Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0110
Competitor Name
W12
Synonyms
31127-39-6; 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime; 1,4-Benzodioxin-6-carboxaldehyde, 2,3-dihydro-, oxime; (E)-N-[(2,3-dihydro-1,4-benzodioxin-6-yl)methylidene]hydroxylamine; 3,4-Ethylenedioxybenzaldehyde oxime; (E)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime; SCHEMBL5563987; MQTBKHWWMQAHAF-UXBLZVDNSA-N; ALBB-033893; MFCD00862517; AKOS008939494; DS-2932; CS-0072819; J-501843; 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehydeoxime; F2163-0258; N-[(2,3-dihydro-1,4-benzodioxin-6-yl)methylidene]hydroxylamine
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 179.17
Lipid-water partition coefficient (xlogp) 1.2
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C9H9NO3
IUPAC Name
(NE)-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethylidene)hydroxylamine
Canonical SMILES
C1COC2=C(O1)C=CC(=C2)C=NO
InChI
InChI=1S/C9H9NO3/c11-10-6-7-1-2-8-9(5-7)13-4-3-12-8/h1-2,5-6,11H,3-4H2/b10-6+
InChIKey
MQTBKHWWMQAHAF-UXBLZVDNSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
W1
 Probe Info  		500 uM Human hepatoblastoma cells (Hep-G2) [1]

Target(s) List of this Competitor

53 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) LDTP02356 6.81  LDD0237 
6-phosphogluconate dehydrogenase, decarboxylating (PGD) LDTP04499 0.63  LDD0237 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 0.88; 0.99  LDD0237 
Actin, cytoplasmic 2 (ACTG1) LDTP05059 0.61; 0.88; 0.88 ...  LDD0237 
Aldo-keto reductase family 1 member C2 (AKR1C2) LDTP04543 1.26; 2.12; 2.12  LDD0237 
Aldo-keto reductase family 1 member C3 (AKR1C3) LDTP03976 1.98; 2.12; 2.12  LDD0237 
Alpha-enolase (ENO1) LDTP02159 1.48; 1.48; 1.48 ...  LDD0237 
Carbonyl reductase [NADPH] 1 (CBR1) LDTP02831 23.54  LDD0237 
Catalase (CAT) LDTP02001 1.06  LDD0237 
Chromatin-remodeling ATPase INO80 (INO80) LDTP13544 14.73  LDD0237 
Cytochrome c oxidase subunit NDUFA4 (NDUFA4) LDTP00293 0.96  LDD0237 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 1.07  LDD0237 
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) LDTP05809 0.67; 1.79; 2.05 ...  LDD0237 
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) LDTP04646 13.22  LDD0237 
Dihydropyrimidinase-related protein 5 (DPYSL5) LDTP11035 1.16  LDD0237 
Diphosphomevalonate decarboxylase (MVD) LDTP04567 3.30  LDD0237 
DNA replication licensing factor MCM3 (MCM3) LDTP03316 14.65  LDD0237 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 34.77  LDD0237 
Endoplasmic reticulum chaperone BiP (HSPA5) LDTP02534 0.76  LDD0237 
Fatty acid synthase (FASN) LDTP04243 7.71  LDD0237 
Fructosamine-3-kinase (FN3K) LDTP11904 24.37  LDD0237 
Glucose-6-phosphate 1-dehydrogenase (G6PD) LDTP02569 19.29  LDD0237 
Glutamate dehydrogenase 1, mitochondrial (GLUD1) LDTP01768 0.82; 0.90  LDD0237 
Glutathione reductase, mitochondrial (GSR) LDTP01771 26.13  LDD0237 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 6.77; 24.30  LDD0237 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 32.92  LDD0237 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 19.66  LDD0237 
Guanidino acid hydrolase, mitochondrial (AGMAT) LDTP15873 1.04  LDD0237 
Heme oxygenase 2 (HMOX2) LDTP03540 14.15  LDD0237 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 7.93  LDD0237 
Macrophage migration inhibitory factor (MIF) LDTP02713 13.62  LDD0237 
Microsomal glutathione S-transferase 1 (MGST1) LDTP02506 4.55  LDD0237 
Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) LDTP09598 4.21  LDD0237 
NAD(P)H dehydrogenase [quinone] 1 (NQO1) LDTP02798 1.14  LDD0237 
NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) LDTP01984 2.98  LDD0237 
Nucleoside diphosphate kinase A (NME1) LDTP02796 0.63; 0.63  LDD0237 
Peroxiredoxin-6 (PRDX6) LDTP03510 0.62; 2.23  LDD0237 
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) LDTP06638 1.03  LDD0237 
Probable ATP-dependent RNA helicase DDX5 (DDX5) LDTP02924 1.95  LDD0237 
Protein disulfide-isomerase (P4HB) LDTP02188 1.39; 1.42  LDD0237 
Quinone oxidoreductase (CRYZ) LDTP05551 3.47  LDD0237 
