Details of the Target

General Information of Target

Target ID LDTP01771
Target Name Glutathione reductase, mitochondrial (GSR)
Gene Name GSR
Gene ID 2936
Synonyms
GLUR; GRD1; Glutathione reductase, mitochondrial; GR; GRase; EC 1.8.1.7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Class-I pyridine nucleotide-disulfide oxidoreductase family
Subcellular location
Cytoplasm; Mitochondrion
Function Maintains high levels of reduced glutathione in the cytosol.
TTD ID
T30803
Uniprot ID
P00390
DrugMap ID
TTEP6RV
Ensemble ID
ENST00000221130.11
HGNC ID
HGNC:4623
ChEMBL ID
CHEMBL2755

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BXPC3 SNV: p.S216T DBIA    Probe Info 
IGR37 SNV: p.P384L DBIA    Probe Info 
IGR39 SNV: p.P384L .
NALM6 SNV: p.G498R DBIA    Probe Info 
U2OS SNV: p.L382V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		4.43  LDD0215  [2]
TH211
 Probe Info  		Y158(15.03)  LDD0257  [3]
YN-1
 Probe Info  		4.41  LDD0444  [4]
YN-4
 Probe Info  		100.00  LDD0445  [4]
STPyne
 Probe Info  		K97(4.61)  LDD0277  [5]
Probe 1
 Probe Info  		Y150(28.60); Y158(64.87)  LDD3495  [6]
BTD
 Probe Info  		C467(2.15)  LDD1700  [7]
DA-P3
 Probe Info  		4.86  LDD0181  [8]
AHL-Pu-1
 Probe Info  		C107(9.03)  LDD0170  [9]
HHS-475
 Probe Info  		Y400(0.72); Y158(0.84)  LDD0264  [10]
HHS-465
 Probe Info  		Y158(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C102(0.99); C107(0.91)  LDD0078  [12]
W1
 Probe Info  		C107(26.13)  LDD0237  [13]
5E-2FA
 Probe Info  		H96(0.00); H173(0.00); H418(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		N.A.  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C107(0.00); C102(0.00); C328(0.00); C467(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C484(0.00); C278(0.00); C377(0.00)  LDD0032  [17]
Lodoacetamide azide
 Probe Info  		C377(0.00); C107(0.00); C102(0.00); C328(0.00)  LDD0037  [16]
NAIA_4
 Probe Info  		C102(0.00); C278(0.00); C484(0.00)  LDD2226  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [19]
WYneN
 Probe Info  		C377(0.00); C102(0.00)  LDD0021  [20]
WYneO
 Probe Info  		C102(0.00); C107(0.00); C377(0.00)  LDD0022  [20]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
Compound 11
 Probe Info  		N.A.  LDD2213  [21]
IPM
 Probe Info  		N.A.  LDD0005  [20]
SF
 Probe Info  		N.A.  LDD0028  [22]
Phosphinate-6
 Probe Info  		C102(0.00); C46(0.00)  LDD0018  [23]
Acrolein
 Probe Info  		C467(0.00); C278(0.00); C102(0.00)  LDD0217  [24]
Methacrolein
 Probe Info  		C102(0.00); C467(0.00); C107(0.00)  LDD0218  [24]
AOyne
 Probe Info  		9.80  LDD0443  [25]
NAIA_5
 Probe Info  		C102(0.00); C377(0.00); C328(0.00); C134(0.00)  LDD2223  [18]
HHS-482
 Probe Info  		Y400(1.65)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C280
 Probe Info  		10.63  LDD1950  [26]
FFF probe13
 Probe Info  		6.00  LDD0475  [27]
FFF probe14
 Probe Info  		20.00  LDD0477  [27]
FFF probe3
 Probe Info  		7.07  LDD0465  [27]
FFF probe4
 Probe Info  		20.00  LDD0466  [27]
STS-1
 Probe Info  		N.A.  LDD0136  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]
DA-2
 Probe Info  		N.A.  LDD0070  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C467(0.80); C461(0.98); C107(0.46)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C467(1.44)  LDD2152  [7]
 LDCM0025  4SU-RNA DM93 C107(9.03)  LDD0170  [9]
 LDCM0214  AC1 HCT 116 C102(1.19); C107(1.19)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C102(1.19); C107(1.47)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C102(0.91)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C102(1.05)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C102(0.93)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C102(1.06)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C102(1.08)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C102(1.03)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C102(0.96)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C102(1.21)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C102(1.13)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C102(1.11)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C102(1.31); C107(1.47)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C102(1.01)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C102(0.94)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C102(1.89)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C102(0.97); C107(1.09)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C102(1.09); C107(1.13)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C102(1.06); C107(1.14)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C102(1.26); C107(1.12)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C102(1.15); C107(1.20)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C102(1.02); C107(1.14)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C102(1.07); C107(1.20)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C102(1.12); C107(1.24)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C102(1.01); C107(1.08)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C102(0.92); C107(0.97)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C102(0.97); C107(1.16)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C102(0.94); C107(0.92)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C102(0.94); C107(1.04)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C102(0.95); C107(0.98)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C102(0.93); C107(1.05)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C102(1.03); C107(1.15)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C102(1.17); C107(1.17)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C102(0.91); C107(0.91)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C102(1.17); C107(1.17)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C102(0.87); C107(0.87)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C102(0.99); C107(0.99)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C102(1.13); C107(1.13)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C102(1.06); C107(1.06)