Details of the Target

General Information of Target

Target ID LDTP02569
Target Name Glucose-6-phosphate 1-dehydrogenase (G6PD)
Gene Name G6PD
Gene ID 2539
Synonyms
Glucose-6-phosphate 1-dehydrogenase; G6PD; EC 1.1.1.49
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR
LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS
DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP
FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK
ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL
DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI
PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
Target Type
Successful
Target Bioclass
Enzyme
Family
Glucose-6-phosphate dehydrogenase family
Subcellular location
Cytoplasm, cytosol
Function
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
TTD ID
T63484
Uniprot ID
P11413
DrugMap ID
TTKN8W0
Ensemble ID
ENST00000369620.6
HGNC ID
HGNC:4057
ChEMBL ID
CHEMBL5347

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SNU5 SNV: p.E419K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.37  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y424(16.76); Y249(11.30)  LDD0257  [4]
TH216
 Probe Info  		Y424(10.37)  LDD0259  [4]
AZ-9
 Probe Info  		E475(10.00); E504(10.00)  LDD2209  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
OPA-S-S-alkyne
 Probe Info  		K432(1.85); K360(2.07); K497(3.47); K171(6.51)  LDD3494  [7]
Probe 1
 Probe Info  		Y70(7.57); Y107(30.19); Y112(17.94); Y118(16.85)  LDD3495  [8]
BTD
 Probe Info  		C13(1.60)  LDD1700  [9]
AHL-Pu-1
 Probe Info  		C158(2.81); C13(3.03)  LDD0168  [10]
DBIA
 Probe Info  		C13(16.44)  LDD0209  [11]
HHS-482
 Probe Info  		Y112(0.96); Y249(1.15)  LDD0285  [12]
HHS-475
 Probe Info  		Y507(0.71); Y249(0.73)  LDD0264  [13]
HHS-465
 Probe Info  		Y202(9.39); Y249(10.00)  LDD2237  [14]
5E-2FA
 Probe Info  		H470(0.00); H129(0.00); H124(0.00); H382(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K403(0.00); K497(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C232(0.00); C269(0.00); C446(0.00); C385(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C446(0.00); C158(0.00); C232(0.00)  LDD0032  [18]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [19]
IPIAA_L
 Probe Info  		C385(0.00); C232(0.00); C269(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C294(0.00); C232(0.00); C269(0.00); C446(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		N.A.  LDD0035  [20]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [21]
NAIA_4
 Probe Info  		N.A.  LDD2226  [22]
WYneN
 Probe Info  		C13(0.00); C385(0.00); C158(0.00)  LDD0021  [23]
WYneO
 Probe Info  		C13(0.00); C385(0.00)  LDD0022  [23]
1d-yne
 Probe Info  		N.A.  LDD0356  [24]
Compound 10
 Probe Info  		N.A.  LDD2216  [25]
ENE
 Probe Info  		N.A.  LDD0006  [23]
IPM
 Probe Info  		N.A.  LDD0005  [23]
SF
 Probe Info  		Y401(0.00); Y249(0.00); Y507(0.00); Y503(0.00)  LDD0028  [26]
STPyne
 Probe Info  		N.A.  LDD0009  [23]
TFBX
 Probe Info  		C385(0.00); C13(0.00)  LDD0148  [21]
Phosphinate-6
 Probe Info  		C13(0.00); C385(0.00)  LDD0018  [27]
1c-yne
 Probe Info  		N.A.  LDD0228  [24]
Acrolein
 Probe Info  		C385(0.00); C13(0.00); H201(0.00)  LDD0217  [28]
Crotonaldehyde
 Probe Info  		H186(0.00); C13(0.00)  LDD0219  [28]
Methacrolein
 Probe Info  		C385(0.00); C13(0.00); H186(0.00)  LDD0218  [28]
W1
 Probe Info  		C13(0.00); C385(0.00)  LDD0236  [29]
AOyne
 Probe Info  		11.40  LDD0443  [30]
NAIA_5
 Probe Info  		C294(0.00); C232(0.00); C269(0.00); C446(0.00)  LDD2223  [22]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C233
 Probe Info  		19.84  LDD1906  [31]
C270
 Probe Info  		14.72  LDD1940  [31]
C278
