Probe ID	LDPC0202
Probe Name	Alkylaryl probe 1
Synonyms	(Prop-2-yn-1-yl)hydrazine; 6068-67-3; prop-2-ynylhydrazine; PROP-2-YNYL-HYDRAZINE; 1-(2-propynyl)hydrazine; propargylhydrazine; N-(prop-2-yn-1-yl)-hydrazine; DTXSID20574430; CYCYZHMUOSKYBG-UHFFFAOYSA-N; AKOS006307124; EN300-261024
Probe Type	ABPP Probe
Structure
	3D MOL			2D MOL
Ro5 Violations (Lipinski): 0	Molecular Weight (mw)		70.09
	Lipid-water partition coefficient (xlogp)		-0.8
	Rotatable Bond Count (rotbonds)		1
	Hydrogen Bond Donor Count (hbonddonor)		2
	Hydrogen Bond Acceptor Count (hbondacc)		2
Chemical Identifiers	Formula C3H6N2 IUPAC Name prop-2-ynylhydrazine Canonical SMILES C#CCNN InChI InChI=1S/C3H6N2/c1-2-3-5-4/h1,5H,3-4H2 InChIKey CYCYZHMUOSKYBG-UHFFFAOYSA-N

55 Enzyme Labeled by This Probe Target Name Target ID Binding Site(Ratio) Interaction ID 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) LDTP04232 12.00  LDD0385  5'-3' exonuclease PLD3 (PLD3) LDTP08476 12.00  LDD0385  5'-nucleotidase domain-containing protein 2 (NT5DC2) LDTP18414 11.00  LDD0385  Acid ceramidase (ASAH1) LDTP05905 20.00  LDD0387  Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9) LDTP16274 3.00  LDD0388  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 6.00  LDD0385  Aldehyde dehydrogenase, mitochondrial (ALDH2) LDTP02074 8.00  LDD0385  Alpha-galactosidase A (GLA) LDTP02141 11.00  LDD0385  Beta-galactosidase (GLB1) LDTP02837 12.00  LDD0385  Beta-glucuronidase (GUSB) LDTP02260 4.00  LDD0388  Beta-hexosaminidase subunit beta (HEXB) LDTP02216 12.00  LDD0387  Bleomycin hydrolase (BLMH) LDTP05992 9.00  LDD0385  Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) LDTP04622 4.00  LDD0388  Cathepsin B (CTSB) LDTP02223 9.00  LDD0387  Cathepsin D (CTSD) LDTP02198 13.00  LDD0385  Cathepsin S (CTSS) LDTP03329 4.00  LDD0388  Cathepsin Z (CTSZ) LDTP13147 13.00  LDD0387  Cytosol aminopeptidase (LAP3) LDTP03455 3.00  LDD0388  DCN1-like protein 5 (DCUN1D5) LDTP11199 6.00  LDD0385  Dipeptidyl peptidase 1 (CTSC) LDTP04572 3.00  LDD0386  FAST kinase domain-containing protein 5, mitochondrial (FASTKD5) LDTP07979 18.00  LDD0385  Flavin reductase (NADPH) (BLVRB) LDTP03511 20.00  LDD0385  Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 16.00  LDD0385  Fructose-bisphosphate aldolase C (ALDOC) LDTP02386 16.00  LDD0385  Gamma-glutamyl hydrolase (GGH) LDTP09886 5.00  LDD0387  Inorganic pyrophosphatase 2, mitochondrial (PPA2) LDTP11842 7.00  LDD0385  Kynurenine--oxoglutarate transaminase 3 (KYAT3) LDTP07763 10.00  LDD0385  Legumain (LGMN) LDTP10888 20.00  LDD0385  Leucine carboxyl methyltransferase 1 (LCMT1) LDTP13337 3.00  LDD0386  Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) LDTP03858 7.00  LDD0387  Lysosomal alpha-glucosidase (GAA) LDTP02486 9.00  LDD0387  Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 20.00  LDD0387  Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 3.00  LDD0388  Lysosomal protective protein (CTSA) LDTP02505 4.00  LDD0388  Matrix metalloproteinase-14 (MMP14) LDTP04352 13.00  LDD0388  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) LDTP07651 3.00  LDD0388  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) LDTP01005 14.00  LDD0387  N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 10.00  LDD0387  Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 5.00  LDD0388  Presequence protease, mitochondrial (PITRM1) LDTP07003 12.00  