Details of the Target

General Information of Target

Target ID LDTP18414
Target Name 5'-nucleotidase domain-containing protein 2 (NT5DC2)
Gene Name NT5DC2
Gene ID 64943
Synonyms
5'-nucleotidase domain-containing protein 2; EC 3.1.3.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRHQQTERQDPSQPLSRQHGTYRQIFHPEQLITGKEDAANNYAWGHYTIGKEFIDLLLDR
IRKLADQCTGLQGFLVFHSLGRGTGSDVTSFLMEWLSVNYGKKSKLGFSIYPAPQVSTAM
VQPYNSILTTHTTLEHSDCAFMVDNKAIYDICHCNLDIERPTYTNLNRLISQIVSSITAS
LRFDGALNVDLTEFQTNLVSYLTSTSPWPPMHQSSLQKRYTTSSCWWQRLPMPALSLPTR
W
Target Bioclass
Enzyme
Family
5'(3')-deoxyribonucleotidase family
Uniprot ID
Q9H857
Ensemble ID
ENST00000307076.8
HGNC ID
HGNC:25717
ChEMBL ID
CHEMBL4295945

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		11.00  LDD0385  [1]
Alkylaryl probe 2
 Probe Info  		16.00  LDD0389  [1]
TH211
 Probe Info  		Y457(20.00); Y110(6.46)  LDD0257  [2]
TH214
 Probe Info  		Y457(14.95)  LDD0258  [2]
TH216
 Probe Info  		Y457(9.01)  LDD0259  [2]
Probe 1
 Probe Info  		Y414(79.40)  LDD3495  [3]
P11
 Probe Info  		12.66  LDD0201  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C504(6.51); C507(6.51)  LDD0080  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
SF
 Probe Info  		Y457(0.00); K109(0.00)  LDD0028  [10]
TPP-AC
 Probe Info  		N.A.  LDD0427  [11]
HHS-465
 Probe Info  		N.A.  LDD2240  [12]
HHS-475
 Probe Info  		Y457(0.61)  LDD2238  [13]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.94  LDD1714  [14]
C017
 Probe Info  		6.19  LDD1725  [14]
C063
 Probe Info  		10.13  LDD1760  [14]
C087
 Probe Info  		9.38  LDD1779  [14]
C158
 Probe Info  		9.32  LDD1838  [14]
C252
 Probe Info  		10.63  LDD1925  [14]
C278
 Probe Info  		72.00  LDD1948  [14]
C280
 Probe Info  		9.71  LDD1950  [14]
C284
 Probe Info  		24.25  LDD1954  [14]
C338
 Probe Info  		12.04  LDD2001  [14]
C403
 Probe Info  		15.67  LDD2061  [14]
FFF probe11
 Probe Info  		12.41  LDD0471  [15]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe14
 Probe Info  		20.00  LDD0477  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [15]
FFF probe3
 Probe Info  		9.09  LDD0464  [15]
FFF probe6
 Probe Info  		20.00  LDD0467  [15]
JN0003
 Probe Info  		7.37  LDD0469  [15]
OEA-DA
 Probe Info  		4.74  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C504(2.67); C507(1.52)  LDD0812  [6]
 LDCM0215  AC10 PaTu 8988t C504(1.43); C507(1.43)  LDD1094  [6]
 LDCM0216  AC100 HEK-293T C504(0.98)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C504(0.84)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C504(0.95)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C504(1.06)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C504(1.08)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C504(0.75)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C504(0.75)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C504(1.03)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C504(0.82)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C504(0.93)  LDD0823  [6]
 LDCM0226  AC11 PaTu 8988t C504(1.22); C507(1.22)  LDD1105  [6]
 LDCM0227  AC110 HEK-293T C504(1.54)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C504(1.64)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C504(1.51)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C504(0.90); C507(0.85)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C504(1.22); C507(1.60)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C504(1.33); C507(1.10)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C504(1.67); C507(1.33)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C504(1.22); C507(1.37)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C504(1.13); C507(1.49)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C504(2.00); C507(2.10)  LDD0834  [6]
 LDCM0237  AC12 PaTu 8988t C504(1.47); C507(1.47)  LDD1116  [6]
 LDCM0238  AC120 HEK-293T C504(1.33); C507(1.59)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C504(1.23); C507(1.70)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C504(1.79); C507(2.35)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C504(1.73); C507(2.53)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C504(1.21); C507(1.95)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C504(1.58); C507(2.85)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C504(1.96); C507(4.36)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C504(2.62); C507(2.85)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C507(0.79)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C507(1.35)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C507(1.03)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C507(1.10)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C507(1.27)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C507(1.62)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C507(1.67)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C507(1.70)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C507(1.61)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C507(2.44)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C507(2.44)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C507(3.00)  LDD0856  [6]
 LDCM0259  AC14 PaTu 8988t C504(1.32); C507(1.32)  LDD1138  [6]
 LDCM0260  AC140 HEK-293T C507(1.63)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C507(1.79)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C507(1.62)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C504(0.61)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C504(1.15)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C504(0.84)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C504(1.01)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C504(1.00)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C504(0.86)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C504(0.63)  LDD0867  [6]
 LDCM0270  AC15 PaTu 8988t C504(1.72); C507(1.72)  LDD1149  [6]
 LDCM0271  AC150 HEK-293T C504(0.55)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C504(0.91)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C504(0.98)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C504(0.93)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C504(0.84)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C504(0.69)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C504(0.83)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C504(1.53)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C504(6.13)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C504(5.12)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C504(3.62)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C504(1.44); C507(1.37)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C504(4.07)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C504(5.33)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C504(3.18)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C504(4.77)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C504(2.35)  LDD0882  [6]
 LDCM0285  AC25 PaTu 8988t C504(1.04); C507(1.04)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C504(1.12); C507(1.12)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C504(1.20); C507(1.20)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C504(1.35); C507(1.35)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C504(1.04); C507(1.04)  LDD1168  [6]