 Probe Info  		52.71  LDD1948  [31]
C299
 Probe Info  		7.67  LDD1968  [31]
FFF probe13
 Probe Info  		12.28  LDD0475  [32]
FFF probe14
 Probe Info  		20.00  LDD0477  [32]
FFF probe2
 Probe Info  		13.07  LDD0463  [32]
FFF probe3
 Probe Info  		6.82  LDD0465  [32]
JN0003
 Probe Info  		12.22  LDD0469  [32]
STS-2
 Probe Info  		N.A.  LDD0138  [33]
VE-P
 Probe Info  		N.A.  LDD0396  [34]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [35]
DA-2
 Probe Info  		N.A.  LDD0070  [36]
STS-1
 Probe Info  		N.A.  LDD0068  [37]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C158(1.17)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C158(0.97); C13(0.59)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C158(1.02); C13(0.65)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C158(1.27)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C158(0.59)  LDD2132  [9]
 LDCM0025  4SU-RNA HEK-293T C158(2.81); C13(3.03)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C446(2.10); C158(2.56); C13(2.16)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C385(0.95); C294(1.25); C446(0.93); C232(0.98)  LDD1507  [38]
 LDCM0215  AC10 HEK-293T C385(1.05); C294(1.11); C446(0.92); C232(0.86)  LDD1508  [38]
 LDCM0226  AC11 HEK-293T C385(1.01); C294(0.98); C446(0.98); C232(1.05)  LDD1509  [38]
 LDCM0237  AC12 HEK-293T C385(1.07); C294(1.13); C446(1.03); C232(1.05)  LDD1510  [38]
 LDCM0259  AC14 HEK-293T C385(0.99); C294(1.03); C446(0.96); C232(1.06)  LDD1512  [38]
 LDCM0270  AC15 HEK-293T C385(1.01); C294(1.01); C446(0.97); C232(1.02)  LDD1513  [38]
 LDCM0276  AC17 HEK-293T C385(1.06); C294(1.09); C446(0.95); C232(0.80)  LDD1515  [38]
 LDCM0277  AC18 HEK-293T C385(1.09); C294(1.09); C446(0.92); C232(1.11)  LDD1516  [38]
 LDCM0278  AC19 HEK-293T C385(1.07); C294(0.89); C446(0.84); C232(1.04)  LDD1517  [38]
 LDCM0279  AC2 HEK-293T C385(1.15); C294(0.89); C446(0.96); C232(0.96)  LDD1518  [38]
 LDCM0280  AC20 HEK-293T C385(1.08); C294(1.18); C446(1.08); C232(0.92)  LDD1519  [38]
 LDCM0281  AC21 HEK-293T C385(1.09); C294(0.82); C446(0.94); C232(1.03)  LDD1520  [38]
 LDCM0282  AC22 HEK-293T C385(1.02); C294(0.85); C446(0.98); C232(1.03)  LDD1521  [38]
 LDCM0283  AC23 HEK-293T C385(1.08); C294(1.01); C446(0.96); C232(1.24)  LDD1522  [38]
 LDCM0284  AC24 HEK-293T C385(1.11); C294(0.87); C446(1.07); C232(0.92)  LDD1523  [38]
 LDCM0285  AC25 HEK-293T C385(1.03); C294(1.30); C446(0.98); C232(1.00)  LDD1524  [38]
 LDCM0286  AC26 HEK-293T C385(1.10); C294(1.11); C446(0.92); C232(0.94)  LDD1525  [38]
 LDCM0287  AC27 HEK-293T C385(0.98); C294(0.93); C446(0.84); C232(1.12)  LDD1526  [38]
 LDCM0288  AC28 HEK-293T C385(1.01); C294(0.93); C446(1.04); C232(0.98)  LDD1527  [38]
 LDCM0289  AC29 HEK-293T C385(0.98); C294(1.05); C446(0.85); C232(1.08)  LDD1528  [38]
 LDCM0290  AC3 HEK-293T C385(0.99); C294(0.95); C446(0.96); C232(0.97)  LDD1529  [38]
 LDCM0291  AC30 HEK-293T C385(0.99); C294(1.10); C446(0.88); C232(1.11)  LDD1530  [38]
 LDCM0292  AC31 HEK-293T C385(1.03); C294(1.04); C446(0.91); C232(0.94)  LDD1531  [38]
 LDCM0293  AC32 HEK-293T C385(1.04); C294(1.02); C446(0.99); C232(1.13)  LDD1532  [38]
 LDCM0294  AC33 HEK-293T C385(0.99); C294(0.95); C446(0.97); C232(0.96)  LDD1533  [38]
 LDCM0295  AC34 HEK-293T C385(1.04); C294(0.87); C446(0.91); C232(0.90)  LDD1534  [38]
 LDCM0296  AC35 HEK-293T C385(1.03); C294(0.92); C446(0.95); C232(0.96)  LDD1535  [38]
 LDCM0297  AC36 HEK-293T C385(1.05); C294(1.02); C446(1.08); C232(0.99)  LDD1536  [38]
 LDCM0298  AC37 HEK-293T C385(1.03); C294(1.02); C446(0.94); C232(1.05)  LDD1537  [38]
 LDCM0299  AC38 HEK-293T C385(1.03); C294(1.14); C446(0.94); C232(1.15)  LDD1538  [38]
