Details of the Target

General Information of Target

Target ID LDTP12025
Target Name UPF0488 protein C8orf33 (C8orf33)
Gene Name C8orf33
Gene ID 65265
Synonyms
UPF0488 protein C8orf33
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLRLQMTDGHISCTAVEFSYMSKISLNTPPGTKVKLSGIVDIKNGFLLLNDSNTTVLGGE
VEHLIEKWELQRSLSKHNRSNIGTEGGPPPFVPFGQKCVSHVQVDSRELDRRKTLQVTMP
VKPTNDNDEFEKQRTAAIAEVAKSKETKTFGGGGGGARSNLNMNAAGNRNREVLQKEKST
KSEGKHEGVYRELVDEKALKHITEMGFSKEASRQALMDNGNNLEAALNVLLTSNKQKPVM
GPPLRGRGKGRGRIRSEDEEDLGNARPSAPSTLFDFLESKMGTLNVEEPKSQPQQLHQGQ
YRSSNTEQNGVKDNNHLRHPPRNDTRQPRNEKPPRFQRDSQNSKSVLEGSGLPRNRGSER
PSTSSVSEVWAEDRIKCDRPYSRYDRTKDTSYPLGSQHSDGAFKKRDNSMQSRSGKGPSF
AEAKENPLPQGSVDYNNQKRGKRESQTSIPDYFYDRKSQTINNEAFSGIKIEKHFNVNTD
YQNPVRSNSFIGVPNGEVEMPLKGRRIGPIKPAGPVTAVPCDDKIFYNSGPKRRSGPIKP
EKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEV
LLSNIKPIQTEAWEEEGTYDQTLEFRRGGDGQPRRSTRPTQQFYQPPRARN
Target Bioclass
Other
Family
UPF0488 family
Uniprot ID
Q9H7E9
Ensemble ID
ENST00000331434.7
HGNC ID
HGNC:26104

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.R203G .
HUH1 SNV: p.A35D .
MCC13 SNV: p.A95V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		4.21  LDD0348  [2]
TH211
 Probe Info  		Y186(20.00)  LDD0257  [3]
STPyne
 Probe Info  		K135(10.00)  LDD0277  [4]
Probe 1
 Probe Info  		Y186(5.50)  LDD3495  [5]
MCL-14
 Probe Info  		5.20  LDD0050  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
HHS-465
 Probe Info  		Y186(9.50)  LDD2237  [8]
DBIA
 Probe Info  		C50(1.05); C44(1.01)  LDD1492  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
1d-yne
 Probe Info  		N.A.  LDD0358  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
JW-RF-010
 Probe Info  		C44(0.00); C50(0.00); C21(0.00); C42(0.00)  LDD0026  [14]
NAIA_4
 Probe Info  		C21(0.00); C117(0.00)  LDD2226  [15]
TFBX
 Probe Info  		C21(0.00); C42(0.00); C44(0.00); C50(0.00)  LDD0027  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
DA-P3
 Probe Info  		N.A.  LDD0178  [2]
IPM
 Probe Info  		N.A.  LDD0005  [16]
PF-06672131
 Probe Info  		N.A.  LDD0017  [17]
VSF
 Probe Info  		C21(0.00); C44(0.00); C42(0.00); C50(0.00)  LDD0007  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [19]
AOyne
 Probe Info  		15.00  LDD0443  [20]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		12.73  LDD1782  [21]
C092
 Probe Info  		30.70  LDD1783  [21]
C094
 Probe Info  		34.78  LDD1785  [21]
C135
 Probe Info  		16.34  LDD1817  [21]
C169
 Probe Info  		36.00  LDD1849  [21]
C187
 Probe Info  		53.82  LDD1865  [21]
C190
 Probe Info  		7.89  LDD1867  [21]
C191
 Probe Info  		58.08  LDD1868  [21]
C193
 Probe Info  		99.73  LDD1869  [21]
C196
 Probe Info  		16.34  LDD1872  [21]
C225
 Probe Info  		6.50  LDD1898  [21]
C226
 Probe Info  		9.92  LDD1899  [21]
C228
 Probe Info  		30.70  LDD1901  [21]
C243
 Probe Info  		13.09  LDD1916  [21]
C244
 Probe Info  		23.26  LDD1917  [21]
C245
 Probe Info  		23.75  LDD1918  [21]
C249
 Probe Info  		13.83  LDD1922  [21]
C288
 Probe Info  		6.96  LDD1958  [21]
C350
 Probe Info  		47.84  LDD2011  [21]
C429
 Probe Info  		15.56  LDD2084  [21]
C431
 Probe Info  		14.52  LDD2086  [21]
FFF probe11
 Probe Info  		20.00  LDD0471  [22]
DA-2
 Probe Info  		N.A.  LDD0072  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C117(3.77)  LDD0372  [24]
 LDCM0214  AC1 HEK-293T C42(1.26); C44(0.83)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C42(1.05)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C44(1.01)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C42(1.23); C44(1.13)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C42(1.13); C44(1.19)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C42(0.92); C44(1.02)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C42(1.11); C44(1.17)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C42(1.04)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C44(2.58)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C42(1.07)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C42(1.00); C44(1.04)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C42(0.97)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C42(0.80); C44(0.87)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C42(0.79); C44(1.10)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C42(0.91)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C42(0.96); C44(1.16)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C42(1.12)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C44(1.09)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C42(0.88); C44(1.12)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C42(0.89)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C44(1.12)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C42(1.00); C44(1.10)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C42(0.83); C44(1.05)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C42(0.95)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C42(0.92); C44(1.05)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C42(1.20)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C44(1.03)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C42(0.92); C44(1.05)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C42(0.92)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C42(0.92); C44(1.09)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C42(1.01); C44(1.05)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C42(1.14); C44(0.99)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C42(1.01)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C42(1.07); C44(1.07)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C42(1.15)