Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name HPAP  Probe Info 
Probe concentration 25 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name Panhematin  Competitor Info 
Competitor Concentration 100 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cell lysate (K562)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 73 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 10.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 7.4
 LDTP13087  Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) 6.9
 LDTP04581  Holocytochrome c-type synthase (HCCS) 6.0
 LDTP18083  Probable N-acetyltransferase 14 (NAT14) 5.8
 LDTP07931  Heme A synthase COX15 (COX15) 5.7
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 5.6
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 5.1
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 4.9
 LDTP04353  Protoporphyrinogen oxidase (PPOX) 4.8
 LDTP03210  Prostaglandin G/H synthase 1 (PTGS1) 4.5
 LDTP02223  Cathepsin B (CTSB) 4.4
 LDTP09364  Retinol dehydrogenase 11 (RDH11) 4.2
 LDTP11676  E3 ubiquitin-protein ligase makorin-2 (MKRN2) 4.0
 LDTP16274  Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9) 3.9
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 3.8
 LDTP01268  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT) 3.7
 LDTP06294  Lysine--tRNA ligase (KARS1) 3.7
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 3.6
 LDTP11016  Dual specificity protein phosphatase 9 (DUSP9) 3.6
 LDTP06988  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) 3.5
 LDTP04806  Sestrin-2 (SESN2) 3.5
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 3.5
 LDTP09939  Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) 3.5
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) 3.5
 LDTP03679  Dual specificity protein kinase TTK (TTK) 3.5
 LDTP05313  OTU domain-containing protein 4 (OTUD4) 3.5
 LDTP05464  2-5A-dependent ribonuclease (RNASEL) 3.4
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 3.4
 LDTP15217  Probable proline--tRNA ligase, mitochondrial (PARS2) 3.4
 LDTP00464  Glutathione S-transferase 3, mitochondrial (MGST3) 3.4
 LDTP04992  Ras-related protein Rab-11A (RAB11A) 3.4
 LDTP03511  Flavin reductase (NADPH) (BLVRB) 3.4
 LDTP03552  Pyruvate kinase PKLR (PKLR) 3.4
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 3.4
 LDTP06810  Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) 3.3
 LDTP03794  Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) 3.3
 LDTP12538  Ras-related protein Rab-6B (RAB6B) 3.3
 LDTP08722  Retinol dehydrogenase 10 (RDH10) 3.3
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 3.3
 LDTP13940  Nitric oxide synthase-interacting protein (NOSIP) 3.3
 LDTP04636  Adenylate kinase 2, mitochondrial (AK2) 3.3
 LDTP04435  Interleukin-1 receptor-associated kinase 1 (IRAK1) 3.3
 LDTP03662  Long-chain-fatty-acid--CoA ligase 1 (ACSL1) 3.3
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 3.3
 LDTP19892  DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) 3.3
 LDTP03424  ATP-binding cassette sub-family D member 3 (ABCD3) 3.3
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 3.3
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) 3.3
 LDTP11152  Cancer-related nucleoside-triphosphatase (NTPCR) 3.2
 LDTP03497  Non-receptor tyrosine-protein kinase TYK2 (TYK2) 3.2
 LDTP02149  Cyclin-dependent kinase 1 (CDK1) 3.2
 LDTP03330  Proteasome subunit alpha type-1 (PSMA1) 3.2
 LDTP06190  Ubiquitin carboxyl-terminal hydrolase 10 (USP10) 3.2
 LDTP16798  Putative GTP-binding protein 6 (GTPBP6) 3.2
 LDTP04441  26S proteasome non-ATPase regulatory subunit 7 (PSMD7) 3.2
 LDTP10987  Tumor susceptibility gene 101 protein (TSG101) 3.1
 LDTP04890  Signal recognition particle subunit SRP54 (SRP54) 3.1
 LDTP03842  Squalene synthase (FDFT1) 3.1
 LDTP05623  Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) 3.1
 LDTP06142  Squalene monooxygenase (SQLE) 3.1
 LDTP10020  Ras-related protein Rab-24 (RAB24) 3.1
 LDTP00344  Stearoyl-CoA desaturase (SCD) 3.1
 LDTP02925  ATP-dependent 6-phosphofructokinase, liver type (PFKL) 3.1
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 3.1
 LDTP05918  Histone deacetylase 1 (HDAC1) 3.1
 LDTP02565  Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) 3.0
 LDTP04619  5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) 3.0
 LDTP11258  TNF receptor-associated factor 4 (TRAF4) 3.0
 LDTP04403  Ras-related protein Rab-27A (RAB27A) 3.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 3.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 3.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 3.0
Transporter and channel
Click to Show/Hide to Show 36 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 6.8
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 6.2
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 5.6
 LDTP03546  Translocator protein (TSPO) 5.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 5.1
 LDTP11291  Transmembrane emp24 domain-containing protein 9 (TMED9) 5.0
 LDTP15838  Translocation protein SEC62 (SEC62) 4.7
 LDTP18053  Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40) 4.2
 LDTP05303  Interferon-induced transmembrane protein 2 (IFITM2) 4.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 4.1
 LDTP00358  Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD) 3.9
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 3.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 3.8
