Details of the Target

General Information of Target

Target ID LDTP13515
Target Name Zinc finger protein 346 (ZNF346)
Gene Name ZNF346
Gene ID 23567
Synonyms
JAZ; Zinc finger protein 346; Just another zinc finger protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MAVCIAVIAKENYPLYIRSTPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGL
LYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGD
RIQSSRAFDNMVTSMMIQVC
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus
Function Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins.
Uniprot ID
Q9UL40
Ensemble ID
ENST00000358149.8
HGNC ID
HGNC:16403

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 Substitution: p.T8S .
LS180 Deletion: p.K96NfsTer6 .
MDAMB453 SNV: p.E46K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.97  LDD0402  [1]
STPyne
 Probe Info  		K125(6.25)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C68(2.12)  LDD0169  [3]
DBIA
 Probe Info  		C68(0.67); C135(0.90); C79(1.04)  LDD1492  [4]
IA-alkyne
 Probe Info  		C75(0.00); C68(0.00); C78(0.00); C79(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C135(0.00); C136(0.00); C139(0.00); C75(0.00)  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
ENE
 Probe Info  		N.A.  LDD0006  [7]
IPM
 Probe Info  		N.A.  LDD0005  [7]
Phosphinate-6
 Probe Info  		C68(0.00); C135(0.00)  LDD0018  [9]
1d-yne
 Probe Info  		N.A.  LDD0357  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C78(0.00); C241(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C68(2.12)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C68(1.09); C135(0.94); C79(0.90)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C68(1.14); C135(0.76); C79(0.90)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C68(1.11); C135(0.74); C79(0.97)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C68(1.06); C135(0.73); C79(0.93)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C68(1.16); C135(0.84); C79(0.94)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C68(1.21); C135(0.86); C79(0.93)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C68(1.09); C135(0.83); C79(0.88)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C68(1.24); C135(0.95); C79(0.96)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C68(1.07); C135(0.72); C79(0.99)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C68(0.95); C135(0.57); C79(0.94)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C68(1.02); C135(0.65); C79(0.98)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C68(1.10); C135(0.89); C79(0.94)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C68(1.07); C135(0.83); C79(0.99)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C68(1.13); C135(0.81); C79(0.98)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C68(1.10); C135(0.97); C79(0.97)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C68(1.12); C135(1.01); C79(0.91)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C68(1.02); C135(0.82); C79(0.95)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C68(1.09); C135(0.88); C79(1.00)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C68(1.00); C135(0.61); C79(0.96)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C68(1.09); C135(0.81); C79(0.93)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C68(1.05); C135(0.77); C79(0.91)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C68(1.04); C135(0.79); C79(1.01)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C68(1.11); C135(0.88); C79(0.94)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C68(1.11); C135(0.83); C79(1.01)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C68(1.07); C135(0.76); C79(0.89)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C68(1.05); C135(0.84); C79(0.95)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C68(1.09); C135(0.73); C79(0.90)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C68(0.98); C135(0.78); C79(0.99)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C68(1.11); C135(0.87); C79(0.97)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C68(1.08); C135(0.93); C79(0.92)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C68(1.08); C135(0.86); C79(0.96)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C68(0.90); C135(0.61); C79(0.96)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C68(1.62); C135(0.94); C79(0.83)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C68(1.11); C135(0.73); C79(0.92)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C68(1.12); C135(0.56); C79(0.87)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C68(1.07); C135(0.80); C79(0.91)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C68(1.01); C135(0.69); C79(1.02)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C68(1.18); C135(0.79); C79(0.89)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C68(1.16); C135(0.78); C79(0.99)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C68(1.02); C135(0.50); C79(0.88)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C68(1.06); C135(0.53); C79(0.85)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C68(1.09); C135(0.64); C79(0.85)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C68(1.04); C135(0.58); C79(0.94)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C68(1.09); C135(0.50); C79(0.90)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C68(1.09); C135(0.60); C79(0.93)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C68(1.06); C135(0.68); C79(0.94)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C68(1.10); C135(0.75); C79(0.96)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C68(1.13); C135(0.47); C79(0.92)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C68(1.18); C135(1.04); C79(0.94)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C68(1.17); C135(0.88); C79(0.94)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C68(1.08); C135(0.93); C79(0.87)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C68(0.99); C135(0.65); C79(0.91)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C68(1.09); C135(0.87); C79(0.97)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C68(1.09); C135(0.90); C79(0.99)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C68(0.98); C135(0.70); C79(0.94)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C68(1.14); C135(0.86); C79(0.94)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C68(1.11); C135(0.91); C79(0.92)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C68(1.13); C135(0.99); C79(0.93)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C68(1.10); C135(1.07); C79(0.94)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C68(1.05); C135(0.88); C79(0.94)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C68(1.03); C135(0.92); C79(0.98)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C68(1.16); C135(0.78); C79(0.96)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C68(1.12); C135(0.84); C79(0.90)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C68(1.19); C135(0.97); C79(0.96)  LDD1514  [4]
