTP01380  Wolframin (WFS1) 21.6
 LDTP08327  Osteopetrosis-associated transmembrane protein 1 (OSTM1) 21.4
 LDTP00592  Surfeit locus protein 4 (SURF4) 21.3
 LDTP08673  Calcium uptake protein 2, mitochondrial (MICU2) 21.0
 LDTP13716  Exocyst complex component 7 (EXOC7) 21.0
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 20.5
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 19.8
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 19.8
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 19.8
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 19.7
 LDTP12704  Anoctamin-10 (ANO10) 19.4
 LDTP10065  Transmembrane protein 230 (TMEM230) 19.4
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 19.2
 LDTP11229  Transmembrane protein 70, mitochondrial (TMEM70) 19.2
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 19.0
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 18.9
 LDTP07537  Metal transporter CNNM4 (CNNM4) 18.8
 LDTP06581  Occludin (OCLN) 18.8
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 18.6
 LDTP09288  Vang-like protein 1 (VANGL1) 18.6
 LDTP03546  Translocator protein (TSPO) 18.5
 LDTP12665  Cell cycle control protein 50A (TMEM30A) 18.4
 LDTP10533  Sorting nexin-27 (SNX27) 18.4
 LDTP09028  Mitoguardin 1 (MIGA1) 18.1
 LDTP10073  Protein RFT1 homolog (RFT1) 18.1
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 18.0
 LDTP12383  Protein GPR108 (GPR108) 18.0
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) 18.0
 LDTP13256  SUN domain-containing protein 2 (SUN2) 17.9
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 17.9
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 17.8
 LDTP13973  WASH complex subunit 3 (WASHC3) 17.8
 LDTP11213  Nucleoporin NDC1 (NDC1) 17.6
 LDTP11041  Calcium uptake protein 1, mitochondrial (MICU1) 17.3
 LDTP10317  THO complex subunit 1 (THOC1) 17.3
 LDTP14717  ATP synthase subunit e, mitochondrial (ATP5ME) 17.1
 LDTP08029  Nucleoporin p54 (NUP54) 17.1
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 16.9
 LDTP06293  Metal cation symporter ZIP14 (SLC39A14) 16.9
 LDTP07477  Transmembrane protein 214 (TMEM214) 16.8
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 16.7
 LDTP01574  Importin-7 (IPO7) 16.7
 LDTP10754  Pannexin-1 (PANX1) 16.7
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 16.7
 LDTP13953  Endophilin-B1 (SH3GLB1) 16.6
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 16.4
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 16.4
 LDTP06549  Hsp90 co-chaperone Cdc37 (CDC37) 16.1
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 16.1
 LDTP13320  Prenylated Rab acceptor protein 1 (RABAC1) 16.1
 LDTP12981  Proton-transporting V-type ATPase complex assembly regulator TMEM9 (TMEM9) 16.1
 LDTP05780  Syntaxin-5 (STX5) 16.1
 LDTP12725  Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUB) 16.0
 LDTP07667  Transmembrane protein 205 (TMEM205) 16.0
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08006  PHD finger-like domain-containing protein 5A (PHF5A) 26.9
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 23.4
 LDTP02879  Zinc finger protein 24 (ZNF24) 16.6
Immunoglobulin
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 52.0
 LDTP03772  Basigin (BSG) 32.2
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 24.6
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A) 17.6
 LDTP09907  Neogenin (NEO1) 17.3
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 16.8
Other
Click to Show/Hide to Show 159 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 99.7
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 99.7
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 99.7
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 95.7
 LDTP05160  Nucleobindin-2 (NUCB2) 89.3
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 84.4
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 81.6
 LDTP18883  Protein CEBPZOS (CEBPZOS) 76.1
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 72.5
 LDTP11143  Centromere protein K (CENPK) 70.0
 LDTP14939  Membralin (TMEM259) 64.4
