Details of the Probe

General Information of Probe

Probe ID
LDPC0468
Probe Name
C235
Synonyms
Z3410167189
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 377.3
Lipid-water partition coefficient (xlogp) 2.8
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C18H14F3N3O3
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-[4-oxo-2-(trifluoromethyl)chromen-6-yl]propanamide
Canonical SMILES
C#CCCC1(N=N1)CCC(=O)NC2=CC3=C(C=C2)OC(=CC3=O)C(F)(F)F
InChI
InChI=1S/C18H14F3N3O3/c1-2-3-7-17(23-24-17)8-6-16(26)22-11-4-5-14-12(9-11)13(25)10-15(27-14)18(19,20)21/h1,4-5,9-10H,3,6-8H2,(H,22,26)
InChIKey
YMFSMLQCGIHFDY-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

161 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) LDTP06657 20.97  LDD1908 
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH) LDTP07483 24.76  LDD1908 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 36.76  LDD1908 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 44.02  LDD1908 
Acid ceramidase (ASAH1) LDTP05905 28.25  LDD1908 
Acyl-CoA 6-desaturase (FADS2) LDTP01699 17.03  LDD1908 
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1) LDTP09814 19.97  LDD1908 
Acyl-protein thioesterase 2 (LYPLA2) LDTP01573 17.51  LDD1908 
Adenosine 5'-monophosphoramidase HINT3 (HINT3) LDTP12415 22.32  LDD1908 
Adenosine kinase (ADK) LDTP04689 53.82  LDD1908 
Adipocyte plasma membrane-associated protein (APMAP) LDTP12293 39.67  LDD1908 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 18.90  LDD1908 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 43.41  LDD1908 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 20.39  LDD1908 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 19.29  LDD1908 
Alpha/beta hydrolase domain-containing protein 17A (ABHD17A) LDTP10362 20.53  LDD1908 
Atlastin-2 (ATL2) LDTP09251 49.18  LDD1908 
ATP synthase membrane subunit K, mitochondrial (ATP5MK) LDTP10432 19.56  LDD1908 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 18.38  LDD1908 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 26.35  LDD1908 
ATPase family AAA domain-containing protein 3B (ATAD3B) LDTP07154 18.13  LDD1908 
ATPase GET3 (GET3) LDTP00836 34.78  LDD1908 
Atypical kinase COQ8A, mitochondrial (COQ8A) LDTP09285 75.58  LDD1908 
Atypical kinase COQ8B, mitochondrial (COQ8B) LDTP10201 31.12  LDD1908 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 27.67  LDD1908 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 43.71  LDD1908 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 23.59  LDD1908 
Catechol O-methyltransferase (COMT) LDTP03145 36.50  LDD1908 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 63.12  LDD1908 
Ceramide glucosyltransferase (UGCG) LDTP06617 22.63  LDD1908 
Ceramide synthase 2 (CERS2) LDTP10329 35.02  LDD1908 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 39.67  LDD1908 
Cytochrome b-c1 complex subunit 7 (UQCRB) LDTP02757 20.25  LDD1908 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 87.43  LDD1908 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 81.57  LDD1908 
Cytochrome b5 type B (CYB5B) LDTP00697 60.97  LDD1908 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 31.12  LDD1908 
Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L) LDTP14427 25.11  LDD1908 
Cytochrome c oxidase subunit NDUFA4 (NDUFA4) LDTP00293 17.27  LDD1908 
Cytochrome c1, heme protein, mitochondrial (CYC1) LDTP02283 18.90  LDD1908 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 19.43  LDD1908 
Cytosolic 5'-nucleotidase 3A (NT5C3A) LDTP11723 24.25  LDD1908 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 30.27  LDD1908 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 17.75  LDD1908 
Dehydrogenase/reductase SDR family member 7 (DHRS7) LDTP13959 25.11  LDD1908 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 40.22  LDD1908 
Delta(14)-sterol reductase TM7SF2 (TM7SF2) LDTP01389 20.82  LDD1908 
