Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0014
Competitor Name
Panhematin
Synonyms
hemin; Panhematin; Chlorohemin; 16009-13-5; hemin chloride; Ferriprotoporphyrin chloride; HEMIN [VANDF]; HEMIN [JAN]; HEMIN [WHO-DD]; HEMIN [MI]; 743LRP9S7N; BTIJJDXEELBZFS-UHFFFAOYSA-K; AKOS025146500; AKOS032949889; NSC-122707; Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-5-13)-; H0008; Q425165; Hemin chloride is known as an oxidized form of heme.; 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+);chloride; Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen; iron(3+) 4,20-bis(2-carboxyethyl)-9,14-diethenyl-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1(3),?.1?,(1)(1).1(1)(3),(1)?]tetracosa-1,3(24),6,8(23),9,11,13(22),14,16,18(21),19-undecaene-4,5-diide chloride
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski):
1		 Molecular Weight 651.9
Lipid-water partition coefficient Not Available
Rotatable Bond Count 8
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 9
Chemical Identifiers
Formula
C34H32ClFeN4O4
IUPAC Name
3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+);chloride
Canonical SMILES
CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O.[Cl-].[Fe+3]
InChI
InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3
InChIKey
BTIJJDXEELBZFS-UHFFFAOYSA-K

The Competitor Interaction Atlas

Probe(s) Related This Competitor

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
HPAP
 Probe Info  		25 uM Human normal cell lysate (HEK-293T) [1]

Target(s) List of this Competitor

165 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1) LDTP11012 3.04  LDD0062 
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) LDTP02356 3.06  LDD0064 
2'-5'-oligoadenylate synthase 2 (OAS2) LDTP03500 4.96  LDD0064 
2-5A-dependent ribonuclease (RNASEL) LDTP05464 3.43  LDD0063 
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT) LDTP01268 3.30  LDD0062 
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) LDTP06988 3.55  LDD0063 
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) LDTP04441 3.18  LDD0063 
26S proteasome regulatory subunit 10B (PSMC6) LDTP04987 3.31  LDD0064 
26S proteasome regulatory subunit 6B (PSMC4) LDTP04061 3.12  LDD0064 
3-oxoacyl-[acyl-carrier-protein] reductase (CBR4) LDTP08877 3.11  LDD0062 
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) LDTP04620 3.70  LDD0062 
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) LDTP04619 3.70  LDD0062 
Acyl-coenzyme A diphosphatase FITM2 (FITM2) LDTP08943 3.23  LDD0062 
Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9) LDTP16274 3.03  LDD0062 
Acylglycerol kinase, mitochondrial (AGK) LDTP06905 3.04  LDD0062 
Adenylate kinase 2, mitochondrial (AK2) LDTP04636 3.05  LDD0062 
Adipocyte plasma membrane-associated protein (APMAP) LDTP12293 3.07  LDD0062 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 3.06  LDD0062 
All-trans-retinol 13,14-reductase (RETSAT) LDTP15097 3.79  LDD0062 
Antigen peptide transporter 1 (TAP1) LDTP05408 3.37  LDD0064 
ATP-binding cassette sub-family D member 3 (ABCD3) LDTP03424 3.26  LDD0063 
ATP-dependent 6-phosphofructokinase, liver type (PFKL) LDTP02925 3.08  LDD0063 
Atypical kinase COQ8B, mitochondrial (COQ8B) LDTP10201 3.03  LDD0062 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 5.27  LDD0064 
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) LDTP05920 3.00  LDD0062 
Cancer-related nucleoside-triphosphatase (NTPCR) LDTP11152 3.56  LDD0062 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 3.14  LDD0062 
