Details of the Target

General Information of Target

Target ID LDTP10684
Target Name RNA-binding protein 14 (RBM14)
Gene Name RBM14
Gene ID 100526737
Synonyms
SIP; RNA-binding protein 14; Paraspeckle protein 2; PSP2; RNA-binding motif protein 14; RRM-containing coactivator activator/modulator; Synaptotagmin-interacting protein; SYT-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLWASLLAFAPVCGQSAAAHKPVISVHPPWTTFFKGERVTLTCNGFQFYATEKTTWYHR
HYWGEKLTLTPGNTLEVRESGLYRCQARGSPRSNPVRLLFSSDSLILQAPYSVFEGDTLV
LRCHRRRKEKLTAVKYTWNGNILSISNKSWDLLIPQASSNNNGNYRCIGYGDENDVFRSN
FKIIKIQELFPHPELKATDSQPTEGNSVNLSCETQLPPERSDTPLHFNFFRDGEVILSDW
STYPELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVLLETQPSGGQA
VEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIRQSHAGGYYCT
ADNSYGPVQSMVLNVTVRETPGNRDGLVAAGATGGLLSALLLAVALLFHCWRRRKSGVGF
LGDETRLPPAPGPGESSHSICPAQVELQSLYVDVHPKKGDLVYSEIQTTQLGEEEEANTS
RTLLEDKDVSVVYSEVKTQHPDNSAGKISSKDEES
Target Bioclass
Other
Subcellular location
Nucleus
Function
Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Also involved in the regulation of pre-mRNA alternative splicing.
Uniprot ID
Q96PK6
Ensemble ID
ENST00000310137.5
HGNC ID
HGNC:14219

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A268T DBIA    Probe Info 
EFO27 Deletion: p.A441del DBIA    Probe Info 
G361 SNV: p.A513E DBIA    Probe Info 
HCT15 SNV: p.G307E DBIA    Probe Info 
JURKAT SNV: p.A418V Compound 10    Probe Info 
LOXIMVI SNV: p.D589E DBIA    Probe Info 
MCF7 SNV: p.T454S .
NCIH146 SNV: p.T206I DBIA    Probe Info 
RKO SNV: p.G287C DBIA    Probe Info 
TOV21G SNV: p.P304L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.90  LDD0215  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
C-Sul
 Probe Info  		4.73  LDD0066  [3]
TH211
 Probe Info  		Y249(20.00); Y285(20.00); Y540(20.00); Y645(20.00)  LDD0257  [4]
TH216
 Probe Info  		Y114(20.00); Y665(20.00); Y249(17.17); Y614(11.07)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
Probe 1
 Probe Info  		Y237(19.60); Y249(43.68); Y261(48.51); Y273(7.88)  LDD3495  [6]
BTD
 Probe Info  		C108(0.90)  LDD2090  [7]
HPAP
 Probe Info  		3.37  LDD0063  [8]
HHS-475
 Probe Info  		Y540(0.13); Y665(0.53); Y249(1.15); Y226(1.90)  LDD0264  [9]
HHS-465
 Probe Info  		Y665(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C90(0.88)  LDD0078  [11]
5E-2FA
 Probe Info  		H662(0.00); H56(0.00); H642(0.00); H533(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K149(0.00); K152(0.00); K121(0.00); K126(0.00)  LDD0199  [13]
m-APA
 Probe Info  		H662(0.00); H56(0.00); H642(0.00); H533(0.00)  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C31(0.00); C90(0.00); C108(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C90(0.00); C108(0.00)  LDD0032  [15]
IPIAA_L
 Probe Info  		C108(0.00); C90(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C31(0.00); C90(0.00); C108(0.00)  LDD0037  [14]
IPM
