Details of the Target

General Information of Target

Target ID LDTP06320
Target Name [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1)
Gene Name PDK1
Gene ID 5163
Synonyms
PDHK1; [Pyruvate dehydrogenase; acetyl-transferring)] kinase isozyme 1, mitochondrial; EC 2.7.11.2; Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMK
QFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQE
LLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYF
LDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLC
DLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPP
IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLP
ISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDW
CVPSREPKDMTTFRSA
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
PDK/BCKDK protein kinase family
Subcellular location
Mitochondrion matrix
Function
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
TTD ID
T15776
Uniprot ID
Q15118
DrugMap ID
TTCZOF2
Ensemble ID
ENST00000282077.8
HGNC ID
HGNC:8809
ChEMBL ID
CHEMBL4766

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAOV3 SNV: p.Q158Ter .
FUOV1 SNV: p.A407V .
Ishikawa (Heraklio) 02 ER SNV: p.A407V .
MOLT4 SNV: p.L101P IA-alkyne    Probe Info 
NCIH2286 SNV: p.Q61H .
NCIH23 SNV: p.H415L .
REH SNV: p.F48L .
TE10 SNV: p.D47E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.00  LDD0402  [1]
TH211
 Probe Info  		Y365(7.10)  LDD0260  [2]
Acrolein
 Probe Info  		N.A.  LDD0232  [3]
DBIA
 Probe Info  		C240(1.93)  LDD0080  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C223(0.00); C240(0.00); C71(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C223(0.00); C421(0.00); C240(0.00); C71(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C223(0.00); C240(0.00); C71(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
Compound 10
 Probe Info  		C223(0.00); C71(0.00)  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
1c-yne
 Probe Info  		N.A.  LDD0228  [8]
AOyne
 Probe Info  		7.50  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		20.53  LDD1793  [10]
C153
 Probe Info  		19.43  LDD1834  [10]
C158
 Probe Info  		12.04  LDD1838  [10]
C214
 Probe Info  		6.59  LDD1888  [10]
C229
 Probe Info  		7.73  LDD1902  [10]
C231
 Probe Info  		13.83  LDD1904  [10]
C233
 Probe Info  		13.09  LDD1906  [10]
C235
 Probe Info  		18.51  LDD1908  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C71(1.86)  LDD1093  [4]
 LDCM0215  AC10 HEK-293T C71(0.94)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C71(1.03)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C71(0.92)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C71(1.04)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C71(1.00)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C71(1.01)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C71(1.04)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C71(0.93)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C71(0.93)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C71(0.98)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C71(1.01)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C71(0.87)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C71(0.96)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C71(1.01)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C71(1.00)  LDD0827  [4]
 LDCM0237  AC12 HEK-293T C71(0.87)  LDD0835  [4]
 LDCM0246  AC128 PaTu 8988t C71(1.23)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C71(1.24)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C71(1.08)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C71(0.98)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C71(1.02)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C71(1.04)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C71(1.13)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C71(1.08)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C71(1.26)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C71(1.18)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C71(1.06)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C71(1.11)  LDD1137  [4]
 LDCM0259  AC14 HEK-293T C71(0.99)  LDD0857  [4]
 LDCM0260  AC140 PaTu 8988t C71(1.15)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C71(1.15)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C71(1.08)  LDD1141  [4]
 LDCM0263  AC143 HEK-293T C71(1.01)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C71(0.98)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C71(0.91)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C71(1.03)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C71(0.76)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C71(0.86)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C71(0.84)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C71(0.88)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C71(0.82)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C71(1.04)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C71(0.94)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C71(0.83)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C71(1.06)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C71(0.96)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C71(0.93)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C71(0.97)  LDD2165  [4]