LDD0387  Probable arginine--tRNA ligase, mitochondrial (RARS2) LDTP07092 16.00  LDD0385  Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 13.00  LDD0385  Procathepsin L (CTSL) LDTP02217 20.00  LDD0387  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) LDTP05373 6.00  LDD0387  Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 8.00  LDD0387  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) LDTP02679 15.00  LDD0387  Putative transferase CAF17, mitochondrial (IBA57) LDTP07110 14.00  LDD0385  Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 5.00  LDD0385  Ribonuclease T2 (RNASET2) LDTP00316 3.00  LDD0386  Ribose-5-phosphate isomerase (RPIA) LDTP04236 3.00  LDD0386  S-adenosylmethionine decarboxylase proenzyme (AMD1) LDTP02918 20.00  LDD0385  Secernin-2 (SCRN2) LDTP15725 20.00  LDD0385  Secernin-3 (SCRN3) LDTP17022 20.00  LDD0385  Sepiapterin reductase (SPR) LDTP03730 5.00  LDD0387  Tripeptidyl-peptidase 1 (TPP1) LDTP00428 15.00  LDD0387  ------------------------------------------------------------------------------------ ⏷ Show the Full List of 55 Enzyme
7 Transporter and channel Labeled by This Probe Target Name Target ID Binding Site(Ratio) Interaction ID Amyloid-beta precursor protein (APP) LDTP02071 16.00  LDD0387  Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 20.00  LDD0387  Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 12.00  LDD0387  Prosaposin (PSAP) LDTP02215 3.00  LDD0386  Transferrin receptor protein 1 (TFRC) LDTP01969 3.00  LDD0388  Vesicle-associated membrane protein-associated protein A (VAPA) LDTP12966 20.00  LDD0387  Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 6.00  LDD0387  ------------------------------------------------------------------------------------ ⏷ Show the Full List of 7 Transporter and channel
20 Other Labeled by This Probe Target Name Target ID Binding Site(Ratio) Interaction ID Amyloid beta precursor like protein 2 (APLP2) LDTP05491 19.00  LDD0387  Calponin-2 (CNN2) LDTP10864 4.00  LDD0388  Dedicator of cytokinesis protein 7 (DOCK7) LDTP10613 5.00  LDD0388  Density-regulated protein (DENR) LDTP00808 5.00  LDD0387  Galectin-3-binding protein (LGALS3BP) LDTP05558 7.00  LDD0387  Insulin receptor substrate 4 (IRS4) LDTP00398 20.00  LDD0385  Kelch-like ECH-associated protein 1 (KEAP1) LDTP06051 17.00  LDD0385  Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 9.00  LDD0387  Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 20.00  LDD0387  Melanoma-associated antigen D2 (MAGED2) LDTP13657 6.00  LDD0388  Nonsense-mediated mRNA decay factor SMG9 (SMG9) LDTP11737 16.00  LDD0387  NSFL1 cofactor p47 (NSFL1C) LDTP13684 8.00  LDD0387  Plasminogen activator inhibitor 1 (SERPINE1) LDTP02085 17.00  LDD0387  Progranulin (GRN) LDTP03453 20.00  LDD0387  Protein canopy homolog 3 (CNPY3) LDTP11176 5.00  LDD0387  Protein CREG1 (CREG1) LDTP01279 20.00  LDD0387  Protein FAM50A (FAM50A) LDTP06105 5.00  LDD0387  Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 4.00  LDD0386  Thrombospondin-1 (THBS1) LDTP02238 16.00  LDD0387  Zinc finger protein 185 (ZNF185) LDTP00580 20.00  LDD0388  ------------------------------------------------------------------------------------ ⏷ Show the Full List of 20 Other

Competitor ID	Name	Concentration		Cell-system	Ref
LDCM0099	Phenelzine	10 mM		Human normal cells (HEK-293T)	[1]

1	Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.