 LDCM0156  Aniline NCI-H1299 14.96  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C68(1.46)  LDD2214  [14]
 LDCM0632  CL-Sc Hep-G2 C78(20.00); C135(0.74)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C68(2.11); C135(0.70); C79(0.81)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C68(12.26); C135(0.75); C79(0.95)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C135(0.81); C79(0.91)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C68(1.28); C135(0.74); C79(0.96)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C68(1.83); C135(0.69); C79(0.83)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C68(1.11); C135(0.82); C79(0.87)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C135(0.76); C79(0.96)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C68(1.26); C135(0.74); C79(0.91)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C68(1.28); C135(0.74); C79(0.91)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C68(1.13); C135(0.81); C79(1.04)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C135(0.87); C79(0.97)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C68(1.15); C135(0.75); C79(0.90)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C68(2.02); C135(0.82); C79(1.05)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C68(2.50); C135(0.74); C79(0.83)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C68(1.47); C135(0.78); C79(0.92)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C135(0.80); C79(0.91)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C68(1.10); C135(0.72); C79(0.97)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C68(1.46); C135(0.76); C79(0.84)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C68(1.10); C135(0.92); C79(0.87)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C135(0.84); C79(0.91)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C68(1.21); C135(0.79); C79(0.94)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C68(1.17); C135(0.83); C79(0.90)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C68(1.05); C135(0.90); C79(0.92)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C68(1.35); C135(0.63); C79(0.90)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C135(0.52); C79(0.91)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C68(1.24); C135(0.71); C79(0.94)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C68(1.30); C135(0.49); C79(0.93)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C68(3.49); C135(0.76); C79(0.89)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C135(0.53); C79(0.83)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C68(1.23); C135(0.78); C79(0.94)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C68(1.36); C135(0.78); C79(0.90)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C68(1.06); C135(0.71); C79(0.84)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C135(0.90); C79(0.92)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C68(1.86); C135(0.89); C79(1.03)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C68(8.05); C135(1.04); C79(1.06)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C68(1.50); C135(0.74); C79(0.79)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C135(0.87); C79(0.96)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C68(2.69); C135(0.71); C79(0.72)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C68(1.14); C135(0.92); C79(0.97)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C68(1.28); C135(0.87); C79(0.89)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C68(1.34); C135(0.77); C79(1.00)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C68(1.06); C135(0.81); C79(1.05)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C68(2.43); C135(0.77); C79(0.81)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C68(1.49); C135(0.78); C79(0.96)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C68(1.12); C135(0.76); C79(1.03)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C68(1.17); C135(0.65); C79(1.00)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C68(2.34); C135(0.70); C79(1.05)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C68(1.28); C135(0.82); C79(0.99)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C68(1.50); C135(0.97); C79(0.90)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C135(0.80); C79(1.01)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C68(1.11); C135(0.99); C79(0.97)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C68(1.23); C135(0.84); C79(0.92)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C68(1.10); C135(0.94); C79(0.94)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C68(2.96); C135(0.69); C79(0.89)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C68(1.55); C135(0.74); C79(0.98)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C68(5.21); C135(0.67); C79(0.77)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C68(1.43); C135(0.71); C79(1.03)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C68(1.32); C135(0.75); C79(1.06)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C68(1.57); C135(0.62); C79(0.94)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C68(1.23); C135(0.69); C79(0.97)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C68(3.10); C135(0.80); C79(0.83)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C135(0.79); C79(0.84)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C135(0.90); C79(1.01)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C68(1.52); C135(0.99); C79(0.84)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C68(1.14); C135(0.97); C79(0.99)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C68(1.09); C135(0.83); C79(0.98)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C68(1.15); C135(0.76); C79(1.01)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C68(6.67); C135(0.80); C79(0.59)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