 LDCM0276  AC17 PaTu 8988t C71(1.20)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C71(1.68)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C71(1.40)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C71(1.44)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C71(1.53)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C71(1.91)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C71(1.99)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C71(1.76)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C71(1.52)  LDD1163  [4]
 LDCM0285  AC25 PaTu 8988t C71(0.87)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C71(1.03)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C71(1.01)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C71(1.21)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C71(1.06)  LDD1168  [4]
 LDCM0290  AC3 PaTu 8988t C71(1.48)  LDD1169  [4]
 LDCM0291  AC30 PaTu 8988t C71(1.00)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C71(0.88)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C71(1.01)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C71(1.14)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C71(1.48)  LDD1174  [4]
 LDCM0296  AC35 HCT 116 C71(0.95)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C71(0.98)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C71(1.03)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C71(0.94)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C71(1.01)  LDD0617  [4]
 LDCM0301  AC4 PaTu 8988t C71(1.32)  LDD1180  [4]
 LDCM0302  AC40 HCT 116 C71(1.24)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C71(1.13)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C71(1.05)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C71(1.05)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C71(1.07)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C71(1.43)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C421(1.00); C223(0.95); C71(0.98); C240(0.87)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C421(1.12); C223(0.95); C71(1.06); C240(1.01)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C421(0.89); C223(1.08); C71(1.05)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C421(0.99); C223(0.97); C71(1.12)  LDD1550  [11]
 LDCM0312  AC5 PaTu 8988t C71(1.82)  LDD1191  [4]
 LDCM0313  AC50 HEK-293T C421(0.99); C223(0.88); C71(1.18)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C421(1.13); C223(1.03); C71(1.01); C240(1.00)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C421(1.08); C223(0.98); C71(1.06); C240(1.12)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C421(0.98); C223(0.99); C71(1.02); C240(0.99)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C421(1.14); C223(0.98); C71(1.02); C240(0.94)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C421(1.02); C223(0.96); C71(1.04); C240(0.95)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C421(0.91); C223(1.04); C71(0.97)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C421(1.02); C223(0.92); C71(1.17)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C421(1.00); C223(0.88); C71(1.11)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C421(1.03); C223(0.93); C71(1.13); C240(1.13)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C71(0.88)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C421(0.91); C223(1.01); C71(1.04); C240(1.08)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C421(1.01); C223(0.90); C71(1.04); C240(0.89)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C421(0.88); C223(0.95); C71(0.98); C240(0.87)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C421(1.08); C223(0.99); C71(1.04); C240(0.95)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C421(0.84); C223(1.03); C71(1.00)  LDD1567  [11]
 LDCM0332  AC68 HCT 116 C71(0.80)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C71(0.80)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C71(0.80)  LDD0932  [4]
 LDCM0335  AC70 HCT 116 C71(0.93)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C71(0.81)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C71(1.01)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C71(1.12)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C71(0.92)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C71(1.02)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C71(0.97)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C71(0.84)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C71(0.93)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C71(1.00)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C71(0.97)  LDD0943  [4]
 LDCM0346  AC80 HCT 116 C71(0.97)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C71(0.88)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C71(1.04)  LDD0665  [4]
