Details of the Target

General Information of Target

Target ID LDTP06394
Target Name SH2 domain-containing adapter protein B (SHB)
Gene Name SHB
Gene ID 6461
Synonyms
SH2 domain-containing adapter protein B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATA
SCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGE
PGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYIS
PKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKV
TIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTP
YEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKR
QSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDA
ENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPE
VIHYYTTRKLPIKGAEHLSLLYPVAVRTL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Uniprot ID
Q15464
Ensemble ID
ENST00000377707.4
HGNC ID
HGNC:10838

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.R425Ter .
EFO27 Insertion: p.Q42PfsTer204 .
IPC298 SNV: p.P503L .
JHH4 SNV: p.N357K .
LN229 SNV: p.F250L .
MCC13 SNV: p.P364S DBIA    Probe Info 
MCC26 SNV: p.S38L DBIA    Probe Info 
MEC1 SNV: p.R111L .
MFE319 Insertion: p.Q42PfsTer204 .
NCIH716 SNV: p.Y268Ter .
SHP77 SNV: p.S362Ter .
SNU1 SNV: p.C110Y .
SW756 SNV: p.P401S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y272(5.83)  LDD3495  [2]
HPAP
 Probe Info  		4.38  LDD0062  [3]
DBIA
 Probe Info  		C215(0.95); C204(0.94)  LDD0078  [4]
IA-alkyne
 Probe Info  		C224(0.00); C115(0.00)  LDD0165  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
IPM
 Probe Info  		N.A.  LDD0147  [7]
VSF
 Probe Info  		C204(0.00); C224(0.00)  LDD0007  [8]
Phosphinate-6
 Probe Info  		C215(0.00); C224(0.00); C204(0.00)  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C224(2.65)  LDD0372  [11]
 LDCM0214  AC1 HCT 116 C115(0.95); C215(0.86)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C115(0.97); C215(1.01)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C215(0.67)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C215(0.68)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C215(0.69)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C215(0.95)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C215(0.74)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C215(0.91)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C215(1.01)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C215(0.91)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C215(0.70)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C215(0.71)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C115(0.99); C215(1.02)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C215(0.68)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C215(0.70)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C215(0.82)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C215(1.18)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C215(1.28)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C215(1.16)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C215(1.45)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C215(1.17)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C215(1.08)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C215(1.47)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C115(1.02); C215(0.88)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C215(1.12)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C215(1.13)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C215(1.15)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C215(1.08)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C215(0.98)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C215(1.15)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C215(1.33)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C215(1.38)  LDD0562  [4]
 LDCM0259  AC14 HCT 116 C115(0.92); C215(0.81)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C115(1.03); C215(1.17)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C115(0.87); C215(1.24)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C115(1.01); C215(1.02)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C115(0.94); C215(1.31)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C115(0.82); C215(1.33)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C115(0.97); C215(1.56)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C115(1.06); C215(1.28)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C215(0.84); C115(0.86)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C115(0.91); C215(1.01)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C115(0.88); C215(1.06)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C115(1.07); C215(1.33)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C115(1.10); C215(1.82)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C115(0.99); C215(1.41)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C115(1.03); C215(1.40)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C115(1.13); C215(1.23)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C115(1.14); C215(1.18)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C224(1.09)  LDD1515  [12]
 LDCM0278  AC19 HEK-293T C224(1.49)  LDD1517  [12]
 LDCM0279  AC2 HCT 116 C215(0.82); C115(0.89)  LDD0596  [4]
 LDCM0281  AC21 HEK-293T C215(1.01)  LDD1520  [12]
 LDCM0283  AC23 HEK-293T C224(1.04); C215(0.99)  LDD1522  [12]
 LDCM0285  AC25 HEK-293T C224(0.91)  LDD1524  [12]
 LDCM0287  AC27 HEK-293T C224(1.09)  LDD1526  [12]
 LDCM0289  AC29 HEK-293T C215(1.00)  LDD1528  [12]
 LDCM0290  AC3 HCT 116 C215(0.77); C115(1.12)  LDD0607  [4]
 LDCM0292  AC31 HEK-293T C224(1.10); C215(0.97)  LDD1531  [12]
 LDCM0294  AC33 HEK-293T C224(0.87)  LDD1533  [12]
 LDCM0296  AC35 HEK-293T C224(1.00)  LDD1535  [12]
 LDCM0298  AC37 HEK-293T C215(1.00)  LDD1537  [12]