C68(4.96); C135(0.66); C79(0.80)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C68(1.56); C135(0.83); C79(1.01)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C68(1.14); C135(0.72); C79(0.95)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C68(1.31); C135(0.75); C79(0.95)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C68(1.14); C135(0.96); C79(0.97)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C68(1.48); C135(0.75); C79(0.88)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C135(0.96); C79(0.89)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C68(1.38); C135(0.87); C79(0.77)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C68(3.65); C135(0.90); C79(0.82)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C68(1.24); C135(0.84); C79(0.99)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C68(1.35); C135(0.78); C79(0.94)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C68(6.31); C135(0.76); C79(0.84)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C68(2.77); C135(0.77); C79(0.78)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C68(2.83); C135(0.71); C79(0.85)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C68(1.07); C135(0.76); C79(0.96)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C68(1.40); C135(0.73); C79(0.96)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C68(1.05); C135(0.89); C79(0.98)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C68(1.31); C135(0.40); C79(0.82)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C68(1.05); C135(0.87); C79(0.87)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C135(0.76); C79(0.82)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C68(1.11); C135(0.88); C79(0.87)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C68(1.03); C135(0.85); C79(0.93)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C68(1.15); C135(0.89); C79(0.89)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C68(2.00); C135(0.79); C79(0.92)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C68(6.01); C135(0.83); C79(0.90)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C68(3.12); C135(0.79); C79(0.83)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C68(1.31); C135(0.81); C79(0.98)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C68(1.32); C135(0.79); C79(0.93)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C68(1.17); C135(0.66); C79(0.91)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C68(1.29); C135(0.86); C79(0.93)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C68(1.15); C135(0.86); C79(0.95)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C135(0.93); C79(1.03)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C68(2.02); C135(0.93); C79(0.75)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C68(1.05); C135(0.81); C79(0.96)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C68(1.27); C135(0.77); C79(0.95)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C68(5.35); C135(0.67); C79(0.63)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C68(1.06); C135(0.88); C79(1.07)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C68(1.32); C135(0.82); C79(0.98)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C68(1.14); C135(0.76); C79(1.00)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C68(1.14); C135(0.79); C79(0.93)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C68(1.77); C135(0.77); C79(0.79)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C68(1.14); C135(0.83); C79(1.02)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C68(1.29); C135(0.91); C79(1.00)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C68(1.39); C135(0.80); C79(0.82)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C135(0.78); C79(0.92)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C68(1.09); C135(0.88); C79(0.88)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C68(1.40); C135(0.57); C79(0.94)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C68(3.84); C135(0.66); C79(0.72)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C68(1.08); C135(0.78); C79(0.94)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C68(4.07); C135(0.71); C79(0.88)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C68(5.26); C135(0.83); C79(0.92)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C68(4.60); C135(0.76); C79(0.85)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C68(3.63); C135(0.68); C79(0.86)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C68(1.42); C135(0.68); C79(0.81)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C68(1.37); C135(0.65); C79(0.80)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C68(5.81); C135(0.83); C79(0.82)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C68(3.55); C135(0.98); C79(0.72)  LDD1697  [4]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C68(4.25)  LDD0526  [15]
 LDCM0495  E2913 HEK-293T C68(1.35); C135(0.93); C79(0.90)  LDD1698  [4]
 LDCM0201  EV-3 T cell C68(6.88)  LDD0515  [15]
 LDCM0574  Fragment12 MDA-MB-231 C68(20.00)  LDD1468  [16]
 LDCM0575  Fragment13 Ramos C68(20.00)  LDD1470  [16]
 LDCM0576  Fragment14 MDA-MB-231 C68(20.00)  LDD1471  [16]
 LDCM0578  Fragment27 MDA-MB-231 C68(1.89)  LDD1474  [16]
 LDCM0587  Fragment29 Ramos C68(2.35)  LDD1476  [16]
 LDCM0468  Fragment33 HEK-293T C68(3.22); C135(1.03); C79(0.87)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C68(1.17); C135(0.80); C79(1.01)  LDD1631  [4]
 LDCM0571  Fragment9 Ramos C68(20.00)  LDD1464  [16]
 LDCM0022  KB02 Ramos 20.00  LDD0431  [17]
 LDCM0023  KB03 HEK-293T C68(1.01); C135(1.00); C79(0.98)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C68(0.84); C135(0.87); C79(0.99)  LDD1502  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C68(0.82)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C68(0.72); C79(0.53)  LDD2207  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) Ser/Thr protein kinase family P19525
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
NF-kappa-B-repressing factor (NKRF) . O15226
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RISC-loading complex subunit TARBP2 (TARBP2) TARBP2 family Q15633
Spermatid perinuclear RNA-binding protein (STRBP) . Q96SI9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
15 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
16 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
17 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.