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C44(1.49)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C42(1.10); C44(1.17)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C42(1.01)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C42(1.05); C44(1.24)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C42(0.86); C44(1.04)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C42(0.91)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C42(1.04); C44(1.19)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C42(0.90)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C42(0.95)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C44(1.01)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C42(1.10); C44(0.94)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C42(0.91)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C42(1.07); C44(0.96)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C42(0.78); C44(0.95)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C42(0.96)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C42(0.86); C44(0.99)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C42(1.23)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C44(0.97)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C42(1.35); C44(0.95)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C42(0.99); C44(1.15)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C42(1.01)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C42(1.27); C44(0.99)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C42(0.89); C44(1.03)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C42(0.99)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C42(0.82); C44(1.01)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C42(0.94)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C42(0.94)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C42(1.28); C44(1.07)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C42(0.93)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 12.18  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C21(1.88)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C42(1.41); C44(1.09)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C42(1.08); C44(1.19)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C42(1.26); C44(0.96)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C42(0.98); C44(1.08)  LDD1574  [9]
 LDCM0372  CL103 HEK-293T C42(0.91); C44(1.01)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C42(0.88); C44(0.51)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C42(0.99); C44(1.00)  LDD1578  [9]
 LDCM0376  CL107 HEK-293T C42(0.89); C44(1.12)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C42(1.31); C44(0.96)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C42(1.21); C44(1.07)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C42(1.34); C44(1.24)  LDD1583  [9]
 LDCM0381  CL111 HEK-293T C42(0.90); C44(0.93)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C42(1.32); C44(0.86)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C42(1.42); C44(0.91)  LDD1587  [9]
 LDCM0385  CL115 HEK-293T C42(0.88); C44(1.09)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C42(1.25); C44(1.03)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C42(1.06); C44(1.02)  LDD1591  [9]
 LDCM0389  CL119 HEK-293T C42(0.90); C44(1.04)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C42(1.04)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C42(0.98); C44(1.00)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C42(1.15); C44(1.16)  LDD1596  [9]
 LDCM0394  CL123 HEK-293T C42(0.86); C44(0.93)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C42(1.08); C44(1.06)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C42(1.46); C44(1.05)  LDD1600  [9]
 LDCM0398  CL127 HEK-293T C42(0.83); C44(0.99)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C42(1.29); C44(1.12)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C42(1.12); C44(1.08)  LDD1604  [9]
 LDCM0402  CL15 HEK-293T C42(0.67); C44(1.07)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C42(1.17); C44(1.13)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C42(1.21); C44(1.08)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C42(0.98)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C44(0.96)  LDD1610  [9]
 LDCM0408  CL20 HEK-293T C42(1.28); C44(1.39)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C42(1.02)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C42(1.05); C44(1.10)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C42(0.78); C44(1.09)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C42(1.06)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C42(1.09); C44(0.96)  LDD1617  [9]
 LDCM0415  CL27 HEK-293T C42(0.71); C44(1.00)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C42(1.26); C44(1.00)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C42(0.97); C44(1.16)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C42(0.85); C44(0.93)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C42(1.08)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C44(0.99)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C42(1.20); C44(1.20)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C42(1.02)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C42(0.99); C44(1.02)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C42(0.69); C44(1.26)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C42(1.10)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C42(1.11); C44(1.02)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C42(1.13); C44(1.02)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C42(1.03); C44(1.10)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C42(1.11); C44(1.03)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C42(1.13); C44(1.15)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C42(1.01)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C44(1.17)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C42(1.34); C44(1.27)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C42(1.13)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C42(1.16); C44(1.08)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C42(1.31); C44(0.99)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C42(1.04)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C42(0.82); C44(1.15)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C42(1.28); C44(1.02)  LDD1644  [9]
