Details of the Target
General Information of Target
Target ID | LDTP02283 | |||||
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Target Name | Cytochrome c1, heme protein, mitochondrial (CYC1) | |||||
Gene Name | CYC1 | |||||
Gene ID | 1537 | |||||
Synonyms |
Cytochrome c1, heme protein, mitochondrial; EC 7.1.1.8; Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit; Cytochrome c-1
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3D Structure | ||||||
Sequence |
MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVM
LSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQV CASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYP NSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQ AIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLV PLVYTIKRHKWSVLKSRKLAYRPPK |
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Target Bioclass |
Enzyme
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Family |
Cytochrome c family
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Subcellular location |
Mitochondrion inner membrane
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Function |
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID | ||||||
ChEMBL ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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CHEMBL5175495 Probe Info |
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7.10 | LDD0196 | [1] | |
N1 Probe Info |
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100.00 | LDD0242 | [2] | |
TH211 Probe Info |
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Y179(20.00); Y174(10.52); Y218(8.65) | LDD0260 | [3] | |
STPyne Probe Info |
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K177(1.46); K310(5.80); K318(8.29) | LDD0277 | [4] | |
m-APA Probe Info |
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10.38 | LDD0403 | [5] | |
BTD Probe Info |
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C139(0.99); C271(0.65) | LDD2089 | [6] | |
AHL-Pu-1 Probe Info |
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C271(2.62) | LDD0168 | [7] | |
DBIA Probe Info |
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C139(1.19); C271(0.98) | LDD0531 | [8] | |
5E-2FA Probe Info |
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H205(0.00); H107(0.00) | LDD2235 | [9] | |
4-Iodoacetamidophenylacetylene Probe Info |
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C271(0.00); C219(0.00); C139(0.00) | LDD0038 | [10] | |
IA-alkyne Probe Info |
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C139(0.00); C219(0.00) | LDD0032 | [11] | |
IPIAA_H Probe Info |
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C219(0.00); C139(0.00) | LDD0030 | [12] | |
IPIAA_L Probe Info |
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C219(0.00); C139(0.00) | LDD0031 | [12] | |
Lodoacetamide azide Probe Info |
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C271(0.00); C219(0.00); C139(0.00) | LDD0037 | [10] | |
ATP probe Probe Info |
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N.A. | LDD0035 | [13] | |
IPM Probe Info |
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N.A. | LDD0025 | [14] | |
JW-RF-010 Probe Info |
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C219(0.00); C271(0.00) | LDD0026 | [14] | |
TFBX Probe Info |
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N.A. | LDD0027 | [14] | |
PF-06672131 Probe Info |
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N.A. | LDD0152 | [15] | |
SF Probe Info |
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N.A. | LDD0028 | [16] | |
1c-yne Probe Info |
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N.A. | LDD0228 | [17] | |
Acrolein Probe Info |
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H107(0.00); H284(0.00); C271(0.00); H134(0.00) | LDD0217 | [18] | |