Cathepsin B (CTSB) LDTP02223 3.15  LDD0062 
Cell division cycle 7-related protein kinase (CDC7) LDTP00249 3.11  LDD0062 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 3.07  LDD0062 
Choline dehydrogenase, mitochondrial (CHDH) LDTP15505 3.13  LDD0062 
Cyclin-dependent kinase 1 (CDK1) LDTP02149 3.23  LDD0063 
Cyclin-dependent kinase 17 (CDK17) LDTP05247 3.11  LDD0062 
Cytochrome b5 (CYB5A) LDTP01763 3.15  LDD0062 
Cytochrome b5 type B (CYB5B) LDTP00697 3.16  LDD0062 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 3.26  LDD0064 
Cytochrome c oxidase subunit 6C (COX6C) LDTP02367 4.55  LDD0064 
Cytochrome c oxidase subunit NDUFA4 (NDUFA4) LDTP00293 3.08  LDD0064 
Dehydrogenase/reductase SDR family member 7 (DHRS7) LDTP13959 3.90  LDD0064 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 3.44  LDD0062 
Deoxycytidine kinase (DCK) LDTP03400 3.56  LDD0064 
Deubiquitinase DESI2 (DESI2) LDTP11174 3.18  LDD0062 
DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) LDTP19892 3.26  LDD0063 
Diacylglycerol kinase alpha (DGKA) LDTP03251 3.70  LDD0064 
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LDTP13087 6.85  LDD0063 
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) LDTP04103 3.48  LDD0062 
Dual specificity protein kinase TTK (TTK) LDTP03679 5.70  LDD0062 
Dual specificity protein phosphatase 9 (DUSP9) LDTP11016 3.60  LDD0063 
E3 ubiquitin-protein ligase makorin-2 (MKRN2) LDTP11676 4.04  LDD0063 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 3.21  LDD0064 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 3.26  LDD0063 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 3.20  LDD0062 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 3.27  LDD0062 
Ferrochelatase, mitochondrial (FECH) LDTP03198 3.22  LDD0062 
Flavin reductase (NADPH) (BLVRB) LDTP03511 3.41  LDD0063 
Folylpolyglutamate synthase, mitochondrial (FPGS) LDTP05468 3.27  LDD0062 
Glutaminase kidney isoform, mitochondrial (GLS) LDTP01465 3.13  LDD0064 
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (GFPT2) LDTP01423 3.31  LDD0062 
Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) LDTP09939 3.30  LDD0062 
Glutathione peroxidase 1 (GPX1) LDTP02184 3.33  LDD0064 
Glutathione S-transferase 3, mitochondrial (MGST3) LDTP00464 3.49  LDD0062 
Glycogen [starch] synthase, muscle (GYS1) LDTP02696 3.35  LDD0062 
GTPase IMAP family member 5 (GIMAP5) LDTP10291 3.25  LDD0064 
GTPase IMAP family member 8 (GIMAP8) LDTP15496 3.28  LDD0064 
Heme A synthase COX15 (COX15) LDTP07931 3.14  LDD0062 
Heme oxygenase 1 (HMOX1) LDTP02359 3.37  LDD0062 
Heme oxygenase 2 (HMOX2) LDTP03540 3.37  LDD0062 
Histone deacetylase 1 (HDAC1) LDTP05918 3.07  LDD0063 
Holocytochrome c-type synthase (HCCS) LDTP04581 3.35  LDD0062 
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) LDTP03794 3.33  LDD0063 
Hydroxysteroid dehydrogenase-like protein 2 (HSDL2) LDTP07762 3.41  LDD0062 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 3.41  LDD0062 
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) LDTP00538 3.00  LDD0064 
Interleukin-1 receptor-associated kinase 1 (IRAK1) LDTP04435 3.43  LDD0062 
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (IDH3B) LDTP00885 3.42  LDD0062 
L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) LDTP12105 3.43  LDD0062 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 3.16  LDD0062 
Legumain (LGMN) LDTP10888 3.45  LDD0062 