Delta(24)-sterol reductase (DHCR24) LDTP06375 29.65  LDD1908 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 29.24  LDD1908 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 49.52  LDD1908 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 34.06  LDD1908 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 64.45  LDD1908 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 18.13  LDD1908 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 17.51  LDD1908 
Epimerase family protein SDR39U1 (SDR39U1) LDTP16070 16.80  LDD1908 
Epoxide hydrolase 1 (EPHX1) LDTP02175 28.25  LDD1908 
Glutathione S-transferase 3, mitochondrial (MGST3) LDTP00464 18.64  LDD1908 
Glyoxalase domain-containing protein 4 (GLOD4) LDTP16040 20.39  LDD1908 
GTP-binding protein Rheb (RHEB) LDTP06371 22.63  LDD1908 
GTP-binding protein SAR1a (SAR1A) LDTP12470 26.35  LDD1908 
Heme A synthase COX15 (COX15) LDTP07931 36.00  LDD1908 
Heme oxygenase 1 (HMOX1) LDTP02359 35.51  LDD1908 
Heme oxygenase 2 (HMOX2) LDTP03540 78.79  LDD1908 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 32.00  LDD1908 
Holocytochrome c-type synthase (HCCS) LDTP04581 62.25  LDD1908 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 42.52  LDD1908 
Inorganic pyrophosphatase 2, mitochondrial (PPA2) LDTP11842 19.70  LDD1908 
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) LDTP04211 24.25  LDD1908 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 26.54  LDD1908 
Lanosterol synthase (LSS) LDTP04183 16.91  LDD1908 
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) LDTP03662 17.51  LDD1908 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 17.88  LDD1908 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 18.51  LDD1908 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 18.77  LDD1908 
Lysosomal acid phosphatase (ACP2) LDTP02539 19.56  LDD1908 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 19.29  LDD1908 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 26.54  LDD1908 
Macrophage migration inhibitory factor (MIF) LDTP02713 18.13  LDD1908 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 34.30  LDD1908 
Minor histocompatibility antigen H13 (HM13) LDTP09396 32.00  LDD1908 
Mitochondrial cardiolipin hydrolase (PLD6) LDTP08790 19.56  LDD1908 
Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) LDTP06810 19.29  LDD1908 
Mitofusin-1 (MFN1) LDTP08530 21.56  LDD1908 
NAD kinase 2, mitochondrial (NADK2) LDTP06839 22.32  LDD1908 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 17.51  LDD1908 
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) LDTP08598 41.07  LDD1908 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 74.03  LDD1908 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 55.33  LDD1908 
NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) LDTP01219 28.84  LDD1908 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 17.15  LDD1908 
NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) LDTP12752 20.25  LDD1908 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 77.17  LDD1908 
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) LDTP14276 34.54  LDD1908 
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) LDTP01168 19.03  LDD1908 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 45.89  LDD1908 
NADPH--cytochrome P450 reductase (POR) LDTP02848 19.43  LDD1908 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 27.47  LDD1908 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 92.41  LDD1908 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 24.42  LDD1908 
Palmitoyltransferase ZDHHC13 (ZDHHC13) LDTP08455 22.63  LDD1908 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 20.53  LDD1908 
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) LDTP09578 17.51  LDD1908 
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) LDTP12608 19.03  LDD1908 
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) LDTP13220 30.91  LDD1908 
Pirin (PIR) LDTP00325 45.25  LDD1908 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 23.92  LDD1908 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 20.53  LDD1908 