 Probe Info  		N.A.  LDD0025  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
Compound 10
 Probe Info  		C108(0.00); C90(0.00)  LDD2216  [19]
Compound 11
 Probe Info  		N.A.  LDD2213  [19]
ENE
 Probe Info  		N.A.  LDD0006  [18]
NHS
 Probe Info  		K149(0.00); K153(0.00); K135(0.00); K126(0.00)  LDD0010  [18]
PF-06672131
 Probe Info  		C90(0.00); C108(0.00)  LDD0017  [20]
SF
 Probe Info  		Y285(0.00); Y645(0.00); Y261(0.00); Y588(0.00)  LDD0028  [21]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
Acrolein
 Probe Info  		C90(0.00); C108(0.00); H642(0.00); H58(0.00)  LDD0217  [22]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [22]
Crotonaldehyde
 Probe Info  		H533(0.00); C90(0.00); H58(0.00); C108(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C90(0.00); C31(0.00); C108(0.00)  LDD0218  [22]
W1
 Probe Info  		C108(0.00); C90(0.00)  LDD0236  [23]
NAIA_5
 Probe Info  		C108(0.00); C31(0.00); C90(0.00)  LDD2223  [24]
HHS-482
 Probe Info  		Y226(0.54); Y237(0.55); Y249(0.29); Y273(0.32)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		13.09  LDD1845  [25]
C187
 Probe Info  		25.99  LDD1865  [25]
C191
 Probe Info  		22.32  LDD1868  [25]
C193
 Probe Info  		7.78  LDD1869  [25]
C232
 Probe Info  		33.82  LDD1905  [25]
C338
 Probe Info  		14.22  LDD2001  [25]
C348
 Probe Info  		10.27  LDD2009  [25]
FFF probe11
 Probe Info  		14.30  LDD0471  [26]
FFF probe12
 Probe Info  		5.67  LDD0473  [26]
FFF probe13
 Probe Info  		19.98  LDD0475  [26]
FFF probe14
 Probe Info  		12.54  LDD0477  [26]
FFF probe2
 Probe Info  		20.00  LDD0463  [26]
FFF probe3
 Probe Info  		14.25  LDD0464  [26]
FFF probe4
 Probe Info  		12.18  LDD0466  [26]
FFF probe6
 Probe Info  		13.32  LDD0467  [26]
JN0003
 Probe Info  		20.00  LDD0469  [26]
OEA-DA
 Probe Info  		8.52  LDD0046  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C108(0.80)  LDD2117  [7]
 LDCM0214  AC1 HEK-293T C108(0.90); C90(0.83)  LDD1507  [28]
 LDCM0215  AC10 HEK-293T C108(0.90); C90(0.85); C31(1.07)  LDD1508  [28]
 LDCM0226  AC11 HEK-293T C108(0.92); C90(0.94); C31(1.05)  LDD1509  [28]
 LDCM0237  AC12 HEK-293T C108(0.97); C90(1.08); C31(1.20)  LDD1510  [28]
 LDCM0259  AC14 HEK-293T C108(0.84); C90(0.98)  LDD1512  [28]
 LDCM0270  AC15 HEK-293T C108(0.92); C90(0.96)  LDD1513  [28]
 LDCM0276  AC17 HEK-293T C108(0.90); C90(1.00)  LDD1515  [28]
 LDCM0277  AC18 HEK-293T C108(1.04); C90(1.07); C31(0.99)  LDD1516  [28]
 LDCM0278  AC19 HEK-293T C108(0.90); C90(1.12); C31(0.55)  LDD1517  [28]
 LDCM0279  AC2 HEK-293T C108(0.97); C90(1.07); C31(0.79)  LDD1518  [28]
 LDCM0280  AC20 HEK-293T C108(0.97); C90(1.09); C31(1.13)  LDD1519  [28]
 LDCM0281  AC21 HEK-293T C108(0.97); C90(1.00); C31(0.91)  LDD1520  [28]
 LDCM0282  AC22 HEK-293T C108(0.97); C90(0.98)  LDD1521  [28]
 LDCM0283  AC23 HEK-293T C108(1.04); C90(1.13)  LDD1522  [28]
 LDCM0284  AC24 HEK-293T C108(0.97); C90(1.04)  LDD1523  [28]