Cinnamaldehyde Probe Info |
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N.A. | LDD0220 | [18] | |
Crotonaldehyde Probe Info |
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C139(0.00); H107(0.00); C271(0.00); H282(0.00) | LDD0219 | [18] | |
Methacrolein Probe Info |
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C139(0.00); C271(0.00) | LDD0218 | [18] | |
W1 Probe Info |
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N.A. | LDD0236 | [19] | |
MPP-AC Probe Info |
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N.A. | LDD0428 | [20] | |
NAIA_5 Probe Info |
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C219(0.00); C271(0.00); C139(0.00) | LDD2223 | [21] | |
TER-AC Probe Info |
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N.A. | LDD0426 | [20] | |
TPP-AC Probe Info |
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N.A. | LDD0427 | [20] |
PAL-AfBPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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C231 Probe Info |
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14.72 | LDD1904 | [22] | |
C235 Probe Info |
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18.90 | LDD1908 | [22] | |
FFF probe11 Probe Info |
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13.27 | LDD0471 | [23] | |
FFF probe13 Probe Info |
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20.00 | LDD0475 | [23] | |
FFF probe14 Probe Info |
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17.54 | LDD0477 | [23] | |
FFF probe2 Probe Info |
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20.00 | LDD0463 | [23] | |
FFF probe3 Probe Info |
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16.52 | LDD0464 | [23] | |
JN0003 Probe Info |
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20.00 | LDD0469 | [23] | |
STS-2 Probe Info |
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N.A. | LDD0138 | [24] | |
DA-2 Probe Info |
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N.A. | LDD0072 | [25] | |
OEA-DA Probe Info |
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4.09 | LDD0046 | [26] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
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LDCM0548 | 1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one | MDA-MB-231 | C139(0.68); C271(0.63) | LDD2142 | [6] |
LDCM0519 | 1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one | MDA-MB-231 | C139(1.09); C271(0.83) | LDD2112 | [6] |
LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C271(0.96) | LDD2117 | [6] |
LDCM0510 | 3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile | MDA-MB-231 | C271(0.94) | LDD2103 | [6] |
LDCM0538 | 4-(Cyanoacetyl)morpholine | MDA-MB-231 | C271(0.88) | LDD2131 | [6] |
LDCM0025 | 4SU-RNA | HEK-293T | C271(2.62) | LDD0168 | [7] |
LDCM0214 | AC1 | HCT 116 | C139(1.19); C271(0.98) | LDD0531 | [8] |
LDCM0215 | AC10 | HCT 116 | C139(1.33); C271(1.05) | LDD0532 | [8] |
LDCM0216 | AC100 | HCT 116 | C271(1.75) | LDD0533 | [8] |
LDCM0217 | AC101 | HCT 116 | C271(0.98) | LDD0534 | [8] |
LDCM0218 | AC102 | HCT 116 | C271(0.90) | LDD0535 | [8] |
LDCM0219 | AC103 | HCT 116 | C271(0.71) | LDD0536 | [8] |
LDCM0220 | AC104 | HCT 116 | C271(0.94) | LDD0537 | [8] |
LDCM0221 | AC105 | HCT 116 | C271(0.89) | LDD0538 | [8] |
LDCM0222 | AC106 | HCT 116 | C271(1.02) | LDD0539 | [8] |
LDCM0223 | AC107 | HCT 116 | C271(0.73) | LDD0540 | [8] |
LDCM0224 | AC108 | HCT 116 | C271(1.04) | LDD0541 | [8] |
LDCM0225 | AC109 | HCT 116 | C271(1.05) | LDD0542 | [8] |
LDCM0226 | AC11 | HCT 116 | C139(1.21); C271(1.06) | LDD0543 | [8] |
LDCM0227 | AC110 | HCT 116 | C271(1.24) | LDD0544 | [8] |
LDCM0228 | AC111 | HCT 116 | C271(0.83) | LDD0545 | [8] |
LDCM0229 | AC112 | HCT 116 | C271(0.85) | LDD0546 | [8] |
