Details of the Target

General Information of Target

Target ID LDTP11842
Target Name Inorganic pyrophosphatase 2, mitochondrial (PPA2)
Gene Name PPA2
Gene ID 27068
Synonyms
Inorganic pyrophosphatase 2, mitochondrial; EC 3.6.1.1; Pyrophosphatase SID6-306; Pyrophosphate phospho-hydrolase 2; PPase 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSYDYHQNWGRDGGPRSSGGGYGGGPAGGHGGNRGSGGGGGGGGGGRGGRGRHPGHLKGR
EIGMWYAKKQGQKNKEAERQERAVVHMDERREEQIVQLLNSVQAKNDKESEAQISWFAPE
DHGYGTEVSTKNTPCSENKLDIQEKKLINQEKKMFRIRNRSYIDRDSEYLLQENEPDGTL
DQKLLEDLQKKKNDLRYIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQV
TQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRL
PRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDL
KVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDVIEKIRYVPEQKEHRSQFKR
GFMQGHVNRQEKEEKEAIYKERWPDYVRELRRRYSASTVDVIEMMEDDKVDLNLIVALIR
YIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFLIIPLHSLMPTVNQTQVFKRT
PPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRK
GRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMD
PPSNEAVLLSIRHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLT
IAASLSFKDPFVIPLGKEKIADARRKELAKDTRSDHLTVVNAFEGWEEARRRGFRYEKDY
CWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNINSDNEKIIKAVICAGLY
PKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLY
DCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIVFQSPARIAHLVKELRKELDILLQEK
IESPHPVDWNDTKSRDCAVLSAIIDLIKTQEKATPRNFPPRFQDGYYS
Target Bioclass
Enzyme
Family
PPase family
Subcellular location
Mitochondrion
Function Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function.
Uniprot ID
Q9H2U2
Ensemble ID
ENST00000341695.10
HGNC ID
HGNC:28883

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.L240S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Alkylaryl probe 1
 Probe Info  		7.00  LDD0385  [2]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y142(14.66); Y88(12.66); Y230(10.53)  LDD0260  [4]
ONAyne
 Probe Info  		K224(7.78)  LDD0274  [5]
BTD
 Probe Info  		C44(7.38)  LDD1699  [6]
Probe 1
 Probe Info  		Y48(28.82)  LDD3495  [7]
AHL-Pu-1
 Probe Info  		C274(4.11)  LDD0170  [8]
DBIA
 Probe Info  		C161(13.91); C171(13.91)  LDD0209  [9]
HHS-482
 Probe Info  		Y135(0.93)  LDD0285  [10]
HHS-465
 Probe Info  		Y135(8.66); Y88(7.71)  LDD2237  [11]
5E-2FA
 Probe Info  		H330(0.00); H153(0.00); H58(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K111(0.00); K53(0.00); K69(0.00); K73(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C302(0.00); C44(0.00); C180(0.00); C274(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C44(0.00); C180(0.00); C274(0.00); C302(0.00)  LDD0036  [14]
IPIAA_L
 Probe Info  		C302(0.00); C44(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C180(0.00); C302(0.00); C44(0.00); C274(0.00)  LDD0037  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
WYneN
 Probe Info  		C44(0.00); C180(0.00)  LDD0021  [17]
Compound 10
 Probe Info  		C302(0.00); C44(0.00)  LDD2216  [18]
Compound 11
 Probe Info  		C302(0.00); C44(0.00)  LDD2213  [18]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		K224(0.00); K259(0.00)  LDD0010  [17]
STPyne
 Probe Info  		K276(0.00); K69(0.00)  LDD0009  [17]
Phosphinate-6
 Probe Info  		C274(0.00); C44(0.00)  LDD0018  [19]
1c-yne
