Details of the Target

General Information of Target

Target ID LDTP06190
Target Name Ubiquitin carboxyl-terminal hydrolase 10 (USP10)
Gene Name USP10
Gene ID 9100
Synonyms
KIAA0190; Ubiquitin carboxyl-terminal hydrolase 10; EC 3.4.19.12; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALHSPQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFG
VDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGS
ALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGH
ANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAG
QPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATN
GVELHTTESIDLDPTKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYV
ETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINK
GNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPK
PRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEML
NLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQT
PITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYT
TKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPG
VKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVK
PTAERTAYLLYYRRVDLL
Target Type
Preclinical
Target Bioclass
Enzyme
Family
Peptidase C19 family, USP10 subfamily
Subcellular location
Cytoplasm
Function
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits. Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules. Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization. Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation.
TTD ID
T73582
Uniprot ID
Q14694
DrugMap ID
TT5IH09
Ensemble ID
ENST00000219473.12
HGNC ID
HGNC:12608
ChEMBL ID
CHEMBL3407323

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.R730Ter DBIA    Probe Info 
HEC1B SNV: p.R730Ter .
IM95 SNV: p.K340R DBIA    Probe Info 
JVM3 SNV: p.Q7K DBIA    Probe Info 
MELHO SNV: p.P391L DBIA    Probe Info 
MFE319 SNV: p.P585S DBIA    Probe Info 
MOLT4 SNV: p.R641H IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DAyne
 Probe Info  		2.73  LDD0261  [2]
TH211
 Probe Info  		Y34(20.00); Y659(20.00); Y364(12.92); Y706(7.67)  LDD0257  [3]
TH216
 Probe Info  		Y503(20.00); Y505(10.57)  LDD0259  [3]
STPyne
 Probe Info  		K512(10.00); K677(10.00); K693(10.00)  LDD0277  [4]
Probe 1
 Probe Info  		Y54(9.34); Y503(9.23); Y615(100.25); Y691(15.72)  LDD3495  [5]
DBIA
 Probe Info  		C302(1.08); C504(2.79)  LDD3310  [6]
BTD
 Probe Info  		C456(1.31)  LDD2090  [7]
Sulforaphane-probe2
 Probe Info  		2.14  LDD0160  [8]
AHL-Pu-1
 Probe Info  		C115(3.49)  LDD0168  [9]
HPAP
 Probe Info  		3.20  LDD0063  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
HHS-475
 Probe Info  		Y359(0.77); Y659(1.31)  LDD0264  [12]
ATP probe
 Probe Info  		K543(0.00); K544(0.00); K780(0.00); K350(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C254(0.00); C456(0.00); C40(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [14]
Lodoacetamide azide
 Probe Info  		C254(0.00); C456(0.00); C40(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_4
 Probe Info  		C40(0.00); C94(0.00); C115(0.00); C209(0.00)  LDD2226  [16]
DA-P3
 Probe Info  		C254(0.00); C94(0.00)  LDD0178  [17]
1d-yne
 Probe Info  		K518(0.00); K381(0.00)  LDD0356  [18]
Compound 10
 Probe Info  		C40(0.00); C456(0.00)  LDD2216  [19]
Compound 11
 Probe Info  		C40(0.00); C456(0.00)  LDD2213  [19]
IPM
 Probe Info  		C456(0.00); C94(0.00)  LDD0005  [20]
SF
 Probe Info  		Y615(0.00); Y776(0.00)  LDD0028  [21]
TFBX