LDCM0230 | AC113 | HCT 116 | C139(1.05) | LDD0547 | [8] |
LDCM0231 | AC114 | HCT 116 | C139(0.98) | LDD0548 | [8] |
LDCM0232 | AC115 | HCT 116 | C139(1.01) | LDD0549 | [8] |
LDCM0233 | AC116 | HCT 116 | C139(1.10) | LDD0550 | [8] |
LDCM0234 | AC117 | HCT 116 | C139(1.07) | LDD0551 | [8] |
LDCM0235 | AC118 | HCT 116 | C139(1.01) | LDD0552 | [8] |
LDCM0236 | AC119 | HCT 116 | C139(1.18) | LDD0553 | [8] |
LDCM0237 | AC12 | HCT 116 | C139(1.11); C271(1.68) | LDD0554 | [8] |
LDCM0238 | AC120 | HCT 116 | C139(0.82) | LDD0555 | [8] |
LDCM0239 | AC121 | HCT 116 | C139(1.15) | LDD0556 | [8] |
LDCM0240 | AC122 | HCT 116 | C139(1.03) | LDD0557 | [8] |
LDCM0241 | AC123 | HCT 116 | C139(0.76) | LDD0558 | [8] |
LDCM0242 | AC124 | HCT 116 | C139(1.21) | LDD0559 | [8] |
LDCM0243 | AC125 | HCT 116 | C139(0.87) | LDD0560 | [8] |
LDCM0244 | AC126 | HCT 116 | C139(0.90) | LDD0561 | [8] |
LDCM0245 | AC127 | HCT 116 | C139(1.10) | LDD0562 | [8] |
LDCM0246 | AC128 | HCT 116 | C271(0.87) | LDD0563 | [8] |
LDCM0247 | AC129 | HCT 116 | C271(1.04) | LDD0564 | [8] |
LDCM0249 | AC130 | HCT 116 | C271(0.91) | LDD0566 | [8] |
LDCM0250 | AC131 | HCT 116 | C271(1.63) | LDD0567 | [8] |
LDCM0251 | AC132 | HCT 116 | C271(1.10) | LDD0568 | [8] |
LDCM0252 | AC133 | HCT 116 | C271(1.00) | LDD0569 | [8] |
LDCM0253 | AC134 | HCT 116 | C271(0.88) | LDD0570 | [8] |
LDCM0254 | AC135 | HCT 116 | C271(0.96) | LDD0571 | [8] |
LDCM0255 | AC136 | HCT 116 | C271(1.05) | LDD0572 | [8] |
LDCM0256 | AC137 | HCT 116 | C271(1.02) | LDD0573 | [8] |
LDCM0257 | AC138 | HCT 116 | C271(0.89) | LDD0574 | [8] |
LDCM0258 | AC139 | HCT 116 | C271(1.06) | LDD0575 | [8] |
LDCM0259 | AC14 | HCT 116 | C139(1.12); C271(0.98) | LDD0576 | [8] |
LDCM0260 | AC140 | HCT 116 | C271(0.75) | LDD0577 | [8] |
LDCM0261 | AC141 | HCT 116 | C271(0.79) | LDD0578 | [8] |
LDCM0262 | AC142 | HCT 116 | C271(1.15) | LDD0579 | [8] |
LDCM0263 | AC143 | HCT 116 | C271(0.83) | LDD0580 | [8] |
LDCM0264 | AC144 | HCT 116 | C271(0.82) | LDD0581 | [8] |
LDCM0265 | AC145 | HCT 116 | C271(0.91) | LDD0582 | [8] |
LDCM0266 | AC146 | HCT 116 | C271(1.26) | LDD0583 | [8] |
LDCM0267 | AC147 | HCT 116 | C271(1.06) | LDD0584 | [8] |
LDCM0268 | AC148 | HCT 116 | C271(2.94) | LDD0585 | [8] |
LDCM0269 | AC149 | HCT 116 | C271(2.75) | LDD0586 | [8] |
LDCM0270 | AC15 | HCT 116 | C139(1.13); C271(1.24) | LDD0587 | [8] |
LDCM0271 | AC150 | HCT 116 | C271(0.98) | LDD0588 | [8] |
LDCM0272 | AC151 | HCT 116 | C271(0.91) | LDD0589 | [8] |
LDCM0273 | AC152 | HCT 116 | C271(0.98) | LDD0590 | [8] |
LDCM0274 | AC153 | HCT 116 | C271(2.01) | LDD0591 | [8] |
LDCM0621 | AC154 | HCT 116 | C271(0.76) | LDD2158 | [8] |
LDCM0622 | AC155 | HCT 116 | C271(0.97) | LDD2159 | [8] |
LDCM0623 | AC156 | HCT 116 | C271(1.00) | LDD2160 | [8] |
LDCM0624 | AC157 | HCT 116 | C271(1.13) | LDD2161 | [8] |
LDCM0276 | AC17 | HCT 116 | C271(0.99) | LDD0593 | [8] |
LDCM0277 | AC18 | HCT 116 | C271(1.61) | LDD0594 | [8] |
LDCM0278 | AC19 | HCT 116 | C271(1.32) | LDD0595 | [8] |
LDCM0279 | AC2 | HCT 116 | C271(1.03); C139(1.09) | LDD0596 | [8] |
LDCM0280 | AC20 | HCT 116 | C271(1.20) | LDD0597 | [8] |
LDCM0281 | AC21 | HCT 116 | C271(1.08) | LDD0598 | [8] |
LDCM0282 | AC22 | HCT 116 | C271(0.97) | LDD0599 | [8] |
LDCM0283 | AC23 | HCT 116 | C271(1.21) | LDD0600 | [8] |
LDCM0284 | AC24 | HCT 116 | C271(1.11) | LDD0601 | [8] |
LDCM0285 | AC25 | HCT 116 | C271(0.72); C139(1.06) | LDD0602 | [8] |
LDCM0286 | AC26 | HCT 116 | C271(0.82); C139(1.14) | LDD0603 | [8] |
LDCM0287 | AC27 | HCT 116 | C271(0.69); C139(1.11) | LDD0604 | [8] |
LDCM0288 | AC28 | HCT 116 | C271(0.81); C139(1.14) | LDD0605 | [8] |
LDCM0289 | AC29 | HCT 116 | C271(0.79); C139(1.08) | LDD0606 | [8] |
LDCM0290 | AC3 | HCT 116 | C271(1.12); C139(1.41) | LDD0607 | [8] |
LDCM0291 | AC30 | HCT 116 | C271(0.73); C139(1.00) | LDD0608 | [8] |