 LDCM0285  AC25 HEK-293T C108(0.98); C90(0.95)  LDD1524  [28]
 LDCM0286  AC26 HEK-293T C108(1.03); C90(0.91); C31(0.96)  LDD1525  [28]
 LDCM0287  AC27 HEK-293T C108(0.92); C90(1.13); C31(1.07)  LDD1526  [28]
 LDCM0288  AC28 HEK-293T C108(1.00); C90(0.98); C31(1.15)  LDD1527  [28]
 LDCM0289  AC29 HEK-293T C108(0.96); C90(1.00); C31(1.11)  LDD1528  [28]
 LDCM0290  AC3 HEK-293T C108(0.92); C90(0.91); C31(1.06)  LDD1529  [28]
 LDCM0291  AC30 HEK-293T C108(1.06); C90(1.04)  LDD1530  [28]
 LDCM0292  AC31 HEK-293T C108(1.01); C90(0.93)  LDD1531  [28]
 LDCM0293  AC32 HEK-293T C108(1.07); C90(0.96)  LDD1532  [28]
 LDCM0294  AC33 HEK-293T C108(0.88); C90(0.83)  LDD1533  [28]
 LDCM0295  AC34 HEK-293T C108(0.90); C90(0.93); C31(1.16)  LDD1534  [28]
 LDCM0296  AC35 HEK-293T C108(0.89); C90(1.06); C31(1.05)  LDD1535  [28]
 LDCM0297  AC36 HEK-293T C108(1.04); C90(0.97); C31(1.15)  LDD1536  [28]
 LDCM0298  AC37 HEK-293T C108(0.96); C90(1.01); C31(1.03)  LDD1537  [28]
 LDCM0299  AC38 HEK-293T C108(0.86); C90(1.11)  LDD1538  [28]
 LDCM0300  AC39 HEK-293T C108(0.96); C90(1.04)  LDD1539  [28]
 LDCM0301  AC4 HEK-293T C108(0.98); C90(0.94); C31(1.28)  LDD1540  [28]
 LDCM0302  AC40 HEK-293T C108(0.89); C90(1.11)  LDD1541  [28]
 LDCM0303  AC41 HEK-293T C108(0.92); C90(0.97)  LDD1542  [28]
 LDCM0304  AC42 HEK-293T C108(0.82); C90(0.95); C31(1.16)  LDD1543  [28]
 LDCM0305  AC43 HEK-293T C108(0.90); C90(1.06); C31(1.23)  LDD1544  [28]
 LDCM0306  AC44 HEK-293T C108(1.03); C90(1.06); C31(1.09)  LDD1545  [28]
 LDCM0307  AC45 HEK-293T C108(0.89); C90(0.89); C31(0.98)  LDD1546  [28]
 LDCM0308  AC46 HEK-293T C108(0.86); C90(1.03)  LDD1547  [28]
 LDCM0309  AC47 HEK-293T C108(0.92); C90(1.00)  LDD1548  [28]
 LDCM0310  AC48 HEK-293T C108(0.88); C90(0.94)  LDD1549  [28]
 LDCM0311  AC49 HEK-293T C108(0.90); C90(1.11)  LDD1550  [28]
 LDCM0312  AC5 HEK-293T C108(0.90); C90(1.05); C31(1.00)  LDD1551  [28]
 LDCM0313  AC50 HEK-293T C108(0.90); C90(1.01); C31(1.00)  LDD1552  [28]
 LDCM0314  AC51 HEK-293T C108(0.99); C90(1.15); C31(0.95)  LDD1553  [28]
 LDCM0315  AC52 HEK-293T C108(0.98); C90(0.92); C31(1.02)  LDD1554  [28]
 LDCM0316  AC53 HEK-293T C108(0.97); C90(1.09); C31(0.99)  LDD1555  [28]
 LDCM0317  AC54 HEK-293T C108(0.90); C90(1.07)  LDD1556  [28]
 LDCM0318  AC55 HEK-293T C108(0.98); C90(0.94)  LDD1557  [28]
 LDCM0319  AC56 HEK-293T C108(0.90); C90(0.98)  LDD1558  [28]
 LDCM0320  AC57 HEK-293T C108(0.88); C90(0.98)  LDD1559  [28]
 LDCM0321  AC58 HEK-293T C108(0.92); C90(0.91); C31(1.00)  LDD1560  [28]
 LDCM0322  AC59 HEK-293T C108(0.96); C90(1.00); C31(1.04)  LDD1561  [28]
 LDCM0323  AC6 HEK-293T C108(0.88); C90(0.96)  LDD1562  [28]
 LDCM0324  AC60 HEK-293T C108(1.02); C90(0.95); C31(1.13)  LDD1563  [28]
 LDCM0325  AC61 HEK-293T C108(0.91); C90(1.01); C31(1.08)  LDD1564  [28]
 LDCM0326  AC62 HEK-293T C108(0.90); C90(1.03)  LDD1565  [28]
 LDCM0327  AC63 HEK-293T C108(0.92); C90(1.02)  LDD1566  [28]