Presequence protease, mitochondrial (PITRM1) LDTP07003 16.80  LDD1908 
Probable glutathione peroxidase 8 (GPX8) LDTP09495 36.76  LDD1908 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 36.00  LDD1908 
Protein arginine N-methyltransferase 9 (PRMT9) LDTP07525 18.25  LDD1908 
Protein disulfide-isomerase TMX3 (TMX3) LDTP10471 24.42  LDD1908 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 27.47  LDD1908 
Protein SCO2 homolog, mitochondrial (SCO2) LDTP00877 29.86  LDD1908 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 47.18  LDD1908 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 17.39  LDD1908 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 20.25  LDD1908 
Ras-related protein Rab-10 (RAB10) LDTP04895 23.10  LDD1908 
Ras-related protein Rab-11B (RAB11B) LDTP06501 33.13  LDD1908 
Ras-related protein Rab-18 (RAB18) LDTP12312 20.25  LDD1908 
Ras-related protein Rab-1A (RAB1A) LDTP05006 31.56  LDD1908 
Ras-related protein Rab-1B (RAB1B) LDTP11733 24.93  LDD1908 
Ras-related protein Rab-24 (RAB24) LDTP10020 40.79  LDD1908 
Ras-related protein Rab-2A (RAB2A) LDTP04892 28.25  LDD1908 
Ras-related protein Rab-34 (RAB34) LDTP11535 17.63  LDD1908 
Ras-related protein Rab-3D (RAB3D) LDTP01659 18.00  LDD1908 
Ras-related protein Rab-5A (RAB5A) LDTP03050 17.27  LDD1908 
Ras-related protein Rab-6A (RAB6A) LDTP03051 24.59  LDD1908 
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) LDTP05917 99.73  LDD1908 
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) LDTP09666 71.51  LDD1908 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 39.67  LDD1908 
Retinol dehydrogenase 13 (RDH13) LDTP09061 22.78  LDD1908 
Retinol dehydrogenase 14 (RDH14) LDTP12180 17.39  LDD1908 
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) LDTP06384 17.75  LDD1908 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 17.39  LDD1908 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 21.56  LDD1908 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 36.50  LDD1908 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 23.59  LDD1908 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 99.73  LDD1908 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 30.91  LDD1908 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 27.28  LDD1908 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 19.97  LDD1908 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 29.24  LDD1908 
Squalene monooxygenase (SQLE) LDTP06142 23.43  LDD1908 
Stearoyl-CoA desaturase (SCD) LDTP00344 25.46  LDD1908 
Sterol carrier protein 2 (SCP2) LDTP03163 19.16  LDD1908 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 38.32  LDD1908 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 32.00  LDD1908 
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) LDTP07227 30.70  LDD1908 
Torsin-1B (TOR1B) LDTP00400 17.75  LDD1908 
Transmembrane protein with metallophosphoesterase domain (TMPPE) LDTP07831 79.34  LDD1908 
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 23.75  LDD1908 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 20.39  LDD1908 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 17.15  LDD1908 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 37.01  LDD1908 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 31.12  LDD1908 
Vesicle transport protein GOT1B (GOLT1B) LDTP13986 21.41  LDD1908 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 41.36  LDD1908 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 33.82  LDD1908 
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) LDTP06320 18.51  LDD1908 
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3) LDTP06322 19.70  LDD1908 
------------------------------------------------------------------------------------
⏷ Show the Full List of 161 Enzyme
132 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Acetyl-coenzyme A transporter 1 (SLC33A1) LDTP00262 19.29  LDD1908 
