Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DA-P3  Probe Info 
Probe concentration 15 uM
Criteria Qualitation: Labeling site identification
Quantitative Method
Isotope tag
Experiment Method
ISO-TOP ABPP
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP07447  2',5'-phosphodiesterase 12 (PDE12) C108
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) C568
 LDTP01697  3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1) T41
 LDTP03770  Alpha-adducin (ADD1) C525
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) C744
 LDTP04622  Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) C8
 LDTP11152  Cancer-related nucleoside-triphosphatase (NTPCR) C101
 LDTP08891  Ceramide synthase 5 (CERS5) C369
 LDTP13574  E3 ubiquitin-protein ligase HECTD1 (HECTD1) C1389
 LDTP08135  E3 ubiquitin-protein ligase HUWE1 (HUWE1) C2721
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) C43
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297
 LDTP03540  Heme oxygenase 2 (HMOX2) C265
 LDTP03540  Heme oxygenase 2 (HMOX2) C282
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24
 LDTP07967  Lysophosphatidylcholine acyltransferase 2 (LPCAT2) C4
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) C15
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) C52
 LDTP07867  Lysophospholipid acyltransferase 2 (MBOAT2) C505
 LDTP08621  Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) C55
 LDTP00616  Protein phosphatase 1G (PPM1G) C241
 LDTP03259  Ribonucleoside-diphosphate reductase large subunit (RRM1) C779
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) C997
 LDTP13272  Septin-9 (SEPTIN9) C248
 LDTP00598  Serine palmitoyltransferase 2 (SPTLC2) C19
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C878
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) C17
 LDTP13137  Spastin (SPAST) C220
 LDTP11361  Sphingosine-1-phosphate phosphatase 1 (SGPP1) C76
 LDTP11819  STE20-like serine/threonine-protein kinase (SLK) C1212
 LDTP08171  Stearoyl-CoA desaturase 5 (SCD5) C14
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) C538
 LDTP13682  Transcription termination factor 2 (TTF2) C224
 LDTP13682  Transcription termination factor 2 (TTF2) C204
 LDTP02935  Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) C344
 LDTP06190  Ubiquitin carboxyl-terminal hydrolase 10 (USP10) C254
 LDTP06190  Ubiquitin carboxyl-terminal hydrolase 10 (USP10) C94
Transporter and channel
Click to Show/Hide to Show 17 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP01197  Filamin-B (FLNB) C2501
 LDTP12292  Junctophilin-1 (JPH1) C626
 LDTP04597  Methylosome subunit pICln (CLNS1A) C73
 LDTP04309  Nuclear pore complex protein Nup153 (NUP153) C68
 LDTP04309  Nuclear pore complex protein Nup153 (NUP153) C21
 LDTP04309  Nuclear pore complex protein Nup153 (NUP153) C1065
 LDTP05642  Nuclear pore complex protein Nup160 (NUP160) C1166
 LDTP09204  Nucleoporin NUP35 (NUP35) C255
 LDTP12043  Phosphorylated adapter RNA export protein (PHAX) C51
 LDTP01060  PRA1 family protein 2 (PRAF2) C28
 LDTP12272  Prolactin regulatory element-binding protein (PREB) C128
 LDTP09742  Protein ELYS (AHCTF1) C1628
 LDTP09742  Protein ELYS (AHCTF1) C1412
 LDTP01228  Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) C538
 LDTP10148  Store-operated calcium entry-associated regulatory factor (SARAF) C320
 LDTP12635  Transmembrane protein 106B (TMEM106B) C61
 LDTP07058  Transmembrane protein 201 (TMEM201) C617
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) C380
 LDTP05101  General transcription factor II-I (GTF2I) C215