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) LDTP03662 3.27  LDD0063 
Lysine--tRNA ligase (KARS1) LDTP06294 3.67  LDD0063 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 3.45  LDD0062 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 3.02  LDD0062 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 3.32  LDD0063 
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) LDTP02565 3.03  LDD0062 
Methylated-DNA--protein-cysteine methyltransferase (MGMT) LDTP02852 3.30  LDD0064 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 3.07  LDD0063 
Minor histocompatibility antigen H13 (HM13) LDTP09396 3.29  LDD0064 
Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) LDTP06810 4.65  LDD0062 
Mitochondrial Rho GTPase 2 (RHOT2) LDTP08596 3.14  LDD0064 
Mitochondrial tRNA methylthiotransferase CDK5RAP1 (CDK5RAP1) LDTP10829 3.12  LDD0062 
NADH-cytochrome b5 reductase 1 (CYB5R1) LDTP13303 3.12  LDD0064 
Neutral cholesterol ester hydrolase 1 (NCEH1) LDTP07591 3.55  LDD0062 
Nitric oxide synthase-interacting protein (NOSIP) LDTP13940 3.29  LDD0063 
Non-receptor tyrosine-protein kinase TYK2 (TYK2) LDTP03497 3.23  LDD0063 
ORC ubiquitin ligase 1 (OBI1) LDTP07266 3.82  LDD0062 
OTU domain-containing protein 4 (OTUD4) LDTP05313 3.59  LDD0062 
Oxidoreductase HTATIP2 (HTATIP2) LDTP11247 3.21  LDD0064 
Patatin-like phospholipase domain-containing protein 2 (PNPLA2) LDTP10077 3.67  LDD0062 
Peroxiredoxin-6 (PRDX6) LDTP03510 3.70  LDD0062 
Phosphatidate cytidylyltransferase 2 (CDS2) LDTP01649 3.28  LDD0064 
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) LDTP12608 3.26  LDD0064 
Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) LDTP05623 3.29  LDD0062 
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) LDTP02380 3.74  LDD0064 
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) LDTP02936 3.60  LDD0064 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 3.00  LDD0063 
Probable helicase with zinc finger domain (HELZ) LDTP03993 3.36  LDD0062 
Probable hydrolase PNKD (PNKD) LDTP08858 3.21  LDD0064 
Probable N-acetyltransferase 14 (NAT14) LDTP18083 3.55  LDD0062 
Probable proline--tRNA ligase, mitochondrial (PARS2) LDTP15217 3.59  LDD0062 
Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 3.45  LDD0062 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 4.88  LDD0063 
Prostaglandin G/H synthase 1 (PTGS1) LDTP03210 4.47  LDD0063 
Proteasome subunit alpha type-1 (PSMA1) LDTP03330 3.22  LDD0063 
Protein disulfide-isomerase TMX3 (TMX3) LDTP10471 3.15  LDD0064 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 4.16  LDD0062 
Protoporphyrinogen oxidase (PPOX) LDTP04353 3.67  LDD0062 
Putative GTP-binding protein 6 (GTPBP6) LDTP16798 3.19  LDD0063 
Pyruvate kinase PKLR (PKLR) LDTP03552 3.38  LDD0063 
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (RSAD1) LDTP16027 3.89  LDD0062 
Ras-related protein Rab-10 (RAB10) LDTP04895 3.05  LDD0064 
Ras-related protein Rab-11A (RAB11A) LDTP04992 3.70  LDD0062 
Ras-related protein Rab-14 (RAB14) LDTP04901 3.65  LDD0064 
Ras-related protein Rab-18 (RAB18) LDTP12312 4.32  LDD0064 
Ras-related protein Rab-24 (RAB24) LDTP10020 3.09  LDD0063 
Ras-related protein Rab-27A (RAB27A) LDTP04403 3.01  LDD0063 
Ras-related protein Rab-27B (RAB27B) LDTP00210 3.07  LDD0064 
Ras-related protein Rab-2A (RAB2A) LDTP04892 3.72  LDD0062 
Ras-related protein Rab-32 (RAB32) LDTP05958 3.19  LDD0064 
Ras-related protein Rab-5C (RAB5C) LDTP04398 3.36  LDD0064 
Ras-related protein Rab-6B (RAB6B) LDTP12538 3.32  LDD0063 
