Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C280  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 104 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 50.6
 LDTP01803  Adenosine deaminase (ADA) 47.2
 LDTP01769  Dihydrofolate reductase (DHFR) 39.7
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 36.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 32.9
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 28.8
 LDTP12197  Ethanolamine kinase 1 (ETNK1) 26.4
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 26.4
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 25.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 23.9
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 23.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 23.1
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 23.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 21.4
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 20.7
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 19.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 18.8
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 18.6
 LDTP07503  Endoplasmic reticulum aminopeptidase 2 (ERAP2) 17.5
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 16.9
 LDTP14814  CTD small phosphatase-like protein 2 (CTDSPL2) 16.7
 LDTP02359  Heme oxygenase 1 (HMOX1) 16.3
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 16.2
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 15.9
 LDTP05905  Acid ceramidase (ASAH1) 15.7
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 15.5
 LDTP05920  Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) 15.3
 LDTP15879  Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) 15.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 15.0
 LDTP13814  Phospholipase A-2-activating protein (PLAA) 15.0
 LDTP02976  Peptidyl-glycine alpha-amidating monooxygenase (PAM) 14.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 13.9
 LDTP06617  Ceramide glucosyltransferase (UGCG) 13.7
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 13.6
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 13.4
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 13.2
 LDTP13352  GTP:AMP phosphotransferase AK3, mitochondrial (AK3) 12.9
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 12.9
 LDTP11199  DCN1-like protein 5 (DCUN1D5) 12.8
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 12.7
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 12.6
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) 12.5
 LDTP02713  Macrophage migration inhibitory factor (MIF) 12.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 12.0
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 12.0
 LDTP12386  Polyamine-transporting ATPase 13A2 (ATP13A2) 12.0
 LDTP09971  Exostosin-2 (EXT2) 11.9
 LDTP06645  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) 11.9
 LDTP04565  Methionine aminopeptidase 1 (METAP1) 11.9
 LDTP13751  Exonuclease 1 (EXO1) 11.8
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 11.8
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 11.8
 LDTP00497  Cyclin-G-associated kinase (GAK) 11.6
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 11.6
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 11.6
 LDTP02505  Lysosomal protective protein (CTSA) 11.6
 LDTP03607  RAC-alpha serine/threonine-protein kinase (AKT1) 11.4
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 11.2
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 11.2
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 11.1
 LDTP09355  Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) 11.1
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 11.1
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 10.9
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 10.8
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 10.6
 LDTP01771  Glutathione reductase, mitochondrial (GSR) 10.6
 LDTP04925  Pterin-4-alpha-carbinolamine dehydratase (PCBD1) 10.6
 LDTP03394  Ceramide synthase 1 (CERS1) 10.3
 LDTP00773  Serine protease HTRA2, mitochondrial (HTRA2) 10.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 10.3
 LDTP11648  NIF3-like protein 1 (NIF3L1) 10.3
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 10.2
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 10.1
 LDTP04119  Glycogenin-1 (GYG1) 10.1
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 10.1
 LDTP05078  Platelet-activating factor acetylhydrolase IB subunit alpha2 (PAFAH1B2) 10.1
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) 10.1
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 10.1
 LDTP08352  Histone-arginine methyltransferase CARM1 (CARM1) 10.0
 LDTP11318  ADP-ribose pyrophosphatase, mitochondrial (NUDT9) 9.9
 LDTP10329  Ceramide synthase 2 (CERS2) 9.9
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 9.8
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 9.8
 LDTP18414  5'-nucleotidase domain-containing protein 2 (NT5DC2) 9.7
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 9.7
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 9.6
 LDTP14141  Mannose-1-phosphate guanyltransferase beta (GMPPB) 9.4
 LDTP04555  Serine/threonine-protein kinase PLK1 (PLK1) 9.4
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 9.3
 LDTP14073  Cyanocobalamin reductase / alkylcobalamin dealkylase (MMACHC) 9.3
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 9.3
 LDTP06513  Septin-7 (SEPTIN7) 9.2
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 9.1
 LDTP14231  GTP-binding protein SAR1b (SAR1B) 9.1
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 9.1
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 9.0
 LDTP12135  Sialate O-acetylesterase (SIAE) 9.0
 LDTP05493  Sulfotransferase 2A1 (SULT2A1) 9.0
 LDTP02260  Beta-glucuronidase (GUSB) 8.9
 LDTP07763  Kynurenine--oxoglutarate transaminase 3 (KYAT3) 8.9