 LDCM0290  AC3 HEK-293T C504(1.04); C507(0.87)  LDD0888  [6]
 LDCM0291  AC30 PaTu 8988t C504(0.98); C507(0.98)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C504(1.15); C507(1.15)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C504(1.12); C507(1.12)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C504(1.28); C507(1.28)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C504(1.26); C507(1.26)  LDD1174  [6]
 LDCM0296  AC35 HEK-293T C507(1.00)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C507(0.75)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C507(0.92)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C507(1.67)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C507(0.78)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C504(1.34); C507(1.08)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C507(1.01)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C507(1.06)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C507(1.35)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C507(1.17)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C507(1.01)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C507(0.87)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C504(0.76); C507(0.95)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C504(0.89); C507(0.86)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C504(0.88); C507(1.04)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C504(1.55); C507(1.85)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C504(1.29); C507(1.69)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C504(1.31); C507(1.38)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C504(1.11); C507(1.54)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C504(1.27); C507(1.64)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C504(0.96); C507(1.11)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C504(1.03); C507(1.29)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C504(1.65); C507(1.23)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C504(1.04); C507(1.09)  LDD0917  [6]
 LDCM0320  AC57 HEK-293T C504(1.04)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C504(0.95)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C504(1.13)  LDD0920  [6]
 LDCM0323  AC6 PaTu 8988t C504(1.30); C507(1.30)  LDD1202  [6]
 LDCM0324  AC60 HEK-293T C504(0.92)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C504(1.45)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C504(0.88)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C504(1.55)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C504(1.03)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C504(1.27)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C504(1.05)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C504(1.13)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C507(0.98)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C507(1.24)  LDD0931  [6]
 LDCM0334  AC7 PaTu 8988t C504(1.05); C507(1.05)  LDD1213  [6]
 LDCM0335  AC70 HEK-293T C507(1.45)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C507(1.48)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C507(1.19)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C507(1.46)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C507(1.57)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C507(1.13)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C507(0.93)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C507(1.17)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C507(1.33)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C507(1.08)  LDD0942  [6]
 LDCM0345  AC8 PaTu 8988t C504(1.09); C507(1.09)  LDD1224  [6]
 LDCM0346  AC80 HEK-293T C507(1.50)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C507(1.39)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C507(2.24)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C504(0.80); C507(1.05)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C504(1.21); C507(1.71)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C504(1.05); C507(1.39)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C504(1.18); C507(1.28)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C504(0.88); C507(1.53)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C504(1.04); C507(1.59)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C504(1.49); C507(1.97)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C504(2.74); C507(3.08)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C504(1.10); C507(2.19)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C504(1.15); C507(1.65)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C504(1.22); C507(2.38)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C504(1.72); C507(1.74)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C504(1.17); C507(2.09)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C504(1.37); C507(1.80)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C504(2.58); C507(3.08)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C504(0.80)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C504(0.87)  LDD0964  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C504(1.28); C507(1.28)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C504(1.27); C507(1.27)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C504(1.41); C507(1.41)  LDD1154  [6]
 LDCM0088  C45 HEK-293T 12.66  LDD0201  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C504(2.00); C507(1.93)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C504(1.66); C507(6.11)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C504(1.15); C507(1.38)  LDD0967  [6]
 LDCM0370  CL101 PaTu 8988t C504(1.38); C507(1.38)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C504(1.32); C507(1.32)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C504(1.48); C507(1.48)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C504(1.32); C507(1.32)  LDD1252  [6]
 LDCM0374  CL105 HEK-293T C504(2.61)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C504(2.26)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C504(3.91)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C504(3.44)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C504(2.77)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C504(1.58); C507(4.34)  LDD0977  [6]
 LDCM0380  CL110 HEK-293T C504(4.75)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C504(4.38)  LDD0979  [6]
 LDCM0382  CL112 PaTu 8988t C504(1.31); C507(1.31)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C504(1.15); C507(1.15)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C504(2.03); C507(2.03)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C504(1.24); C507(1.24)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C504(1.39); C507(1.39)  LDD1265  [6]
 LDCM0387  CL117 HEK-293T C507(0.97)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C507(0.89)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C507(1.40)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C504(1.04); C507(1.17)  LDD0988  [6]