S-phase kinase-associated protein 1 (SKP1) LDTP05052 38.61  LDD0237 
Squalene synthase (FDFT1) LDTP03842 9.07  LDD0237 
Sulfotransferase 1A4 (SULT1A4) LDTP02431 31.11  LDD0237 
Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) LDTP03515 18.75  LDD0237 
Transitional endoplasmic reticulum ATPase (VCP) LDTP04665 0.60; 0.64; 0.64  LDD0237 
Triosephosphate isomerase (TPI1) LDTP04851 1.39  LDD0237 
Tubulin alpha-1B chain (TUBA1B) LDTP05074 2.12; 2.23; 2.49  LDD0237 
Tubulin alpha-1C chain (TUBA1C) LDTP11074 1.62  LDD0237 
Ubiquitin-like modifier-activating enzyme 1 (UBA1) LDTP03166 1.42  LDD0237 
V-type proton ATPase catalytic subunit A (ATP6V1A) LDTP03859 36.69  LDD0237 
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) LDTP04289 0.83  LDD0237 
X-ray repair cross-complementing protein 5 (XRCC5) LDTP02642 0.52; 0.73  LDD0237 
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⏷ Show the Full List of 53 Enzyme
23 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
14-3-3 protein theta (YWHAQ) LDTP03385 0.98; 1.04  LDD0237 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 0.53  LDD0237 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 0.75  LDD0237 
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 0.56; 0.56  LDD0237 
Calnexin (CANX) LDTP03405 0.76; 0.76  LDD0237 
Calreticulin (CALR) LDTP03402 0.54; 0.54; 0.58 ...  LDD0237 
Catenin delta-1 (CTNND1) LDTP01037 9.27  LDD0237 
Chloride intracellular channel protein 1 (CLIC1) LDTP00244 26.14  LDD0237 
Chloride intracellular channel protein 4 (CLIC4) LDTP14222 24.94  LDD0237 
Clathrin heavy chain 1 (CLTC) LDTP05252 22.63  LDD0237 
Eukaryotic translation initiation factor 5A-2 (EIF5A2) LDTP11657 0.87  LDD0237 
Exportin-5 (XPO5) LDTP12142 17.82  LDD0237 
Filamin-A (FLNA) LDTP03107 9.89  LDD0237 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 0.68  LDD0237 
Oligosaccharyltransferase complex subunit OSTC (OSTC) LDTP12526 2.24  LDD0237 
Protein SEC13 homolog (SEC13) LDTP04707 4.62  LDD0237 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 14.24  LDD0237 
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) LDTP05273 0.60; 0.60; 0.73 ...  LDD0237 
Surfeit locus protein 4 (SURF4) LDTP00592 0.68; 0.68  LDD0237 
Thioredoxin domain-containing protein 17 (TXNDC17) LDTP11103 8.99  LDD0237 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 6.20  LDD0237 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 0.58; 1.41  LDD0237 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 14.56  LDD0237 
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⏷ Show the Full List of 23 Transporter and channel
1 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Zinc finger protein 43 (ZNF43) LDTP14645 22.52  LDD0237 
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74 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
10 kDa heat shock protein, mitochondrial (HSPE1) LDTP04931 1.78  LDD0237 
14-3-3 protein beta/alpha (YWHAB) LDTP03617 1.33; 1.33  LDD0237 
Acyl-CoA-binding protein (DBI) LDTP02177 4.49; 4.49  LDD0237 
Alpha-1-antitrypsin (SERPINA1) LDTP01811 6.85  LDD0237 
Anamorsin (CIAPIN1) LDTP07385 23.21  LDD0237 
Arf-GAP domain and FG repeat-containing protein 2 (AGFG2) LDTP16839 22.94  LDD0237 
Beta-actin-like protein 2 (ACTBL2) LDTP14951 0.61  LDD0237 
CCHC-type zinc finger nucleic acid binding protein (CNBP) LDTP04995 2.42  LDD0237 
Cofilin-1 (CFL1) LDTP03244 35.45  LDD0237 
Coronin-7 (CORO7) LDTP04798 14.82  LDD0237 
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 6.57  LDD0237 
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) LDTP01677 8.25  LDD0237 
Endoplasmin (HSP90B1) LDTP02734 0.54  LDD0237 
F-actin-capping protein subunit beta (CAPZB) LDTP04127 7.81  LDD0237 
Fatty acid-binding protein, liver (FABP1) LDTP02178 5.11; 5.14  LDD0237 
Glypican-3 (GPC3) LDTP04439 0.54; 0.56; 8.64  LDD0237 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 23.86  LDD0237 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 30.87  LDD0237 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 15.61  LDD0237 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 0.64; 0.92  LDD0237 