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 62.7
 LDTP14458  Tetraspanin-6 (TSPAN6) 62.7
 LDTP01522  Reticulon-3 (RTN3) 59.7
 LDTP10056  Protein FAM162A (FAM162A) 57.3
 LDTP02927  Ganglioside GM2 activator (GM2A) 56.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 56.5
 LDTP06097  Reticulocalbin-2 (RCN2) 50.9
 LDTP12287  Ran guanine nucleotide release factor (RANGRF) 50.6
 LDTP13086  Syntaxin-18 (STX18) 50.2
 LDTP08224  Protein LYRIC (MTDH) 48.2
 LDTP06892  Protein Hikeshi (HIKESHI) 46.5
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 45.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 43.4
 LDTP19963  TraB domain-containing protein (TRABD) 43.1
 LDTP03926  Centrin-2 (CETN2) 42.5
 LDTP08606  Nurim (NRM) 40.5
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 38.9
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 37.3
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 37.0
 LDTP00417  Programmed cell death protein 5 (PDCD5) 36.8
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 36.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 36.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 35.5
 LDTP11825  Phosducin-like protein 3 (PDCL3) 35.5
 LDTP01494  Protein YIF1A (YIF1A) 35.3
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 35.3
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 34.3
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 32.9
 LDTP16006  Optic atrophy 3 protein (OPA3) 32.2
 LDTP10027  Cytoplasmic 60S subunit biogenesis factor ZNF622 (ZNF622) 31.3
 LDTP09069  Kinetochore protein Spc24 (SPC24) 30.9
 LDTP05734  Protein flightless-1 homolog (FLII) 30.7
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 30.1
 LDTP12412  Reticulon-4 (RTN4) 29.2
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 29.0
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 28.4
 LDTP10113  Mitochondrial import receptor subunit TOM6 homolog (TOMM6) 28.4
 LDTP05277  Protein SET (SET) 28.4
 LDTP19859  Small integral membrane protein 12 (SMIM12) 28.4
 LDTP15095  Receptor expression-enhancing protein 3 (REEP3) 28.2
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 27.7
 LDTP00986  Syntaxin-10 (STX10) 27.7
 LDTP08796  Protein SYS1 homolog (SYS1) 27.1
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 25.5
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 25.3
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 25.1
 LDTP10442  Thioredoxin domain-containing protein 15 (TXNDC15) 24.9
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 24.8
 LDTP00913  Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) 24.8
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 24.8
 LDTP02297  Vimentin (VIM) 24.8
 LDTP10403  DDRGK domain-containing protein 1 (DDRGK1) 24.1
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 24.1
 LDTP02181  Neurofilament medium polypeptide (NEFM) 23.8
 LDTP10908  Protein S100-A13 (S100A13) 23.8
 LDTP15599  UPF0729 protein C18orf32 (C18orf32) 23.4
 LDTP13125  Protein UXT (UXT) 22.9
 LDTP17721  Refilin-B (RFLNB) 22.9
 LDTP00887  Calumenin (CALU) 22.8
 LDTP05719  Cleavage stimulation factor subunit 3 (CSTF3) 22.3
 LDTP04527  RNA-binding protein 5 (RBM5) 22.3
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 22.2
 LDTP19005  SLC35A4 upstream open reading frame protein (SLC35A4) 22.2
 LDTP08766  Vacuolar protein sorting-associated protein 52 homolog (VPS52) 22.2
 LDTP07031  Collectin-12 (COLEC12) 22.0
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 22.0
 LDTP03775  RNA-binding protein FUS (FUS) 22.0
 LDTP13402  Dynactin subunit 4 (DCTN4) 21.9
 LDTP05375  Nucleobindin-1 (NUCB1) 21.7
 LDTP13807  PRELI domain-containing protein 1, mitochondrial (PRELID1) 21.7
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 21.4
 LDTP14125  Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B) 21.4
 LDTP02180  Neurofilament light polypeptide (NEFL) 21.4
 LDTP04207  Heat shock 70 kDa protein 13 (HSPA13) 21.3
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 21.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 21.0