 LDCM0328  AC64 HEK-293T C108(0.96); C90(1.02)  LDD1567  [28]
 LDCM0334  AC7 HEK-293T C108(1.02); C90(0.94)  LDD1568  [28]
 LDCM0345  AC8 HEK-293T C108(0.89); C90(0.87)  LDD1569  [28]
 LDCM0248  AKOS034007472 HEK-293T C108(0.97); C90(1.05); C31(1.19)  LDD1511  [28]
 LDCM0356  AKOS034007680 HEK-293T C108(0.89); C90(0.92)  LDD1570  [28]
 LDCM0275  AKOS034007705 HEK-293T C108(0.89); C90(0.95)  LDD1514  [28]
 LDCM0020  ARS-1620 HCC44 C90(0.88)  LDD0078  [11]
 LDCM0108  Chloroacetamide HeLa C90(0.00); H58(0.00); C108(0.00); H41(0.00)  LDD0222  [22]
 LDCM0367  CL1 HEK-293T C108(0.91); C90(0.93); C31(1.32)  LDD1571  [28]
 LDCM0368  CL10 HEK-293T C108(0.76); C90(1.04)  LDD1572  [28]
 LDCM0369  CL100 HEK-293T C108(0.91); C90(0.97)  LDD1573  [28]
 LDCM0370  CL101 HEK-293T C108(0.88); C90(0.90); C31(0.97)  LDD1574  [28]
 LDCM0371  CL102 HEK-293T C108(0.82); C90(0.91); C31(1.08)  LDD1575  [28]
 LDCM0372  CL103 HEK-293T C108(0.94); C90(1.01)  LDD1576  [28]
 LDCM0373  CL104 HEK-293T C108(0.91); C90(0.96)  LDD1577  [28]
 LDCM0374  CL105 HEK-293T C108(0.91); C90(0.98); C31(1.11)  LDD1578  [28]
 LDCM0375  CL106 HEK-293T C108(0.94); C90(0.87); C31(0.83)  LDD1579  [28]
 LDCM0376  CL107 HEK-293T C108(1.03); C90(0.90)  LDD1580  [28]
 LDCM0377  CL108 HEK-293T C108(0.95); C90(1.04)  LDD1581  [28]
 LDCM0378  CL109 HEK-293T C108(0.95); C90(0.93); C31(1.12)  LDD1582  [28]
 LDCM0379  CL11 HEK-293T C108(0.93); C90(0.96)  LDD1583  [28]
 LDCM0380  CL110 HEK-293T C108(0.96); C90(0.83); C31(0.83)  LDD1584  [28]
 LDCM0381  CL111 HEK-293T C108(0.97); C90(0.94)  LDD1585  [28]
 LDCM0382  CL112 HEK-293T C108(0.94); C90(0.84)  LDD1586  [28]
 LDCM0383  CL113 HEK-293T C108(0.90); C90(0.94); C31(0.98)  LDD1587  [28]
 LDCM0384  CL114 HEK-293T C108(0.78); C90(0.80); C31(0.89)  LDD1588  [28]
 LDCM0385  CL115 HEK-293T C108(0.88); C90(1.07)  LDD1589  [28]
 LDCM0386  CL116 HEK-293T C108(0.94); C90(0.91)  LDD1590  [28]
 LDCM0387  CL117 HEK-293T C108(0.92); C90(0.93); C31(1.21)  LDD1591  [28]
 LDCM0388  CL118 HEK-293T C108(0.90); C90(0.95); C31(1.00)  LDD1592  [28]
 LDCM0389  CL119 HEK-293T C108(0.95); C90(1.01)  LDD1593  [28]
 LDCM0390  CL12 HEK-293T C108(0.90); C90(0.95)  LDD1594  [28]
 LDCM0391  CL120 HEK-293T C108(0.91); C90(1.00)  LDD1595  [28]
 LDCM0392  CL121 HEK-293T C108(0.87); C90(0.96); C31(1.29)  LDD1596  [28]
 LDCM0393  CL122 HEK-293T C108(0.86); C90(0.88); C31(0.96)  LDD1597  [28]
 LDCM0394  CL123 HEK-293T C108(0.87); C90(0.89)  LDD1598  [28]
 LDCM0395  CL124 HEK-293T C108(0.90); C90(0.95)  LDD1599  [28]
 LDCM0396  CL125 HEK-293T C108(0.89); C90(0.97); C31(1.48)  LDD1600  [28]
 LDCM0397  CL126 HEK-293T C108(0.89); C90(0.90); C31(1.01)  LDD1601  [28]
 LDCM0398  CL127 HEK-293T C108(0.90); C90(0.97)  LDD1602  [28]
 LDCM0399  CL128 HEK-293T C108(0.90); C90(1.00)  LDD1603  [28]
 LDCM0400  CL13 HEK-293T C108(0.91); C90(0.98); C31(1.12)  LDD1604  [28]