 Probe Info  		K111(0.00); K320(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		C161(0.00); C180(0.00); C274(0.00); C171(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		C161(0.00); C180(0.00); C44(0.00); C274(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		C161(0.00); C180(0.00); C274(0.00); C171(0.00)  LDD0218  [21]
W1
 Probe Info  		C44(0.00); C274(0.00); C161(0.00)  LDD0236  [22]
AOyne
 Probe Info  		15.00  LDD0443  [23]
NAIA_5
 Probe Info  		C274(0.00); C302(0.00); C44(0.00); C180(0.00)  LDD2223  [24]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C232
 Probe Info  		37.79  LDD1905  [25]
C235
 Probe Info  		19.70  LDD1908  [25]
FFF probe2
 Probe Info  		13.06  LDD0463  [26]
FFF probe3
 Probe Info  		5.53  LDD0464  [26]
STS-2
 Probe Info  		1.00  LDD0139  [27]
DA-2
 Probe Info  		N.A.  LDD0072  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C44(0.73)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C180(0.60); C44(0.88)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C180(1.29); C44(0.54)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C274(1.38)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C44(1.05)  LDD2103  [6]
 LDCM0025  4SU-RNA DM93 C274(4.11)  LDD0170  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C44(2.64); C302(2.47); C274(2.01)  LDD0372  [8]
 LDCM0214  AC1 HEK-293T C44(0.98); C274(0.86); C180(0.76); C302(0.80)  LDD1507  [29]
 LDCM0215  AC10 HEK-293T C44(0.85); C274(0.88); C180(0.83); C302(0.96)  LDD1508  [29]
 LDCM0226  AC11 HEK-293T C44(1.01); C274(0.93); C180(0.87); C302(0.97)  LDD1509  [29]
 LDCM0237  AC12 HEK-293T C44(1.04); C274(0.96); C180(0.90); C161(0.89)  LDD1510  [29]
 LDCM0259  AC14 HEK-293T C44(0.94); C274(0.99); C180(0.92); C161(1.03)  LDD1512  [29]
 LDCM0270  AC15 HEK-293T C44(1.01); C274(0.91); C180(0.90); C161(1.09)  LDD1513  [29]
 LDCM0276  AC17 HEK-293T C44(0.90); C274(0.90); C180(0.74); C302(0.94)  LDD1515  [29]
 LDCM0277  AC18 HEK-293T C44(0.96); C274(0.94); C180(0.80); C302(0.84)  LDD1516  [29]
 LDCM0278  AC19 HEK-293T C44(0.78); C274(0.59); C180(0.42); C302(0.79)  LDD1517  [29]
 LDCM0279  AC2 HEK-293T C44(1.12); C274(1.06); C180(1.04); C302(1.02)  LDD1518  [29]
 LDCM0280  AC20 HEK-293T C44(0.99); C274(0.87); C180(0.96); C161(0.90)  LDD1519  [29]
 LDCM0281  AC21 HEK-293T C44(0.97); C274(0.88); C180(0.95); C161(0.95)  LDD1520  [29]
 LDCM0282  AC22 HEK-293T C44(1.01); C274(0.95); C180(0.93); C161(0.85)  LDD1521  [29]
 LDCM0283  AC23 HEK-293T C44(1.04); C274(1.01); C180(1.09); C161(1.01)  LDD1522  [29]
 LDCM0284  AC24 HEK-293T C44(1.00); C274(1.12); C180(1.19); C161(1.04)  LDD1523  [29]
 LDCM0285  AC25 HEK-293T C44(0.89); C274(0.85); C180(0.79); C302(1.02)  LDD1524  [29]
 LDCM0286  AC26 HEK-293T C44(0.92); C274(0.90); C180(0.84); C302(0.87)  LDD1525  [29]
 LDCM0287  AC27 HEK-293T C44(0.96); C274(0.87); C180(0.80); C302(1.03)  LDD1526  [29]
 LDCM0288  AC28 HEK-293T C44(1.00); C274(0.94); C180(0.90); C161(0.94)  LDD1527  [29]
 LDCM0289  AC29 HEK-293T C44(0.94); C274(0.91); C180(0.91); C161(0.96)  LDD1528  [29]
 LDCM0290  AC3 HEK-293T C44(0.96); C274(0.94); C180(0.84); C302(0.89)  LDD1529  [29]
 LDCM0291  AC30 HEK-293T C44(1.05); C274(0.91); C180(0.90); C161(1.01)  LDD1530  [29]
 LDCM0292  AC31 HEK-293T C44(1.02); C274(0.92); C180(0.94); C161(0.96)  LDD1531  [29]
 LDCM0293  AC32 HEK-293T C44(0.97); C274(0.98); C180(0.96); C161(0.97)  LDD1532  [29]
 LDCM0294  AC33 HEK-293T C44(0.89); C274(0.89); C180(0.76); C302(1.22)  LDD1533  [29]
 LDCM0295  AC34 HEK-293T C44(0.92); C274(0.88); C180(0.83); C302(0.85)  LDD1534  [29]