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C102(1.14); C107(1.14)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C102(1.14); C107(1.14)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C102(1.04); C107(1.04)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C102(1.13); C107(1.13)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C102(1.08); C107(1.08)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C102(1.25); C107(1.34)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C102(1.12); C107(1.12)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C102(1.03); C107(1.03)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C102(0.99); C107(0.99)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C102(1.13); C107(1.13)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C102(1.27); C107(1.27)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C102(1.31); C107(1.31)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C102(1.24); C107(1.24)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C102(1.28); C107(1.28)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C102(1.19); C107(1.19)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C102(1.27); C107(1.27)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C102(0.95); C107(1.37)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C102(1.31); C107(1.31)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C102(1.18); C107(1.18)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C102(1.43); C107(1.43)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C102(1.47); C107(1.47)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C102(1.41); C107(1.41)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C102(1.34); C107(1.34)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C102(1.21); C107(1.21)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C102(1.22); C107(1.22)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C107(1.12); C102(1.17)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C107(1.29); C102(1.34)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C107(1.08); C102(1.08)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C102(1.39); C107(1.39)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C107(1.05); C102(1.09)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C102(1.05); C107(1.12)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C102(1.04); C107(1.08)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C107(1.03); C102(1.08)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C107(1.00); C102(1.08)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C102(0.71); C107(0.90)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C102(0.64); C107(0.80)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C102(0.73); C107(0.85)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C102(0.72); C107(0.82)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C102(0.84); C107(0.99)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C102(1.07); C107(1.07)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C102(0.87); C107(1.06)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C102(0.61); C107(0.73)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C102(0.78); C107(0.87)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C107(1.03); C102(1.10)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C102(0.79); C107(1.01)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C102(0.96); C107(0.96)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C102(1.02); C107(1.02)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C102(0.98); C107(0.98)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C102(0.98); C107(0.98)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C102(1.21); C107(1.21)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C102(1.19); C107(1.19)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C102(1.04); C107(1.04)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C102(1.11); C107(1.11)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C102(1.09); C107(1.09)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C102(1.21); C107(1.21)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C102(0.98); C107(0.98)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C102(1.02); C107(1.02)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C102(1.10); C107(1.10)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C102(1.09); C107(1.09)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C102(1.22); C107(1.22)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C102(1.12); C107(1.12)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C102(1.26); C107(1.26)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C102(1.09); C107(1.09)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C102(0.99); C107(0.99)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C102(1.12); C107(1.12)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C102(1.05); C107(1.05)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C102(1.06); C107(1.06)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C102(1.09); C107(1.09)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C102(1.26); C107(1.26)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C102(1.25); C107(1.53)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C102(1.06); C107(1.39)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C102(1.27); C107(1.38)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C102(1.07); C107(1.28)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C102(1.33); C107(1.71)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C102(1.26); C107(1.84)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C102(1.06); C107(1.50)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C102(1.17); C107(1.78)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C102(1.29); C107(1.56)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C102(1.53); C107(1.96)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C102(1.59); C107(1.76)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