 LDCM0365  AC98 HEK-293T C71(0.90)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C71(0.98)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C71(0.91)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C71(0.82)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C71(0.92)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 12.54  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C71(2.36)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C71(5.16)  LDD1247  [4]
 LDCM0369  CL100 PaTu 8988t C71(1.24)  LDD1248  [4]
 LDCM0370  CL101 HEK-293T C71(1.03)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C71(1.40)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C71(0.92)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C71(0.89)  LDD0971  [4]
 LDCM0374  CL105 PaTu 8988t C71(1.46)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C71(1.22)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C71(1.41)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C71(1.24)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C71(1.47)  LDD1257  [4]
 LDCM0379  CL11 PaTu 8988t C71(1.49)  LDD1258  [4]
 LDCM0380  CL110 PaTu 8988t C71(2.13)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C71(2.56)  LDD1260  [4]
 LDCM0382  CL112 PaTu 8988t C71(1.17)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C71(0.89)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C71(1.24)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C71(1.15)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C71(0.93)  LDD1265  [4]
 LDCM0387  CL117 HCT 116 C71(2.11)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C71(1.06)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C71(1.00)  LDD0706  [4]
 LDCM0390  CL12 PaTu 8988t C71(1.33)  LDD1269  [4]
 LDCM0391  CL120 HCT 116 C71(1.03)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C421(0.95); C223(0.98); C71(1.08); C240(0.88)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C421(0.95); C223(0.89); C71(1.02); C240(0.90)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C421(0.89); C223(1.01); C71(1.33); C240(1.01)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C421(1.03); C223(0.98); C71(0.99); C240(0.84)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C421(0.95); C223(0.86); C71(1.13); C240(0.85)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C421(0.93); C223(0.91); C71(1.08); C240(0.71)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C421(1.03); C223(0.85); C71(1.10); C240(1.00)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C421(0.98); C223(0.82); C71(1.11); C240(0.79)  LDD1603  [11]
 LDCM0400  CL13 PaTu 8988t C71(2.26)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C71(2.67)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C71(1.88)  LDD1281  [4]
 LDCM0403  CL16 PaTu 8988t C71(1.29)  LDD1282  [4]
 LDCM0404  CL17 HCT 116 C71(2.03)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C71(1.00)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C71(1.12)  LDD0723  [4]
 LDCM0407  CL2 PaTu 8988t C71(1.24)  LDD1286  [4]
 LDCM0408  CL20 HCT 116 C71(1.30)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C71(1.80)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C71(1.60)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C71(1.13)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C71(1.02)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C71(1.01)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C71(1.03)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C71(0.98)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C71(1.38)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C71(1.14)  LDD0734  [4]
 LDCM0418  CL3 PaTu 8988t C71(1.34)  LDD1297  [4]
 LDCM0419  CL30 HCT 116 C71(0.98)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C71(1.71)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C71(1.04)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C71(1.32)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C71(1.31)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C71(1.07)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C71(1.45)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C71(1.27)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C71(1.08)  LDD0745  [4]
 LDCM0429  CL4 PaTu 8988t C71(1.38)  LDD1308  [4]
 LDCM0430  CL40 HCT 116 C71(7.33)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C71(1.04)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C71(1.27)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C71(1.31)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C71(1.51)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C71(1.42)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C71(2.21)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C71(1.09)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C71(1.23)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C71(0.96)  LDD0756  [4]
 LDCM0440  CL5 PaTu 8988t C71(1.56)  LDD1319  [4]