LDCM0292 | AC31 | HCT 116 | C271(0.83); C139(1.10) | LDD0609 | [8] |
LDCM0293 | AC32 | HCT 116 | C271(0.85); C139(1.05) | LDD0610 | [8] |
LDCM0294 | AC33 | HCT 116 | C271(0.70); C139(1.01) | LDD0611 | [8] |
LDCM0295 | AC34 | HCT 116 | C271(0.70); C139(0.98) | LDD0612 | [8] |
LDCM0296 | AC35 | HCT 116 | C139(0.98); C271(1.03) | LDD0613 | [8] |
LDCM0297 | AC36 | HCT 116 | C139(0.94); C271(1.25) | LDD0614 | [8] |
LDCM0298 | AC37 | HCT 116 | C271(1.13); C139(1.19) | LDD0615 | [8] |
LDCM0299 | AC38 | HCT 116 | C139(1.12); C271(1.13) | LDD0616 | [8] |
LDCM0300 | AC39 | HCT 116 | C139(0.96); C271(1.29) | LDD0617 | [8] |
LDCM0301 | AC4 | HCT 116 | C271(1.07); C139(1.34) | LDD0618 | [8] |
LDCM0302 | AC40 | HCT 116 | C139(0.83); C271(1.32) | LDD0619 | [8] |
LDCM0303 | AC41 | HCT 116 | C139(1.04); C271(1.06) | LDD0620 | [8] |
LDCM0304 | AC42 | HCT 116 | C139(0.95); C271(0.97) | LDD0621 | [8] |
LDCM0305 | AC43 | HCT 116 | C139(1.01); C271(1.08) | LDD0622 | [8] |
LDCM0306 | AC44 | HCT 116 | C139(0.87); C271(0.88) | LDD0623 | [8] |
LDCM0307 | AC45 | HCT 116 | C139(0.81); C271(1.00) | LDD0624 | [8] |
LDCM0308 | AC46 | HCT 116 | C271(1.02) | LDD0625 | [8] |
LDCM0309 | AC47 | HCT 116 | C271(0.94) | LDD0626 | [8] |
LDCM0310 | AC48 | HCT 116 | C271(0.90) | LDD0627 | [8] |
LDCM0311 | AC49 | HCT 116 | C271(0.92) | LDD0628 | [8] |
LDCM0312 | AC5 | HCT 116 | C271(1.15); C139(1.36) | LDD0629 | [8] |
LDCM0313 | AC50 | HCT 116 | C271(0.92) | LDD0630 | [8] |
LDCM0314 | AC51 | HCT 116 | C271(0.80) | LDD0631 | [8] |
LDCM0315 | AC52 | HCT 116 | C271(0.95) | LDD0632 | [8] |
LDCM0316 | AC53 | HCT 116 | C271(1.79) | LDD0633 | [8] |
LDCM0317 | AC54 | HCT 116 | C271(0.96) | LDD0634 | [8] |
LDCM0318 | AC55 | HCT 116 | C271(1.22) | LDD0635 | [8] |
LDCM0319 | AC56 | HCT 116 | C271(1.15) | LDD0636 | [8] |
LDCM0320 | AC57 | HCT 116 | C271(1.09) | LDD0637 | [8] |
LDCM0321 | AC58 | HCT 116 | C271(1.15) | LDD0638 | [8] |
LDCM0322 | AC59 | HCT 116 | C271(0.96) | LDD0639 | [8] |
LDCM0323 | AC6 | HCT 116 | C271(1.04); C139(1.10) | LDD0640 | [8] |
LDCM0324 | AC60 | HCT 116 | C271(1.05) | LDD0641 | [8] |
LDCM0325 | AC61 | HCT 116 | C271(1.04) | LDD0642 | [8] |
LDCM0326 | AC62 | HCT 116 | C271(0.82) | LDD0643 | [8] |
LDCM0327 | AC63 | HCT 116 | C271(1.25) | LDD0644 | [8] |
LDCM0328 | AC64 | HCT 116 | C271(0.91) | LDD0645 | [8] |
LDCM0329 | AC65 | HCT 116 | C271(1.07) | LDD0646 | [8] |
LDCM0330 | AC66 | HCT 116 | C271(1.14) | LDD0647 | [8] |
LDCM0331 | AC67 | HCT 116 | C271(0.69) | LDD0648 | [8] |
LDCM0332 | AC68 | HCT 116 | C271(0.76); C139(0.94) | LDD0649 | [8] |
LDCM0333 | AC69 | HCT 116 | C271(0.72); C139(0.94) | LDD0650 | [8] |
LDCM0334 | AC7 | HCT 116 | C271(0.93); C139(1.06) | LDD0651 | [8] |
LDCM0335 | AC70 | HCT 116 | C271(0.73); C139(0.91) | LDD0652 | [8] |
LDCM0336 | AC71 | HCT 116 | C139(0.89); C271(1.01) | LDD0653 | [8] |
LDCM0337 | AC72 | HCT 116 | C271(0.83); C139(0.88) | LDD0654 | [8] |
LDCM0338 | AC73 | HCT 116 | C271(0.62); C139(0.94) | LDD0655 | [8] |
LDCM0339 | AC74 | HCT 116 | C271(0.70); C139(0.87) | LDD0656 | [8] |
LDCM0340 | AC75 | HCT 116 | C271(0.52); C139(1.14) | LDD0657 | [8] |
LDCM0341 | AC76 | HCT 116 | C271(0.80); C139(0.98) | LDD0658 | [8] |
LDCM0342 | AC77 | HCT 116 | C271(0.70); C139(0.92) | LDD0659 | [8] |
LDCM0343 | AC78 | HCT 116 | C271(0.87); C139(0.90) | LDD0660 | [8] |
LDCM0344 | AC79 | HCT 116 | C271(0.79); C139(1.11) | LDD0661 | [8] |
LDCM0345 | AC8 | HCT 116 | C271(0.85); C139(1.06) | LDD0662 | [8] |
LDCM0346 | AC80 | HCT 116 | C271(0.89); C139(0.95) | LDD0663 | [8] |
LDCM0347 | AC81 | HCT 116 | C271(0.88); C139(0.94) | LDD0664 | [8] |
LDCM0348 | AC82 | HCT 116 | C271(0.59); C139(1.05) | LDD0665 | [8] |
LDCM0349 | AC83 | HCT 116 | C271(0.78); C139(0.79) | LDD0666 | [8] |
LDCM0350 | AC84 | HCT 116 | C271(0.83); C139(0.84) | LDD0667 | [8] |