 LDCM0296  AC35 HEK-293T C44(0.94); C274(0.88); C180(0.82); C302(0.85)  LDD1535  [29]
 LDCM0297  AC36 HEK-293T C44(1.00); C274(0.99); C180(0.91); C161(0.97)  LDD1536  [29]
 LDCM0298  AC37 HEK-293T C44(1.06); C274(1.30); C180(1.22); C161(1.01)  LDD1537  [29]
 LDCM0299  AC38 HEK-293T C44(0.95); C274(1.07); C180(1.03); C161(0.95)  LDD1538  [29]
 LDCM0300  AC39 HEK-293T C44(0.95); C274(0.99); C180(0.90); C161(0.92)  LDD1539  [29]
 LDCM0301  AC4 HEK-293T C44(1.06); C274(1.01); C180(0.92); C161(0.96)  LDD1540  [29]
 LDCM0302  AC40 HEK-293T C44(1.00); C274(0.99); C180(1.00); C161(0.92)  LDD1541  [29]
 LDCM0303  AC41 HEK-293T C44(0.81); C274(0.90); C180(0.79); C302(1.00)  LDD1542  [29]
 LDCM0304  AC42 HEK-293T C44(0.94); C274(0.79); C180(0.77); C302(0.80)  LDD1543  [29]
 LDCM0305  AC43 HEK-293T C44(0.95); C274(0.90); C180(0.90); C302(0.99)  LDD1544  [29]
 LDCM0306  AC44 HEK-293T C44(1.02); C274(0.94); C180(0.91); C161(0.96)  LDD1545  [29]
 LDCM0307  AC45 HEK-293T C44(0.97); C274(1.01); C180(0.91); C161(0.93)  LDD1546  [29]
 LDCM0308  AC46 HEK-293T C44(0.92); C274(0.94); C180(0.96); C161(0.92)  LDD1547  [29]
 LDCM0309  AC47 HEK-293T C44(0.97); C274(1.00); C180(0.90); C161(0.93)  LDD1548  [29]
 LDCM0310  AC48 HEK-293T C44(0.99); C274(1.01); C180(1.12); C161(1.02)  LDD1549  [29]
 LDCM0311  AC49 HEK-293T C44(0.68); C274(0.79); C180(0.80); C302(1.18)  LDD1550  [29]
 LDCM0312  AC5 HEK-293T C44(1.05); C274(1.07); C180(1.04); C161(0.91)  LDD1551  [29]
 LDCM0313  AC50 HEK-293T C44(0.83); C274(0.92); C180(0.93); C302(0.90)  LDD1552  [29]
 LDCM0314  AC51 HEK-293T C44(1.02); C274(1.03); C180(1.07); C302(1.14)  LDD1553  [29]
 LDCM0315  AC52 HEK-293T C44(0.96); C274(0.88); C180(0.92); C161(0.95)  LDD1554  [29]
 LDCM0316  AC53 HEK-293T C44(1.00); C274(1.05); C180(1.02); C161(1.01)  LDD1555  [29]
 LDCM0317  AC54 HEK-293T C44(0.92); C274(0.93); C180(0.92); C161(0.90)  LDD1556  [29]
 LDCM0318  AC55 HEK-293T C44(1.00); C274(0.85); C180(0.91); C161(1.01)  LDD1557  [29]
 LDCM0319  AC56 HEK-293T C44(0.98); C274(0.94); C180(0.98); C161(0.91)  LDD1558  [29]
 LDCM0320  AC57 HEK-293T C44(0.97); C274(0.79); C180(0.75); C302(0.82)  LDD1559  [29]
 LDCM0321  AC58 HEK-293T C44(0.99); C274(0.90); C180(0.91); C302(0.83)  LDD1560  [29]
 LDCM0322  AC59 HEK-293T C44(1.00); C274(0.94); C180(0.95); C302(0.98)  LDD1561  [29]
 LDCM0323  AC6 HEK-293T C44(1.02); C274(0.91); C180(0.88); C161(1.02)  LDD1562  [29]
 LDCM0324  AC60 HEK-293T C44(0.97); C274(0.87); C180(0.87); C161(0.90)  LDD1563  [29]
 LDCM0325  AC61 HEK-293T C44(0.97); C274(0.89); C180(0.86); C161(0.92)  LDD1564  [29]
 LDCM0326  AC62 HEK-293T C44(0.87); C274(0.84); C180(0.91); C161(0.92)  LDD1565  [29]
 LDCM0327  AC63 HEK-293T C44(0.94); C274(0.92); C180(0.93); C161(0.98)  LDD1566  [29]
 LDCM0328  AC64 HEK-293T C44(0.99); C274(0.91); C180(1.09); C161(1.05)  LDD1567  [29]
 LDCM0334  AC7 HEK-293T C44(1.06); C274(1.16); C180(1.11); C161(1.11)  LDD1568  [29]
 LDCM0345  AC8 HEK-293T C44(1.09); C274(1.01); C180(0.98); C161(0.86)  LDD1569  [29]
 LDCM0520  AKOS000195272 MDA-MB-231 C180(0.99)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C44(1.02); C274(1.08); C180(1.07); C161(1.07)  LDD1511  [29]
 LDCM0356  AKOS034007680 HEK-293T C44(0.84); C274(0.89); C180(0.75); C302(0.85)  LDD1570  [29]
 LDCM0275  AKOS034007705 HEK-293T C44(0.98); C274(0.95); C180(0.93); C161(1.00)  LDD1514  [29]