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 20.8
 LDTP11113  Receptor expression-enhancing protein 2 (REEP2) 20.8
 LDTP07718  MICOS complex subunit MIC27 (APOOL) 20.4
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 20.3
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 20.3
 LDTP12379  Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) 20.1
 LDTP01652  Centrosomal protein 43 (CEP43) 20.0
 LDTP09850  Proline-rich protein PRCC (PRCC) 20.0
 LDTP08908  Ephexin-1 (NGEF) 19.7
 LDTP00513  Plexin-B2 (PLXNB2) 19.7
 LDTP04395  RNA-binding protein FXR1 (FXR1) 19.7
 LDTP13338  Vacuolar protein sorting-associated protein 51 homolog (VPS51) 19.7
 LDTP01171  Zinc finger protein ZPR1 (ZPR1) 19.7
 LDTP04356  Emerin (EMD) 19.6
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 19.6
 LDTP12764  MICOS complex subunit MIC19 (CHCHD3) 19.6
 LDTP04425  Translocon-associated protein subunit delta (SSR4) 19.6
 LDTP01163  Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) 19.6
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 19.4
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 19.4
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 19.4
 LDTP08081  Hepatoma-derived growth factor-related protein 2 (HDGFL2) 19.3
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 19.2
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 19.2
 LDTP05224  RNA-binding protein 10 (RBM10) 19.2
 LDTP08000  Dymeclin (DYM) 19.0
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 19.0
 LDTP14716  ATP synthase subunit ATP5MJ, mitochondrial (ATP5MJ) 18.9
 LDTP09787  Nicastrin (NCSTN) 18.9
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 18.9
 LDTP13982  Mitochondrial fission 1 protein (FIS1) 18.8
 LDTP08793  Armadillo repeat-containing protein 10 (ARMC10) 18.6
 LDTP10927  COP9 signalosome complex subunit 8 (COPS8) 18.5
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 18.5
 LDTP11167  Protein YIPF4 (YIPF4) 18.5
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 18.5
 LDTP15398  Protein FAM177A1 (FAM177A1) 18.4
 LDTP10255  Protein Hook homolog 2 (HOOK2) 18.3
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 18.3
 LDTP01510  Zinc finger protein-like 1 (ZFPL1) 18.3
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 18.0
 LDTP13162  Mortality factor 4-like protein 1 (MORF4L1) 18.0
 LDTP09410  Protein bicaudal D homolog 2 (BICD2) 17.9
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 17.8
 LDTP00397  Golgi SNAP receptor complex member 2 (GOSR2) 17.8
 LDTP10184  HAUS augmin-like complex subunit 1 (HAUS1) 17.8
 LDTP09615  Sec1 family domain-containing protein 1 (SCFD1) 17.8
 LDTP13964  MOB-like protein phocein (MOB4) 17.5
 LDTP01661  Synaptosomal-associated protein 29 (SNAP29) 17.3
 LDTP13159  Alpha-catulin (CTNNAL1) 17.1
 LDTP13230  Gamma-tubulin complex component 4 (TUBGCP4) 17.1
 LDTP09920  Golgi apparatus protein 1 (GLG1) 17.1
 LDTP19924  Protein PBDC1 (PBDC1) 17.1
 LDTP09183  Periphilin-1 (PPHLN1) 17.0
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 17.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 16.9
 LDTP14136  Mitochondrial import inner membrane translocase subunit Tim13 (TIMM13) 16.8
 LDTP05501  Fragile X messenger ribonucleoprotein 1 (FMR1) 16.7
 LDTP05741  Large ribosomal subunit protein bL28m (MRPL28) 16.7
 LDTP05318  RNA-binding protein EWS (EWSR1) 16.7
 LDTP08682  Ankyrin repeat domain-containing protein 13A (ANKRD13A) 16.6
 LDTP04557  Arfaptin-2 (ARFIP2) 16.6
 LDTP15741  Cytochrome c oxidase assembly protein COX14 (COX14) 16.4
 LDTP00859  Synaptogyrin-2 (SYNGR2) 16.4
 LDTP06431  Thyroid receptor-interacting protein 11 (TRIP11) 16.4
 LDTP13689  Conserved oligomeric Golgi complex subunit 5 (COG5) 16.2
 LDTP01361  DnaJ homolog subfamily C member 8 (DNAJC8) 16.2
 LDTP15623  Neuferricin (CYB5D2) 16.2
 LDTP04917  Proteasome activator complex subunit 3 (PSME3) 16.2
 LDTP12729  Required for meiotic nuclear division protein 1 homolog (RMND1) 16.1
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 16.0
 LDTP05400  Lamin-B2 (LMNB2) 16.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587