 Probe Info  		C456(0.00); C697(0.00); C254(0.00)  LDD0148  [15]
VSF
 Probe Info  		C94(0.00); C40(0.00); C254(0.00); C456(0.00)  LDD0007  [20]
Phosphinate-6
 Probe Info  		C728(0.00); C94(0.00); C456(0.00); C254(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		K381(0.00); K395(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		C254(0.00); C40(0.00); C456(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		C254(0.00); C456(0.00)  LDD0236  [24]
AOyne
 Probe Info  		12.30  LDD0443  [25]
NAIA_5
 Probe Info  		C254(0.00); C94(0.00); C456(0.00)  LDD2223  [16]
HHS-482
 Probe Info  		Y359(0.76)  LDD2239  [26]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.50  LDD0472  [27]
FFF probe13
 Probe Info  		5.73  LDD0476  [27]
FFF probe2
 Probe Info  		5.00  LDD0463  [27]
FFF probe3
 Probe Info  		11.09  LDD0464  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C456(1.15)  LDD2117  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C456(1.05)  LDD2103  [7]
 LDCM0025  4SU-RNA HEK-293T C115(3.49)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C40(3.49); C115(3.52)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C254(1.07); C456(1.00); C40(1.08); C209(1.10)  LDD1507  [28]
 LDCM0215  AC10 HEK-293T C254(0.98); C456(0.96); C40(1.05); C209(0.96)  LDD1508  [28]
 LDCM0226  AC11 HEK-293T C254(1.05); C456(1.04); C40(1.07); C209(1.18)  LDD1509  [28]
 LDCM0237  AC12 HEK-293T C254(1.13); C456(1.05); C40(1.05); C209(1.04)  LDD1510  [28]
 LDCM0259  AC14 HEK-293T C254(1.02); C456(1.01); C40(1.00); C209(1.18)  LDD1512  [28]
 LDCM0270  AC15 HEK-293T C254(1.00); C456(0.96); C40(1.00); C94(0.93)  LDD1513  [28]
 LDCM0276  AC17 HEK-293T C254(1.06); C456(1.04); C40(1.19); C209(1.00)  LDD1515  [28]
 LDCM0277  AC18 HEK-293T C254(1.07); C456(1.02); C40(1.04); C209(0.78)  LDD1516  [28]
 LDCM0278  AC19 HEK-293T C254(1.48); C456(0.99); C40(0.90); C209(1.00)  LDD1517  [28]
 LDCM0279  AC2 HEK-293T C254(0.97); C456(0.99); C40(1.06); C209(0.99)  LDD1518  [28]
 LDCM0280  AC20 HEK-293T C254(0.98); C456(1.00); C40(1.07); C209(0.97)  LDD1519  [28]
 LDCM0281  AC21 HEK-293T C254(1.08); C456(0.95); C40(1.04); C209(0.99)  LDD1520  [28]
 LDCM0282  AC22 HEK-293T C254(1.08); C456(0.99); C40(1.06); C209(0.94)  LDD1521  [28]
 LDCM0283  AC23 HEK-293T C254(1.02); C456(1.01); C40(1.01); C94(1.05)  LDD1522  [28]
 LDCM0284  AC24 HEK-293T C254(0.81); C456(1.04); C40(1.10); C209(0.91)  LDD1523  [28]
 LDCM0285  AC25 HEK-293T C254(1.03); C456(1.00); C40(1.12); C209(1.07)  LDD1524  [28]
 LDCM0286  AC26 HEK-293T C254(1.03); C456(0.98); C40(1.08); C209(0.80)  LDD1525  [28]
 LDCM0287  AC27 HEK-293T C254(0.90); C456(0.99); C40(0.98); C209(0.93)  LDD1526  [28]
 LDCM0288  AC28 HEK-293T C254(0.99); C456(0.93); C40(1.05); C209(1.06)  LDD1527  [28]
 LDCM0289  AC29 HEK-293T C254(1.12); C456(0.97); C40(0.93); C209(1.04)  LDD1528  [28]
 LDCM0290  AC3 HEK-293T C254(0.84); C456(1.06); C40(0.87); C209(0.93)  LDD1529  [28]
 LDCM0291  AC30 HEK-293T C254(0.96); C456(1.00); C40(1.02); C209(1.01)  LDD1530  [28]
 LDCM0292  AC31 HEK-293T C254(0.89); C456(0.96); C40(1.10); C94(1.02)  LDD1531  [28]
 LDCM0293  AC32 HEK-293T C254(0.93); C456(1.02); C40(1.06); C209(0.72)  LDD1532  [28]
 LDCM0294  AC33 HEK-293T C254(1.13); C456(1.05); C40(1.05); C209(1.18)  LDD1533  [28]
 LDCM0295  AC34 HEK-293T C254(1.02); C456(0.97); C40(1.06); C209(1.11)  LDD1534  [28]
 LDCM0296  AC35 HEK-293T C254(0.81); C456(1.02); C40(1.01); C209(0.98)  LDD1535  [28]