 LDCM0443  CL52 HEK-293T C42(1.12); C44(1.02)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C42(1.16); C44(1.13)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C42(1.01)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C44(1.15)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C42(1.08); C44(1.05)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C42(1.20)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C42(1.06); C44(1.01)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C42(0.87); C44(1.12)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C42(0.91)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C42(0.98)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C42(1.15); C44(1.00)  LDD1656  [9]
 LDCM0455  CL63 HEK-293T C42(0.84); C44(1.13)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C42(1.39); C44(0.98)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C42(0.96); C44(1.15)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C42(1.24)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C44(0.96)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C42(0.94); C44(1.05)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C42(1.33)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C44(1.10)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C42(1.19); C44(0.98)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C42(0.72); C44(1.05)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C42(1.13)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C42(1.07); C44(1.04)  LDD1669  [9]
 LDCM0469  CL76 HEK-293T C42(1.55); C44(1.20)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C42(1.08); C44(1.03)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C42(1.21)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C44(0.87)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C42(1.12); C44(0.79)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C42(1.12); C44(1.17)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C42(1.06)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C42(0.93); C44(1.00)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C42(0.82); C44(1.05)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C42(1.06)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C42(1.06); C44(1.22)  LDD1682  [9]
 LDCM0481  CL87 HEK-293T C42(1.15); C44(1.10)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C42(0.89); C44(0.95)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C42(0.93); C44(1.02)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C42(1.09)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C42(1.87)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C44(0.90)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C42(1.04); C44(1.08)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C42(1.25)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C42(0.97); C44(1.10)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C42(0.82); C44(1.01)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C42(1.18)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C42(1.05); C44(0.96)  LDD1695  [9]
 LDCM0494  CL99 HEK-293T C42(0.83); C44(1.01)  LDD1697  [9]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C42, C44, C50(12.07)  LDD0526  [25]
 LDCM0028  Dobutamine HEK-293T 4.03  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 4.97  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C42(1.34); C44(1.16)  LDD1698  [9]
 LDCM0031  Epigallocatechin gallate HEK-293T 10.51  LDD0183  [2]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0468  Fragment33 HEK-293T C42(0.86); C44(1.15)  LDD1671  [9]
 LDCM0022  KB02 HEK-293T C50(1.05); C44(1.01)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C50(0.93); C44(1.07)  LDD1497  [9]
 LDCM0024  KB05 HEK-293T C50(1.10); C44(1.01)  LDD1502  [9]
 LDCM0006  Micheliolide M9-ENL1 5.20  LDD0050  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C21(0.49); C44(0.37)  LDD2206  [26]
 LDCM0032  Oleacein HEK-293T 5.30  LDD0184  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C21(1.01)  LDD2207  [26]
 LDCM0029  Quercetin HEK-293T 6.97  LDD0181  [2]
 LDCM0131  RA190 MM1.R C42(1.25); C44(1.25); C50(1.25)  LDD0304  [27]
 LDCM0170  Structure8 Ramos 7.32  LDD0433  [28]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Nucleus accumbens-associated protein 1 (NACC1) . Q96RE7
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Colorectal mutant cancer protein (MCC) MCC family P23508
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
PRKCA-binding protein (PICK1) . Q9NRD5
TNFAIP3-interacting protein 1 (TNIP1) . Q15025

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
24 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
25 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
28 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.