 LDCM0300  AC39 HEK-293T C385(1.03); C294(1.08); C446(1.01); C232(0.92)  LDD1539  [38]
 LDCM0301  AC4 HEK-293T C385(1.08); C294(0.86); C446(1.03); C232(0.85)  LDD1540  [38]
 LDCM0302  AC40 HEK-293T C385(1.05); C294(1.03); C446(0.93); C232(0.97)  LDD1541  [38]
 LDCM0303  AC41 HEK-293T C385(1.01); C294(1.06); C446(0.97); C232(0.87)  LDD1542  [38]
 LDCM0304  AC42 HEK-293T C385(1.05); C294(1.30); C446(0.91); C232(0.99)  LDD1543  [38]
 LDCM0305  AC43 HEK-293T C385(1.06); C294(0.85); C446(0.98); C232(0.96)  LDD1544  [38]
 LDCM0306  AC44 HEK-293T C385(1.05); C294(1.00); C446(0.95); C232(1.12)  LDD1545  [38]
 LDCM0307  AC45 HEK-293T C385(0.97); C294(0.92); C446(0.84); C232(1.14)  LDD1546  [38]
 LDCM0308  AC46 HEK-293T C385(1.02); C294(1.11); C446(0.98); C232(1.18)  LDD1547  [38]
 LDCM0309  AC47 HEK-293T C385(1.03); C294(0.97); C446(1.01); C232(1.22)  LDD1548  [38]
 LDCM0310  AC48 HEK-293T C385(1.04); C294(0.99); C446(1.06); C232(0.98)  LDD1549  [38]
 LDCM0311  AC49 HEK-293T C385(1.02); C294(1.14); C446(0.98); C232(1.05)  LDD1550  [38]
 LDCM0312  AC5 HEK-293T C385(1.06); C294(0.94); C446(1.07); C232(1.04)  LDD1551  [38]
 LDCM0313  AC50 HEK-293T C385(1.12); C294(0.97); C446(0.95); C232(0.82)  LDD1552  [38]
 LDCM0314  AC51 HEK-293T C385(0.98); C294(1.08); C446(0.97); C232(0.94)  LDD1553  [38]
 LDCM0315  AC52 HEK-293T C385(1.06); C294(1.03); C446(1.01); C232(0.91)  LDD1554  [38]
 LDCM0316  AC53 HEK-293T C385(1.01); C294(0.90); C446(0.89); C232(1.10)  LDD1555  [38]
 LDCM0317  AC54 HEK-293T C385(1.03); C294(1.03); C446(0.91); C232(1.13)  LDD1556  [38]
 LDCM0318  AC55 HEK-293T C385(1.01); C294(1.02); C446(1.03); C232(1.13)  LDD1557  [38]
 LDCM0319  AC56 HEK-293T C385(1.03); C294(0.98); C446(1.03); C232(1.05)  LDD1558  [38]
 LDCM0320  AC57 HEK-293T C385(1.02); C294(1.19); C446(0.96); C232(0.84)  LDD1559  [38]
 LDCM0321  AC58 HEK-293T C385(1.12); C294(0.93); C446(0.88); C232(1.15)  LDD1560  [38]
 LDCM0322  AC59 HEK-293T C385(1.06); C294(1.10); C446(0.96); C232(1.00)  LDD1561  [38]
 LDCM0323  AC6 HEK-293T C385(1.01); C294(1.11); C446(0.91); C232(1.07)  LDD1562  [38]
 LDCM0324  AC60 HEK-293T C385(1.08); C294(1.11); C446(0.97); C232(1.01)  LDD1563  [38]
 LDCM0325  AC61 HEK-293T C385(1.02); C294(0.98); C446(0.90); C232(1.01)  LDD1564  [38]
 LDCM0326  AC62 HEK-293T C385(1.02); C294(1.11); C446(0.79); C232(1.05)  LDD1565  [38]
 LDCM0327  AC63 HEK-293T C385(1.17); C294(1.01); C446(0.89); C232(1.13)  LDD1566  [38]
 LDCM0328  AC64 HEK-293T C385(1.11); C294(1.07); C446(1.02); C232(1.07)  LDD1567  [38]
 LDCM0334  AC7 HEK-293T C385(1.06); C294(1.01); C446(0.99); C232(1.00)  LDD1568  [38]
 LDCM0345  AC8 HEK-293T C385(1.08); C294(0.95); C446(1.06); C232(1.04)  LDD1569  [38]
 LDCM0545  Acetamide MDA-MB-231 C13(0.42)  LDD2138  [9]
 LDCM0248  AKOS034007472 HEK-293T C385(1.00); C294(0.88); C446(0.94); C232(1.25)  LDD1511  [38]
 LDCM0356  AKOS034007680 HEK-293T C385(0.99); C294(1.26); C446(0.96); C232(0.95)  LDD1570  [38]
 LDCM0275  AKOS034007705 HEK-293T C385(1.01); C294(0.93); C446(0.95); C232(0.98)  LDD1514  [38]
 LDCM0156  Aniline NCI-H1299 11.95  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C158(0.99)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C385(0.00); H186(0.00); H201(0.00); C13(0.00)  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C446(1.32); C13(1.16); C385(0.91); C385(0.90)  LDD2227  [22]
 LDCM0367  CL1 HEK-293T C385(1.04); C294(0.96); C446(1.13); C232(0.92)  LDD1571  [38]
 LDCM0368  CL10 HEK-293T C385(0.94); C294(0.95); C446(0.76); C232(0.92)  LDD1572  [38]
 LDCM0369  CL100 HEK-293T C385(0.96); C294(0.99); C446(0.97); C232(0.92)  LDD1573  [38]