Acyl-CoA-binding domain-containing protein 5 (ACBD5) LDTP07152 21.11  LDD1908 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 50.21  LDD1908 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 17.63  LDD1908 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 33.36  LDD1908 
ATP synthase subunit a (MT-ATP6) LDTP01804 81.01  LDD1908 
ATP synthase subunit e, mitochondrial (ATP5ME) LDTP14717 22.94  LDD1908 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 77.17  LDD1908 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 24.42  LDD1908 
BRI3-binding protein (BRI3BP) LDTP15648 99.73  LDD1908 
Calcium load-activated calcium channel (TMCO1) LDTP13599 20.68  LDD1908 
Calcium uptake protein 1, mitochondrial (MICU1) LDTP11041 16.80  LDD1908 
Calnexin (CANX) LDTP03405 19.16  LDD1908 
Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) LDTP08469 60.97  LDD1908 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 39.12  LDD1908 
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) LDTP03064 22.94  LDD1908 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 65.80  LDD1908 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 33.13  LDD1908 
Derlin-1 (DERL1) LDTP11245 27.10  LDD1908 
Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) LDTP12331 52.35  LDD1908 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 29.86  LDD1908 
ER membrane protein complex subunit 3 (EMC3) LDTP12958 24.08  LDD1908 
ER membrane protein complex subunit 4 (EMC4) LDTP06994 24.42  LDD1908 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 71.51  LDD1908 
Essential MCU regulator, mitochondrial (SMDT1) LDTP11927 73.52  LDD1908 
Golgin subfamily A member 5 (GOLGA5) LDTP09333 22.47  LDD1908 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 39.12  LDD1908 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 22.32  LDD1908 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 22.01  LDD1908 
Integral membrane protein 2B (ITM2B) LDTP13833 33.36  LDD1908 
Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) LDTP01100 16.91  LDD1908 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 23.75  LDD1908 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 25.81  LDD1908 
Lysosome membrane protein 2 (SCARB2) LDTP06034 46.53  LDD1908 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 22.32  LDD1908 
Magnesium transporter protein 1 (MAGT1) LDTP11732 26.72  LDD1908 
Major facilitator superfamily domain-containing protein 8 (MFSD8) LDTP09261 29.65  LDD1908 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 38.59  LDD1908 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 25.63  LDD1908 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 51.27  LDD1908 
Metaxin-1 (MTX1) LDTP05900 24.76  LDD1908 
Metaxin-2 (MTX2) LDTP01217 17.88  LDD1908 
MFS-type transporter SLC18B1 (SLC18B1) LDTP07462 20.82  LDD1908 
MICOS complex subunit MIC26 (APOO) LDTP11250 30.48  LDD1908 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 23.92  LDD1908 
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) LDTP07472 32.45  LDD1908 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 22.01  LDD1908 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 31.78  LDD1908 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 25.63  LDD1908 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 50.21  LDD1908 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 39.95  LDD1908 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 43.41  LDD1908 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 76.64  LDD1908 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 52.71  LDD1908 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 30.70  LDD1908 
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) LDTP00821 18.00  LDD1908 
Mitochondrial import receptor subunit TOM40 homolog (TOMM40) LDTP01748 18.51  LDD1908 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 39.12  LDD1908 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 20.97  LDD1908 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 28.05  LDD1908 