 LDCM0401  CL14 HEK-293T C108(0.96); C90(0.92); C31(1.12)  LDD1605  [28]
 LDCM0402  CL15 HEK-293T C108(0.82); C90(0.82)  LDD1606  [28]
 LDCM0403  CL16 HEK-293T C108(0.99); C90(0.97)  LDD1607  [28]
 LDCM0404  CL17 HEK-293T C108(0.85); C90(0.72)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C108(0.93); C90(0.85); C31(0.97)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C108(0.90); C90(0.98); C31(1.06)  LDD1610  [28]
 LDCM0407  CL2 HEK-293T C108(0.87); C90(0.91); C31(0.99)  LDD1611  [28]
 LDCM0408  CL20 HEK-293T C108(1.03); C90(0.89); C31(1.06)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C108(0.83); C90(0.94); C31(0.81)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C108(0.84); C90(1.16)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C108(0.95); C90(0.96)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C108(0.90); C90(1.01)  LDD1616  [28]
 LDCM0413  CL25 HEK-293T C108(0.97); C90(1.02); C31(1.34)  LDD1617  [28]
 LDCM0414  CL26 HEK-293T C108(1.05); C90(0.93); C31(0.89)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C108(1.00); C90(1.00)  LDD1619  [28]
 LDCM0416  CL28 HEK-293T C108(0.99); C90(1.02)  LDD1620  [28]
 LDCM0417  CL29 HEK-293T C108(1.00); C90(0.88)  LDD1621  [28]
 LDCM0418  CL3 HEK-293T C108(0.84); C90(1.03)  LDD1622  [28]
 LDCM0419  CL30 HEK-293T C108(1.01); C90(1.00); C31(0.91)  LDD1623  [28]
 LDCM0420  CL31 HEK-293T C108(0.93); C90(1.04); C31(0.90)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C108(1.02); C90(1.07); C31(1.03)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C108(0.87); C90(1.03); C31(0.79)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C108(1.06); C90(0.98)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C108(1.04); C90(1.05)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C108(0.97); C90(0.98)  LDD1629  [28]
 LDCM0426  CL37 HEK-293T C108(1.01); C90(1.02); C31(1.16)  LDD1630  [28]
 LDCM0428  CL39 HEK-293T C108(1.02); C90(1.02)  LDD1632  [28]
 LDCM0429  CL4 HEK-293T C108(0.93); C90(0.89)  LDD1633  [28]
 LDCM0430  CL40 HEK-293T C108(1.02); C90(1.03)  LDD1634  [28]
 LDCM0431  CL41 HEK-293T C108(0.99); C90(0.92)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C108(1.05); C90(0.96); C31(0.85)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C108(1.07); C90(1.04); C31(0.86)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C108(0.99); C90(1.05); C31(0.98)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C108(0.94); C90(0.94); C31(0.84)  LDD1639  [28]
 LDCM0436  CL46 HEK-293T C108(0.90); C90(1.08)  LDD1640  [28]
 LDCM0437  CL47 HEK-293T C108(0.98); C90(0.96)  LDD1641  [28]
 LDCM0438  CL48 HEK-293T C108(1.02); C90(0.94)  LDD1642  [28]
 LDCM0439  CL49 HEK-293T C108(0.93); C90(1.01); C31(1.26)  LDD1643  [28]
 LDCM0440  CL5 HEK-293T C108(0.94); C90(0.88)  LDD1644  [28]
 LDCM0441  CL50 HEK-293T C108(0.90); C90(0.89); C31(1.11)  LDD1645  [28]