 LDCM0370  CL101 HEK-293T C385(1.01); C294(1.17); C446(0.97); C232(0.91)  LDD1574  [38]
 LDCM0371  CL102 HEK-293T C385(0.90); C446(1.00); C232(1.05); C269(1.07)  LDD1575  [38]
 LDCM0372  CL103 HEK-293T C385(1.07); C294(1.03); C446(0.97); C232(1.05)  LDD1576  [38]
 LDCM0373  CL104 HEK-293T C385(0.98); C294(1.17); C446(0.91); C232(1.01)  LDD1577  [38]
 LDCM0374  CL105 HEK-293T C385(1.00); C294(1.09); C446(1.01); C232(0.81)  LDD1578  [38]
 LDCM0375  CL106 HEK-293T C385(1.04); C446(0.91); C232(1.18); C269(0.85)  LDD1579  [38]
 LDCM0376  CL107 HEK-293T C385(1.10); C294(1.02); C446(1.06); C232(1.01)  LDD1580  [38]
 LDCM0377  CL108 HEK-293T C385(1.13); C294(0.92); C446(0.96); C232(1.11)  LDD1581  [38]
 LDCM0378  CL109 HEK-293T C385(0.97); C294(0.97); C446(0.99); C232(0.92)  LDD1582  [38]
 LDCM0379  CL11 HEK-293T C385(0.96); C294(1.09); C446(0.98); C232(1.19)  LDD1583  [38]
 LDCM0380  CL110 HEK-293T C385(0.89); C446(0.90); C232(1.11); C269(1.09)  LDD1584  [38]
 LDCM0381  CL111 HEK-293T C385(1.02); C294(0.80); C446(0.95); C232(1.04)  LDD1585  [38]
 LDCM0382  CL112 HEK-293T C385(0.98); C294(1.06); C446(0.99); C232(1.18)  LDD1586  [38]
 LDCM0383  CL113 HEK-293T C385(0.97); C294(1.11); C446(1.09); C232(0.99)  LDD1587  [38]
 LDCM0384  CL114 HEK-293T C385(0.88); C446(1.02); C232(1.05); C269(1.29)  LDD1588  [38]
 LDCM0385  CL115 HEK-293T C385(0.79); C294(1.57); C446(0.99); C232(1.09)  LDD1589  [38]
 LDCM0386  CL116 HEK-293T C385(1.00); C294(1.11); C446(1.06); C232(0.92)  LDD1590  [38]
 LDCM0387  CL117 HEK-293T C385(0.94); C294(1.24); C446(0.96); C232(0.83)  LDD1591  [38]
 LDCM0388  CL118 HEK-293T C385(1.00); C446(0.98); C232(1.17); C269(1.10)  LDD1592  [38]
 LDCM0389  CL119 HEK-293T C385(1.04); C294(1.47); C446(1.07); C232(1.07)  LDD1593  [38]
 LDCM0390  CL12 HEK-293T C385(1.14); C294(1.01); C446(0.97); C232(1.08)  LDD1594  [38]
 LDCM0391  CL120 HEK-293T C385(1.01); C294(1.09); C446(1.09); C232(1.30)  LDD1595  [38]
 LDCM0392  CL121 HEK-293T C385(1.05); C294(1.06); C446(1.01); C232(0.90)  LDD1596  [38]
 LDCM0393  CL122 HEK-293T C385(0.88); C446(0.97); C232(1.23); C269(1.07)  LDD1597  [38]
 LDCM0394  CL123 HEK-293T C385(0.94); C294(1.12); C446(0.94); C232(1.00)  LDD1598  [38]
 LDCM0395  CL124 HEK-293T C385(0.96); C294(1.11); C446(0.95); C232(0.91)  LDD1599  [38]
 LDCM0396  CL125 HEK-293T C385(1.01); C294(1.19); C446(0.96); C232(1.04)  LDD1600  [38]
 LDCM0397  CL126 HEK-293T C385(0.94); C446(0.93); C232(1.39); C269(1.29)  LDD1601  [38]
 LDCM0398  CL127 HEK-293T C385(1.09); C294(0.95); C446(0.84); C232(1.31)  LDD1602  [38]
 LDCM0399  CL128 HEK-293T C385(1.06); C294(1.09); C446(0.93); C232(1.01)  LDD1603  [38]
 LDCM0400  CL13 HEK-293T C385(0.93); C294(1.04); C446(0.91); C232(0.81)  LDD1604  [38]
 LDCM0401  CL14 HEK-293T C385(0.96); C446(1.03); C232(1.10); C269(1.08)  LDD1605  [38]
 LDCM0402  CL15 HEK-293T C385(0.92); C294(1.01); C446(0.80); C232(0.98)  LDD1606  [38]
 LDCM0403  CL16 HEK-293T C385(1.07); C294(1.09); C446(0.92); C232(1.15)  LDD1607  [38]
 LDCM0404  CL17 HEK-293T C385(0.69); C294(1.04); C446(0.82); C232(0.75)  LDD1608  [38]
 LDCM0405  CL18 HEK-293T C385(1.13); C294(1.10); C446(0.92); C232(1.07)  LDD1609  [38]
 LDCM0406  CL19 HEK-293T C385(0.95); C294(1.03); C446(0.97); C232(1.04)  LDD1610  [38]
 LDCM0407  CL2 HEK-293T C385(0.84); C446(0.98); C232(1.06); C269(1.24)  LDD1611  [38]
 LDCM0408  CL20 HEK-293T C385(0.89); C294(0.95); C446(1.01); C232(0.96)  LDD1612  [38]
 LDCM0409  CL21 HEK-293T C385(0.95); C294(0.89); C446(0.57); C232(0.88)  LDD1613  [38]
 LDCM0410  CL22 HEK-293T C385(1.00); C294(0.98); C446(0.90); C232(1.17)  LDD1614  [38]
 LDCM0411  CL23 HEK-293T C385(0.97); C294(1.00); C446(0.98); C232(1.23)  LDD1615  [38]