C102(1.08); C107(1.49)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C102(0.92); C107(0.93)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C107(0.97); C102(0.99)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C102(1.22); C107(1.54)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C107(0.94); C102(1.02)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C102(0.90); C107(0.91)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C107(0.94); C102(0.98)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C102(0.96); C107(0.97)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C102(0.93); C107(0.94)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C107(0.90); C102(0.95)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C102(0.91); C107(0.94)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C102(0.91); C107(0.92)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C102(0.97); C107(0.98)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C107(1.02); C102(1.05)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C102(1.15); C107(1.36)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C102(0.94); C107(1.02)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C107(0.94); C102(0.96)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C102(0.73); C107(0.74)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C107(1.25); C102(1.48)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C107(1.44); C102(1.49)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C102(1.33); C107(1.34)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C107(1.11); C102(1.22)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C107(0.99); C102(1.02)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C102(0.99); C107(1.07)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C107(1.04); C102(1.07)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C102(0.85); C107(1.05)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C107(1.14); C102(1.30)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C102(0.91); C107(1.19)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C102(0.95); C107(1.17)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C107(1.09); C102(1.14)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C107(1.05); C102(1.12)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C102(0.97); C107(1.24)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C107(1.24); C102(1.33)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C102(1.11)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C102(0.98)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C467(0.42)  LDD2138  [7]
 LDCM0248  AKOS034007472 HCT 116 C102(1.06); C107(1.20)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C102(1.22); C107(1.36)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C102(1.07); C107(1.49)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 12.61  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C102(0.99); C107(0.91)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C467(0.61)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C278(0.00); C467(0.00); C102(0.00); C107(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C102(20.00); C102(2.11)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C102(1.12); C107(1.28)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C102(1.85); C107(2.41)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C102(0.93); C107(0.93)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C107(1.26); C102(1.27)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C107(1.14); C102(1.34)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C102(1.27); C107(1.30)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C107(1.11); C102(1.38)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C107(1.08); C102(1.10)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C107(1.16); C102(1.24)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C107(1.16); C102(1.21)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C107(1.09); C102(1.32)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C107(1.06); C102(1.12)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C102(1.43); C107(1.46)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C107(1.21); C102(1.34)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C102(1.06); C107(1.08)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C102(0.56); C107(0.58)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C102(0.68); C107(0.79)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C102(0.96); C107(0.97)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C102(0.72); C107(0.77)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C102(0.88); C107(1.05)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C102(1.17); C107(1.17)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C102(1.12); C107(1.12)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C102(1.13); C107(1.13)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C107(1.14); C102(1.27)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C102(1.10); C107(1.10)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C102(1.52); C107(1.52)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C102(1.33); C107(1.33)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C102(1.64); C107(1.64)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C102(1.10); C107(1.10)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C102(1.07); C107(1.13)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C107(1.34); C102(1.52)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C102(1.22); C107(1.28)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C102(1.05); C107(1.31)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C102(0.95); C107(1.08)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C102(0.92); C107(1.06)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C102(1.06); C107(1.22)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C102(0.92); C107(0.93)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C102(1.21); C