 LDCM0297  AC36 HEK-293T C254(1.08); C456(1.01); C40(1.06); C209(1.16)  LDD1536  [28]
 LDCM0298  AC37 HEK-293T C254(0.95); C456(0.97); C40(0.90); C209(1.09)  LDD1537  [28]
 LDCM0299  AC38 HEK-293T C254(1.11); C456(1.03); C40(0.93); C209(1.00)  LDD1538  [28]
 LDCM0300  AC39 HEK-293T C254(1.09); C456(1.01); C40(1.05); C94(1.04)  LDD1539  [28]
 LDCM0301  AC4 HEK-293T C254(1.15); C456(0.99); C40(1.06); C209(1.03)  LDD1540  [28]
 LDCM0302  AC40 HEK-293T C254(1.03); C456(1.01); C40(1.08); C209(0.87)  LDD1541  [28]
 LDCM0303  AC41 HEK-293T C254(1.05); C456(0.96); C40(1.10); C209(1.44)  LDD1542  [28]
 LDCM0304  AC42 HEK-293T C254(1.04); C456(1.03); C40(1.10); C209(1.06)  LDD1543  [28]
 LDCM0305  AC43 HEK-293T C254(0.96); C456(1.03); C40(0.97); C209(0.84)  LDD1544  [28]
 LDCM0306  AC44 HEK-293T C254(1.18); C456(0.98); C40(1.11); C209(1.33)  LDD1545  [28]
 LDCM0307  AC45 HEK-293T C254(1.00); C456(0.96); C40(1.15); C209(1.02)  LDD1546  [28]
 LDCM0308  AC46 HEK-293T C254(1.01); C456(1.01); C40(1.00); C209(1.23)  LDD1547  [28]
 LDCM0309  AC47 HEK-293T C254(1.14); C456(0.93); C40(1.07); C94(0.96)  LDD1548  [28]
 LDCM0310  AC48 HEK-293T C254(0.97); C456(1.08); C40(1.17); C209(0.87)  LDD1549  [28]
 LDCM0311  AC49 HEK-293T C254(1.03); C456(1.05); C40(1.03); C209(1.18)  LDD1550  [28]
 LDCM0312  AC5 HEK-293T C254(1.03); C456(0.98); C40(0.97); C209(1.02)  LDD1551  [28]
 LDCM0313  AC50 HEK-293T C254(0.91); C456(0.98); C40(1.14); C209(0.89)  LDD1552  [28]
 LDCM0314  AC51 HEK-293T C254(0.86); C456(1.05); C40(0.91); C209(1.11)  LDD1553  [28]
 LDCM0315  AC52 HEK-293T C254(1.21); C456(0.98); C40(1.10); C209(1.28)  LDD1554  [28]
 LDCM0316  AC53 HEK-293T C254(0.96); C456(1.00); C40(0.92); C209(1.18)  LDD1555  [28]
 LDCM0317  AC54 HEK-293T C254(1.09); C456(1.08); C40(1.00); C209(0.90)  LDD1556  [28]
 LDCM0318  AC55 HEK-293T C254(1.02); C456(1.03); C40(1.01); C94(0.92)  LDD1557  [28]
 LDCM0319  AC56 HEK-293T C254(1.16); C456(1.05); C40(1.07); C209(0.87)  LDD1558  [28]
 LDCM0320  AC57 HEK-293T C254(1.06); C456(1.07); C40(1.05); C209(1.32)  LDD1559  [28]
 LDCM0321  AC58 HEK-293T C254(1.03); C456(1.02); C40(1.05); C209(0.82)  LDD1560  [28]
 LDCM0322  AC59 HEK-293T C254(1.02); C456(1.01); C40(0.95); C209(1.01)  LDD1561  [28]
 LDCM0323  AC6 HEK-293T C254(1.02); C456(1.02); C40(0.97); C209(1.11)  LDD1562  [28]
 LDCM0324  AC60 HEK-293T C254(1.19); C456(0.99); C40(1.11); C209(1.27)  LDD1563  [28]
 LDCM0325  AC61 HEK-293T C254(1.05); C456(0.95); C40(1.02); C209(1.16)  LDD1564  [28]
 LDCM0326  AC62 HEK-293T C254(1.05); C456(1.01); C40(1.06); C209(0.95)  LDD1565  [28]
 LDCM0327  AC63 HEK-293T C254(1.15); C456(0.97); C40(1.08); C94(0.97)  LDD1566  [28]
 LDCM0328  AC64 HEK-293T C254(0.94); C456(1.03); C40(1.01); C209(0.65)  LDD1567  [28]
 LDCM0334  AC7 HEK-293T C254(0.98); C456(1.04); C40(1.05); C94(1.02)  LDD1568  [28]
 LDCM0345  AC8 HEK-293T C254(1.10); C456(1.12); C40(1.01); C209(0.69)  LDD1569  [28]
 LDCM0520  AKOS000195272 MDA-MB-231 C456(0.68)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C254(0.96); C456(1.01); C40(1.08); C209(0.99)  LDD1511  [28]
 LDCM0356  AKOS034007680 HEK-293T C254(1.09); C456(1.04); C40(1.16); C209(1.16)  LDD1570  [28]
 LDCM0275  AKOS034007705 HEK-293T C254(1.05); C456(1.00); C40(1.10); C209(1.00)  LDD1514  [28]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C456(0.51); C728(0.83)  LDD2091  [7]
 LDCM0087  Capsaicin HEK-293T 32.28  LDD0185  [17]