 LDCM0412  CL24 HEK-293T C385(1.06); C294(1.07); C446(0.95); C232(1.48)  LDD1616  [38]
 LDCM0413  CL25 HEK-293T C385(0.90); C294(1.08); C446(0.73); C232(0.87)  LDD1617  [38]
 LDCM0414  CL26 HEK-293T C385(0.91); C446(0.96); C232(1.06); C269(0.95)  LDD1618  [38]
 LDCM0415  CL27 HEK-293T C385(0.99); C294(1.92); C446(0.96); C232(1.14)  LDD1619  [38]
 LDCM0416  CL28 HEK-293T C385(0.95); C294(1.11); C446(0.92); C232(1.12)  LDD1620  [38]
 LDCM0417  CL29 HEK-293T C385(0.94); C294(1.02); C446(0.87); C232(1.18)  LDD1621  [38]
 LDCM0418  CL3 HEK-293T C385(0.93); C294(0.92); C446(0.94); C232(1.12)  LDD1622  [38]
 LDCM0419  CL30 HEK-293T C385(1.09); C294(1.12); C446(0.84); C232(0.78)  LDD1623  [38]
 LDCM0420  CL31 HEK-293T C385(1.02); C294(0.92); C446(0.83); C232(1.13)  LDD1624  [38]
 LDCM0421  CL32 HEK-293T C385(1.04); C294(0.94); C446(1.06); C232(0.85)  LDD1625  [38]
 LDCM0422  CL33 HEK-293T C385(0.90); C294(1.04); C446(0.62); C232(1.02)  LDD1626  [38]
 LDCM0423  CL34 HEK-293T C385(0.98); C294(1.24); C446(0.89); C232(1.12)  LDD1627  [38]
 LDCM0424  CL35 HEK-293T C385(1.04); C294(1.07); C446(0.93); C232(1.70)  LDD1628  [38]
 LDCM0425  CL36 HEK-293T C385(1.05); C294(1.19); C446(0.91); C232(1.31)  LDD1629  [38]
 LDCM0426  CL37 HEK-293T C385(1.00); C294(1.04); C446(0.96); C232(0.87)  LDD1630  [38]
 LDCM0428  CL39 HEK-293T C385(0.98); C294(1.27); C446(1.03); C232(1.15)  LDD1632  [38]
 LDCM0429  CL4 HEK-293T C385(1.00); C294(1.09); C446(0.91); C232(1.01)  LDD1633  [38]
 LDCM0430  CL40 HEK-293T C385(0.98); C294(1.05); C446(0.92); C232(1.22)  LDD1634  [38]
 LDCM0431  CL41 HEK-293T C385(0.92); C294(1.08); C446(0.91); C232(0.87)  LDD1635  [38]
 LDCM0432  CL42 HEK-293T C385(1.10); C294(1.13); C446(0.85); C232(0.83)  LDD1636  [38]
 LDCM0433  CL43 HEK-293T C385(0.98); C294(1.05); C446(0.83); C232(1.06)  LDD1637  [38]
 LDCM0434  CL44 HEK-293T C385(1.04); C294(1.05); C446(0.92); C232(1.09)  LDD1638  [38]
 LDCM0435  CL45 HEK-293T C385(0.93); C294(1.02); C446(0.76); C232(0.91)  LDD1639  [38]
 LDCM0436  CL46 HEK-293T C385(1.02); C294(1.13); C446(0.85); C232(1.04)  LDD1640  [38]
 LDCM0437  CL47 HEK-293T C385(1.07); C294(1.07); C446(0.98); C232(1.32)  LDD1641  [38]
 LDCM0438  CL48 HEK-293T C385(1.01); C294(0.89); C446(0.86); C232(1.31)  LDD1642  [38]
 LDCM0439  CL49 HEK-293T C385(0.95); C294(1.30); C446(0.95); C232(1.00)  LDD1643  [38]
 LDCM0440  CL5 HEK-293T C385(0.87); C294(1.14); C446(0.89); C232(0.93)  LDD1644  [38]
 LDCM0441  CL50 HEK-293T C385(0.88); C446(0.93); C232(1.04); C269(1.09)  LDD1645  [38]
 LDCM0443  CL52 HEK-293T C385(0.93); C294(0.96); C446(0.99); C232(1.19)  LDD1646  [38]
 LDCM0444  CL53 HEK-293T C385(0.78); C294(1.10); C446(0.88); C232(1.09)  LDD1647  [38]
 LDCM0445  CL54 HEK-293T C385(0.92); C294(0.99); C446(0.76); C232(0.78)  LDD1648  [38]
 LDCM0446  CL55 HEK-293T C385(0.96); C294(0.93); C446(0.83); C232(1.06)  LDD1649  [38]
 LDCM0447  CL56 HEK-293T C385(0.98); C294(0.93); C446(0.94); C232(1.09)  LDD1650  [38]
 LDCM0448  CL57 HEK-293T C385(0.92); C294(0.98); C446(0.73); C232(0.81)  LDD1651  [38]
 LDCM0449  CL58 HEK-293T C385(0.94); C294(1.18); C446(0.78); C232(1.12)  LDD1652  [38]
 LDCM0450  CL59 HEK-293T C385(1.00); C294(1.02); C446(0.94); C232(1.09)  LDD1653  [38]
 LDCM0451  CL6 HEK-293T C385(1.02); C294(1.03); C446(0.80); C232(1.07)  LDD1654  [38]
 LDCM0452  CL60 HEK-293T C385(1.04); C294(0.93); C446(1.01); C232(1.25)  LDD1655  [38]
 LDCM0453  CL61 HEK-293T C385(0.94); C294(1.16); C446(0.99); C232(1.02)  LDD1656  [38]
 LDCM0454  CL62 HEK-293T C385(0.96); C446(1.05); C232(1.06); C269(1.06)  LDD1657  [38]
 LDCM0455  CL63 HEK-293T C385(1.00); C294(1.89); C446(0.97); C232(1.04)  LDD1658  [38]