Mitochondrial pyruvate carrier 2 (MPC2) LDTP01631 21.41  LDD1908 
Mpv17-like protein 2 (MPV17L2) LDTP14952 39.40  LDD1908 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 16.91  LDD1908 
Nucleoporin NDC1 (NDC1) LDTP11213 25.28  LDD1908 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 35.51  LDD1908 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 29.45  LDD1908 
Peroxisomal biogenesis factor 3 (PEX3) LDTP04749 20.11  LDD1908 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 77.17  LDD1908 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 20.97  LDD1908 
Peroxisomal membrane protein PEX16 (PEX16) LDTP14181 52.71  LDD1908 
Peroxisomal membrane protein PMP34 (SLC25A17) LDTP00872 25.11  LDD1908 
PRA1 family protein 2 (PRAF2) LDTP01060 30.91  LDD1908 
PRA1 family protein 3 (ARL6IP5) LDTP01352 26.72  LDD1908 
Prosaposin (PSAP) LDTP02215 30.70  LDD1908 
Protein ARV1 (ARV1) LDTP11812 18.64  LDD1908 
Protein FAM8A1 (FAM8A1) LDTP16190 23.92  LDD1908 
Protein GPR107 (GPR107) LDTP07236 19.84  LDD1908 
Protein GPR108 (GPR108) LDTP12383 42.22  LDD1908 
Protein RER1 (RER1) LDTP00590 32.22  LDD1908 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 30.27  LDD1908 
Protein tweety homolog 3 (TTYH3) LDTP11615 27.10  LDD1908 
Protein wntless homolog (WLS) LDTP07156 59.71  LDD1908 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 99.73  LDD1908 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 39.12  LDD1908 
Rhomboid domain-containing protein 2 (RHBDD2) LDTP07467 30.27  LDD1908 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 29.04  LDD1908 
Secretory carrier-associated membrane protein 1 (SCAMP1) LDTP00546 19.56  LDD1908 
Sideroflexin-4 (SFXN4) LDTP07531 29.86  LDD1908 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 19.97  LDD1908 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 96.34  LDD1908 
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) LDTP10731 29.24  LDD1908 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 40.79  LDD1908 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 32.90  LDD1908 
Solute carrier family 35 member F1 (SLC35F1) LDTP15000 34.54  LDD1908 
Solute carrier family 41 member 3 (SLC41A3) LDTP10370 17.39  LDD1908 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 21.71  LDD1908 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 29.45  LDD1908 
Store-operated calcium entry-associated regulatory factor (SARAF) LDTP10148 19.43  LDD1908 
SUN domain-containing protein 1 (SUN1) LDTP01454 26.91  LDD1908 
Surfeit locus protein 4 (SURF4) LDTP00592 71.51  LDD1908 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 62.25  LDD1908 
Synaptophysin (SYP) LDTP02266 27.28  LDD1908 
Syntaxin-4 (STX4) LDTP05667 20.82  LDD1908 
Syntaxin-5 (STX5) LDTP05780 25.46  LDD1908 
Tetraspanin-3 (TSPAN3) LDTP16813 99.73  LDD1908 
Thioredoxin-related transmembrane protein 2 (TMX2) LDTP13943 21.41  LDD1908 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 66.26  LDD1908 
Translocator protein (TSPO) LDTP03546 25.46  LDD1908 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 99.73  LDD1908 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 40.79  LDD1908 
Transmembrane emp24 domain-containing protein 10 (TMED10) LDTP04293 19.70  LDD1908 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 20.97  LDD1908 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 17.39  LDD1908 
Transmembrane protein 126A (TMEM126A) LDTP15948 58.08  LDD1908 
Transmembrane protein 14C (TMEM14C) LDTP12979 19.16  LDD1908 
Transmembrane protein 160 (TMEM160) LDTP20002 53.82  LDD1908 
Transmembrane protein 199 (TMEM199) LDTP08881 47.50  LDD1908 
Transmembrane protein 201 (TMEM201) LDTP07058 32.45  LDD1908 
Transmembrane protein 205 (TMEM205) LDTP07667 32.90  LDD1908 
Transmembrane protein 230 (TMEM230) LDTP10065 47.84  LDD1908 
Transmembrane protein 33 (TMEM33) LDTP04787 30.91  LDD1908 
Transmembrane protein 87A (TMEM87A) LDTP15481 63.12  LDD1908 