Retinol dehydrogenase 10 (RDH10) LDTP08722 3.32  LDD0063 
Retinol dehydrogenase 11 (RDH11) LDTP09364 4.18  LDD0063 
Retinol dehydrogenase 13 (RDH13) LDTP09061 3.37  LDD0063 
RNA ligase 1 (RLIG1) LDTP19750 3.09  LDD0062 
S-phase kinase-associated protein 2 (SKP2) LDTP05820 4.41  LDD0062 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 3.58  LDD0064 
Schlafen family member 5 (SLFN5) LDTP17014 3.36  LDD0064 
Sentrin-specific protease 1 (SENP1) LDTP12983 4.35  LDD0062 
Serine/threonine-protein kinase A-Raf (ARAF) LDTP02493 3.07  LDD0062 
Serine/threonine-protein kinase SIK2 (SIK2) LDTP11716 4.39  LDD0062 
Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C) LDTP00333 3.67  LDD0062 
Sestrin-2 (SESN2) LDTP04806 3.52  LDD0063 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 4.30  LDD0062 
Signal recognition particle subunit SRP54 (SRP54) LDTP04890 3.13  LDD0063 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 4.36  LDD0062 
Squalene monooxygenase (SQLE) LDTP06142 4.42  LDD0062 
Squalene synthase (FDFT1) LDTP03842 3.13  LDD0063 
STE20/SPS1-related proline-alanine-rich protein kinase (STK39) LDTP13203 4.44  LDD0062 
Stearoyl-CoA desaturase (SCD) LDTP00344 4.05  LDD0062 
Stearoyl-CoA desaturase 5 (SCD5) LDTP08171 4.06  LDD0062 
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) LDTP06455 3.56  LDD0062 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 4.24  LDD0062 
Thiol S-methyltransferase TMT1B (TMT1B) LDTP15155 3.48  LDD0062 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 5.18  LDD0062 
TNF receptor-associated factor 4 (TRAF4) LDTP11258 3.03  LDD0063 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 5.46  LDD0062 
Tubulin alpha-4A chain (TUBA4A) LDTP05075 5.71  LDD0062 
Tubulin alpha-8 chain (TUBA8) LDTP12810 3.04  LDD0064 
Tumor susceptibility gene 101 protein (TSG101) LDTP10987 3.15  LDD0063 
Ubiquitin carboxyl-terminal hydrolase 10 (USP10) LDTP06190 3.20  LDD0063 
Ubiquitin carboxyl-terminal hydrolase 22 (USP22) LDTP13719 5.91  LDD0062 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 3.41  LDD0062 
Vitamin K epoxide reductase complex subunit 1 (VKORC1) LDTP11070 3.85  LDD0064 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 3.01  LDD0063 
Xyloside xylosyltransferase 1 (XXYLT1) LDTP09053 6.71  LDD0062 
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⏷ Show the Full List of 165 Enzyme
65 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Apoptotic protease-activating factor 1 (APAF1) LDTP00411 3.59  LDD0064 
ATP-binding cassette sub-family F member 2 (ABCF2) LDTP18526 3.02  LDD0062 
ATP-binding cassette sub-family F member 3 (ABCF3) LDTP16103 3.25  LDD0063 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 3.78  LDD0064 
Calcium load-activated calcium channel (TMCO1) LDTP13599 3.17  LDD0063 
Cation-dependent mannose-6-phosphate receptor (M6PR) LDTP03061 3.83  LDD0064 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 3.13  LDD0063 
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) LDTP03064 3.96  LDD0064 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 3.31  LDD0064 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 3.14  LDD0062 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 3.83  LDD0062 
Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) LDTP12331 3.86  LDD0063 
Etoposide-induced protein 2.4 homolog (EI24) LDTP00405 3.44  LDD0063 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 3.32  LDD0062 