 LDTP13549  Myocardin-related transcription factor B (MRTFB) C636
Other
Click to Show/Hide to Show 59 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP08950  ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) C351
 LDTP07385  Anamorsin (CIAPIN1) C237
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) C286
 LDTP01684  BAG family molecular chaperone regulator 3 (BAG3) C179
 LDTP00493  Calmegin (CLGN) C511
 LDTP03079  Calpastatin (CAST) C408
 LDTP10864  Calponin-2 (CNN2) C175
 LDTP06383  Calponin-3 (CNN3) C173
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) C92
 LDTP07071  Centrosomal protein of 170 kDa (CEP170) C212
 LDTP12216  Chromobox protein homolog 8 (CBX8) C261
 LDTP01129  CLIP-associating protein 2 (CLASP2) C976
 LDTP16005  Coiled-coil domain-containing protein 86 (CCDC86) C116
 LDTP09652  Cytoskeleton-associated protein 2 (CKAP2) C674
 LDTP13863  DnaJ homolog subfamily C member 16 (DNAJC16) C744
 LDTP01677  Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) C574
 LDTP09201  Folliculin (FLCN) C335
 LDTP12640  Gamma-taxilin (TXLNG) C56
 LDTP08069  HAUS augmin-like complex subunit 6 (HAUS6) C926
 LDTP13913  Inner nuclear membrane protein Man1 (LEMD3) C346
 LDTP00398  Insulin receptor substrate 4 (IRS4) C522
 LDTP00398  Insulin receptor substrate 4 (IRS4) C545
 LDTP02756  Junction plakoglobin (JUP) C49
 LDTP12077  Jupiter microtubule associated homolog 2 (JPT2) C118
 LDTP09820  La-related protein 4B (LARP4B) C590
 LDTP15887  Lipase maturation factor 2 (LMF2) C696
 LDTP04385  Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) C1228
 LDTP04112  Microtubule-associated protein 1B (MAP1B) C2041
 LDTP03404  Microtubule-associated protein 4 (MAP4) C635
 LDTP03404  Microtubule-associated protein 4 (MAP4) C535
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) C283
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) C708
 LDTP11367  Oxysterol-binding protein-related protein 11 (OSBPL11) C34
 LDTP01021  Perilipin-3 (PLIN3) C60
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194
 LDTP01932  Prelamin-A/C (LMNA) C591
 LDTP01392  Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1) C234
 LDTP12596  Protein diaphanous homolog 3 (DIAPH3) C1125
 LDTP01711  Protein ecdysoneless homolog (ECD) C557
 LDTP07784  Protein lin-28 homolog B (LIN28B) C201
 LDTP00512  Protein transport protein Sec16A (SEC16A) C2293
 LDTP12000  RNA polymerase II-associated protein 3 (RPAP3) C519
 LDTP09081  SERPINE1 mRNA-binding protein 1 (SERBP1) C11
 LDTP06587  Survival motor neuron protein (SMN1; SMN2) C60
 LDTP09363  TBC1 domain family member 15 (TBC1D15) C686
 LDTP15840  Tetratricopeptide repeat protein 1 (TTC1) C28
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) C47
 LDTP01210  Transforming acidic coiled-coil-containing protein 1 (TACC1) C482
 LDTP01210  Transforming acidic coiled-coil-containing protein 1 (TACC1) C174
 LDTP14228  Transforming acidic coiled-coil-containing protein 3 (TACC3) S424
 LDTP13318  Translation initiation factor eIF2B subunit delta (EIF2B4) C69
 LDTP07491  Transmembrane anterior posterior transformation protein 1 homolog (TAPT1) C474
 LDTP07491  Transmembrane anterior posterior transformation protein 1 homolog (TAPT1) C487
 LDTP18115  Transmembrane protein 131 (TMEM131) C1188
 LDTP18362  Transmembrane protein 39B (TMEM39B) C18
 LDTP07404  Twinfilin-2 (TWF2) C141
 LDTP09806  UBX domain-containing protein 4 (UBXN4) C144
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) C50
 LDTP15599  UPF0729 protein C18orf32 (C18orf32) C71

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348