Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Dimethyl Fumarate(DMF)  Competitor Info 
Competitor Concentration 50 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (T cell)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 20 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05893  Baculoviral IAP repeat-containing protein 2 (BIRC2) C45 20.0
 LDTP03985  Caspase-2 (CASP2) C366, C370 20.0
 LDTP00497  Cyclin-G-associated kinase (GAK) C87 20.0
 LDTP12744  Interleukin-1 receptor-associated kinase 4 (IRAK4) C13 20.0
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130 16.5
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C315 15.0
 LDTP09895  Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) C1088 12.1
 LDTP14074  Ribosomal biogenesis protein LAS1L (LAS1L) C456 11.8
 LDTP14535  6-phosphogluconolactonase (PGLS) C32, C33 11.0
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 7.5
 LDTP01803  Adenosine deaminase (ADA) C75 6.9
 LDTP08942  Deubiquitinase OTUD6B (OTUD6B) C172 5.9
 LDTP04565  Methionine aminopeptidase 1 (METAP1) C36, C40, C41 5.6
 LDTP05433  Protein kinase C theta type (PRKCQ) C14, C17, C20 5.1
 LDTP14266  2'-5'-oligoadenylate synthase 3 (OAS3) C648 4.9
 LDTP13195  Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) C71 4.4
 LDTP10716  CCA tRNA nucleotidyltransferase 1, mitochondrial (TRNT1) C373 4.3
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C86, C98 4.3
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 4.1
 LDTP05716  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) C295 4.0
Transporter and channel
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02959  Protein SON (SON) C92 11.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 10.1
 LDTP13243  Translocation protein SEC63 homolog (SEC63) C295 8.3
 LDTP01133  Copine-3 (CPNE3) C54 7.5
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C229 5.2
 LDTP10989  Copine-1 (CPNE1) C53 4.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C36 4.1
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 20.0
Other
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 20.0
 LDTP06348  Ras GTPase-activating protein 2 (RASA2) C567 20.0
 LDTP12830  U3 small nucleolar RNA-associated protein 6 homolog (UTP6) C370 20.0
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) C42, C44, C50 12.1
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 8.1
 LDTP06182  Ribosomal RNA processing protein 1 homolog B (RRP1B) C155 7.9
 LDTP15388  Centromere protein L (CENPL) C52 5.0
 LDTP04092  Crk-like protein (CRKL) C249 4.7
 LDTP00202  AH receptor-interacting protein (AIP) C121, C122, C123 4.4
 LDTP13515  Zinc finger protein 346 (ZNF346) C68 4.3
 LDTP15462  Chromodomain Y-like protein 2 (CDYL2) C288 4.1
 LDTP06020  Pro-interleukin-16 (IL16) C1004, C1011, C1016, C1017 4.1

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.