 LDCM0630  CCW28-3 231MFP C94(1.26)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa C254(0.00); H685(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C94(1.54); C456(1.31)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C254(0.88); C456(1.01); C40(1.08); C209(1.21)  LDD1571  [28]
 LDCM0368  CL10 HEK-293T C254(0.92); C456(1.11); C40(1.01); C209(1.14)  LDD1572  [28]
 LDCM0369  CL100 HEK-293T C254(1.05); C456(0.95); C40(1.02); C209(1.06)  LDD1573  [28]
 LDCM0370  CL101 HEK-293T C254(0.93); C456(1.01); C40(1.14); C209(1.15)  LDD1574  [28]
 LDCM0371  CL102 HEK-293T C254(1.05); C456(1.04); C40(0.97); C94(0.99)  LDD1575  [28]
 LDCM0372  CL103 HEK-293T C254(1.14); C456(0.98); C40(0.96); C94(1.06)  LDD1576  [28]
 LDCM0373  CL104 HEK-293T C254(1.13); C456(0.95); C40(1.07); C209(1.12)  LDD1577  [28]
 LDCM0374  CL105 HEK-293T C254(0.93); C456(1.00); C40(1.08); C209(1.25)  LDD1578  [28]
 LDCM0375  CL106 HEK-293T C254(1.07); C456(1.02); C40(0.99); C94(1.08)  LDD1579  [28]
 LDCM0376  CL107 HEK-293T C254(1.08); C456(0.94); C40(1.18); C94(0.89)  LDD1580  [28]
 LDCM0377  CL108 HEK-293T C254(1.11); C456(0.95); C40(1.05); C209(1.14)  LDD1581  [28]
 LDCM0378  CL109 HEK-293T C254(1.00); C456(0.96); C40(1.24); C209(0.94)  LDD1582  [28]
 LDCM0379  CL11 HEK-293T C254(0.99); C456(0.98); C40(0.93); C94(1.04)  LDD1583  [28]
 LDCM0380  CL110 HEK-293T C254(1.11); C456(1.01); C40(0.97); C94(1.05)  LDD1584  [28]
 LDCM0381  CL111 HEK-293T C254(1.02); C456(0.98); C40(0.95); C94(0.93)  LDD1585  [28]
 LDCM0382  CL112 HEK-293T C254(0.99); C456(0.97); C40(1.09); C209(0.93)  LDD1586  [28]
 LDCM0383  CL113 HEK-293T C254(1.18); C456(0.95); C40(1.15); C209(1.14)  LDD1587  [28]
 LDCM0384  CL114 HEK-293T C254(1.10); C456(1.08); C40(0.87); C94(1.03)  LDD1588  [28]
 LDCM0385  CL115 HEK-293T C254(1.32); C456(0.99); C40(0.96); C94(1.05)  LDD1589  [28]
 LDCM0386  CL116 HEK-293T C254(1.11); C456(0.99); C40(0.99); C209(1.25)  LDD1590  [28]
 LDCM0387  CL117 HEK-293T C254(1.10); C456(0.98); C40(1.15); C209(1.12)  LDD1591  [28]
 LDCM0388  CL118 HEK-293T C254(1.65); C456(1.02); C40(1.03); C94(1.15)  LDD1592  [28]
 LDCM0389  CL119 HEK-293T C254(1.09); C456(0.99); C40(1.02); C94(1.03)  LDD1593  [28]
 LDCM0390  CL12 HEK-293T C254(1.06); C456(1.08); C40(1.20); C209(0.99)  LDD1594  [28]
 LDCM0391  CL120 HEK-293T C254(1.04); C456(0.99); C40(1.01); C209(1.02)  LDD1595  [28]
 LDCM0392  CL121 HEK-293T C254(1.16); C456(1.01); C40(1.16); C209(1.09)  LDD1596  [28]
 LDCM0393  CL122 HEK-293T C254(1.14); C456(1.01); C40(1.11); C94(1.08)  LDD1597  [28]
 LDCM0394  CL123 HEK-293T C254(1.26); C456(1.05); C40(0.95); C94(0.87)  LDD1598  [28]
 LDCM0395  CL124 HEK-293T C254(0.99); C456(1.02); C40(1.00); C209(1.09)  LDD1599  [28]
 LDCM0396  CL125 HEK-293T C254(0.93); C456(0.94); C40(1.09); C209(1.24)  LDD1600  [28]
 LDCM0397  CL126 HEK-293T C254(1.06); C456(0.99); C40(1.02); C94(1.04)  LDD1601  [28]
 LDCM0398  CL127 HEK-293T C254(1.13); C456(1.00); C40(1.04); C94(1.01)  LDD1602  [28]
 LDCM0399  CL128 HEK-293T C254(1.02); C456(0.94); C40(1.02); C209(1.02)  LDD1603  [28]
 LDCM0400  CL13 HEK-293T C254(1.34); C456(0.97); C40(1.16); C209(1.29)  LDD1604  [28]
 LDCM0401  CL14 HEK-293T C254(1.04); C456(1.05); C40(1.00); C94(0.96)  LDD1605  [28]
 LDCM0402  CL15 HEK-293T C254(1.44); C456(1.02); C40(0.92); C94(1.16)  LDD1606  [28]
 LDCM0403  CL16 HEK-293T C254(1.05); C456(0.97); C40(1.14); C209(1.01)  LDD1607  [28]