 LDCM0156  Aniline NCI-H1299 12.81  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C274(0.00); C180(0.00); C44(0.00); C161(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C274(20.00)  LDD2227  [24]
 LDCM0367  CL1 HEK-293T C44(0.91); C274(0.90); C180(1.00); C161(1.04)  LDD1571  [29]
 LDCM0368  CL10 HEK-293T C44(0.84); C274(1.06); C180(0.70); C161(0.85)  LDD1572  [29]
 LDCM0369  CL100 HEK-293T C44(0.92); C274(0.86); C180(0.85); C161(0.89)  LDD1573  [29]
 LDCM0370  CL101 HEK-293T C44(0.98); C274(0.84); C180(0.87); C161(1.08)  LDD1574  [29]
 LDCM0371  CL102 HEK-293T C44(0.91); C274(0.85); C180(0.86); C302(0.84)  LDD1575  [29]
 LDCM0372  CL103 HEK-293T C44(0.90); C274(1.02); C180(0.96); C161(0.99)  LDD1576  [29]
 LDCM0373  CL104 HEK-293T C44(1.03); C274(0.90); C180(0.92); C161(0.99)  LDD1577  [29]
 LDCM0374  CL105 HEK-293T C44(0.94); C274(1.00); C180(0.93); C161(0.92)  LDD1578  [29]
 LDCM0375  CL106 HEK-293T C44(0.97); C274(0.88); C180(0.85); C302(0.99)  LDD1579  [29]
 LDCM0376  CL107 HEK-293T C44(0.85); C274(0.93); C180(0.97); C161(1.05)  LDD1580  [29]
 LDCM0377  CL108 HEK-293T C44(0.96); C274(0.88); C180(0.91); C161(0.84)  LDD1581  [29]
 LDCM0378  CL109 HEK-293T C44(0.95); C274(1.01); C180(0.92); C161(0.99)  LDD1582  [29]
 LDCM0379  CL11 HEK-293T C44(0.84); C274(0.95); C180(0.83); C161(0.97)  LDD1583  [29]
 LDCM0380  CL110 HEK-293T C44(0.85); C274(0.79); C180(0.74); C302(0.78)  LDD1584  [29]
 LDCM0381  CL111 HEK-293T C44(0.92); C274(0.96); C180(0.86); C161(0.97)  LDD1585  [29]
 LDCM0382  CL112 HEK-293T C44(0.96); C274(0.84); C180(0.86); C161(0.83)  LDD1586  [29]
 LDCM0383  CL113 HEK-293T C44(1.01); C274(0.95); C180(1.02); C161(1.04)  LDD1587  [29]
 LDCM0384  CL114 HEK-293T C44(0.87); C274(0.83); C180(0.79); C302(0.77)  LDD1588  [29]
 LDCM0385  CL115 HEK-293T C44(0.92); C274(0.98); C180(0.97); C161(0.99)  LDD1589  [29]
 LDCM0386  CL116 HEK-293T C44(0.97); C274(0.94); C180(0.91); C161(0.86)  LDD1590  [29]
 LDCM0387  CL117 HEK-293T C44(0.99); C274(0.89); C180(0.96); C161(0.98)  LDD1591  [29]
 LDCM0388  CL118 HEK-293T C44(1.04); C274(0.88); C180(0.96); C302(1.01)  LDD1592  [29]
 LDCM0389  CL119 HEK-293T C44(0.98); C274(1.10); C180(1.02); C161(1.07)  LDD1593  [29]
 LDCM0390  CL12 HEK-293T C44(0.94); C274(0.90); C180(0.95); C161(0.96)  LDD1594  [29]
 LDCM0391  CL120 HEK-293T C44(1.03); C274(0.88); C180(0.92); C161(1.04)  LDD1595  [29]
 LDCM0392  CL121 HEK-293T C44(0.97); C274(0.89); C180(0.93); C161(0.92)  LDD1596  [29]
 LDCM0393  CL122 HEK-293T C44(0.93); C274(0.86); C180(0.87); C302(0.98)  LDD1597  [29]
 LDCM0394  CL123 HEK-293T C44(0.77); C274(0.85); C180(0.81); C161(0.87)  LDD1598  [29]
 LDCM0395  CL124 HEK-293T C44(0.86); C274(0.77); C180(0.87); C161(0.89)  LDD1599  [29]
 LDCM0396  CL125 HEK-293T C44(0.99); C274(0.78); C180(1.01); C161(1.17)  LDD1600  [29]
 LDCM0397  CL126 HEK-293T C44(0.94); C274(0.75); C180(0.86); C302(0.98)  LDD1601  [29]
 LDCM0398  CL127 HEK-293T C44(0.96); C274(0.87); C180(0.95); C161(0.93)  LDD1602  [29]
 LDCM0399  CL128 HEK-293T C44(0.99); C274(0.75); C180(0.85); C161(0.91)  LDD1603  [29]
 LDCM0400  CL13 HEK-293T C44(0.85); C274(0.87); C180(0.88); C161(0.98)  LDD1604  [29]
 LDCM0401  CL14 HEK-293T C44(0.98); C274(0.98); C180(0.94); C302(1.06)  LDD1605  [29]
 LDCM0402  CL15 HEK-293T C44(0.81); C274(0.88); C180(0.83); C161(0.86)  LDD1606  [29]
 LDCM0403  CL16 HEK-293T C44(1.08); C274(0.98); C180(0.95); C161(1.03)  LDD1607  [29]