 LDCM0443  CL52 HEK-293T C108(0.93); C90(0.93)  LDD1646  [28]
 LDCM0444  CL53 HEK-293T C108(0.86); C90(0.82)  LDD1647  [28]
 LDCM0445  CL54 HEK-293T C108(0.85); C90(0.85); C31(0.87)  LDD1648  [28]
 LDCM0446  CL55 HEK-293T C108(0.99); C90(1.12); C31(1.11)  LDD1649  [28]
 LDCM0447  CL56 HEK-293T C108(1.03); C90(0.97); C31(1.18)  LDD1650  [28]
 LDCM0448  CL57 HEK-293T C108(0.77); C90(0.83); C31(0.81)  LDD1651  [28]
 LDCM0449  CL58 HEK-293T C108(0.84); C90(1.08)  LDD1652  [28]
 LDCM0450  CL59 HEK-293T C108(0.91); C90(0.96)  LDD1653  [28]
 LDCM0451  CL6 HEK-293T C108(0.88); C90(0.97); C31(0.82)  LDD1654  [28]
 LDCM0452  CL60 HEK-293T C108(0.87); C90(1.01)  LDD1655  [28]
 LDCM0453  CL61 HEK-293T C108(1.01); C90(1.00); C31(1.31)  LDD1656  [28]
 LDCM0454  CL62 HEK-293T C108(0.98); C90(0.96); C31(0.91)  LDD1657  [28]
 LDCM0455  CL63 HEK-293T C108(0.96); C90(1.04)  LDD1658  [28]
 LDCM0456  CL64 HEK-293T C108(0.89); C90(0.92)  LDD1659  [28]
 LDCM0457  CL65 HEK-293T C108(0.96); C90(1.10)  LDD1660  [28]
 LDCM0458  CL66 HEK-293T C108(0.94); C90(1.03); C31(1.01)  LDD1661  [28]
 LDCM0459  CL67 HEK-293T C108(0.95); C90(1.08); C31(1.06)  LDD1662  [28]
 LDCM0460  CL68 HEK-293T C108(1.11); C90(1.02); C31(1.36)  LDD1663  [28]
 LDCM0461  CL69 HEK-293T C108(0.92); C90(0.97); C31(0.92)  LDD1664  [28]
 LDCM0462  CL7 HEK-293T C108(0.84); C90(0.99); C31(0.85)  LDD1665  [28]
 LDCM0463  CL70 HEK-293T C108(0.84); C90(1.05)  LDD1666  [28]
 LDCM0464  CL71 HEK-293T C108(0.92); C90(0.99)  LDD1667  [28]
 LDCM0465  CL72 HEK-293T C108(0.92); C90(1.06)  LDD1668  [28]
 LDCM0466  CL73 HEK-293T C108(0.89); C90(0.96); C31(1.22)  LDD1669  [28]
 LDCM0467  CL74 HEK-293T C108(0.97); C90(0.95); C31(1.03)  LDD1670  [28]
 LDCM0469  CL76 HEK-293T C108(0.92); C90(0.93)  LDD1672  [28]
 LDCM0470  CL77 HEK-293T C108(0.90); C90(0.94)  LDD1673  [28]
 LDCM0471  CL78 HEK-293T C108(0.95); C90(1.08); C31(0.97)  LDD1674  [28]
 LDCM0472  CL79 HEK-293T C108(0.99); C90(1.10); C31(0.87)  LDD1675  [28]
 LDCM0473  CL8 HEK-293T C108(0.85); C90(0.83); C31(1.04)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C108(1.06); C90(1.09); C31(1.16)  LDD1677  [28]
 LDCM0475  CL81 HEK-293T C108(0.95); C90(0.98); C31(0.87)  LDD1678  [28]
 LDCM0476  CL82 HEK-293T C108(0.94); C90(1.08)  LDD1679  [28]
 LDCM0477  CL83 HEK-293T C108(0.98); C90(1.00)  LDD1680  [28]
 LDCM0478  CL84 HEK-293T C108(0.86); C90(0.94)  LDD1681  [28]
 LDCM0479  CL85 HEK-293T C108(0.96); C90(1.10); C31(1.38)  LDD1682  [28]
 LDCM0480  CL86 HEK-293T C108(0.94); C90(0.90); C31(1.02)  LDD1683  [28]
 LDCM0481  CL87 HEK-293T C108(0.91); C90(0.95)  LDD1684  [28]
 LDCM0482  CL88 HEK-293T C108(1.02); C90(0.92)  LDD1685  [28]
 LDCM0483  CL89 HEK-293T C108(0.97); C90(0.88)  LDD1686  [28]
 LDCM0484  CL9 HEK-293T C108(0.93); C90(0.95); C31(0.94)  LDD1687  [28]
 LDCM0485  CL90 HEK-293T C108(0.78); C90(0.83); C31(0.77)  LDD1688  [28]
 LDCM0486  CL91 HEK-293T C108(0.98); C90(0.97); C31(1.07)  LDD1689  [28]