LDCM0351 | AC85 | HCT 116 | C139(1.01); C271(1.21) | LDD0668 | [8] |
LDCM0352 | AC86 | HCT 116 | C139(1.09); C271(1.16) | LDD0669 | [8] |
LDCM0353 | AC87 | HCT 116 | C139(0.99); C271(1.08) | LDD0670 | [8] |
LDCM0354 | AC88 | HCT 116 | C139(1.05); C271(1.08) | LDD0671 | [8] |
LDCM0355 | AC89 | HCT 116 | C271(1.00); C139(1.04) | LDD0672 | [8] |
LDCM0357 | AC90 | HCT 116 | C139(1.06); C271(1.17) | LDD0674 | [8] |
LDCM0358 | AC91 | HCT 116 | C271(0.73); C139(0.76) | LDD0675 | [8] |
LDCM0359 | AC92 | HCT 116 | C271(0.75); C139(0.86) | LDD0676 | [8] |
LDCM0360 | AC93 | HCT 116 | C139(0.92); C271(1.16) | LDD0677 | [8] |
LDCM0361 | AC94 | HCT 116 | C271(0.93); C139(0.98) | LDD0678 | [8] |
LDCM0362 | AC95 | HCT 116 | C271(0.86); C139(0.93) | LDD0679 | [8] |
LDCM0363 | AC96 | HCT 116 | C271(0.98); C139(1.02) | LDD0680 | [8] |
LDCM0364 | AC97 | HCT 116 | C139(0.88); C271(0.93) | LDD0681 | [8] |
LDCM0365 | AC98 | HCT 116 | C271(0.48) | LDD0682 | [8] |
LDCM0366 | AC99 | HCT 116 | C271(0.77) | LDD0683 | [8] |
LDCM0520 | AKOS000195272 | MDA-MB-231 | C139(0.98) | LDD2113 | [6] |
LDCM0248 | AKOS034007472 | HCT 116 | C139(1.25); C271(1.37) | LDD0565 | [8] |
LDCM0356 | AKOS034007680 | HCT 116 | C139(1.25); C271(1.41) | LDD0673 | [8] |
LDCM0275 | AKOS034007705 | HCT 116 | C271(1.18); C139(1.24) | LDD0592 | [8] |
LDCM0156 | Aniline | NCI-H1299 | 10.38 | LDD0403 | [5] |
LDCM0498 | BS-3668 | MDA-MB-231 | C271(0.76) | LDD2091 | [6] |
LDCM0630 | CCW28-3 | 231MFP | C219(1.10) | LDD2214 | [27] |
LDCM0108 | Chloroacetamide | HeLa | C139(0.00); C219(0.00); H107(0.00); H284(0.00) | LDD0222 | [18] |
LDCM0367 | CL1 | HCT 116 | C139(0.82); C271(1.29) | LDD0684 | [8] |
LDCM0368 | CL10 | HCT 116 | C139(0.71); C271(0.95) | LDD0685 | [8] |
LDCM0369 | CL100 | HCT 116 | C271(1.11); C139(1.17) | LDD0686 | [8] |
LDCM0370 | CL101 | HCT 116 | C271(1.02); C139(1.11) | LDD0687 | [8] |
LDCM0371 | CL102 | HCT 116 | C139(1.00); C271(1.63) | LDD0688 | [8] |
LDCM0372 | CL103 | HCT 116 | C139(0.98); C271(1.07) | LDD0689 | [8] |
LDCM0373 | CL104 | HCT 116 | C139(1.16); C271(1.30) | LDD0690 | [8] |
LDCM0374 | CL105 | HCT 116 | C271(1.11) | LDD0691 | [8] |
LDCM0375 | CL106 | HCT 116 | C271(0.91) | LDD0692 | [8] |
LDCM0376 | CL107 | HCT 116 | C271(1.10) | LDD0693 | [8] |
LDCM0377 | CL108 | HCT 116 | C271(0.95) | LDD0694 | [8] |
LDCM0378 | CL109 | HCT 116 | C271(1.42) | LDD0695 | [8] |
LDCM0379 | CL11 | HCT 116 | C139(0.70); C271(0.94) | LDD0696 | [8] |
LDCM0380 | CL110 | HCT 116 | C271(1.34) | LDD0697 | [8] |
LDCM0381 | CL111 | HCT 116 | C271(1.30) | LDD0698 | [8] |
LDCM0382 | CL112 | HCT 116 | C271(0.77); C139(1.02) | LDD0699 | [8] |
LDCM0383 | CL113 | HCT 116 | C271(0.73); C139(0.86) | LDD0700 | [8] |
LDCM0384 | CL114 | HCT 116 | C271(0.99); C139(1.07) | LDD0701 | [8] |
LDCM0385 | CL115 | HCT 116 | C271(0.71); C139(0.99) | LDD0702 | [8] |
LDCM0386 | CL116 | HCT 116 | C271(0.66); C139(1.07) | LDD0703 | [8] |
LDCM0387 | CL117 | HCT 116 | C139(0.55); C271(1.01) | LDD0704 | [8] |
LDCM0388 | CL118 | HCT 116 | C139(1.01); C271(1.02) | LDD0705 | [8] |
LDCM0389 | CL119 | HCT 116 | C271(0.91); C139(1.00) | LDD0706 | [8] |
LDCM0390 | CL12 | HCT 116 | C271(0.59); C139(0.59) | LDD0707 | [8] |
LDCM0391 | CL120 | HCT 116 | C271(0.93); C139(1.10) | LDD0708 | [8] |
LDCM0392 | CL121 | HCT 116 | C271(0.95) | LDD0709 | [8] |
LDCM0393 | CL122 | HCT 116 | C271(1.16) | LDD0710 | [8] |
LDCM0394 | CL123 | HCT 116 | C271(1.02) | LDD0711 | [8] |
LDCM0395 | CL124 | HCT 116 | C271(1.03) | LDD0712 | [8] |
LDCM0396 | CL125 | HCT 116 | C271(1.08) | LDD0713 | [8] |
LDCM0397 | CL126 | HCT 116 | C271(1.37) | LDD0714 | [8] |
LDCM0398 | CL127 | HCT 116 | C271(1.00) | LDD0715 | [8] |
LDCM0399 | CL128 | HCT 116 | C271(0.98) | LDD0716 | [8] |
LDCM0400 | CL13 | HCT 116 | C139(0.70); C271(0.92) | LDD0717 | [8] |