 LDCM0404  CL17 HEK-293T C44(0.77); C274(0.77); C180(0.61); C302(0.82)  LDD1608  [29]
 LDCM0405  CL18 HEK-293T C44(0.90); C274(1.01); C180(0.86); C302(0.93)  LDD1609  [29]
 LDCM0406  CL19 HEK-293T C44(0.90); C274(0.86); C180(0.84); C302(0.94)  LDD1610  [29]
 LDCM0407  CL2 HEK-293T C44(0.94); C274(0.94); C180(0.90); C302(0.85)  LDD1611  [29]
 LDCM0408  CL20 HEK-293T C44(0.94); C274(0.91); C180(0.88); C161(0.94)  LDD1612  [29]
 LDCM0409  CL21 HEK-293T C44(0.77); C274(0.88); C180(0.83); C161(0.81)  LDD1613  [29]
 LDCM0410  CL22 HEK-293T C44(0.96); C274(1.07); C180(0.94); C161(0.87)  LDD1614  [29]
 LDCM0411  CL23 HEK-293T C44(0.97); C274(1.11); C180(0.94); C161(1.02)  LDD1615  [29]
 LDCM0412  CL24 HEK-293T C44(0.96); C274(0.93); C180(0.99); C161(1.01)  LDD1616  [29]
 LDCM0413  CL25 HEK-293T C44(0.88); C274(0.86); C180(0.96); C161(0.97)  LDD1617  [29]
 LDCM0414  CL26 HEK-293T C44(1.01); C274(0.98); C180(1.02); C302(1.06)  LDD1618  [29]
 LDCM0415  CL27 HEK-293T C44(0.92); C274(0.93); C180(0.98); C161(1.04)  LDD1619  [29]
 LDCM0416  CL28 HEK-293T C44(0.95); C274(0.95); C180(0.91); C161(0.91)  LDD1620  [29]
 LDCM0417  CL29 HEK-293T C44(0.88); C274(0.99); C180(0.92); C302(0.86)  LDD1621  [29]
 LDCM0418  CL3 HEK-293T C44(0.90); C274(0.93); C180(0.99); C161(0.93)  LDD1622  [29]
 LDCM0419  CL30 HEK-293T C44(0.93); C274(1.07); C180(0.96); C302(0.96)  LDD1623  [29]
 LDCM0420  CL31 HEK-293T C44(0.95); C274(0.91); C180(0.86); C302(0.91)  LDD1624  [29]
 LDCM0421  CL32 HEK-293T C44(0.99); C274(0.89); C180(0.90); C161(0.89)  LDD1625  [29]
 LDCM0422  CL33 HEK-293T C44(0.80); C274(0.76); C180(0.82); C161(0.79)  LDD1626  [29]
 LDCM0423  CL34 HEK-293T C44(0.95); C274(0.99); C180(0.95); C161(0.87)  LDD1627  [29]
 LDCM0424  CL35 HEK-293T C44(0.97); C274(1.01); C180(0.83); C161(1.03)  LDD1628  [29]
 LDCM0425  CL36 HEK-293T C44(1.01); C274(1.00); C180(0.96); C161(0.89)  LDD1629  [29]
 LDCM0426  CL37 HEK-293T C44(1.07); C274(0.90); C180(1.04); C161(1.07)  LDD1630  [29]
 LDCM0428  CL39 HEK-293T C44(0.99); C274(0.94); C180(0.91); C161(1.01)  LDD1632  [29]
 LDCM0429  CL4 HEK-293T C44(0.98); C274(0.92); C180(0.83); C161(1.06)  LDD1633  [29]
 LDCM0430  CL40 HEK-293T C44(1.03); C274(1.03); C180(0.97); C161(1.08)  LDD1634  [29]
 LDCM0431  CL41 HEK-293T C44(0.92); C274(0.89); C180(0.83); C302(0.85)  LDD1635  [29]
 LDCM0432  CL42 HEK-293T C44(1.06); C274(1.03); C180(0.95); C302(0.95)  LDD1636  [29]
 LDCM0433  CL43 HEK-293T C44(1.11); C274(1.13); C180(1.05); C302(1.11)  LDD1637  [29]
 LDCM0434  CL44 HEK-293T C44(1.03); C274(0.93); C180(0.90); C161(0.97)  LDD1638  [29]
 LDCM0435  CL45 HEK-293T C44(0.90); C274(0.81); C180(0.81); C161(0.88)  LDD1639  [29]
 LDCM0436  CL46 HEK-293T C44(1.06); C274(0.99); C180(0.96); C161(1.05)  LDD1640  [29]
 LDCM0437  CL47 HEK-293T C44(0.97); C274(0.94); C180(0.93); C161(1.10)  LDD1641  [29]
 LDCM0438  CL48 HEK-293T C44(1.06); C274(1.04); C180(1.02); C161(0.99)  LDD1642  [29]
 LDCM0439  CL49 HEK-293T C44(1.02); C274(0.90); C180(1.06); C161(1.05)  LDD1643  [29]
 LDCM0440  CL5 HEK-293T C44(1.03); C274(0.81); C180(0.76); C302(0.79)  LDD1644  [29]
 LDCM0441  CL50 HEK-293T C44(0.99); C274(0.91); C180(0.91); C302(0.87)  LDD1645  [29]
 LDCM0443  CL52 HEK-293T C44(1.06); C274(0.96); C180(0.88); C161(0.95)  LDD1646  [29]
 LDCM0444  CL53 HEK-293T C44(0.82); C274(0.81); C180(0.70); C302(0.77)  LDD1647  [29]
 LDCM0445  CL54 HEK-293T C44(0.69); C274(0.78); C180(0.72); C302(0.74)  LDD1648  [29]