 LDCM0441  CL50 HCT 116 C71(1.05)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C71(1.08)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C71(1.31)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C71(1.03)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C71(1.09)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C71(1.34)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C71(0.89)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C71(1.02)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C71(1.84)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C71(0.97)  LDD0767  [4]
 LDCM0451  CL6 PaTu 8988t C71(1.99)  LDD1330  [4]
 LDCM0452  CL60 HCT 116 C71(1.00)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C71(1.43)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C71(1.44)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C71(1.76)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C71(1.44)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C71(1.24)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C71(1.77)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C71(1.20)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C71(2.16)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C71(2.43)  LDD0778  [4]
 LDCM0462  CL7 PaTu 8988t C71(1.57)  LDD1341  [4]
 LDCM0463  CL70 HCT 116 C71(1.25)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C71(1.27)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C71(1.43)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C71(1.45)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C71(1.32)  LDD0784  [4]
 LDCM0469  CL76 PaTu 8988t C71(0.97)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C71(1.66)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C71(1.32)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C71(1.49)  LDD1351  [4]
 LDCM0473  CL8 PaTu 8988t C71(3.51)  LDD1352  [4]
 LDCM0474  CL80 PaTu 8988t C71(1.34)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C71(1.48)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C71(1.44)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C71(1.94)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C71(1.26)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C71(1.25)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C71(1.46)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C71(1.93)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C71(1.51)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C71(1.04)  LDD1362  [4]
 LDCM0484  CL9 PaTu 8988t C71(1.56)  LDD1363  [4]
 LDCM0485  CL90 PaTu 8988t C71(8.56)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C71(1.54)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C71(4.10)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C71(2.08)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C71(2.67)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C71(3.25)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C71(1.51)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C71(1.67)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C71(2.48)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C71(2.34)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C421(1.04); C223(0.96); C71(1.14); C240(1.07)  LDD1698  [11]
 LDCM0572  Fragment10 MDA-MB-231 C71(18.01)  LDD1465  [12]
 LDCM0573  Fragment11 MDA-MB-231 C71(0.62)  LDD1467  [12]
 LDCM0575  Fragment13 MDA-MB-231 C71(1.62)  LDD1469  [12]
 LDCM0576  Fragment14 MDA-MB-231 C71(4.39)  LDD1471  [12]
 LDCM0580  Fragment21 MDA-MB-231 C71(1.71)  LDD1473  [12]
 LDCM0578  Fragment27 MDA-MB-231 C71(1.53)  LDD1474  [12]
 LDCM0586  Fragment28 Ramos C71(2.97)  LDD2198  [13]
 LDCM0587  Fragment29 Ramos C71(1.82)  LDD1476  [12]
 LDCM0468  Fragment33 HCT 116 C71(2.25)  LDD0785  [4]
 LDCM0596  Fragment38 MDA-MB-231 C71(1.27)  LDD1480  [12]
 LDCM0566  Fragment4 MDA-MB-231 C71(20.00)  LDD1461  [12]
 LDCM0603  Fragment45 MDA-MB-231 C71(20.00)  LDD1482  [12]
 LDCM0427  Fragment51 HCT 116 C71(7.27)  LDD0744  [4]
 LDCM0569  Fragment7 Ramos C71(0.97)  LDD2186  [13]
 LDCM0570  Fragment8 MDA-MB-231 C71(20.00)  LDD1462  [12]
 LDCM0015  HNE MDA-MB-231 C71(0.80)  LDD0346  [13]
 LDCM0022  KB02 HCT 116 C240(1.93)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C240(2.32)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C240(2.64)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0232  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C71(0.78)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C71(0.41)  LDD2207  [14]
 LDCM0131  RA190 MM1.R C71(1.63); C240(1.00)  LDD0304  [15]
 LDCM0170  Structure8 Ramos 12.02  LDD0433  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase N2 (PKN2) AGC Ser/Thr protein kinase family Q16513
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) . P08559
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dichloroacetic Acid . DB08809
Phase 4
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dichloroacetate Small molecular drug D7I9JH
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4-[(3-chloro-4-{[(2r)-333-trifluoro-2-hydroxy-2-methylpropanoyl]Amino}Phenyl)Sulfonyl]-nn-dimethylbenzamide Small molecular drug DB07403
Patented
