Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment29					Competitor Info
Competitor Concentration	200 uM
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cells (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	20.0
LDTP12539	DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)				C130	13.3
LDTP02074	Aldehyde dehydrogenase, mitochondrial (ALDH2)				C319	10.5
LDTP11617	Myotubularin-related protein 12 (MTMR12)				C152	4.6
LDTP09200	FAD synthase (FLAD1)				C499	3.4
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	3.0
LDTP10429	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1)				C309	3.0
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	2.6
LDTP02055	Thymidylate synthase (TYMS)				C199	2.5
LDTP00481	Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6)				C98	2.4
LDTP10177	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2)				C64	2.3
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	2.3
LDTP10386	ERO1-like protein alpha (ERO1A)				C37	2.1
LDTP12363	Lysophosphatidic acid phosphatase type 6 (ACP6)				C267	2.1
LDTP12313	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13)				C86	2.0
LDTP02502	Thioredoxin (TXN)				C32	1.9
LDTP04690	Double-stranded RNA-specific adenosine deaminase (ADAR)				C1224	1.8
LDTP06320	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1)				C71	1.8
LDTP03401	Multifunctional protein CAD (CAD)				C73	1.8
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	1.7
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	1.7
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	1.7
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	1.6
LDTP03258	Thymidylate kinase (DTYMK)				C117	1.6
LDTP06211	Caspase-8 (CASP8)				C360	1.6
LDTP05480	Amidophosphoribosyltransferase (PPAT)				C100	1.6
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	1.6
LDTP10973	Thioredoxin, mitochondrial (TXN2)				C90	1.6
LDTP11059	ADP-ribose glycohydrolase MACROD1 (MACROD1)				C186	1.5
LDTP05795	Nucleoside diphosphate kinase 3 (NME3)				C158	1.5
LDTP18330	Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5)				C392	1.5
LDTP01633	Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)				C170	1.5
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.5
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.5
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	1.5
LDTP05943	Myotubularin-related protein 1 (MTMR1)				C117	1.5
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.4
LDTP17384	Lysine-specific demethylase RSBN1L (RSBN1L)				C280	1.4
LDTP00042	Probable ribonuclease ZC3H12D (ZC3H12D)				C367	1.3
LDTP13527	Aspartyl aminopeptidase (DNPEP)				C144	1.3
LDTP07110	Putative transferase CAF17, mitochondrial (IBA57)				C170	1.3
LDTP04471	Ribosomal protein S6 kinase alpha-3 (RPS6KA3)				C436	1.3
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	1.3
LDTP03316	DNA replication licensing factor MCM3 (MCM3)				C119	1.3
LDTP12405	Fructose-2,6-bisphosphatase TIGAR (TIGAR)				C161	1.3
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.3
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	1.2
LDTP02493	Serine/threonine-protein kinase A-Raf (ARAF)				C597	1.2
LDTP01245	Enoyl-CoA delta isomerase 2 (ECI2)				C380	1.2
LDTP12837	Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)				C22	1.2
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.2
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	1.2
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	1.2
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.2
LDTP05346	Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1)				C317	1.2
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C57	1.2
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	1.2
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.2
LDTP14092	Protein phosphatase methylesterase 1 (PPME1)				C381	1.2
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	1.2
LDTP10774	Elongation factor G, mitochondrial (GFM1)				C153	1.2
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	1.1
LDTP08401	All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2)				C71	1.1
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.1
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	1.1
LDTP18123	Isochorismatase domain-containing protein 2 (ISOC2)				C114	1.1
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	1.1
LDTP04262	Alanine--tRNA ligase, cytoplasmic (AARS1)				C773	1.1
LDTP07407	Desumoylating isopeptidase 1 (DESI1)				C108	1.0
LDTP00479	Histone acetyltransferase type B catalytic subunit (HAT1)				C101	1.0
LDTP09962	Ubiquitin carboxyl-terminal hydrolase 7 (USP7)				C223	1.0
LDTP04374	Dynamin-2 (DNM2)				C27	1.0
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.0
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	1.0
LDTP04438	Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1)				C340	1.0
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C190	1.0
LDTP00414	Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)				C131	1.0
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C54	1.0
LDTP12405	Fructose-2,6-bisphosphatase TIGAR (TIGAR)				C114	0.9
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	0.9
LDTP01055	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2)				C158	0.9