 LDCM0404  CL17 HEK-293T C254(1.03); C456(0.98); C40(1.14); C209(1.03)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C254(0.96); C456(1.04); C40(1.21); C209(1.14)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C254(0.92); C456(1.07); C40(1.23); C209(1.17)  LDD1610  [28]
 LDCM0407  CL2 HEK-293T C254(1.15); C456(1.09); C40(0.99); C94(0.95)  LDD1611  [28]
 LDCM0408  CL20 HEK-293T C254(1.19); C456(1.02); C40(0.91); C209(1.35)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C254(0.95); C456(1.01); C40(1.08); C209(1.08)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C254(1.15); C456(1.05); C40(1.19); C209(1.06)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C254(1.03); C456(1.01); C40(1.01); C94(1.08)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C254(1.02); C456(1.08); C40(1.24); C209(0.77)  LDD1616  [28]
 LDCM0413  CL25 HEK-293T C254(1.00); C456(1.01); C40(1.14); C209(1.05)  LDD1617  [28]
 LDCM0414  CL26 HEK-293T C254(0.89); C456(1.01); C40(1.04); C94(1.11)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C254(1.19); C456(0.97); C40(1.04); C94(1.01)  LDD1619  [28]
 LDCM0416  CL28 HEK-293T C254(0.98); C456(0.96); C40(1.11); C209(1.01)  LDD1620  [28]
 LDCM0417  CL29 HEK-293T C254(0.95); C456(0.96); C40(1.11); C209(0.97)  LDD1621  [28]
 LDCM0418  CL3 HEK-293T C254(1.32); C456(1.03); C40(0.94); C94(0.91)  LDD1622  [28]
 LDCM0419  CL30 HEK-293T C254(0.99); C456(1.01); C40(1.15); C209(1.07)  LDD1623  [28]
 LDCM0420  CL31 HEK-293T C254(0.81); C456(1.09); C40(1.13); C209(0.96)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C254(1.05); C456(1.04); C40(0.90); C209(1.50)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C254(1.07); C456(0.98); C40(0.93); C209(0.92)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C254(1.20); C456(1.06); C40(1.10); C209(0.89)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C254(0.91); C456(1.00); C40(0.90); C94(0.88)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C254(0.90); C456(1.02); C40(1.26); C209(0.87)  LDD1629  [28]
 LDCM0426  CL37 HEK-293T C254(0.96); C456(0.99); C40(0.93); C209(0.92)  LDD1630  [28]
 LDCM0428  CL39 HEK-293T C254(1.15); C456(0.94); C40(1.09); C94(1.00)  LDD1632  [28]
 LDCM0429  CL4 HEK-293T C254(1.07); C456(1.02); C40(1.04); C209(1.25)  LDD1633  [28]
 LDCM0430  CL40 HEK-293T C254(1.01); C456(0.98); C40(0.96); C209(1.00)  LDD1634  [28]
 LDCM0431  CL41 HEK-293T C254(0.99); C456(1.01); C40(1.07); C209(1.23)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C254(0.95); C456(0.99); C40(1.09); C209(0.95)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C254(0.93); C456(1.02); C40(1.08); C209(0.93)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C254(1.11); C456(0.94); C40(0.88); C209(1.05)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C254(1.04); C456(0.90); C40(1.16); C209(1.18)  LDD1639  [28]
 LDCM0436  CL46 HEK-293T C254(0.97); C456(0.98); C40(1.18); C209(1.31)  LDD1640  [28]
 LDCM0437  CL47 HEK-293T C254(0.94); C456(0.97); C40(0.94); C94(0.94)  LDD1641  [28]
 LDCM0438  CL48 HEK-293T C254(1.04); C456(1.02); C40(1.15); C209(1.04)  LDD1642  [28]
 LDCM0439  CL49 HEK-293T C254(1.02); C456(1.00); C40(1.07); C209(1.20)  LDD1643  [28]
 LDCM0440  CL5 HEK-293T C254(1.22); C456(1.01); C40(1.06); C209(1.31)  LDD1644  [28]
 LDCM0441  CL50 HEK-293T C254(1.15); C456(1.09); C40(1.13); C94(1.04)  LDD1645  [28]