Integrin beta-1 (ITGB1) LDTP02122 3.19  LDD0064 
Interferon-induced transmembrane protein 2 (IFITM2) LDTP05303 4.17  LDD0063 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 3.50  LDD0064 
Lysosome membrane protein 2 (SCARB2) LDTP06034 4.04  LDD0062 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 3.59  LDD0062 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 3.61  LDD0062 
MICOS complex subunit MIC26 (APOO) LDTP11250 3.07  LDD0062 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 3.53  LDD0063 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 3.05  LDD0064 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 3.54  LDD0062 
Mitochondrial import receptor subunit TOM40 homolog (TOMM40) LDTP01748 5.40  LDD0062 
Mitochondrial pyruvate carrier 2 (MPC2) LDTP01631 3.25  LDD0063 
Nuclear pore complex protein Nup88 (NUP88) LDTP10897 3.57  LDD0062 
Nuclear pore membrane glycoprotein 210 (NUP210) LDTP09502 3.57  LDD0062 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 3.01  LDD0063 
Platelet glycoprotein 4 (CD36) LDTP02863 3.10  LDD0064 
PRA1 family protein 2 (PRAF2) LDTP01060 3.67  LDD0062 
PRA1 family protein 3 (ARL6IP5) LDTP01352 3.08  LDD0062 
Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40) LDTP18053 4.18  LDD0063 
Prohibitin 1 (PHB1) LDTP03717 3.72  LDD0064 
Protein RER1 (RER1) LDTP00590 3.60  LDD0064 
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) LDTP04932 4.33  LDD0062 
Reticulon-1 (RTN1) LDTP06633 5.14  LDD0064 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 4.01  LDD0062 
Secretory carrier-associated membrane protein 3 (SCAMP3) LDTP00451 4.02  LDD0062 
Sideroflexin-1 (SFXN1) LDTP12090 4.36  LDD0062 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 5.03  LDD0062 
Sodium channel modifier 1 (SCNM1) LDTP11325 4.11  LDD0062 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 2.99  LDD0063 
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD) LDTP00358 4.28  LDD0062 
THO complex subunit 6 homolog (THOC6) LDTP08315 4.64  LDD0062 
Translocation protein SEC62 (SEC62) LDTP15838 4.33  LDD0062 
Translocator protein (TSPO) LDTP03546 5.57  LDD0062 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 4.42  LDD0062 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 3.02  LDD0063 
Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1) LDTP11301 5.17  LDD0062 
Transmembrane emp24 domain-containing protein 1 (TMED1) LDTP05875 4.68  LDD0062 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 3.16  LDD0063 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 3.87  LDD0064 
Transmembrane emp24 domain-containing protein 9 (TMED9) LDTP11291 5.03  LDD0063 
Transmembrane protein 126A (TMEM126A) LDTP15948 4.79  LDD0062 
Transmembrane protein 14C (TMEM14C) LDTP12979 3.77  LDD0063 
Transmembrane protein 164 (TMEM164) LDTP17258 3.04  LDD0063 
Transmembrane protein 201 (TMEM201) LDTP07058 4.89  LDD0062 
Transmembrane protein 214 (TMEM214) LDTP07477 4.99  LDD0062 
Tubulin beta-1 chain (TUBB1) LDTP11916 3.23  LDD0064 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 6.13  LDD0062 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 6.44  LDD0062 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 6.51  LDD0062 
Voltage-gated monoatomic cation channel TMEM109 (TMEM109) LDTP11281 4.70  LDD0062 
Zinc transporter SLC39A7 (SLC39A7) LDTP09769 3.83  LDD0063 
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⏷ Show the Full List of 65 Transporter and channel
20 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