LDCM0401 | CL14 | HCT 116 | C139(0.90); C271(1.20) | LDD0718 | [8] |
LDCM0402 | CL15 | HCT 116 | C139(0.76); C271(0.85) | LDD0719 | [8] |
LDCM0403 | CL16 | HCT 116 | C271(1.17) | LDD0720 | [8] |
LDCM0404 | CL17 | HCT 116 | C271(1.23) | LDD0721 | [8] |
LDCM0405 | CL18 | HCT 116 | C271(1.07) | LDD0722 | [8] |
LDCM0406 | CL19 | HCT 116 | C271(0.96) | LDD0723 | [8] |
LDCM0407 | CL2 | HCT 116 | C139(0.70); C271(1.04) | LDD0724 | [8] |
LDCM0408 | CL20 | HCT 116 | C271(0.88) | LDD0725 | [8] |
LDCM0409 | CL21 | HCT 116 | C271(0.77) | LDD0726 | [8] |
LDCM0410 | CL22 | HCT 116 | C271(0.65) | LDD0727 | [8] |
LDCM0411 | CL23 | HCT 116 | C271(0.81) | LDD0728 | [8] |
LDCM0412 | CL24 | HCT 116 | C271(0.84) | LDD0729 | [8] |
LDCM0413 | CL25 | HCT 116 | C271(0.79) | LDD0730 | [8] |
LDCM0414 | CL26 | HCT 116 | C271(1.10) | LDD0731 | [8] |
LDCM0415 | CL27 | HCT 116 | C271(1.06) | LDD0732 | [8] |
LDCM0416 | CL28 | HCT 116 | C271(0.91) | LDD0733 | [8] |
LDCM0417 | CL29 | HCT 116 | C271(0.97) | LDD0734 | [8] |
LDCM0418 | CL3 | HCT 116 | C139(0.61); C271(0.96) | LDD0735 | [8] |
LDCM0419 | CL30 | HCT 116 | C271(1.02) | LDD0736 | [8] |
LDCM0420 | CL31 | HCT 116 | C139(1.06); C271(1.03) | LDD0737 | [8] |
LDCM0421 | CL32 | HCT 116 | C139(1.19); C271(0.92) | LDD0738 | [8] |
LDCM0422 | CL33 | HCT 116 | C139(1.01); C271(1.38) | LDD0739 | [8] |
LDCM0423 | CL34 | HCT 116 | C139(1.22); C271(0.98) | LDD0740 | [8] |
LDCM0424 | CL35 | HCT 116 | C139(1.10); C271(1.08) | LDD0741 | [8] |
LDCM0425 | CL36 | HCT 116 | C139(1.18); C271(1.25) | LDD0742 | [8] |
LDCM0426 | CL37 | HCT 116 | C139(1.02); C271(0.87) | LDD0743 | [8] |
LDCM0428 | CL39 | HCT 116 | C139(1.14); C271(0.96) | LDD0745 | [8] |
LDCM0429 | CL4 | HCT 116 | C139(0.99); C271(1.05) | LDD0746 | [8] |
LDCM0430 | CL40 | HCT 116 | C139(1.09); C271(1.17) | LDD0747 | [8] |
LDCM0431 | CL41 | HCT 116 | C139(1.15); C271(0.94) | LDD0748 | [8] |
LDCM0432 | CL42 | HCT 116 | C139(1.04); C271(0.95) | LDD0749 | [8] |
LDCM0433 | CL43 | HCT 116 | C139(1.08); C271(0.84) | LDD0750 | [8] |
LDCM0434 | CL44 | HCT 116 | C139(1.15); C271(0.94) | LDD0751 | [8] |
LDCM0435 | CL45 | HCT 116 | C139(1.14); C271(1.22) | LDD0752 | [8] |
LDCM0436 | CL46 | HCT 116 | C139(1.18); C271(0.96) | LDD0753 | [8] |
LDCM0437 | CL47 | HCT 116 | C139(1.08); C271(1.18) | LDD0754 | [8] |
LDCM0438 | CL48 | HCT 116 | C139(1.11); C271(0.60) | LDD0755 | [8] |
LDCM0439 | CL49 | HCT 116 | C139(1.13); C271(1.08) | LDD0756 | [8] |
LDCM0440 | CL5 | HCT 116 | C139(0.78); C271(0.98) | LDD0757 | [8] |
LDCM0441 | CL50 | HCT 116 | C139(0.98); C271(0.94) | LDD0758 | [8] |
LDCM0442 | CL51 | HCT 116 | C139(1.09); C271(1.01) | LDD0759 | [8] |
LDCM0443 | CL52 | HCT 116 | C139(1.15); C271(1.04) | LDD0760 | [8] |
LDCM0444 | CL53 | HCT 116 | C139(0.90); C271(1.19) | LDD0761 | [8] |
LDCM0445 | CL54 | HCT 116 | C139(1.06); C271(1.05) | LDD0762 | [8] |
LDCM0446 | CL55 | HCT 116 | C139(0.99); C271(0.93) | LDD0763 | [8] |
LDCM0447 | CL56 | HCT 116 | C139(0.87); C271(1.00) | LDD0764 | [8] |
LDCM0448 | CL57 | HCT 116 | C139(1.43); C271(1.21) | LDD0765 | [8] |
LDCM0449 | CL58 | HCT 116 | C139(1.19); C271(1.05) | LDD0766 | [8] |
LDCM0450 | CL59 | HCT 116 | C139(1.06); C271(1.05) | LDD0767 | [8] |
LDCM0451 | CL6 | HCT 116 | C139(1.02); C271(1.21) | LDD0768 | [8] |
LDCM0452 | CL60 | HCT 116 | C139(1.20); C271(0.93) | LDD0769 | [8] |
LDCM0453 | CL61 | HCT 116 | C271(1.04) | LDD0770 | [8] |
LDCM0454 | CL62 | HCT 116 | C271(1.15) | LDD0771 | [8] |
LDCM0455 | CL63 | HCT 116 | C271(1.16) | LDD0772 | [8] |
LDCM0456 | CL64 | HCT 116 | C271(1.02) | LDD0773 | [8] |
LDCM0457 | CL65 | HCT 116 | C271(1.04) | LDD0774 | [8] |
LDCM0458 | CL66 | HCT 116 | C271(0.91) | LDD0775 | [8] |
LDCM0459 | CL67 | HCT 116 | C271(0.93) | LDD0776 | [8] |
LDCM0460 | CL68 | HCT 116 | C271(0.87) | LDD0777 | [8] |