 LDCM0446  CL55 HEK-293T C44(0.98); C274(1.00); C180(0.85); C302(0.90)  LDD1649  [29]
 LDCM0447  CL56 HEK-293T C44(1.02); C274(0.96); C180(0.87); C161(0.92)  LDD1650  [29]
 LDCM0448  CL57 HEK-293T C44(0.83); C274(0.86); C180(0.78); C161(0.80)  LDD1651  [29]
 LDCM0449  CL58 HEK-293T C44(0.86); C274(1.05); C180(0.90); C161(0.85)  LDD1652  [29]
 LDCM0450  CL59 HEK-293T C44(0.94); C274(0.98); C180(0.84); C161(0.99)  LDD1653  [29]
 LDCM0451  CL6 HEK-293T C44(0.93); C274(0.89); C180(0.75); C302(0.74)  LDD1654  [29]
 LDCM0452  CL60 HEK-293T C44(1.01); C274(1.00); C180(1.06); C161(0.92)  LDD1655  [29]
 LDCM0453  CL61 HEK-293T C44(1.08); C274(0.92); C180(1.10); C161(1.05)  LDD1656  [29]
 LDCM0454  CL62 HEK-293T C44(1.06); C274(1.02); C180(1.08); C302(1.07)  LDD1657  [29]
 LDCM0455  CL63 HEK-293T C44(1.00); C274(1.04); C180(1.10); C161(1.13)  LDD1658  [29]
 LDCM0456  CL64 HEK-293T C44(0.96); C274(0.86); C180(0.90); C161(0.96)  LDD1659  [29]
 LDCM0457  CL65 HEK-293T C44(0.92); C274(0.88); C180(0.81); C302(0.86)  LDD1660  [29]
 LDCM0458  CL66 HEK-293T C44(0.98); C274(0.91); C180(0.86); C302(0.89)  LDD1661  [29]
 LDCM0459  CL67 HEK-293T C44(1.02); C274(1.00); C180(0.91); C302(0.99)  LDD1662  [29]
 LDCM0460  CL68 HEK-293T C44(1.05); C274(0.98); C180(0.99); C161(1.04)  LDD1663  [29]
 LDCM0461  CL69 HEK-293T C44(0.89); C274(1.00); C180(0.88); C161(0.89)  LDD1664  [29]
 LDCM0462  CL7 HEK-293T C44(0.91); C274(0.83); C180(0.84); C302(0.79)  LDD1665  [29]
 LDCM0463  CL70 HEK-293T C44(1.03); C274(1.07); C180(0.98); C161(0.93)  LDD1666  [29]
 LDCM0464  CL71 HEK-293T C44(0.96); C274(0.94); C180(0.89); C161(1.02)  LDD1667  [29]
 LDCM0465  CL72 HEK-293T C44(1.03); C274(1.00); C180(1.00); C161(0.88)  LDD1668  [29]
 LDCM0466  CL73 HEK-293T C44(0.95); C274(0.82); C180(1.07); C161(0.98)  LDD1669  [29]
 LDCM0467  CL74 HEK-293T C44(1.02); C274(0.92); C180(1.00); C302(1.01)  LDD1670  [29]
 LDCM0469  CL76 HEK-293T C44(1.01); C274(0.95); C180(0.97); C161(1.01)  LDD1672  [29]
 LDCM0470  CL77 HEK-293T C44(0.78); C274(0.75); C180(0.71); C302(0.86)  LDD1673  [29]
 LDCM0471  CL78 HEK-293T C44(0.90); C274(1.02); C180(0.92); C302(0.90)  LDD1674  [29]
 LDCM0472  CL79 HEK-293T C44(1.06); C274(1.00); C180(0.93); C302(1.10)  LDD1675  [29]
 LDCM0473  CL8 HEK-293T C44(0.64); C274(0.51); C180(0.62); C161(0.67)  LDD1676  [29]
 LDCM0474  CL80 HEK-293T C44(1.03); C274(1.02); C180(1.04); C161(1.02)  LDD1677  [29]
 LDCM0475  CL81 HEK-293T C44(0.92); C274(0.96); C180(1.02); C161(0.96)  LDD1678  [29]
 LDCM0476  CL82 HEK-293T C44(0.95); C274(1.02); C180(1.01); C161(0.90)  LDD1679  [29]
 LDCM0477  CL83 HEK-293T C44(0.94); C274(0.95); C180(0.88); C161(0.99)  LDD1680  [29]
 LDCM0478  CL84 HEK-293T C44(0.97); C274(0.88); C180(0.98); C161(0.91)  LDD1681  [29]
 LDCM0479  CL85 HEK-293T C44(1.05); C274(0.76); C180(1.05); C161(1.03)  LDD1682  [29]
 LDCM0480  CL86 HEK-293T C44(0.99); C274(0.77); C180(0.93); C302(0.95)  LDD1683  [29]
 LDCM0481  CL87 HEK-293T C44(1.00); C274(0.91); C180(0.92); C161(1.04)  LDD1684  [29]
 LDCM0482  CL88 HEK-293T C44(1.03); C274(0.80); C180(0.95); C161(1.07)  LDD1685  [29]
 LDCM0483  CL89 HEK-293T C44(1.00); C274(0.78); C180(0.80); C302(1.27)  LDD1686  [29]
 LDCM0484  CL9 HEK-293T C44(0.90); C274(0.98); C180(1.01); C161(0.92)  LDD1687  [29]
 LDCM0485  CL90 HEK-293T C44(0.85); C274(0.64); C180(0.67); C302(0.61)  LDD1688  [29]