 LDCM0456  CL64 HEK-293T C385(0.89); C294(1.07); C446(0.91); C232(0.99)  LDD1659  [38]
 LDCM0457  CL65 HEK-293T C385(0.99); C294(0.98); C446(0.91); C232(1.01)  LDD1660  [38]
 LDCM0458  CL66 HEK-293T C385(1.04); C294(1.04); C446(0.93); C232(0.74)  LDD1661  [38]
 LDCM0459  CL67 HEK-293T C385(1.10); C294(0.87); C446(0.87); C232(0.99)  LDD1662  [38]
 LDCM0460  CL68 HEK-293T C385(1.02); C294(0.97); C446(0.98); C232(0.95)  LDD1663  [38]
 LDCM0461  CL69 HEK-293T C385(0.97); C294(0.98); C446(0.79); C232(1.10)  LDD1664  [38]
 LDCM0462  CL7 HEK-293T C385(0.99); C294(1.04); C446(0.93); C232(0.98)  LDD1665  [38]
 LDCM0463  CL70 HEK-293T C385(1.02); C294(1.01); C446(0.85); C232(1.21)  LDD1666  [38]
 LDCM0464  CL71 HEK-293T C385(0.97); C294(1.03); C446(0.91); C232(1.10)  LDD1667  [38]
 LDCM0465  CL72 HEK-293T C385(1.02); C294(1.00); C446(0.98); C232(1.37)  LDD1668  [38]
 LDCM0466  CL73 HEK-293T C385(0.94); C294(1.11); C446(0.97); C232(1.08)  LDD1669  [38]
 LDCM0467  CL74 HEK-293T C385(1.01); C446(0.95); C232(0.93); C269(1.03)  LDD1670  [38]
 LDCM0469  CL76 HEK-293T C385(0.91); C294(1.10); C446(0.96); C232(1.61)  LDD1672  [38]
 LDCM0470  CL77 HEK-293T C385(0.93); C294(1.19); C446(0.83); C232(0.78)  LDD1673  [38]
 LDCM0471  CL78 HEK-293T C385(1.09); C294(1.21); C446(0.90); C232(0.96)  LDD1674  [38]
 LDCM0472  CL79 HEK-293T C385(1.04); C294(1.05); C446(0.88); C232(0.99)  LDD1675  [38]
 LDCM0473  CL8 HEK-293T C385(0.85); C294(0.98); C446(0.75); C232(1.00)  LDD1676  [38]
 LDCM0474  CL80 HEK-293T C385(1.01); C294(1.06); C446(1.02); C232(0.98)  LDD1677  [38]
 LDCM0475  CL81 HEK-293T C385(1.00); C294(0.97); C446(0.93); C232(0.97)  LDD1678  [38]
 LDCM0476  CL82 HEK-293T C385(1.06); C294(1.20); C446(0.78); C232(1.18)  LDD1679  [38]
 LDCM0477  CL83 HEK-293T C385(1.00); C294(1.13); C446(0.91); C232(1.23)  LDD1680  [38]
 LDCM0478  CL84 HEK-293T C385(1.07); C294(0.85); C446(0.84); C232(1.11)  LDD1681  [38]
 LDCM0479  CL85 HEK-293T C385(0.86); C294(1.32); C446(0.94); C232(0.89)  LDD1682  [38]
 LDCM0480  CL86 HEK-293T C385(0.88); C446(0.97); C232(1.10); C269(1.06)  LDD1683  [38]
 LDCM0481  CL87 HEK-293T C385(0.95); C294(1.17); C446(0.84); C232(1.12)  LDD1684  [38]
 LDCM0482  CL88 HEK-293T C385(1.04); C294(1.08); C446(0.95); C232(0.89)  LDD1685  [38]
 LDCM0483  CL89 HEK-293T C385(0.98); C294(1.14); C446(0.84); C232(0.83)  LDD1686  [38]
 LDCM0484  CL9 HEK-293T C385(1.10); C294(0.92); C446(0.85); C232(0.94)  LDD1687  [38]
 LDCM0485  CL90 HEK-293T C385(0.96); C294(1.03); C446(0.71); C232(0.77)  LDD1688  [38]
 LDCM0486  CL91 HEK-293T C385(0.98); C294(1.01); C446(0.86); C232(0.94)  LDD1689  [38]
 LDCM0487  CL92 HEK-293T C385(1.02); C294(1.07); C446(0.87); C232(0.91)  LDD1690  [38]
 LDCM0488  CL93 HEK-293T C385(0.97); C294(0.92); C446(0.76); C232(1.05)  LDD1691  [38]
 LDCM0489  CL94 HEK-293T C385(0.93); C294(1.02); C446(0.91); C232(1.07)  LDD1692  [38]
 LDCM0490  CL95 HEK-293T C385(0.84); C294(0.98); C446(0.86); C232(0.89)  LDD1693  [38]
 LDCM0491  CL96 HEK-293T C385(0.98); C294(0.90); C446(0.87); C232(1.30)  LDD1694  [38]
 LDCM0492  CL97 HEK-293T C385(0.95); C294(0.92); C446(0.87); C232(0.85)  LDD1695  [38]
 LDCM0493  CL98 HEK-293T C385(0.94); C446(0.96); C232(1.09); C269(1.17)  LDD1696  [38]
 LDCM0494  CL99 HEK-293T C385(1.03); C294(1.44); C446(0.98); C232(1.11)  LDD1697  [38]
 LDCM0185  Compound 17 HEK-293T 3.75  LDD0512  [32]
 LDCM0634  CY-0357 Hep-G2 C13(0.77); C385(0.51)  LDD2228  [22]
 LDCM0495  E2913 HEK-293T C385(0.99); C294(1.00); C446(1.04); C232(1.00)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C385(1.75); C13(1.19)  LDD1702  [9]
 LDCM0625  F8 Ramos C13(0.44); C158(1.27); C385(1.39); C446(0.27)  LDD2187  [39]