Click To Hide/Show 98 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1,2-dihydroindazolo[4,3-bc][1,5]Benzoxazepine Derivative 1 Small molecular drug D0PJ7M
Benzimidazole And Imidazopyridine Derivative 1 Small molecular drug D06WAN
Benzonaphthyridine Derivative 1 Small molecular drug D0U3IS
Benzonaphthyridine Derivative 2 Small molecular drug D0IR8B
Bis-indolylmaleimide Derivative 1 Small molecular drug D0DM2G
Dibenzo [C,F]-[2,7]Naphthyridine Derivative 1 Small molecular drug D0I5KI
Heterocyclic-carboxamide Derivative 1 Small molecular drug D0RY6M
Heterocyclic-carboxamide Derivative 2 Small molecular drug D0CQ1M
Imidazo Quinoline Derivative 1 Small molecular drug D0D5YE
Indazole Derivative 1 Small molecular drug D0CK8H
Indolinone Derivative 1 Small molecular drug D0ZE5U
Pmid25684022-compound-ep20041486488 Small molecular drug D0YD1Q
Pmid25684022-compound-wo2004087707 Small molecular drug D06RGW
Pmid25684022-compound-wo2006015124 Small molecular drug D0RP4U
Pmid25684022-compound-wo2008005457 Small molecular drug D08EGT
Pmid25684022-compound-wo2008079988 Small molecular drug D04UHW
Pmid25684022-compound-wo2008107444 Small molecular drug D0MI3E
Pmid25684022-compound-wo2009153313 Small molecular drug D06LLS
Pmid25684022-compound-wo2010127754 Small molecular drug D0C6VX
Pyrazole Derivative 61 Small molecular drug D00MLJ
Pyrazolopyridines And Imidazopyridine Derivative 1 Small molecular drug D0I1YQ
Pyridinone Carboxamide Derivative 1 Small molecular drug D05GMT
Pyrido[4,3-d]Pyrimidin-5(6h)-one Derivative 1 Small molecular drug D0ZV9P
Pyrimidine Derivative 3 Small molecular drug D02MMG
Pyrimidinone Derivative 1 Small molecular drug D0P1VT
Thieno[3,2-c]Pyridine-7-carboxamide Derivative 1 Small molecular drug D06BSG
Thieno[3,2-c]Pyridine-7-carboxamide Derivative 2 Small molecular drug D03GFZ
Heteroaryl-carboxamide Derivative 1 . D0H7SO
Heteroaryl-carboxamide Derivative 10 . D0TB2H
Heteroaryl-carboxamide Derivative 2 . D08SNT
Heteroaryl-carboxamide Derivative 3 . D00ZXR
Heteroaryl-carboxamide Derivative 4 . D00LMA
Heteroaryl-carboxamide Derivative 5 . D0MG4D
Heteroaryl-carboxamide Derivative 6 . D0GH9W
Heteroaryl-carboxamide Derivative 7 . D0MW7L
Heteroaryl-carboxamide Derivative 8 . D0WT9J
Heteroaryl-carboxamide Derivative 9 . D03WFI
Heterocyclic Derivative 10 . D07IQE
Heterocyclic Derivative 11 . D09BNP
Heterocyclic Derivative 12 . D04BBT
Heterocyclic Derivative 13 . D0HI8X
Heterocyclic Derivative 14 . D0EH9Z
Heterocyclic Derivative 15 . D02USE
Heterocyclic Derivative 16 . D0RH6G
Heterocyclic Derivative 17 . D04MHV
Heterocyclic Derivative 18 . D0FW3M
Heterocyclic Derivative 19 . D0WX4H
Heterocyclic Derivative 4 . D05OTD
Heterocyclic Derivative 5 . D0J9DI
Heterocyclic Derivative 6 . D0D0ML
Heterocyclic Derivative 7 . D0W3JC
Heterocyclic Derivative 8 . D0AM2D
Heterocyclic Derivative 9 . D07HOA
Pmid25684022-compound-us20120277229 39(1.1) . D09FQP
Pmid25684022-compound-us20120277229 40(1.2) . D06LSZ
Pmid25684022-compound-us20120277229 41(1.3) . D04EDM
Pmid25684022-compound-us20120277229 44(1.4) . D0RE3R
Pmid25684022-compound-us20120277229 45(1.5) . D07ZKE
Pmid25684022-compound-us20130053382 35(1-11) . D0SB4A
Pmid25684022-compound-us20130053382 36(3-5) . D07XBA
Pmid25684022-compound-us20130053382 37(4-6) . D0Y0RG
Pmid25684022-compound-us20130053382 38(5-7) . D07FMW
Pmid25684022-compound-wo2011137219 35(1-11) . D0P0WF
Pmid25684022-compound-wo2011137219 36(3-5) . D0B8OB
Pmid25684022-compound-wo2011137219 37(4-6) . D00SVK
Pmid25684022-compound-wo2011137219 38(5-7) . D0IO2X
Pmid25684022-compound-wo2012135799 42(1.4) . D0DC2P
Pmid25684022-compound-wo2012135799 43(1.5) . D0R0SJ
Thiazole Carboxamide Derivative 1 . D0Q6RC
Thiazole Carboxamide Derivative 10 . D0K8XT
Thiazole Carboxamide Derivative 11 . D07MSB
Thiazole Carboxamide Derivative 12 . D06PTW
Thiazole Carboxamide Derivative 13 . D0ZG0K
Thiazole Carboxamide Derivative 14 . D06WXJ
Thiazole Carboxamide Derivative 15 . D0Q8JK
Thiazole Carboxamide Derivative 16 . D0D8PF
Thiazole Carboxamide Derivative 17 . D0GE6F
Thiazole Carboxamide Derivative 18 . D0FJ4A
Thiazole Carboxamide Derivative 19 . D0GY8G
Thiazole Carboxamide Derivative 2 . D0HP8K
Thiazole Carboxamide Derivative 20 . D0B2GM
Thiazole Carboxamide Derivative 21 . D0P6PT
Thiazole Carboxamide Derivative 22 . D0KN7T
Thiazole Carboxamide Derivative 23 . D0DO6K
Thiazole Carboxamide Derivative 24 . D04BBA
Thiazole Carboxamide Derivative 25 . D0JR0F
Thiazole Carboxamide Derivative 26 . D0U7LW
Thiazole Carboxamide Derivative 27 . D04QRX
Thiazole Carboxamide Derivative 28 . D0QV1E
Thiazole Carboxamide Derivative 29 . D07ZMG
Thiazole Carboxamide Derivative 3 . D0R3VG
Thiazole Carboxamide Derivative 30 . D0Z3HW
Thiazole Carboxamide Derivative 4 . D0H6AF
Thiazole Carboxamide Derivative 5 . D0U5HB
Thiazole Carboxamide Derivative 6 . D0Z5HL
Thiazole Carboxamide Derivative 7 . D08YPQ
Thiazole Carboxamide Derivative 8 . D0PD2I
Thiazole Carboxamide Derivative 9 . D06LCB

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
16 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.