DNA methyltransferase 1-associated protein 1 (DMAP1) LDTP12355 3.23  LDD0063 
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 3.20  LDD0062 
ETS domain-containing transcription factor ERF (ERF) LDTP04370 3.20  LDD0062 
Forkhead box protein C1 (FOXC1) LDTP05702 3.23  LDD0062 
Forkhead box protein D3 (FOXD3) LDTP13398 3.24  LDD0062 
Forkhead box protein G1 (FOXG1) LDTP04700 3.24  LDD0062 
Homeobox protein Hox-B6 (HOXB6) LDTP02901 3.38  LDD0062 
Homeobox protein Hox-B9 (HOXB9) LDTP02899 3.81  LDD0063 
Homeobox protein Hox-C9 (HOXC9) LDTP03586 3.39  LDD0062 
Motor neuron and pancreas homeobox protein 1 (MNX1) LDTP04346 3.51  LDD0062 
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) LDTP01645 3.56  LDD0062 
Pituitary homeobox 1 (PITX1) LDTP05097 3.63  LDD0062 
Pituitary homeobox 2 (PITX2) LDTP10945 3.63  LDD0062 
Sal-like protein 2 (SALL2) LDTP14024 3.94  LDD0062 
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) LDTP12989 3.45  LDD0063 
Transcription factor 12 (TCF12) LDTP10852 3.69  LDD0063 
Transcription factor 7 (TCF7) LDTP03804 4.04  LDD0064 
Vacuolar protein sorting-associated protein 72 homolog (VPS72) LDTP06500 6.55  LDD0062 
Zinc finger protein 217 (ZNF217) LDTP01191 7.02  LDD0062 
Zinc finger protein ZFPM1 (ZFPM1) LDTP08582 3.09  LDD0063 
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⏷ Show the Full List of 20 Transcription factor
1 Immunoglobulin Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Leukocyte surface antigen CD47 (CD47) LDTP05572 3.09  LDD0064 
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118 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
A-kinase anchor protein 8 (AKAP8) LDTP00880 3.06  LDD0062 
A-kinase anchor protein 8-like (AKAP8L) LDTP13591 3.06  LDD0062 
Actin-related protein 2 (ACTR2) LDTP04903 3.03  LDD0062 
BAG family molecular chaperone regulator 4 (BAG4) LDTP01600 6.53  LDD0063 
BCL-6 corepressor (BCOR) LDTP07738 3.08  LDD0062 
BET1 homolog (BET1) LDTP00555 3.08  LDD0062 
BRCA1-associated ATM activator 1 (BRAT1) LDTP07598 3.54  LDD0063 
CCR4-NOT transcription complex subunit 2 (CNOT2) LDTP12925 3.14  LDD0062 
CDGSH iron-sulfur domain-containing protein 3, mitochondrial (CISD3) LDTP02398 3.14  LDD0062 
Centrosomal protein of 85 kDa (CEP85) LDTP07522 3.12  LDD0062 
Chromatin remodeling regulator CECR2 (CECR2) LDTP11373 3.12  LDD0062 
Chromosome transmission fidelity protein 18 homolog (CHTF18) LDTP09603 3.13  LDD0062 
CREB-regulated transcription coactivator 2 (CRTC2) LDTP06884 3.15  LDD0062 
DDB1- and CUL4-associated factor 16 (DCAF16) LDTP16129 3.17  LDD0062 
DENN domain-containing protein 2D (DENND2D) LDTP18400 4.43  LDD0064 
DISP complex protein LRCH3 (LRCH3) LDTP10417 3.46  LDD0062 
DnaJ homolog subfamily A member 2 (DNAJA2) LDTP01073 3.19  LDD0062 
DnaJ homolog subfamily C member 5 (DNAJC5) LDTP11894 3.20  LDD0062 
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) LDTP01677 3.30  LDD0063 
Double-stranded RNA-binding protein Staufen homolog 2 (STAU2) LDTP12631 3.15  LDD0063 
Dynactin subunit 4 (DCTN4) LDTP13402 3.17  LDD0062 
Far upstream element-binding protein 3 (FUBP3) LDTP10408 4.49  LDD0063 
Formin-like protein 1 (FMNL1) LDTP01611 3.15  LDD0064 
G patch domain-containing protein 8 (GPATCH8) LDTP16223 3.32  LDD0062 
Genetic suppressor element 1 (GSE1) LDTP06184 3.33  LDD0062 
Guanine nucleotide exchange factor for Rab-3A (RAB3IL1) LDTP09353 4.41  LDD0063 
Heat shock protein beta-1 (HSPB1) LDTP02053 4.61  LDD0063 