 LDTP09769  Zinc transporter SLC39A7 (SLC39A7) 3.8
 LDTP12979  Transmembrane protein 14C (TMEM14C) 3.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 3.7
 LDTP11281  Voltage-gated monoatomic cation channel TMEM109 (TMEM109) 3.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 3.7
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 3.7
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 3.5
 LDTP07477  Transmembrane protein 214 (TMEM214) 3.5
 LDTP08315  THO complex subunit 6 homolog (THOC6) 3.5
 LDTP00405  Etoposide-induced protein 2.4 homolog (EI24) 3.4
 LDTP11301  Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1) 3.4
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 3.4
 LDTP16103  ATP-binding cassette sub-family F member 3 (ABCF3) 3.3
 LDTP01631  Mitochondrial pyruvate carrier 2 (MPC2) 3.2
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 3.2
 LDTP13599  Calcium load-activated calcium channel (TMCO1) 3.2
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 3.2
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 3.1
 LDTP07058  Transmembrane protein 201 (TMEM201) 3.1
 LDTP17258  Transmembrane protein 164 (TMEM164) 3.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 3.0
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 3.0
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 3.0
Transcription factor
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04370  ETS domain-containing transcription factor ERF (ERF) 5.0
 LDTP05097  Pituitary homeobox 1 (PITX1) 4.8
 LDTP02899  Homeobox protein Hox-B9 (HOXB9) 3.8
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 3.7
 LDTP10852  Transcription factor 12 (TCF12) 3.7
 LDTP12989  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) 3.5
 LDTP12355  DNA methyltransferase 1-associated protein 1 (DMAP1) 3.2
 LDTP08582  Zinc finger protein ZFPM1 (ZFPM1) 3.1
Other
Click to Show/Hide to Show 59 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04500  Heterogeneous nuclear ribonucleoprotein M (HNRNPM) 8.6
 LDTP11324  RNA-binding protein 4 (RBM4) 7.8
 LDTP01600  BAG family molecular chaperone regulator 4 (BAG4) 6.5
 LDTP10357  RUS family member 1 (RUSF1) 5.8
 LDTP10216  RNA-binding protein Musashi homolog 2 (MSI2) 5.3
 LDTP00009  RNA-binding protein 47 (RBM47) 5.2
 LDTP00880  A-kinase anchor protein 8 (AKAP8) 4.7
 LDTP01522  Reticulon-3 (RTN3) 4.6
 LDTP02053  Heat shock protein beta-1 (HSPB1) 4.6
 LDTP06184  Genetic suppressor element 1 (GSE1) 4.6
 LDTP11046  RNA-binding protein 4B (RBM4B) 4.6
 LDTP00507  Zinc finger protein 609 (ZNF609) 4.5
 LDTP10408  Far upstream element-binding protein 3 (FUBP3) 4.5
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) 4.5
 LDTP08577  SURP and G-patch domain-containing protein 1 (SUGP1) 4.4
 LDTP04903  Actin-related protein 2 (ACTR2) 4.4
 LDTP09353  Guanine nucleotide exchange factor for Rab-3A (RAB3IL1) 4.4
 LDTP00822  Trafficking protein particle complex subunit 3 (TRAPPC3) 4.3
 LDTP03065  Lamin-B1 (LMNB1) 4.2
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) 4.2
 LDTP14105  YTH domain-containing family protein 2 (YTHDF2) 4.0
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) 3.9
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 3.8
 LDTP13591  A-kinase anchor protein 8-like (AKAP8L) 3.8
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 3.8
 LDTP15922  Large ribosomal subunit protein mL37 (MRPL37) 3.8
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 3.7
 LDTP02205  Tubulin beta chain (TUBB) 3.7
 LDTP12706  Pre-mRNA-splicing factor RBM22 (RBM22) 3.6
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 3.6
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) 3.5
 LDTP06066  Malectin (MLEC) 3.5
 LDTP11238  Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) 3.5
 LDTP11466  YTH domain-containing family protein 1 (YTHDF1) 3.5
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 3.5
 LDTP13402  Dynactin subunit 4 (DCTN4) 3.5
 LDTP11645  SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP) 3.4
 LDTP04111  Small ribosomal subunit protein eS10 (RPS10) 3.4
 LDTP16202  Zinc finger HIT domain-containing protein 2 (ZNHIT2) 3.4
 LDTP05998  Tubulin beta-2A chain (TUBB2A) 3.4
 LDTP10684  RNA-binding protein 14 (RBM14) 3.4
 LDTP01677  Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) 3.3
 LDTP00512  Protein transport protein Sec16A (SEC16A) 3.3
 LDTP11233  Tubulin beta-6 chain (TUBB6) 3.2
 LDTP19963  TraB domain-containing protein (TRABD) 3.2
 LDTP08264  Protein FAM83A (FAM83A) 3.2
 LDTP10232  Large ribosomal subunit protein mL38 (MRPL38) 3.2
 LDTP01021  Perilipin-3 (PLIN3) 3.2
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) 3.2
 LDTP02037  Tubulin beta-4A chain (TUBB4A) 3.2
 LDTP02365  U2 small nuclear ribonucleoprotein A' (SNRPA1) 3.2
 LDTP12631  Double-stranded RNA-binding protein Staufen homolog 2 (STAU2) 3.1
 LDTP17065  Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) 3.1
 LDTP10849  Regulator of microtubule dynamics protein 3 (RMDN3) 3.1
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 3.1
 LDTP10417  DISP complex protein LRCH3 (LRCH3) 3.0
 LDTP12155  Pleckstrin homology domain-containing family A member 2 (PLEKHA2) 3.0
 LDTP00555  BET1 homolog (BET1) 3.0
 LDTP01922  Hemoglobin subunit epsilon (HBE1) 3.0

References

1 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651