 LDCM0443  CL52 HEK-293T C254(1.00); C456(0.98); C40(1.16); C209(1.19)  LDD1646  [28]
 LDCM0444  CL53 HEK-293T C254(0.96); C456(1.03); C40(1.12); C209(0.93)  LDD1647  [28]
 LDCM0445  CL54 HEK-293T C254(1.02); C456(0.99); C40(1.04); C209(1.02)  LDD1648  [28]
 LDCM0446  CL55 HEK-293T C254(1.00); C456(1.02); C40(1.06); C209(1.08)  LDD1649  [28]
 LDCM0447  CL56 HEK-293T C254(0.97); C456(0.94); C40(0.92); C209(1.57)  LDD1650  [28]
 LDCM0448  CL57 HEK-293T C254(1.37); C456(0.96); C40(1.10); C209(1.12)  LDD1651  [28]
 LDCM0449  CL58 HEK-293T C254(1.14); C456(1.05); C40(1.16); C209(1.03)  LDD1652  [28]
 LDCM0450  CL59 HEK-293T C254(0.92); C456(1.00); C40(0.97); C94(1.10)  LDD1653  [28]
 LDCM0451  CL6 HEK-293T C254(1.05); C456(1.04); C40(1.01); C209(0.77)  LDD1654  [28]
 LDCM0452  CL60 HEK-293T C254(1.16); C456(1.05); C40(1.20); C209(1.00)  LDD1655  [28]
 LDCM0453  CL61 HEK-293T C254(1.02); C456(0.97); C40(1.00); C209(1.19)  LDD1656  [28]
 LDCM0454  CL62 HEK-293T C254(1.28); C456(0.99); C40(0.96); C94(0.98)  LDD1657  [28]
 LDCM0455  CL63 HEK-293T C254(1.26); C456(1.00); C40(0.98); C94(0.99)  LDD1658  [28]
 LDCM0456  CL64 HEK-293T C254(1.10); C456(0.99); C40(1.07); C209(1.16)  LDD1659  [28]
 LDCM0457  CL65 HEK-293T C254(1.03); C456(1.03); C40(1.06); C209(1.11)  LDD1660  [28]
 LDCM0458  CL66 HEK-293T C254(0.95); C456(0.97); C40(1.24); C209(1.21)  LDD1661  [28]
 LDCM0459  CL67 HEK-293T C254(1.02); C456(1.07); C40(1.02); C209(1.04)  LDD1662  [28]
 LDCM0460  CL68 HEK-293T C254(1.08); C456(1.00); C40(0.90); C209(1.05)  LDD1663  [28]
 LDCM0461  CL69 HEK-293T C254(1.04); C456(1.00); C40(1.06); C209(1.19)  LDD1664  [28]
 LDCM0462  CL7 HEK-293T C254(0.90); C456(1.07); C40(1.10); C209(0.87)  LDD1665  [28]
 LDCM0463  CL70 HEK-293T C254(1.11); C456(1.08); C40(1.10); C209(1.15)  LDD1666  [28]
 LDCM0464  CL71 HEK-293T C254(0.97); C456(0.96); C40(0.99); C94(1.05)  LDD1667  [28]
 LDCM0465  CL72 HEK-293T C254(0.98); C456(1.08); C40(1.25); C209(0.71)  LDD1668  [28]
 LDCM0466  CL73 HEK-293T C254(1.03); C456(1.00); C40(1.01); C209(1.14)  LDD1669  [28]
 LDCM0467  CL74 HEK-293T C254(1.02); C456(0.98); C40(0.97); C94(1.04)  LDD1670  [28]
 LDCM0469  CL76 HEK-293T C254(1.05); C456(1.01); C40(1.01); C209(1.10)  LDD1672  [28]
 LDCM0470  CL77 HEK-293T C254(0.99); C456(0.96); C40(1.04); C209(1.00)  LDD1673  [28]
 LDCM0471  CL78 HEK-293T C254(1.03); C456(0.99); C40(1.12); C209(0.90)  LDD1674  [28]
 LDCM0472  CL79 HEK-293T C254(0.99); C456(0.99); C40(1.07); C209(1.02)  LDD1675  [28]
 LDCM0473  CL8 HEK-293T C254(1.20); C456(0.97); C40(0.72); C209(0.73)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C254(1.05); C456(1.02); C40(0.89); C209(1.16)  LDD1677  [28]
 LDCM0475  CL81 HEK-293T C254(1.11); C456(0.99); C40(1.08); C209(1.12)  LDD1678  [28]
 LDCM0476  CL82 HEK-293T C254(0.98); C456(1.09); C40(1.12); C209(1.04)  LDD1679  [28]
 LDCM0477  CL83 HEK-293T C254(0.94); C456(0.96); C40(0.95); C94(0.98)  LDD1680  [28]
 LDCM0478  CL84 HEK-293T C254(0.99); C456(1.14); C40(1.12); C209(0.84)  LDD1681  [28]
 LDCM0479  CL85 HEK-293T C254(0.90); C456(0.93); C40(0.98); C209(1.07)  LDD1682  [28]
 LDCM0480  CL86 HEK-293T C254(1.15); C456(1.03); C40(0.94); C94(1.08)  LDD1683  [28]
 LDCM0481  CL87 HEK-293T C254(1.34); C456(0.99); C40(1.04); C94(0.97)  LDD1684  [28]
 LDCM0482  CL88 HEK-293T C254(1.17); C456(0.99); C40(1.08); C209(1.07)  LDD1685  [28]
 LDCM0483  CL89 HEK-293T C254(1.15); C456(1.02); C40(1.09); C209(1.06)  LDD1686  [28]