Histone H1.2 (H1-2) LDTP02845 0.58  LDD0237 
Histone H1.4 (H1-4) LDTP02494 0.58  LDD0237 
Histone H1.5 (H1-5) LDTP02843 0.56  LDD0237 
Histone H2A type 1-C (H2AC6) LDTP09974 0.51; 1.14; 1.14  LDD0237 
Histone H2B type 1-C/E/F/G/I (H2BC4; H2BC6; H2BC7; H2BC8; H2BC10) LDTP05005 0.59; 0.92; 0.99 ...  LDD0237 
Histone H2B type 1-L (H2BC13) LDTP11001 0.50; 0.59; 0.59 ...  LDD0237 
Histone H3.2 (H3C15; H3C14; H3C13) LDTP07899 0.54; 0.60; 0.65 ...  LDD0237 
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) LDTP05004 0.50; 0.86; 0.87 ...  LDD0237 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 18.87  LDD0237 
Large ribosomal subunit protein eL14 (RPL14) LDTP04389 0.83  LDD0237 
Large ribosomal subunit protein eL18 (RPL18) LDTP05509 0.54; 0.55  LDD0237 
Large ribosomal subunit protein eL20 (RPL18A) LDTP05360 0.77; 0.77  LDD0237 
Large ribosomal subunit protein eL22 (RPL22) LDTP03728 0.84  LDD0237 
Large ribosomal subunit protein eL33 (RPL35A) LDTP02940 1.20; 1.86; 1.86  LDD0237 
Large ribosomal subunit protein eL34 (RPL34) LDTP04233 1.24; 13.56; 36.65  LDD0237 
Large ribosomal subunit protein uL16 (RPL10) LDTP03395 1.67  LDD0237 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 0.75; 0.75  LDD0237 
Large ribosomal subunit protein uL30 (RPL7) LDTP02944 0.54; 0.56; 0.56 ...  LDD0237 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 0.51; 0.56  LDD0237 
Lupus La protein (SSB) LDTP02116 29.82  LDD0237 
Mucin-16 (MUC16) LDTP09708 0.88; 0.88; 0.88  LDD0237 
Nucleolar protein 56 (NOP56) LDTP00313 1.50  LDD0237 
Nucleolar protein 58 (NOP58) LDTP13925 19.32  LDD0237 
Perilipin-3 (PLIN3) LDTP01021 5.62  LDD0237 
Piwi-like protein 4 (PIWIL4) LDTP08047 8.85; 8.85  LDD0237 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 10.87; 16.53  LDD0237 
Poly(rC)-binding protein 2 (PCBP2) LDTP06367 1.64; 15.42  LDD0237 
Polypyrimidine tract-binding protein 1 (PTBP1) LDTP03364 0.93  LDD0237 
Pre-mRNA-processing-splicing factor 8 (PRPF8) LDTP07526 0.63  LDD0237 
Prelamin-A/C (LMNA) LDTP01932 9.07; 26.42  LDD0237 
Profilin-1 (PFN1) LDTP02218 0.67; 0.67  LDD0237 
Protein DEK (DEK) LDTP03778 0.95; 1.00  LDD0237 
Protein THEM6 (THEM6) LDTP19831 15.29  LDD0237 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 6.42  LDD0237 
Reticulon-4 (RTN4) LDTP12412 10.39  LDD0237 
Ribosome-binding protein 1 (RRBP1) LDTP13044 1.29  LDD0237 
Serine/arginine-rich splicing factor 3 (SRSF3) LDTP05197 25.02  LDD0237 
Serine/arginine-rich splicing factor 7 (SRSF7) LDTP06583 5.20  LDD0237 
Small nuclear ribonucleoprotein Sm D2 (SNRPD2) LDTP04982 1.13  LDD0237 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 1.00  LDD0237 
Small ribosomal subunit protein eS19 (RPS19) LDTP03864 0.88; 0.93  LDD0237 
Small ribosomal subunit protein eS8 (RPS8) LDTP04964 0.64  LDD0237 
Small ribosomal subunit protein uS2 (RPSA) LDTP02312 0.86; 0.86  LDD0237 
SPATS2-like protein (SPATS2L) LDTP16102 21.99  LDD0237 
Src substrate cortactin (CTTN) LDTP06094 31.61  LDD0237 
Stress-induced-phosphoprotein 1 (STIP1) LDTP03619 0.82; 0.82; 0.83 ...  LDD0237 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 8.90  LDD0237 
T-complex protein 1 subunit theta (CCT8) LDTP04390 6.33  LDD0237 
TAR DNA-binding protein 43 (TARDBP) LDTP05767 4.47  LDD0237 
Targeting protein for Xklp2 (TPX2) LDTP13583 1.69  LDD0237 
Thymosin beta-15B (TMSB15B) LDTP14615 2.18  LDD0237 
Tubulin beta chain (TUBB) LDTP02205 0.77; 1.14  LDD0237 
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) LDTP05033 0.85  LDD0237 
WD repeat-containing protein 64 (WDR64) LDTP18915 0.64  LDD0237 
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⏷ Show the Full List of 74 Other

Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 500 uM
Quantitative Method SILAC
Competitor Name W12
Competitor Concentration 500 uM
In Vitro Experiment Model Model Type
Living cell
Derived Tissue
Liver
Disease Model Hepatoblastoma [ICD-11:DB91]
Model Name Human hepatoblastoma cells (Hep-G2)
Interaction Atlas ID  LDD0237  Download The Altas

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.