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 8.9
 LDTP01430  E3 ubiquitin-protein ligase listerin (LTN1) 8.8
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 8.8
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 8.8
Transporter and channel
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15948  Transmembrane protein 126A (TMEM126A) 51.3
 LDTP12383  Protein GPR108 (GPR108) 46.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 32.4
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 32.4
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 29.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 28.4
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 27.5
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 23.4
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 19.8
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 18.9
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 18.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 18.6
 LDTP07236  Protein GPR107 (GPR107) 18.3
 LDTP03546  Translocator protein (TSPO) 17.9
 LDTP01804  ATP synthase subunit a (MT-ATP6) 17.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 17.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 15.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 15.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 15.0
 LDTP15481  Transmembrane protein 87A (TMEM87A) 15.0
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 14.8
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 14.2
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 14.2
 LDTP12738  Ceroid-lipofuscinosis neuronal protein 6 (CLN6) 14.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 13.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 13.6
 LDTP04462  H(+)/Cl(-) exchange transporter 6 (CLCN6) 13.4
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 13.1
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 12.9
 LDTP15648  BRI3-binding protein (BRI3BP) 12.3
 LDTP10343  Vacuole membrane protein 1 (VMP1) 12.2
 LDTP15967  Tetraspanin-10 (TSPAN10) 12.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 11.7
 LDTP05900  Metaxin-1 (MTX1) 11.6
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 11.2
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 11.2
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 11.2
 LDTP12191  Vezatin (VEZT) 10.8
 LDTP06198  Major facilitator superfamily domain-containing protein 10 (MFSD10) 10.7
 LDTP03952  Reduced folate transporter (SLC19A1) 10.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 10.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 10.4
 LDTP03380  Stomatin (STOM) 10.3
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 10.3
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 10.1
 LDTP09180  Zinc transporter 7 (SLC30A7) 10.1
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 9.8
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.8
 LDTP13833  Integral membrane protein 2B (ITM2B) 9.8
 LDTP00592  Surfeit locus protein 4 (SURF4) 9.6
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 9.6
 LDTP02010  Annexin A1 (ANXA1) 9.4
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 9.3
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 8.9
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10891  DnaJ homolog subfamily C member 2 (DNAJC2) 11.7
 LDTP05065  Y-box-binding protein 1 (YBX1) 9.6
Other
Click to Show/Hide to Show 46 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15283  Nucleolar protein 9 (NOP9) 41.9
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 40.2
 LDTP00105  Protein unc-119 homolog B (UNC119B) 32.4
 LDTP14819  Heat shock 70 kDa protein 14 (HSPA14) 22.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 18.8
 LDTP16080  Protein FAM114A2 (FAM114A2) 16.2
 LDTP18883  Protein CEBPZOS (CEBPZOS) 14.5
 LDTP05175  Small ribosomal subunit protein mS22 (MRPS22) 14.2
 LDTP11076  Apolipoprotein L2 (APOL2) 13.7
 LDTP01075  Protein CutA (CUTA) 13.5
 LDTP05160  Nucleobindin-2 (NUCB2) 13.3
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 13.2
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 13.2
 LDTP02927  Ganglioside GM2 activator (GM2A) 12.9
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 12.6
 LDTP01522  Reticulon-3 (RTN3) 12.6
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 12.2
 LDTP11108  Vacuolar protein-sorting-associated protein 25 (VPS25) 12.1
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 11.3
 LDTP09069  Kinetochore protein Spc24 (SPC24) 11.3
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 11.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 11.0
 LDTP12591  Kinesin light chain 4 (KLC4) 10.9
 LDTP11825  Phosducin-like protein 3 (PDCL3) 10.6
 LDTP05960  Trophoblast glycoprotein (TPBG) 10.6
 LDTP04127  F-actin-capping protein subunit beta (CAPZB) 10.4
 LDTP03108  Neurofibromin (NF1) 10.1
 LDTP05226  RNA-binding protein 3 (RBM3) 10.1
 LDTP15057  TBC1 domain family member 9B (TBC1D9B) 10.1
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 10.0
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 9.9
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 9.9
 LDTP04396  RNA-binding protein FXR2 (FXR2) 9.9
 LDTP04395  RNA-binding protein FXR1 (FXR1) 9.7
 LDTP16006  Optic atrophy 3 protein (OPA3) 9.6
 LDTP17659  ELMO domain-containing protein 2 (ELMOD2) 9.6
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 9.6
 LDTP08000  Dymeclin (DYM) 9.5
 LDTP10056  Protein FAM162A (FAM162A) 9.3
 LDTP09410  Protein bicaudal D homolog 2 (BICD2) 9.2
 LDTP13430  Protein TASOR (TASOR) 9.2
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 9.1
 LDTP13170  COP9 signalosome complex subunit 7a (COPS7A) 9.1
 LDTP05741  Large ribosomal subunit protein bL28m (MRPL28) 8.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 8.8
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 8.8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587