Heme-binding protein 1 (HEBP1) LDTP16078 3.35  LDD0062 
Hemoglobin subunit epsilon (HBE1) LDTP01922 3.00  LDD0063 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 3.56  LDD0063 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 3.74  LDD0063 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 3.77  LDD0063 
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) LDTP04500 3.37  LDD0062 
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) LDTP11238 3.53  LDD0063 
Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) LDTP17065 3.14  LDD0063 
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) LDTP03526 3.99  LDD0064 
Hippocalcin-like protein 1 (HPCAL1) LDTP03841 3.90  LDD0063 
Hippocalcin-like protein 4 (HPCAL4) LDTP13604 3.39  LDD0062 
KH domain-containing RNA-binding protein QKI (QKI) LDTP10700 4.45  LDD0063 
Lamin-B1 (LMNB1) LDTP03065 4.23  LDD0063 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 5.05  LDD0062 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 5.10  LDD0062 
Large proline-rich protein BAG6 (BAG6) LDTP04094 3.09  LDD0063 
Large ribosomal subunit protein mL37 (MRPL37) LDTP15922 3.51  LDD0062 
Large ribosomal subunit protein mL38 (MRPL38) LDTP10232 3.20  LDD0063 
Leucine zipper putative tumor suppressor 2 (LZTS2) LDTP11115 3.46  LDD0062 
Malectin (MLEC) LDTP06066 3.50  LDD0062 
Melanoma-associated antigen D1 (MAGED1) LDTP14165 3.47  LDD0062 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 3.10  LDD0062 
MMS19 nucleotide excision repair protein homolog (MMS19) LDTP10843 3.17  LDD0063 
mRNA decay activator protein ZFP36L2 (ZFP36L2) LDTP04143 6.89  LDD0062 
Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) LDTP13323 5.53  LDD0062 
Neudesin (NENF) LDTP13630 3.56  LDD0062 
Pentatricopeptide repeat-containing protein 1, mitochondrial (PTCD1) LDTP01130 3.70  LDD0062 
Perilipin-3 (PLIN3) LDTP01021 3.65  LDD0062 
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) LDTP12155 3.02  LDD0063 
Pleckstrin homology-like domain family B member 3 (PHLDB3) LDTP17355 3.62  LDD0062 
Pre-mRNA-splicing factor RBM22 (RBM22) LDTP12706 3.65  LDD0063 
Protein FAM83A (FAM83A) LDTP08264 3.23  LDD0063 
Protein Hook homolog 2 (HOOK2) LDTP10255 3.38  LDD0062 
Protein salvador homolog 1 (SAV1) LDTP11915 3.95  LDD0062 
Protein THEM6 (THEM6) LDTP19831 4.51  LDD0062 
Protein transport protein Sec16A (SEC16A) LDTP00512 4.32  LDD0062 
RAS guanyl-releasing protein 2 (RASGRP2) LDTP07986 4.00  LDD0064 
RAS protein activator like-3 (RASAL3) LDTP08418 6.67  LDD0064 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 3.79  LDD0062 
Refilin-B (RFLNB) LDTP17721 3.21  LDD0062 
Regulator of microtubule dynamics protein 3 (RMDN3) LDTP10849 3.22  LDD0062 
Reticulon-3 (RTN3) LDTP01522 3.94  LDD0062 
Reticulon-4 (RTN4) LDTP12412 5.72  LDD0064 
Ribonucleoprotein PTB-binding 2 (RAVER2) LDTP18440 3.74  LDD0062 
RNA-binding motif, single-stranded-interacting protein 1 (RBMS1) LDTP03495 3.76  LDD0062 
RNA-binding motif, single-stranded-interacting protein 2 (RBMS2) LDTP17046 3.77  LDD0062 
RNA-binding protein 14 (RBM14) LDTP10684 3.37  LDD0063 
RNA-binding protein 4 (RBM4) LDTP11324 3.75  LDD0062 
RNA-binding protein 47 (RBM47) LDTP00009 5.15  LDD0063 
RNA-binding protein 4B (RBM4B) LDTP11046 3.75  LDD0062 
RNA-binding protein Musashi homolog 1 (MSI1) LDTP14453 3.52  LDD0062 
RNA-binding protein Musashi homolog 2 (MSI2) LDTP10216 3.53  LDD0062 
RUS family member 1 (RUSF1) LDTP10357 3.10  LDD0062 