 LDCM0572  Fragment10 Ramos C13(5.32); C158(0.64); C385(1.03); C294(0.48)  LDD2189  [39]
 LDCM0573  Fragment11 Ramos C13(0.31); C158(0.77); C385(0.42); C446(0.62)  LDD2190  [39]
 LDCM0574  Fragment12 Ramos C13(1.68); C158(0.73); C385(1.01); C294(0.29)  LDD2191  [39]
 LDCM0575  Fragment13 Ramos C13(0.99); C158(0.98); C385(1.80); C294(0.97)  LDD2192  [39]
 LDCM0576  Fragment14 Ramos C13(1.20); C158(0.68); C385(1.73); C446(0.57)  LDD2193  [39]
 LDCM0579  Fragment20 Ramos C13(1.79); C158(0.51); C385(1.36); C294(0.46)  LDD2194  [39]
 LDCM0580  Fragment21 Ramos C13(1.04); C158(0.84); C385(1.33); C294(0.45)  LDD2195  [39]
 LDCM0582  Fragment23 Ramos C13(3.43); C158(0.60); C385(1.40); C294(0.22)  LDD2196  [39]
 LDCM0578  Fragment27 Ramos C13(1.35); C158(0.93); C385(1.55)  LDD2197  [39]
 LDCM0586  Fragment28 Ramos C13(0.53); C158(0.74); C385(1.11); C446(1.93)  LDD2198  [39]
 LDCM0588  Fragment30 Ramos C13(1.11); C158(1.39); C385(1.81); C294(0.60)  LDD2199  [39]
 LDCM0589  Fragment31 Ramos C13(0.96); C158(1.45); C385(1.21); C294(0.90)  LDD2200  [39]
 LDCM0590  Fragment32 Ramos C13(2.42); C158(0.77); C385(1.13); C294(0.88)  LDD2201  [39]
 LDCM0468  Fragment33 HEK-293T C385(1.06); C294(0.86); C446(0.99); C232(1.18)  LDD1671  [38]
 LDCM0596  Fragment38 Ramos C13(1.35); C158(0.97); C385(2.34); C294(0.49)  LDD2203  [39]
 LDCM0566  Fragment4 Ramos C13(0.58); C158(0.75); C385(1.07); C446(0.44)  LDD2184  [39]
 LDCM0427  Fragment51 HEK-293T C385(0.93); C446(0.97); C232(1.04); C269(0.97)  LDD1631  [38]
 LDCM0610  Fragment52 Ramos C13(1.98); C158(0.94); C385(1.37)  LDD2204  [39]
 LDCM0614  Fragment56 Ramos C13(1.02); C158(1.09); C385(1.06); C294(0.50)  LDD2205  [39]
 LDCM0569  Fragment7 Ramos C13(2.27); C158(0.47); C385(0.93); C446(0.13)  LDD2186  [39]
 LDCM0571  Fragment9 Ramos C13(6.06); C158(0.49); C385(0.99); C294(0.40)  LDD2188  [39]
 LDCM0116  HHS-0101 DM93 Y507(0.71); Y249(0.73)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y249(0.55); Y507(0.62)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y507(0.67); Y249(0.69)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y249(0.63); Y507(1.05)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y249(0.47); Y507(0.95)  LDD0268  [13]
 LDCM0107  IAA HeLa C385(0.00); H382(0.00); H201(0.00); H186(0.00)  LDD0221  [28]
 LDCM0123  JWB131 DM93 Y112(0.96); Y249(1.15)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y112(1.37); Y249(0.74)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y112(1.20); Y249(0.22)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y112(12.57); Y249(3.55)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y112(1.67); Y249(1.75)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y112(0.65); Y249(0.14)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y112(0.66); Y249(0.66)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y112(1.16); Y249(0.97)  LDD0292  [12]
 LDCM0022  KB02 HEK-293T C13(0.97); C385(1.02); C446(1.05); C232(1.00)  LDD1492  [38]
 LDCM0023  KB03 Jurkat C13(16.44)  LDD0209  [11]
 LDCM0024  KB05 COLO792 C492(1.18); C188(1.57); C43(1.79)  LDD3310  [40]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C13(0.68)  LDD2121  [9]