 LDCM0486  CL91 HEK-293T C44(1.11); C274(0.92); C180(0.96); C302(1.06)  LDD1689  [29]
 LDCM0487  CL92 HEK-293T C44(0.95); C274(0.80); C180(0.83); C161(0.88)  LDD1690  [29]
 LDCM0488  CL93 HEK-293T C44(0.95); C274(0.88); C180(0.94); C161(0.71)  LDD1691  [29]
 LDCM0489  CL94 HEK-293T C44(0.99); C274(1.02); C180(0.90); C161(0.99)  LDD1692  [29]
 LDCM0490  CL95 HEK-293T C44(0.78); C274(0.71); C180(0.65); C161(0.73)  LDD1693  [29]
 LDCM0491  CL96 HEK-293T C44(0.97); C274(0.65); C180(0.83); C161(0.81)  LDD1694  [29]
 LDCM0492  CL97 HEK-293T C44(0.94); C274(0.91); C180(0.87); C161(0.83)  LDD1695  [29]
 LDCM0493  CL98 HEK-293T C44(1.00); C274(0.89); C180(0.83); C302(0.82)  LDD1696  [29]
 LDCM0494  CL99 HEK-293T C44(1.00); C274(0.99); C180(0.92); C161(0.99)  LDD1697  [29]
 LDCM0495  E2913 HEK-293T C44(0.96); C274(1.04); C180(1.03); C161(1.03)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C180(2.15); C44(1.48)  LDD1702  [6]
 LDCM0625  F8 Ramos C302(1.13); C44(1.28)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C302(0.61); C44(0.56)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C302(0.55)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C302(0.95); C44(0.68)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C302(1.04); C44(1.02)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C302(0.62); C44(0.79)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C302(0.74); C44(0.40)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C302(1.06); C44(0.88)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C302(0.79); C44(0.78)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C302(1.18); C44(0.92)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C302(0.60); C44(0.50)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C302(1.50); C44(1.11)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C302(0.97); C44(0.91)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C302(0.85); C44(0.67)  LDD2201  [30]
 LDCM0468  Fragment33 HEK-293T C44(0.96); C274(1.04); C180(1.01); C161(1.05)  LDD1671  [29]
 LDCM0596  Fragment38 Ramos C302(1.08); C44(0.63)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C302(0.73); C44(0.71)  LDD2184  [30]
 LDCM0427  Fragment51 HEK-293T C44(1.05); C274(1.03); C180(1.12); C302(1.15)  LDD1631  [29]
 LDCM0610  Fragment52 Ramos C302(1.79); C44(1.10)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C302(2.29); C44(1.48)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C302(0.72); C44(0.54)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C302(0.54); C44(0.64)  LDD2188  [30]
 LDCM0107  IAA HeLa C161(0.00); C171(0.00); C180(0.00)  LDD0221  [21]
 LDCM0123  JWB131 DM93 Y135(0.93)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y135(0.78)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y135(0.89)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y135(7.06)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y135(1.18)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y135(1.78)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y135(0.67)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y135(1.01)  LDD0292  [10]
 LDCM0022  KB02 HEK-293T C44(1.01); C274(0.99); C180(1.05); C171(1.12)  LDD1492  [29]
 LDCM0023  KB03 Jurkat C161(13.91); C171(13.91)  LDD0209  [9]
 LDCM0024  KB05 G361 C317(0.84); C78(1.08)  LDD3311  [31]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C44(1.00)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C44(0.49)  LDD2121  [6]