Selenocysteine insertion sequence-binding protein 2 (SECISBP2) LDTP10830 4.34  LDD0062 
SH2 domain-containing adapter protein B (SHB) LDTP06394 4.38  LDD0062 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 4.16  LDD0064 
Small integral membrane protein 12 (SMIM12) LDTP19859 3.10  LDD0062 
Small ribosomal subunit protein eS10 (RPS10) LDTP04111 3.43  LDD0063 
Small ribosomal subunit protein eS27 (RPS27) LDTP03987 3.87  LDD0062 
Small ribosomal subunit protein mS26 (MRPS26) LDTP15918 3.52  LDD0062 
Small ribosomal subunit protein mS29 (DAP3) LDTP04412 3.17  LDD0062 
Small ribosomal subunit protein uS13 (RPS18) LDTP04972 3.83  LDD0064 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 3.85  LDD0062 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 4.19  LDD0063 
SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP) LDTP11645 3.44  LDD0063 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 3.33  LDD0064 
SUMO-interacting motif-containing protein 1 (SIMC1) LDTP09142 4.41  LDD0062 
SURP and G-patch domain-containing protein 1 (SUGP1) LDTP08577 4.49  LDD0062 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 5.18  LDD0062 
TNFAIP3-interacting protein 1 (TNIP1) LDTP06284 5.28  LDD0062 
Torsin-4A (TOR4A) LDTP18484 4.32  LDD0064 
TraB domain-containing protein (TRABD) LDTP19963 5.52  LDD0062 
Trafficking protein particle complex subunit 3 (TRAPPC3) LDTP00822 4.31  LDD0063 
Transmembrane protein 11, mitochondrial (TMEM11) LDTP02887 4.75  LDD0062 
Transmembrane protein 161A (TMEM161A) LDTP12762 4.86  LDD0062 
Transmembrane protein 40 (TMEM40) LDTP18098 3.07  LDD0064 
Tubulin beta chain (TUBB) LDTP02205 5.79  LDD0062 
Tubulin beta-2A chain (TUBB2A) LDTP05998 3.38  LDD0063 
Tubulin beta-4A chain (TUBB4A) LDTP02037 5.81  LDD0062 
Tubulin beta-6 chain (TUBB6) LDTP11233 5.86  LDD0062 
Type-1 angiotensin II receptor-associated protein (AGTRAP) LDTP07632 3.04  LDD0062 
U2 small nuclear ribonucleoprotein A' (SNRPA1) LDTP02365 3.17  LDD0063 
Uncharacterized protein C15orf39 (C15orf39) LDTP17481 3.09  LDD0062 
Vesicle-trafficking protein SEC22b (SEC22B) LDTP01206 3.11  LDD0064 
YTH domain-containing family protein 1 (YTHDF1) LDTP11466 3.51  LDD0063 
YTH domain-containing family protein 2 (YTHDF2) LDTP14105 4.01  LDD0063 
Zinc finger HIT domain-containing protein 2 (ZNHIT2) LDTP16202 10.69  LDD0062 
Zinc finger protein 318 (ZNF318) LDTP07223 8.15  LDD0062 
Zinc finger protein 503 (ZNF503) LDTP10295 8.68  LDD0062 
Zinc finger protein 609 (ZNF609) LDTP00507 9.45  LDD0062 
Zinc finger protein 703 (ZNF703) LDTP12033 9.98  LDD0062 
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⏷ Show the Full List of 118 Other

Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 25 uM
Quantitative Method TMT
Competitor Name Panhematin
Competitor Concentration 100 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (HEK-293T)
Interaction Atlas ID  LDD0062  Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 25 uM
Quantitative Method TMT
Competitor Name Panhematin
Competitor Concentration 100 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cell lysate (K562)
Interaction Atlas ID  LDD0063  Download The Altas
  
Experiment 3 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 25 uM
Quantitative Method TMT
Competitor Name Panhematin
Competitor Concentration 100 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (hPBMC)
Interaction Atlas ID  LDD0064  Download The Altas

References

1 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651