 LDCM0484  CL9 HEK-293T C254(0.97); C456(1.04); C40(1.13); C209(1.10)  LDD1687  [28]
 LDCM0485  CL90 HEK-293T C254(1.04); C456(0.95); C40(1.02); C209(0.75)  LDD1688  [28]
 LDCM0486  CL91 HEK-293T C254(0.89); C456(1.04); C40(0.95); C209(1.06)  LDD1689  [28]
 LDCM0487  CL92 HEK-293T C254(1.08); C456(1.00); C40(1.02); C209(0.98)  LDD1690  [28]
 LDCM0488  CL93 HEK-293T C254(1.21); C456(1.00); C40(0.97); C209(0.97)  LDD1691  [28]
 LDCM0489  CL94 HEK-293T C254(0.93); C456(1.08); C40(1.16); C209(1.12)  LDD1692  [28]
 LDCM0490  CL95 HEK-293T C254(1.12); C456(1.09); C40(0.95); C94(1.24)  LDD1693  [28]
 LDCM0491  CL96 HEK-293T C254(0.88); C456(1.13); C40(1.08); C209(0.77)  LDD1694  [28]
 LDCM0492  CL97 HEK-293T C254(0.97); C456(1.03); C40(1.04); C209(0.96)  LDD1695  [28]
 LDCM0493  CL98 HEK-293T C254(1.11); C456(1.02); C40(0.97); C94(1.00)  LDD1696  [28]
 LDCM0494  CL99 HEK-293T C254(1.06); C456(0.99); C40(0.94); C94(0.95)  LDD1697  [28]
 LDCM0634  CY-0357 Hep-G2 C94(1.12); C40(0.66); C254(0.50)  LDD2228  [16]
 LDCM0028  Dobutamine HEK-293T 4.52  LDD0180  [17]
 LDCM0495  E2913 HEK-293T C254(1.05); C456(0.92); C40(1.00); C94(0.92)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C456(19.29)  LDD1702  [7]
 LDCM0031  Epigallocatechin gallate HEK-293T 75.51  LDD0183  [17]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0625  F8 Ramos C456(2.12); C40(1.24); C94(1.16)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C456(1.86); C40(1.20)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C456(1.85); C40(0.48)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C456(1.23); C40(0.98); C254(0.78)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C456(0.74); C40(1.04); C254(1.03)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C456(1.36); C40(0.83); C94(1.05); C254(0.64)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C456(1.22); C40(0.81); C254(0.41)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C456(0.73); C40(0.97); C254(0.70)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C456(1.13); C40(1.00)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C456(0.78); C40(1.10); C254(0.82)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C456(0.55); C40(0.42); C254(0.63)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C456(1.17); C40(1.01)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C456(0.89); C40(0.91)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C456(1.46); C40(1.18)  LDD2201  [30]
 LDCM0468  Fragment33 HEK-293T C254(1.08); C456(0.97); C40(0.95); C94(0.97)  LDD1671  [28]
 LDCM0596  Fragment38 Ramos C456(0.79); C40(0.69); C254(0.41)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C456(2.07); C40(0.79); C94(0.73)  LDD2184  [30]
 LDCM0427  Fragment51 HEK-293T C254(1.36); C456(0.96); C40(0.94); C94(1.02)  LDD1631  [28]
 LDCM0610  Fragment52 Ramos C456(0.98); C40(0.97)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C456(1.35); C40(1.15)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C456(1.43); C40(1.00); C94(1.07); C254(1.61)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C456(4.37); C40(0.85)  LDD2188  [30]
 LDCM0116  HHS-0101 DM93 Y359(0.77); Y659(1.31)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y359(0.41)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y659(1.20); Y359(20.00)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y659(1.08)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y359(0.65)  LDD0268  [12]
