Details of the Target

General Information of Target

Target ID LDTP06645
Target Name Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)
Gene Name HADH
Gene ID 3033
Synonyms
HAD; HAD1; HADHSC; SCHAD; Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; EC 1.1.1.35; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTE
DILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAI
VENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKL
VEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDAS
KEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAEN
KFGKKTGEGFYKYK
Target Bioclass
Enzyme
Family
3-hydroxyacyl-CoA dehydrogenase family
Subcellular location
Mitochondrion matrix
Function
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion.
Uniprot ID
Q16836
Ensemble ID
ENST00000309522.8
HGNC ID
HGNC:4799

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
RKO SNV: p.K127E .
SNU1 SNV: p.L204I .
SUPT1 SNV: p.E299G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.56  LDD0066  [1]
TH211
 Probe Info  		Y226(12.81); Y264(11.14); Y254(10.90)  LDD0257  [2]
TH216
 Probe Info  		Y264(20.00)  LDD0259  [2]
BTD
 Probe Info  		C211(2.34)  LDD1699  [3]
HHS-482
 Probe Info  		Y264(0.79)  LDD0285  [4]
HHS-475
 Probe Info  		Y264(2.92)  LDD0264  [5]
HHS-465
 Probe Info  		Y264(2.08)  LDD2237  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		K305(0.00); K304(0.00); K212(0.00)  LDD0199  [8]
m-APA
 Probe Info  		H207(0.00); H141(0.00)  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0025  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
KY-26
 Probe Info  		N.A.  LDD0301  [12]
1d-yne
 Probe Info  		N.A.  LDD0356  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
DBIA
 Probe Info  		C211(0.44)  LDD2236  [15]
NHS
 Probe Info  		K192(0.00); K202(0.00); K185(0.00)  LDD0010  [16]
SF
 Probe Info  		N.A.  LDD0028  [17]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Acrolein
 Probe Info  		H287(0.00); C211(0.00)  LDD0217  [19]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [19]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [19]
Methacrolein
 Probe Info  		N.A.  LDD0218  [19]
MPP-AC
 Probe Info  		N.A.  LDD0428  [20]
NAIA_5
 Probe Info  		N.A.  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		6.87  LDD1711  [22]
C041
 Probe Info  		6.50  LDD1741  [22]
C042
 Probe Info  		6.02  LDD1742  [22]
C051
 Probe Info  		5.10  LDD1749  [22]
C092
 Probe Info  		19.16  LDD1783  [22]
C106
 Probe Info  		16.56  LDD1793  [22]
C108
 Probe Info  		9.25  LDD1795  [22]
C140
 Probe Info  		14.83  LDD1822  [22]
C153
 Probe Info  		18.51  LDD1834  [22]
C158
 Probe Info  		15.14  LDD1838  [22]
C178
 Probe Info  		22.63  LDD1857  [22]
C179
 Probe Info  		9.25  LDD1858  [22]
C201
 Probe Info  		29.24  LDD1877  [22]
C206
 Probe Info  		16.11  LDD1881  [22]
C228
 Probe Info  		14.72  LDD1901  [22]
C232
 Probe Info  		95.67  LDD1905  [22]
C265
 Probe Info  		42.81  LDD1936  [22]
C270
 Probe Info  		8.75  LDD1940  [22]
C280
 Probe Info  		11.88  LDD1950  [22]
C286
 Probe Info  		5.82  LDD1956  [22]
C292
 Probe Info  		5.35  LDD1962  [22]
C293
 Probe Info  		20.53  LDD1963  [22]
C303
 Probe Info  		11.55  LDD1972  [22]
C337
 Probe Info  		5.74  LDD2000  [22]
C382
 Probe Info  		14.42  LDD2041  [22]
FFF probe13
 Probe Info  		14.18  LDD0475  [23]
FFF probe14
 Probe Info  		20.00  LDD0477  [23]
FFF probe2
 Probe Info  		16.63  LDD0463  [23]
FFF probe3
 Probe Info  		6.58  LDD0464  [23]
FFF probe4
 Probe Info  		5.33  LDD0466  [23]
Kambe_55
 Probe Info  		6.94  LDD0129  [24]
BD-F
 Probe Info  		G257(0.00); P258(0.00); Y264(0.00); M256(0.00)  LDD0024  [25]
LD-F
 Probe Info  		M256(0.00); Y264(0.00); E260(0.00)  LDD0015  [25]
DA-2
 Probe Info  		N.A.  LDD0070  [26]
OEA-DA
 Probe Info  		6.65  LDD0046  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C211(0.42)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C211(0.58)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C211(0.53)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C211(0.96)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C211(0.55)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C211(0.99)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C211(0.99)  LDD2103  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C211(0.43)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C211(0.80)  LDD2131  [3]
 LDCM0545  Acetamide MDA-MB-231 C211(0.26)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C211(0.69)  LDD2113  [3]
 LDCM0498  BS-3668 MDA-MB-231 C211(0.30)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa H287(0.00); C211(0.00)  LDD0222  [19]
 LDCM0625  F8 Ramos C211(1.22)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C211(0.31)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C211(0.40)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C211(0.32)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C211(0.37)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C211(0.84)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C211(0.31)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C211(0.34)  LDD2195  [28]
 LDCM0578  Fragment27 Ramos C211(0.37)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C211(0.72)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C211(0.50)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C211(0.45)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C211(0.40)  LDD2201  [28]