107(1.24)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C102(1.05); C107(1.13)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C107(1.03); C102(1.06)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C102(0.86); C107(0.88)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C102(1.22); C107(1.48)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C102(1.33); C107(1.60)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C107(1.18); C102(1.55)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C102(0.90); C107(1.02)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C102(0.92); C107(1.10)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C102(1.08); C107(1.35)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C102(1.07); C107(1.08)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C102(0.86); C107(0.98)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C102(0.99); C107(1.13)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C102(0.88); C107(1.07)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C102(1.36); C107(1.52)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C102(0.88); C107(1.05)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C102(1.17); C107(1.10)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C102(1.34); C107(1.07)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C102(1.61); C107(1.49)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C102(1.64); C107(1.58)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C102(1.27); C107(1.10)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C102(1.43); C107(1.18)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C102(1.24); C107(1.18)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C102(1.17); C107(1.16)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C102(1.19); C107(1.23)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C102(1.56); C107(1.42)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C102(1.26); C107(1.00)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C102(2.57); C107(1.29)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C102(1.24); C107(1.17)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C102(1.24); C107(1.21)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C102(1.44); C107(1.62)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C102(1.17); C107(1.22)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C102(0.90); C107(0.86)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C102(1.05); C107(0.97)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C102(1.03); C107(0.95)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C102(0.94); C107(0.96)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C102(0.95); C107(0.91)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C102(0.98); C107(0.99)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C102(1.20); C107(1.18)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C102(0.99); C107(0.94)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C102(0.94); C107(0.93)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C102(1.00); C107(0.96)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C102(0.97); C107(0.92)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C102(0.95); C107(0.90)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C102(1.14); C107(1.09)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C102(0.95); C107(0.94)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C102(1.16); C107(1.40)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C102(0.98); C107(0.96)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C102(0.97); C107(1.05)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C102(0.88); C107(1.05)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C102(0.92); C107(1.09)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C102(1.03); C107(1.18)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C102(1.06); C107(1.05)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C102(1.06); C107(1.20)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C102(1.17); C107(1.12)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C102(1.09); C107(1.05)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C102(1.04); C107(1.10)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C102(1.02); C107(1.16)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C102(1.11); C107(1.19)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C102(0.98); C107(1.10)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C102(1.01); C107(1.12)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C102(0.99); C107(1.17)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C102(0.98); C107(1.04)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C102(1.19); C107(1.32)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C102(1.07); C107(1.12)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C102(1.15); C107(1.30)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C102(1.27); C107(1.29)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C102(2.07); C107(2.06)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C102(1.13); C107(1.23)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C102(1.17); C107(1.25)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C102(1.57); C107(1.35)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C102(1.30); C107(1.37)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C102(1.66); C107(1.50)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C102(0.98); C107(1.21)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C102(1.10); C107(1.21)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C102(1.10); C107(1.29)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C102(1.20); C107(1.46)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C102(2.05); C107(1.65)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C102(0.89); C107(1.04)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C102(1.21); C107(1.29)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C102(1.18); C107(1.18)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C102(1.10); C107(1.10)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C102(1.14); C107(1.14)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C102(1.29); C107(1.29)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C102(1.43); C107(1.43)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C102(1.03); C107(1.03)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C102(1.05); C107(1.05)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C102(1.09); C107(1.09)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C102(1.12); C107(1.12)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C134(1.16)  LDD1698  [31]
