Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C270  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 96 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01300  Cartilage-associated protein (CRTAP) 37.5
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 35.8
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 29.0
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 28.6
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 28.4
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 20.8
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 20.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 19.8
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 17.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 17.3
 LDTP03484  Lysine-specific demethylase 5A (KDM5A) 16.8
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 16.7
 LDTP04689  Adenosine kinase (ADK) 16.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 15.5
 LDTP02569  Glucose-6-phosphate 1-dehydrogenase (G6PD) 14.7
 LDTP06617  Ceramide glucosyltransferase (UGCG) 14.0
 LDTP05905  Acid ceramidase (ASAH1) 13.9
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 13.7
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 12.4
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 12.4
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) 11.6
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 11.5
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 11.4
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 11.2
 LDTP11016  Dual specificity protein phosphatase 9 (DUSP9) 11.2
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 11.2
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 11.2
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 11.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 10.9
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 10.8
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 10.6
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 10.5
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 10.4
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 10.3
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 9.8
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 9.6
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 9.5
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 9.3
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 9.1
 LDTP07525  Protein arginine N-methyltransferase 9 (PRMT9) 9.1
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 8.9
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 8.9
 LDTP13751  Exonuclease 1 (EXO1) 8.9
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 8.9
 LDTP06645  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) 8.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.7
 LDTP04581  Holocytochrome c-type synthase (HCCS) 8.5
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 8.3
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 8.3
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 8.2
 LDTP02837  Beta-galactosidase (GLB1) 8.1
 LDTP17305  Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) 7.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 7.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 7.8
 LDTP17022  Secernin-3 (SCRN3) 7.8
 LDTP10329  Ceramide synthase 2 (CERS2) 7.7
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 7.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 7.6
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 7.6
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 7.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 7.5
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 7.5
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 7.4
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 7.4
 LDTP12318  Calcium-independent phospholipase A2-gamma (PNPLA8) 7.4
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 7.4
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 7.3
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 7.3
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.2
 LDTP03145  Catechol O-methyltransferase (COMT) 7.0
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 7.0
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 7.0
 LDTP09355  Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) 7.0
 LDTP11127  ADP-dependent glucokinase (ADPGK) 6.9
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 6.9
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 6.9
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 6.9
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 6.9
 LDTP07577  Serine/threonine-protein kinase ULK3 (ULK3) 6.7
 LDTP02260  Beta-glucuronidase (GUSB) 6.6
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 6.5
 LDTP06501  Ras-related protein Rab-11B (RAB11B) 6.5
 LDTP04196  26S proteasome non-ATPase regulatory subunit 8 (PSMD8) 6.5
 LDTP00886  Nardilysin (NRDC) 6.5
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 6.4
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 6.4
 LDTP05140  Arginase-2, mitochondrial (ARG2) 6.3
 LDTP03394  Ceramide synthase 1 (CERS1) 6.3
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 6.3
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 6.2
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 6.1
 LDTP02833  Short-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADS) 6.1
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 6.1
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 6.0
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 6.0
 LDTP03842  Squalene synthase (FDFT1) 6.0
Transporter and channel
Click to Show/Hide to Show 58 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08881  Transmembrane protein 199 (TMEM199) 79.3
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 38.1
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 32.9
 LDTP20002  Transmembrane protein 160 (TMEM160) 30.5
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 28.1
 LDTP15948  Transmembrane protein 126A (TMEM126A) 22.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.4
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 17.8
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 17.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 14.8
 LDTP16813  Tetraspanin-3 (TSPAN3) 14.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 14.5
 LDTP05900  Metaxin-1 (MTX1) 14.4
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 14.1
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 13.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 13.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 13.5
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 13.1
 LDTP07236  Protein GPR107 (GPR107) 12.9
 LDTP06633  Reticulon-1 (RTN1) 12.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 12.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 12.6
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 12.1
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 11.7
 LDTP15481  Transmembrane protein 87A (TMEM87A) 11.6
 LDTP11136  Sugar transporter SWEET1 (SLC50A1) 11.3
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 11.2
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 10.4
 LDTP01217  Metaxin-2 (MTX2) 10.3
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 10.1
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 9.3
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 9.3
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 8.8
 LDTP14181  Peroxisomal membrane protein PEX16 (PEX16) 8.8
 LDTP09261  Major facilitator superfamily domain-containing protein 8 (MFSD8) 8.5
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 8.5
 LDTP15967  Tetraspanin-10 (TSPAN10) 8.2
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 8.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 7.8
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 7.6
 LDTP15648  BRI3-binding protein (BRI3BP) 7.6
 LDTP09515  Importin-4 (IPO4) 7.6
 LDTP00592  Surfeit locus protein 4 (SURF4) 7.5
 LDTP11615  Protein tweety homolog 3 (TTYH3) 7.4
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 7.3
 LDTP02215  Prosaposin (PSAP) 7.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 7.0
 LDTP16190  Protein FAM8A1 (FAM8A1) 6.9
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 6.8
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 6.8
 LDTP11626  Protein YIPF3 (YIPF3) 6.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.6
 LDTP05625  AP-1 complex subunit beta-1 (AP1B1) 6.5
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 6.5
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 6.5
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 6.3
 LDTP09788  Sorting nexin-19 (SNX19) 6.1
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 6.1
Other
Click to Show/Hide to Show 46 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 41.4
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 38.6
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 27.5
 LDTP14939  Membralin (TMEM259) 18.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 17.1
 LDTP00105  Protein unc-119 homolog B (UNC119B) 16.0
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 15.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 12.5
 LDTP05160  Nucleobindin-2 (NUCB2) 12.2
 LDTP01359  Dynactin subunit 3 (DCTN3) 11.9
 LDTP01075  Protein CutA (CUTA) 11.7
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 11.6
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 11.5
 LDTP10056  Protein FAM162A (FAM162A) 11.5
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 11.2
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 11.1
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 10.6
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 10.3
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 10.1
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 9.6
 LDTP11233  Tubulin beta-6 chain (TUBB6) 9.3
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 8.9
 LDTP06097  Reticulocalbin-2 (RCN2) 8.9
 LDTP01522  Reticulon-3 (RTN3) 8.8
 LDTP02205  Tubulin beta chain (TUBB) 8.8
 LDTP16080  Protein FAM114A2 (FAM114A2) 8.8
 LDTP16006  Optic atrophy 3 protein (OPA3) 8.7
 LDTP05998  Tubulin beta-2A chain (TUBB2A) 8.3
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 8.2
 LDTP02927  Ganglioside GM2 activator (GM2A) 8.1
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 8.1
 LDTP05868  Protein unc-119 homolog A (UNC119) 8.1
 LDTP08224  Protein LYRIC (MTDH) 8.0
 LDTP10214  Splicing factor ESS-2 homolog (ESS2) 7.8
 LDTP14458  Tetraspanin-6 (TSPAN6) 7.7
 LDTP19859  Small integral membrane protein 12 (SMIM12) 7.4
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 7.0
 LDTP02037  Tubulin beta-4A chain (TUBB4A) 7.0
 LDTP12412  Reticulon-4 (RTN4) 6.9
 LDTP07335  Rho GTPase-activating protein 17 (ARHGAP17) 6.9
 LDTP13086  Syntaxin-18 (STX18) 6.8
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 6.5
 LDTP00887  Calumenin (CALU) 6.5
 LDTP09773  Protein FAM3C (FAM3C) 6.5
 LDTP11115  Leucine zipper putative tumor suppressor 2 (LZTS2) 6.2
 LDTP15398  Protein FAM177A1 (FAM177A1) 6.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587