Ubiquilin-4 (UBQLN4) LDTP12533 22.47  LDD1908 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 22.47  LDD1908 
Vacuole membrane protein 1 (VMP1) LDTP10343 26.35  LDD1908 
Vang-like protein 1 (VANGL1) LDTP09288 25.46  LDD1908 
Vezatin (VEZT) LDTP12191 31.56  LDD1908 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 64.89  LDD1908 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 70.03  LDD1908 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 35.02  LDD1908 
Voltage-gated monoatomic cation channel TMEM109 (TMEM109) LDTP11281 39.67  LDD1908 
Wolframin (WFS1) LDTP01380 22.32  LDD1908 
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⏷ Show the Full List of 132 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 19.56  LDD1908 
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2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 16.91  LDD1908 
Leukocyte surface antigen CD47 (CD47) LDTP05572 24.25  LDD1908 
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105 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Alpha-internexin (INA) LDTP06527 19.29  LDD1908 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 25.28  LDD1908 
Apolipoprotein L2 (APOL2) LDTP11076 99.73  LDD1908 
Arfaptin-1 (ARFIP1) LDTP04558 26.54  LDD1908 
Armadillo repeat-containing protein 1 (ARMC1) LDTP12692 18.38  LDD1908 
ATP synthase subunit ATP5MJ, mitochondrial (ATP5MJ) LDTP14716 29.65  LDD1908 
Bcl-2-like protein 13 (BCL2L13) LDTP11389 23.59  LDD1908 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 20.39  LDD1908 
Calumenin (CALU) LDTP00887 22.16  LDD1908 
Centrosomal protein 43 (CEP43) LDTP01652 20.25  LDD1908 
Clustered mitochondria protein homolog (CLUH) LDTP14486 24.08  LDD1908 
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) LDTP12379 16.80  LDD1908 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 72.50  LDD1908 
DnaJ homolog subfamily C member 11 (DNAJC11) LDTP12677 19.43  LDD1908 
Emerin (EMD) LDTP04356 21.71  LDD1908 
Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) LDTP10775 17.03  LDD1908 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 40.79  LDD1908 
Engulfment and cell motility protein 2 (ELMO2) LDTP10469 18.00  LDD1908 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 74.54  LDD1908 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 35.75  LDD1908 
FUN14 domain-containing protein 2 (FUNDC2) LDTP11326 38.32  LDD1908 
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) LDTP00729 27.67  LDD1908 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 33.13  LDD1908 
Golgi phosphoprotein 3 (GOLPH3) LDTP11911 41.36  LDD1908 
Golgi phosphoprotein 3-like (GOLPH3L) LDTP11910 18.51  LDD1908 
Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1) LDTP05041 20.11  LDD1908 
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (GNG5) LDTP05054 23.43  LDD1908 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 17.15  LDD1908 
HCLS1-associated protein X-1 (HAX1) LDTP00199 16.80  LDD1908 
Heme-binding protein 1 (HEBP1) LDTP16078 99.73  LDD1908 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 16.80  LDD1908 
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) LDTP05530 20.68  LDD1908 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 17.27  LDD1908 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 99.73  LDD1908 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 30.27  LDD1908 
Large proline-rich protein BAG6 (BAG6) LDTP04094 22.01  LDD1908 
Matrix-remodeling-associated protein 7 (MXRA7) LDTP17003 25.99  LDD1908 
Membralin (TMEM259) LDTP14939 57.68  LDD1908 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 39.40  LDD1908 
MICOS complex subunit MIC27 (APOOL) LDTP07718 20.68  LDD1908 
Mitochondrial antiviral-signaling protein (MAVS) LDTP08058 25.28  LDD1908 
Mitochondrial fission 1 protein (FIS1) LDTP13982 25.99  LDD1908 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 26.91  LDD1908 