LDCM0461 | CL69 | HCT 116 | C271(1.17) | LDD0778 | [8] |
LDCM0462 | CL7 | HCT 116 | C139(1.15); C271(0.82) | LDD0779 | [8] |
LDCM0463 | CL70 | HCT 116 | C271(0.93) | LDD0780 | [8] |
LDCM0464 | CL71 | HCT 116 | C271(0.87) | LDD0781 | [8] |
LDCM0465 | CL72 | HCT 116 | C271(1.00) | LDD0782 | [8] |
LDCM0466 | CL73 | HCT 116 | C271(1.05) | LDD0783 | [8] |
LDCM0467 | CL74 | HCT 116 | C271(0.96) | LDD0784 | [8] |
LDCM0469 | CL76 | HCT 116 | C139(1.22); C271(1.12) | LDD0786 | [8] |
LDCM0470 | CL77 | HCT 116 | C139(1.01); C271(1.28) | LDD0787 | [8] |
LDCM0471 | CL78 | HCT 116 | C139(1.22); C271(1.13) | LDD0788 | [8] |
LDCM0472 | CL79 | HCT 116 | C139(0.89); C271(0.71) | LDD0789 | [8] |
LDCM0473 | CL8 | HCT 116 | C139(0.73); C271(0.90) | LDD0790 | [8] |
LDCM0474 | CL80 | HCT 116 | C139(1.07); C271(1.04) | LDD0791 | [8] |
LDCM0475 | CL81 | HCT 116 | C139(1.13); C271(0.88) | LDD0792 | [8] |
LDCM0476 | CL82 | HCT 116 | C139(0.59); C271(0.44) | LDD0793 | [8] |
LDCM0477 | CL83 | HCT 116 | C139(0.82); C271(0.49) | LDD0794 | [8] |
LDCM0478 | CL84 | HCT 116 | C139(0.45); C271(0.34) | LDD0795 | [8] |
LDCM0479 | CL85 | HCT 116 | C139(1.04); C271(1.19) | LDD0796 | [8] |
LDCM0480 | CL86 | HCT 116 | C139(1.26); C271(1.93) | LDD0797 | [8] |
LDCM0481 | CL87 | HCT 116 | C139(1.18); C271(1.17) | LDD0798 | [8] |
LDCM0482 | CL88 | HCT 116 | C139(0.85); C271(0.68) | LDD0799 | [8] |
LDCM0483 | CL89 | HCT 116 | C139(0.33); C271(0.23) | LDD0800 | [8] |
LDCM0484 | CL9 | HCT 116 | C139(0.80); C271(0.92) | LDD0801 | [8] |
LDCM0485 | CL90 | HCT 116 | C139(1.28); C271(1.61) | LDD0802 | [8] |
LDCM0486 | CL91 | HCT 116 | C139(0.96); C271(0.94) | LDD0803 | [8] |
LDCM0487 | CL92 | HCT 116 | C139(1.02); C271(1.07) | LDD0804 | [8] |
LDCM0488 | CL93 | HCT 116 | C139(1.19); C271(1.54) | LDD0805 | [8] |
LDCM0489 | CL94 | HCT 116 | C139(1.10); C271(1.20) | LDD0806 | [8] |
LDCM0490 | CL95 | HCT 116 | C139(0.95); C271(1.23) | LDD0807 | [8] |
LDCM0491 | CL96 | HCT 116 | C139(1.02); C271(1.07) | LDD0808 | [8] |
LDCM0492 | CL97 | HCT 116 | C139(1.42); C271(1.33) | LDD0809 | [8] |
LDCM0493 | CL98 | HCT 116 | C139(1.42); C271(0.98) | LDD0810 | [8] |
LDCM0494 | CL99 | HCT 116 | C139(1.33); C271(1.01) | LDD0811 | [8] |
LDCM0495 | E2913 | HEK-293T | C139(1.04); C271(1.07); C219(1.00) | LDD1698 | [28] |
LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C139(2.14) | LDD1702 | [6] |
LDCM0625 | F8 | Ramos | C271(0.60) | LDD2187 | [29] |
LDCM0572 | Fragment10 | Ramos | C271(0.50) | LDD2189 | [29] |
LDCM0573 | Fragment11 | Ramos | C271(0.22) | LDD2190 | [29] |
LDCM0574 | Fragment12 | Ramos | C271(0.68) | LDD2191 | [29] |
LDCM0575 | Fragment13 | Ramos | C271(0.98) | LDD2192 | [29] |
LDCM0576 | Fragment14 | Ramos | C271(0.80) | LDD2193 | [29] |
LDCM0579 | Fragment20 | Ramos | C271(0.50) | LDD2194 | [29] |
LDCM0580 | Fragment21 | Ramos | C271(0.94) | LDD2195 | [29] |
LDCM0582 | Fragment23 | Ramos | C271(1.03) | LDD2196 | [29] |
LDCM0578 | Fragment27 | Ramos | C271(1.00) | LDD2197 | [29] |
LDCM0586 | Fragment28 | Ramos | C271(0.39) | LDD2198 | [29] |
LDCM0588 | Fragment30 | Ramos | C271(1.08) | LDD2199 | [29] |
LDCM0589 | Fragment31 | Ramos | C271(1.13) | LDD2200 | [29] |
LDCM0590 | Fragment32 | Ramos | C271(0.46) | LDD2201 | [29] |
LDCM0468 | Fragment33 | HCT 116 | C271(1.07) | LDD0785 | [8] |
LDCM0596 | Fragment38 | Ramos | C271(1.46) | LDD2203 | [29] |
LDCM0566 | Fragment4 | Ramos | C271(0.74) | LDD2184 | [29] |
LDCM0427 | Fragment51 | HCT 116 | C139(1.20); C271(1.07) | LDD0744 | [8] |
LDCM0610 | Fragment52 | Ramos | C271(1.19) | LDD2204 | [29] |
LDCM0614 | Fragment56 | Ramos | C271(1.10) | LDD2205 | [29] |
LDCM0569 | Fragment7 | Ramos | C271(0.60) | LDD2186 | [29] |
LDCM0571 | Fragment9 | Ramos | C271(0.60) | LDD2188 | [29] |
LDCM0107 | IAA | HeLa | H107(0.00); H134(0.00); H284(0.00); C271(0.00) | LDD0221 | [18] |