 LDCM0109  NEM HeLa H58(0.00); H218(0.00); C171(0.00); H64(0.00)  LDD0223  [21]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C180(0.91); C44(1.24)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C44(0.85)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C44(0.92)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C44(1.02)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C44(0.96)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C180(0.98)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C180(0.92); C44(0.80)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C44(0.60); C274(1.93)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C44(0.67)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C180(0.75)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C44(0.80)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C44(1.34)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C180(0.53); C44(0.66)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C180(1.14); C44(0.99)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C44(0.85)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C44(0.61)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C44(1.72)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C180(1.73); C44(0.84)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C180(0.57); C44(0.75)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C180(0.46)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C44(1.06)  LDD2118  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C44(0.96); C274(0.80)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C180(0.13); C44(1.19)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C44(0.86)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C44(1.07)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C180(1.03); C44(0.67)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C44(1.07)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C180(1.05); C44(0.80); C274(0.96)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C44(0.86)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C180(1.37); C44(0.69)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C180(0.53)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C180(0.37); C44(0.47)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C180(1.97); C44(0.87)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C44(0.88); C274(1.32)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C180(1.05); C44(0.81); C274(0.95)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C44(1.14)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C180(1.03); C44(0.48)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C180(0.57); C44(0.88)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C44(1.08)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C44(2.32)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C180(1.07); C44(0.66)  LDD2146  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C44(1.32)  LDD2149  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C44(1.64)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C44(1.85)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C302(1.09); C44(0.31)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C44(0.44)  LDD2207  [32]
 LDCM0131  RA190 MM1.R C180(1.31); C161(0.92); C171(0.92)  LDD0304  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.