Mitochondrial import inner membrane translocase subunit TIM14 (DNAJC19) LDTP10207 19.97  LDD1908 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 22.78  LDD1908 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 88.65  LDD1908 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 86.22  LDD1908 
Mitochondrial import receptor subunit TOM6 homolog (TOMM6) LDTP10113 18.13  LDD1908 
Mitochondrial import receptor subunit TOM7 homolog (TOMM7) LDTP12982 69.55  LDD1908 
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) LDTP13622 21.86  LDD1908 
NLR family member X1 (NLRX1) LDTP08248 33.36  LDD1908 
Nucleobindin-2 (NUCB2) LDTP05160 31.34  LDD1908 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 30.91  LDD1908 
Optic atrophy 3 protein (OPA3) LDTP16006 63.12  LDD1908 
Peroxiredoxin-like 2A (PRXL2A) LDTP11140 20.25  LDD1908 
Phosphatidylethanolamine-binding protein 1 (PEBP1) LDTP03520 69.07  LDD1908 
Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) LDTP11906 25.28  LDD1908 
Plasminogen receptor (KT) (PLGRKT) LDTP18435 19.84  LDD1908 
Polyadenylate-binding protein-interacting protein 2 (PAIP2) LDTP11044 23.75  LDD1908 
Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) LDTP07655 22.01  LDD1908 
Prohibitin-2 (PHB2) LDTP10924 22.63  LDD1908 
Protein ecdysoneless homolog (ECD) LDTP01711 17.27  LDD1908 
Protein FAM114A2 (FAM114A2) LDTP16080 50.91  LDD1908 
Protein FAM136A (FAM136A) LDTP18132 23.92  LDD1908 
Protein FAM162A (FAM162A) LDTP10056 99.73  LDD1908 
Protein FAM177A1 (FAM177A1) LDTP15398 17.03  LDD1908 
Protein jagunal homolog 1 (JAGN1) LDTP08904 33.36  LDD1908 
Protein LYRIC (MTDH) LDTP08224 65.80  LDD1908 
Protein misato homolog 1 (MSTO1) LDTP11239 17.39  LDD1908 
Protein NCBP2AS2 (NCBP2AS2) LDTP19472 28.05  LDD1908 
Protein PRRC1 (PRRC1) LDTP15778 21.11  LDD1908 
Protein unc-119 homolog A (UNC119) LDTP05868 21.71  LDD1908 
Protein unc-119 homolog B (UNC119B) LDTP00105 18.25  LDD1908 
Protein YIF1A (YIF1A) LDTP01494 70.52  LDD1908 
RalBP1-associated Eps domain-containing protein 1 (REPS1) LDTP10203 89.88  LDD1908 
Receptor expression-enhancing protein 4 (REEP4) LDTP11981 16.68  LDD1908 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 35.26  LDD1908 
Reticulocalbin-2 (RCN2) LDTP06097 22.32  LDD1908 
Reticulon-2 (RTN2) LDTP01167 36.50  LDD1908 
Reticulon-3 (RTN3) LDTP01522 99.73  LDD1908 
Reticulon-4 (RTN4) LDTP12412 64.00  LDD1908 
Reticulophagy regulator 3 (RETREG3) LDTP08300 24.08  LDD1908 
RNA-binding protein 3 (RBM3) LDTP05226 17.63  LDD1908 
RUS family member 1 (RUSF1) LDTP10357 32.45  LDD1908 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 18.13  LDD1908 
SLC35A4 upstream open reading frame protein (SLC35A4) LDTP19005 19.29  LDD1908 
Splicing factor U2AF 65 kDa subunit (U2AF2) LDTP03352 28.64  LDD1908 
Striatin (STRN) LDTP00875 21.86  LDD1908 
Structural maintenance of chromosomes protein 4 (SMC4) LDTP12606 22.63  LDD1908 
Surfeit locus protein 1 (SURF1) LDTP06404 17.03  LDD1908 
Synaptogyrin-2 (SYNGR2) LDTP00859 53.45  LDD1908 
Syntaxin-18 (STX18) LDTP13086 44.02  LDD1908 
Syntaxin-8 (STX8) LDTP13664 18.64  LDD1908 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 17.27  LDD1908 
Tetraspanin-6 (TSPAN6) LDTP14458 73.52  LDD1908 
Thioredoxin domain-containing protein 15 (TXNDC15) LDTP10442 30.06  LDD1908 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 43.41  LDD1908 
TraB domain-containing protein (TRABD) LDTP19963 42.81  LDD1908 
Transducin beta-like protein 2 (TBL2) LDTP16285 17.63  LDD1908 
Translocon-associated protein subunit delta (SSR4) LDTP04425 23.26  LDD1908 
Transmembrane emp24 domain-containing protein 5 (TMED5) LDTP13967 18.90  LDD1908 
Transmembrane protein 209 (TMEM209) LDTP18272 28.05  LDD1908 
Trophoblast glycoprotein (TPBG) LDTP05960 17.15  LDD1908 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 34.54  LDD1908 
Vesicle transport protein SEC20 (BNIP1) LDTP05715 31.34  LDD1908 
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⏷ Show the Full List of 105 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1908 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587