 LDCM0109  NEM HeLa H186(0.00); H382(0.00); H201(0.00); C385(0.00)  LDD0223  [28]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C13(1.22)  LDD2090  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C158(1.18)  LDD2093  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C13(0.64)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C158(1.52); C13(0.94)  LDD2099  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C13(1.41)  LDD2101  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C158(1.30); C385(0.85)  LDD2107  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C13(0.53)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C158(1.34); C13(0.83)  LDD2111  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C13(0.46)  LDD2115  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C13(0.67)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C158(1.29); C13(2.08); C385(2.43)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C13(0.66)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C13(0.50)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C158(1.01); C13(0.73); C385(1.60)  LDD2123  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C158(1.10); C13(0.60)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C158(0.90)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C13(0.75)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C158(1.26); C13(0.96)  LDD2129  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C13(0.68)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C158(1.61)  LDD2135  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C13(1.14); C385(1.25)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C13(1.60)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C158(1.05)  LDD2140  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C13(0.77)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C158(1.52); C13(2.18)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C158(1.10); C13(0.89)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C13(1.56)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C13(0.62)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C13(1.12)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C158(0.99)  LDD2150  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C446(0.96); C13(0.55)  LDD2206  [41]
 LDCM0628  OTUB2-COV-1 HEK-293T C13(0.71); C446(0.25)  LDD2207  [41]
 LDCM0131  RA190 MM1.R C385(1.30); C294(1.25); C13(1.24)  LDD0304  [42]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [35]
 LDCM0110  W12 Hep-G2 C13(19.29)  LDD0237  [29]
 LDCM0111  W14 Hep-G2 C13(13.79)  LDD0238  [29]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glucose-6-phosphate 1-dehydrogenase (G6PD) Glucose-6-phosphate dehydrogenase family P11413
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) Sirtuin family Q8IXJ6
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glycolic Acid Small molecular drug DB03085
Prasterone Small molecular drug D0K0EK
Artenimol . DB11638
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Epiandrosterone Small molecular drug D0O8FW
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
16-bromoepiandrosterone Small molecular drug DB05107
2'-monophosphoadenosine 5'-diphosphoribose Small molecular drug D0J2FY
Hydroxyacetic Acid Small molecular drug D01HNP
Metazamide Small molecular drug D0FF3D
Nicotinamide Adenine Dinucleotide Phosphate . DB03461
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cbf-bs2 . D05JCG

References

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Mass spectrometry data entry: PXD037665
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
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Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
26 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
27 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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31 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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36 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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