 LDCM0487  CL92 HEK-293T C108(0.98); C90(0.95); C31(1.11)  LDD1690  [28]
 LDCM0488  CL93 HEK-293T C108(0.86); C90(0.86); C31(1.06)  LDD1691  [28]
 LDCM0489  CL94 HEK-293T C108(0.83); C90(1.11)  LDD1692  [28]
 LDCM0490  CL95 HEK-293T C108(0.79); C90(0.76)  LDD1693  [28]
 LDCM0491  CL96 HEK-293T C108(0.77); C90(0.97)  LDD1694  [28]
 LDCM0492  CL97 HEK-293T C108(0.85); C90(0.83); C31(0.88)  LDD1695  [28]
 LDCM0493  CL98 HEK-293T C108(0.81); C90(0.91); C31(0.91)  LDD1696  [28]
 LDCM0494  CL99 HEK-293T C108(0.85); C90(0.92)  LDD1697  [28]
 LDCM0495  E2913 HEK-293T C108(0.96); C90(0.99)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C31(1.90); C108(1.40)  LDD1702  [7]
 LDCM0468  Fragment33 HEK-293T C108(0.96); C90(1.04)  LDD1671  [28]
 LDCM0427  Fragment51 HEK-293T C108(1.07); C90(0.93); C31(1.06)  LDD1631  [28]
 LDCM0116  HHS-0101 DM93 Y540(0.13); Y665(0.53); Y249(1.15); Y226(1.90)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y665(0.47); Y249(0.92); Y237(1.82); Y226(2.16)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y540(0.13); Y665(0.48); Y237(1.32); Y249(1.78)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y249(0.72); Y665(0.86); Y528(1.71); Y237(2.16)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y540(0.10); Y665(0.28); Y528(1.03); Y249(1.62)  LDD0268  [9]
 LDCM0107  IAA HeLa C90(0.00); H58(0.00); C108(0.00); H56(0.00)  LDD0221  [22]
 LDCM0022  KB02 22RV1 C108(1.31); C31(0.92); C90(1.36)  LDD2243  [29]
 LDCM0023  KB03 MDA-MB-231 C108(4.23); C90(1.49)  LDD1701  [7]
 LDCM0024  KB05 COLO792 C108(1.24); C31(0.84); C90(1.29)  LDD3310  [29]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C108(0.79)  LDD2102  [7]
 LDCM0109  NEM HeLa H533(0.00); H58(0.00); H56(0.00); H642(0.00)  LDD0223  [22]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C108(0.90)  LDD2090  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C108(0.85)  LDD2101  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C108(1.17)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C108(1.23)  LDD2107  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C108(0.54)  LDD2115  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C108(0.77)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C108(1.05)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C108(1.27); C90(0.77)  LDD2125  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C108(0.70)  LDD2134  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C108(1.31)  LDD2136  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C108(2.87)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C108(0.75)  LDD2148  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C90(1.10)  LDD2206  [30]
 LDCM0014  Panhematin K562 3.37  LDD0063  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
RING finger protein 11 (RNF11) . Q9Y3C5

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.