LDCM0022 | KB02 | HEK-293T | C139(0.97); C271(0.94); C219(1.08) | LDD1492 | [28] |
LDCM0023 | KB03 | HEK-293T | C139(0.98); C271(0.86); C219(1.11) | LDD1497 | [28] |
LDCM0024 | KB05 | HMCB | C219(1.49); C139(2.41) | LDD3312 | [30] |
LDCM0509 | N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide | MDA-MB-231 | C271(0.98) | LDD2102 | [6] |
LDCM0528 | N-(4-bromophenyl)-2-cyano-N-phenylacetamide | MDA-MB-231 | C139(0.64); C271(0.76) | LDD2121 | [6] |
LDCM0109 | NEM | HeLa | H107(0.00); C139(0.00); H284(0.00); C271(0.00) | LDD0223 | [18] |
LDCM0496 | Nucleophilic fragment 11a | MDA-MB-231 | C139(0.99); C271(0.65) | LDD2089 | [6] |
LDCM0499 | Nucleophilic fragment 12b | MDA-MB-231 | C139(1.02) | LDD2092 | [6] |
LDCM0501 | Nucleophilic fragment 13b | MDA-MB-231 | C139(1.18) | LDD2094 | [6] |
LDCM0505 | Nucleophilic fragment 15b | MDA-MB-231 | C139(1.03) | LDD2098 | [6] |
LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C139(1.63); C271(0.99) | LDD2099 | [6] |
LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C139(0.83) | LDD2100 | [6] |
LDCM0508 | Nucleophilic fragment 17a | MDA-MB-231 | C139(0.89) | LDD2101 | [6] |
LDCM0511 | Nucleophilic fragment 18b | MDA-MB-231 | C271(0.58) | LDD2104 | [6] |
LDCM0512 | Nucleophilic fragment 19a | MDA-MB-231 | C271(1.02) | LDD2105 | [6] |
LDCM0513 | Nucleophilic fragment 19b | MDA-MB-231 | C139(0.42); C271(0.60) | LDD2106 | [6] |
LDCM0514 | Nucleophilic fragment 20a | MDA-MB-231 | C139(1.20) | LDD2107 | [6] |
LDCM0515 | Nucleophilic fragment 20b | MDA-MB-231 | C139(0.97); C271(0.63) | LDD2108 | [6] |
LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C139(0.71) | LDD2109 | [6] |
LDCM0517 | Nucleophilic fragment 21b | MDA-MB-231 | C139(1.04); C271(0.52) | LDD2110 | [6] |
LDCM0518 | Nucleophilic fragment 22a | MDA-MB-231 | C139(1.41) | LDD2111 | [6] |
LDCM0521 | Nucleophilic fragment 23b | MDA-MB-231 | C139(0.58) | LDD2114 | [6] |
LDCM0527 | Nucleophilic fragment 26b | MDA-MB-231 | C139(0.95) | LDD2120 | [6] |
LDCM0529 | Nucleophilic fragment 27b | MDA-MB-231 | C139(1.28) | LDD2122 | [6] |
LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C139(1.06); C271(0.98) | LDD2123 | [6] |
LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C139(0.76); C271(1.00) | LDD2125 | [6] |
LDCM0533 | Nucleophilic fragment 29b | MDA-MB-231 | C139(1.10) | LDD2126 | [6] |
LDCM0534 | Nucleophilic fragment 30a | MDA-MB-231 | C139(1.21) | LDD2127 | [6] |
LDCM0536 | Nucleophilic fragment 31 | MDA-MB-231 | C139(0.98) | LDD2129 | [6] |
LDCM0541 | Nucleophilic fragment 36 | MDA-MB-231 | C139(0.66) | LDD2134 | [6] |
LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C139(1.57); C271(1.36) | LDD2136 | [6] |
LDCM0544 | Nucleophilic fragment 39 | MDA-MB-231 | C139(0.97); C271(0.93) | LDD2137 | [6] |
LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C139(1.07); C271(0.60) | LDD2141 | [6] |
LDCM0549 | Nucleophilic fragment 43 | MDA-MB-231 | C139(0.91) | LDD2143 | [6] |
LDCM0550 | Nucleophilic fragment 5a | MDA-MB-231 | C139(1.50) | LDD2144 | [6] |
LDCM0551 | Nucleophilic fragment 5b | MDA-MB-231 | C271(1.00) | LDD2145 | [6] |
LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C139(0.96) | LDD2146 | [6] |
LDCM0556 | Nucleophilic fragment 8a | MDA-MB-231 | C271(0.57) | LDD2150 | [6] |
LDCM0559 | Nucleophilic fragment 9b | MDA-MB-231 | C139(1.47) | LDD2153 | [6] |
LDCM0131 | RA190 | MM1.R | C271(1.93); C219(1.15) | LDD0304 | [31] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Transporter and channel
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
Huntingtin (HTT) | Huntingtin family | P42858 |
Other
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
Programmed cell death protein 2 (PDCD2) | . | Q16342 |
The Drug(s) Related To This Target
Investigative
References