 LDCM0468  Fragment33 Ramos C211(0.34)  LDD2202  [28]
 LDCM0596  Fragment38 Ramos C211(0.61)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C211(0.74)  LDD2184  [28]
 LDCM0610  Fragment52 Ramos C211(0.68)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C211(0.44)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C211(0.47)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C211(0.17)  LDD2188  [28]
 LDCM0116  HHS-0101 DM93 Y264(2.92)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y264(16.87)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y264(4.99)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y264(12.28)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y264(15.37)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [19]
 LDCM0123  JWB131 DM93 Y264(0.79)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y264(0.56)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y264(1.44)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y264(1.35)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y264(1.53)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y264(0.99)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y264(0.41)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y264(0.93)  LDD0292  [4]
 LDCM0073  Kambe_cp3 PC-3 6.94  LDD0129  [24]
 LDCM0022  KB02 Ramos C211(0.47)  LDD2182  [28]
 LDCM0023  KB03 Ramos C211(0.64)  LDD2183  [28]
 LDCM0024  KB05 Ramos C211(0.37)  LDD2185  [28]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C211(0.83)  LDD2102  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C211(0.33)  LDD2121  [3]
 LDCM0109  NEM HeLa H287(0.00); H170(0.00)  LDD0223  [19]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C211(0.33)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C211(1.08)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C211(1.04)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C211(0.76)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C211(1.62)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C211(1.05)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C211(0.76)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C211(0.69)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C211(0.52)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C211(0.44)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C211(1.10)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C211(0.49)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C211(1.08)  LDD2105  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C211(0.38)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C211(0.65)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C211(0.56)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C211(0.58)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C211(0.38)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C211(0.74)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C211(0.44)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C211(0.64)  LDD2115  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C211(1.36)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C211(1.36)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C211(1.77)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C211(0.68)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C211(1.10)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C211(0.65)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C211(1.28)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C211(0.61)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C211(1.42)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C211(0.72)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C211(1.00)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C211(0.70)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C211(0.60)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C211(0.51)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C211(0.76)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C211(0.78)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C211(0.82)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C211(1.12)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C211(0.51)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C211(0.61)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C211(0.99)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C211(2.15)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C211(0.56)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C211(0.69)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C211(4.92)  LDD2147  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C211(0.72)  LDD2148  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C211(1.47)  LDD2149  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C211(0.35)  LDD2150  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C211(1.59)  LDD2151  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C211(1.84)  LDD2153  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C211(0.81)  LDD2207  [29]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Omega-3-carboxylic Acids . DB09568
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acetoacetyl-coa Small molecular drug DB03059
3-hydroxybutyryl-coenzyme A . DB03612

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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