 LDCM0107  IAA HeLa H685(0.00); H407(0.00); K408(0.00)  LDD0221  [23]
 LDCM0022  KB02 HEK-293T C254(1.06); C456(0.89); C40(0.96); C209(1.03)  LDD1492  [28]
 LDCM0023  KB03 HEK-293T C254(1.00); C456(1.00); C40(1.02); C209(1.09)  LDD1497  [28]
 LDCM0024  KB05 COLO792 C302(1.08); C504(2.79)  LDD3310  [6]
 LDCM0030  Luteolin HEK-293T 9.14  LDD0182  [17]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C456(1.09)  LDD2102  [7]
 LDCM0109  NEM HeLa H407(0.00); K408(0.00)  LDD0223  [23]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C456(1.31)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C456(0.95)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C456(1.07)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C456(1.11)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C728(0.47)  LDD2096  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C456(0.94)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C456(0.84)  LDD2099  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C456(1.40)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C456(0.78)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C456(0.87)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C456(0.86)  LDD2111  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C456(2.38); C728(1.03)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C456(0.90)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C456(1.03)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C456(0.89); C728(0.83)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C456(0.94)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C456(0.97)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C456(0.91)  LDD2129  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C456(1.20)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C456(1.14)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C456(0.90)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C456(0.71)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C456(0.99)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C456(1.97)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C456(0.95)  LDD2146  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C728(0.94)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C456(0.62)  LDD2206  [31]
 LDCM0032  Oleacein HEK-293T 6.93  LDD0184  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C456(0.27)  LDD2207  [31]
 LDCM0014  Panhematin K562 3.20  LDD0063  [10]
 LDCM0029  Quercetin HEK-293T 8.34  LDD0181  [17]
 LDCM0131  RA190 MM1.R C40(1.26)  LDD0304  [32]
 LDCM0170  Structure8 Ramos 4.67  LDD0433  [33]
 LDCM0003  Sulforaphane MDA-MB-231 2.14  LDD0160  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoribonuclease ZC3H12A (ZC3H12A) ZC3H12 family Q5D1E8
Ras GTPase-activating protein-binding protein 1 (G3BP1) . Q13283
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Small ribosomal subunit protein RACK1 (RACK1) WD repeat G protein beta family P63244
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Ras GTPase-activating protein-binding protein 2 (G3BP2) . Q9UN86

The Drug(s) Related To This Target

Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Spautin 1 Small molecular drug DB0V3R

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
33 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.