 LDCM0391  CL120 HEK-293T C507(1.19)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C504(1.15); C507(1.29)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C504(1.36); C507(1.30)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C504(1.07); C507(1.52)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C504(1.05); C507(1.14)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C504(0.99)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C504(0.82)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C504(0.87)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C504(1.09)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C504(0.75); C507(0.82)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C504(1.12); C507(1.99)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C504(1.36); C507(1.92)  LDD1000  [6]
 LDCM0403  CL16 HEK-293T C504(1.13); C507(0.88)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C504(1.34); C507(1.30)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C504(1.47); C507(1.81)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C504(1.13); C507(1.02)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C504(0.99); C507(1.40)  LDD1005  [6]
 LDCM0408  CL20 HEK-293T C504(1.04); C507(1.03)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C504(1.12); C507(1.45)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C504(1.08); C507(1.32)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C504(0.78); C507(0.82)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C504(1.02); C507(1.15)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C504(1.05); C507(0.99)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C504(0.81); C507(0.65)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C504(0.85); C507(1.08)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C504(0.67); C507(0.85)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C504(0.81); C507(0.73)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C504(1.59); C507(3.20)  LDD1016  [6]
 LDCM0419  CL30 HEK-293T C504(1.12); C507(1.81)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C504(1.57); C507(2.30)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C504(1.63); C507(1.69)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C504(1.81); C507(2.49)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C504(1.54); C507(1.09)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C504(1.61); C507(1.69)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C504(1.18); C507(1.04)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C504(1.42); C507(1.47)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C504(2.06); C507(3.21)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C504(1.37); C507(1.32)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C504(1.52); C507(1.54)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C504(2.25); C507(2.64)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C504(1.60); C507(2.16)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C504(1.71); C507(1.86)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C504(1.34); C507(1.45)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C504(1.89); C507(2.20)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C504(1.80)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C504(1.33)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C504(1.26)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C504(1.24)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C504(1.46); C507(1.29)  LDD1038  [6]
 LDCM0441  CL50 HEK-293T C504(1.39)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C504(1.04)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C504(0.85)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C504(0.90)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C504(1.14)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C504(1.46)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C504(1.21)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C504(1.20)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C504(1.05)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C504(1.58)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C504(1.18); C507(1.69)  LDD1049  [6]
 LDCM0452  CL60 HEK-293T C504(1.56)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C504(2.19)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C504(1.33)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C504(1.72)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C504(1.15)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C504(1.17)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C504(1.06)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C504(1.16)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C504(1.08)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C504(0.93)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C504(1.84); C507(3.36)  LDD1060  [6]
 LDCM0463  CL70 HEK-293T C504(1.03)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C504(1.03)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C504(1.42)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C504(1.00)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C504(1.83)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C507(0.70)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C507(1.00)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C507(0.83)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C507(1.04)  LDD1070  [6]
 LDCM0473  CL8 PaTu 8988t C504(2.56); C507(2.56)  LDD1352  [6]
 LDCM0474  CL80 HEK-293T C507(0.63)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C507(1.48)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C507(1.44)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C507(1.24)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C507(1.02)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C507(0.81)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C507(0.84)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C507(0.94)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C507(1.08)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C507(0.87)  LDD1081  [6]
 LDCM0484  CL9 PaTu 8988t C504(1.56); C507(1.56)  LDD1363  [6]
 LDCM0485  CL90 HEK-293T C507(1.45)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C504(1.39); C507(1.49)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C504(1.48); C507(1.91)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C504(1.27); C507(1.68)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C504(1.85); C507(2.30)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C504(2.79); C507(2.96)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C504(1.99); C507(1.84)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C504(1.43); C507(1.62)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C504(1.36); C507(1.21)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C504(1.04); C507(1.14)  LDD1092  [6]
 LDCM0468  Fragment33 HEK-293T C504(1.83)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C504(1.19); C507(1.17)  LDD1025  [6]
 LDCM0022  KB02 HCT 116 C504(6.51); C507(6.51)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C504(8.11); C507(8.11)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C504(5.33); C507(5.33)  LDD0082  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0099  Phenelzine HEK-293T 3.00  LDD0386  [1]

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD028853
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
12 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570