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	2.3
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)				C522	1.7
LDTP03777	Nuclear pore complex protein Nup214 (NUP214)				C728	1.7
LDTP09204	Nucleoporin NUP35 (NUP35)				C255	1.6
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	1.1
LDTP05591	Nuclear cap-binding protein subunit 1 (NCBP1)				C44	1.1
LDTP00501	Exportin-1 (XPO1)				C528	1.1
LDTP04801	Gasdermin-D (GSDMD)				C268	1.1
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	1.0

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	3.8
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	2.7
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	1.5
LDTP05362	Interferon regulatory factor 8 (IRF8)				C306	1.4
LDTP06475	Mothers against decapentaplegic homolog 2 (SMAD2)				C81	1.3
LDTP12792	CDKN2A-interacting protein (CDKN2AIP)				C516	1.1
LDTP01191	Zinc finger protein 217 (ZNF217)				C286	1.0

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP13402	Dynactin subunit 4 (DCTN4)				C258	20.0
LDTP07598	BRCA1-associated ATM activator 1 (BRAT1)				C673	4.6
LDTP04092	Crk-like protein (CRKL)				C249	4.2
LDTP15861	Acyl-CoA-binding domain-containing protein 6 (ACBD6)				C267	2.5
LDTP13515	Zinc finger protein 346 (ZNF346)				C68	2.4
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	2.0
LDTP13622	NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1)				C213	2.0
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.9
LDTP12753	Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2)				C83	1.9
LDTP15896	Ashwin (C2orf49)				C10	1.8
LDTP13583	Targeting protein for Xklp2 (TPX2)				C536	1.8
LDTP12571	LanC-like protein 2 (LANCL2)				C187	1.7
LDTP12800	Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2)				C22	1.7
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.6
LDTP08018	Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1)				C645	1.6
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C629	1.6
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C6	1.6
LDTP07624	Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC1S3)				C168	1.6
LDTP12669	Mediator of RNA polymerase II transcription subunit 17 (MED17)				C649	1.6
LDTP04078	Proliferation marker protein Ki-67 (MKI67)				C903	1.6
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.6
LDTP11235	Protein PAXX (PAXX)				C180	1.5
LDTP06046	Ribosome biogenesis protein BOP1 (BOP1)				C404	1.5
LDTP05867	Treacle protein (TCOF1)				C38	1.5
LDTP00229	Copper transport protein ATOX1 (ATOX1)				C12	1.4
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C439	1.4
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	1.4
LDTP05257	Receptor expression-enhancing protein 5 (REEP5)				C18	1.4
LDTP03615	Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)				C267	1.4
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	1.3
LDTP05772	FAS-associated death domain protein (FADD)				C98	1.3
LDTP17182	Uncharacterized protein C3orf38 (C3orf38)				C308	1.3
LDTP12651	TBC1 domain family member 23 (TBC1D23)				C283	1.3
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.3
LDTP13964	MOB-like protein phocein (MOB4)				C134	1.2
LDTP01532	ZW10 interactor (ZWINT)				C54	1.2
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	1.2
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	1.2
LDTP04952	Heterogeneous nuclear ribonucleoprotein K (HNRNPK)				C132	1.2
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	1.2
LDTP04487	Cyclin-H (CCNH)				C244	1.1
LDTP14179	Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2)				C72	1.1
LDTP10252	Elongator complex protein 4 (ELP4)				C218	1.1
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	1.1
LDTP10657	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)				C900	1.1
LDTP10284	Multivesicular body subunit 12A (MVB12A)				C231	1.1
LDTP10864	Calponin-2 (CNN2)				C164	1.0
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	1.0
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	1.0
LDTP09650	LIM domain only protein 7 (LMO7)				C228	1.0
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.0
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	1.0
LDTP14351	RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)				C179	1.0
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	0.9
LDTP18494	Tropomodulin-3 (TMOD3)				C132	0.9
LDTP08094	Wings apart-like protein homolog (WAPL)				C160	0.7
LDTP16117	Mediator of RNA polymerase II transcription subunit 9 (MED9)				C139	0.7

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.