 LDCM0468  Fragment33 HCT 116 C102(1.16); C107(1.04)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C102(2.40); C107(2.27)  LDD0744  [12]
 LDCM0116  HHS-0101 DM93 Y400(0.72); Y158(0.84)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y400(0.51); Y158(0.81)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y158(0.81); Y400(0.90)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y400(0.62); Y158(0.76)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y400(0.61); Y158(0.89)  LDD0268  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C102(3.55); C107(3.55); C134(1.22)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C102(4.00); C107(4.00); C134(1.30)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C102(8.87); C107(8.87); C134(1.33)  LDD0082  [12]
 LDCM0030  Luteolin HEK-293T 5.25  LDD0182  [8]
 LDCM0109  NEM HeLa N.A.  LDD0224  [24]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C467(0.90); C461(1.02)  LDD2093  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C467(0.22); C461(0.19); C107(0.46)  LDD2096  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C467(1.17); C461(0.94)  LDD2099  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C467(0.37)  LDD2104  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C467(0.92); C461(0.74)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C467(0.54); C461(0.57); C107(0.85); C377(0.91)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C467(1.04)  LDD2111  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C467(0.48)  LDD2118  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C467(0.71)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C467(0.45)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C467(0.94)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C467(0.24); C461(0.29); C107(0.55)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C467(0.76); C461(0.77)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C467(0.44)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C467(0.80); C461(0.69); C107(0.70); C102(0.43)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C467(0.53)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C467(1.08); C461(0.93)  LDD2129  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C461(1.07)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C467(0.90); C461(0.88); C107(1.56); C377(1.42)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C467(0.90); C461(0.97); C377(2.06)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C467(2.15)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C467(0.80); C461(0.69)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C467(0.56); C461(0.97)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C461(1.09)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C467(0.66)  LDD2146  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C102(0.97); C102(0.57)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C102(0.50); C102(0.48)  LDD2207  [32]
 LDCM0029  Quercetin HEK-293T 4.86  LDD0181  [8]
 LDCM0021  THZ1 HCT 116 C102(1.16); C107(1.06)  LDD2173  [12]
 LDCM0110  W12 Hep-G2 C107(26.13)  LDD0237  [13]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cannabidiol Small molecular drug DB09061
Carmustine Small molecular drug DB00262
Flavin Adenine Dinucleotide Small molecular drug DB03147
Glutathione Small molecular drug DB00143
Glutathione Disulfide Small molecular drug DB03310
Nadh Small molecular drug DB00157
Oxidized Glutathione Small molecular drug D0V4TY
Copper . DB09130
Thimerosal . DB11590
Investigative
Click To Hide/Show 23 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-(2'-chlorophenyl)Penta-1,4-dien-3-one Small molecular drug D0I8HK
2,4,6 Trinitrobenzene Sulfonate 1,3-bis (2-chlorethyl)-1-nitrosourea Small molecular drug D0YQ0G
3,6-dihydroxy-xanthene-9-propionic Acid Small molecular drug D07FGO
3-(Prop-2-ene-1-sulfinyl)-propene-1-thiol Small molecular drug D0W4IK
3-nitro-l-tyrosine Small molecular drug DB03867
3-sulfino-l-alanine Small molecular drug DB02153
3-sulfinoalanine Small molecular drug D0E8JM
36-dihydroxy-xanthene-9-propionic Acid Small molecular drug DB01644
4-nitrobenzo[C][1,2,5]Thiadiazole Small molecular drug D0V8FG
Flavin-adenine Dinucleotide Small molecular drug D00IMW
Glutathionylspermidine Disulfide Small molecular drug D0T9NZ
Glutathionylspermidine Disulfide Small molecular drug DB02553
Meta-nitro-tyrosine Small molecular drug D0K1AW
Nabiximols Small molecular drug DB14011
Nicotinamide-adenine-dinucleotide Small molecular drug D0R6JE
Trans-(1s(R),2s(R))-2-hydroxycyclooctyl Nitrate Small molecular drug D0L1AV
Trans-(R(S))-2-hydroxy-1-phenylethyl Nitrate Small molecular drug D03MJM
2-(2-phenyl-3-pyridin-2-yl-4567-tetrahydro-2h-isophosphindol-1-yl)Pyridine . DB07393
6-(3-methyl-14-dioxo-14-dihydronaphthalen-2-yl)Hexanoic Acid . DB07714
Medical Cannabis . DB14009
N-6060 . D0P5LX
N-6547 . D06ZXT
N-9xxx . D0F4SI
Patented
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acyl Oxymethyl Acrylamide Ester Derivative 1 Small molecular drug D0Z2MX
Golden Phosphorous Acetyletic Compound 1 Small molecular drug D0W1DK
Golden Phosphorous Acetyletic Compound 2 Small molecular drug D02NYT
Terpyridineplatinum(Ii) Complexe 3 Small molecular drug D03BPZ
Terpyridineplatinum(Ii) Complexe 4 Small molecular drug D05SHW

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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