 LDCM0300  AC39 HEK-293T C224(0.96); C215(1.07)  LDD1539  [12]
 LDCM0301  AC4 HCT 116 C215(0.79); C115(0.97)  LDD0618  [4]
 LDCM0303  AC41 HEK-293T C224(0.89)  LDD1542  [12]
 LDCM0305  AC43 HEK-293T C224(0.91)  LDD1544  [12]
 LDCM0307  AC45 HEK-293T C215(1.01)  LDD1546  [12]
 LDCM0308  AC46 HCT 116 C115(1.18)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C115(1.05)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C115(1.21)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C115(1.07)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C215(0.78); C115(1.04)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C115(1.12)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C115(1.17)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C115(1.02)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C115(0.95)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C115(1.01)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C115(1.08)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C115(1.10)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C215(1.27)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C215(1.18)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C215(1.37)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C215(0.94); C115(1.09)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C215(1.39)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C215(1.16)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C215(1.19)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C215(1.17)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C215(1.32)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C215(0.50)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C215(0.50)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C215(0.48)  LDD0648  [4]
 LDCM0334  AC7 HCT 116 C215(0.79); C115(1.16)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C215(0.83); C115(1.14)  LDD0662  [4]
 LDCM0349  AC83 HCT 116 C215(1.60); C115(1.62)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C215(1.35); C115(1.35)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C215(1.01); C115(1.04)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C115(1.16); C215(1.40)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C215(0.92); C115(1.22)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C115(1.39); C215(1.69)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C115(1.24); C215(2.09)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C215(0.67); C115(0.80)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C115(1.76); C215(2.86)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C215(1.91); C115(2.09)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C215(1.29); C115(1.68)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C115(1.28); C215(1.48)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C115(1.21); C215(1.52)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C115(1.39); C215(1.73)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C115(1.33); C215(2.53)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C215(1.61)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C215(0.81)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C115(0.88); C215(0.91)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C215(0.94); C115(1.33)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C115(0.87); C215(0.88)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 9.94  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C215(0.95); C204(0.94)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C224(20.00); C224(0.75)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C215(0.93)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C215(0.99)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C115(0.80); C215(0.98)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C215(0.77); C115(1.11)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C215(0.77); C115(1.16)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C215(0.82); C115(1.24)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C215(0.88); C115(1.10)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C224(0.99)  LDD1578  [12]
 LDCM0376  CL107 HEK-293T C224(1.07)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C224(0.92)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C224(1.16)  LDD1582  [12]
 LDCM0379  CL11 HCT 116 C215(0.96)  LDD0696  [4]
 LDCM0381  CL111 HEK-293T C224(1.06)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C224(1.05)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C224(1.27)  LDD1587  [12]
 LDCM0385  CL115 HEK-293T C224(0.92)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C224(1.01)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C224(1.05)  LDD1591  [12]
 LDCM0389  CL119 HEK-293T C224(0.83)  LDD1593  [12]
 LDCM0390  CL12 HCT 116 C215(1.20)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C224(1.10)  LDD1595  [12]
 LDCM0392  CL121 HCT 116 C115(0.94)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C115(1.12)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C115(1.05)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C115(1.13)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C215(1.04)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C215(0.97)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C215(0.89)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C215(1.41)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C215(1.08)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C215(1.03)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C215(0.91)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C224(1.16)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C224(0.97)  LDD1608  [12]
 LDCM0406  CL19 HEK-293T C224(0.99)  LDD1610  [12]
 LDCM0407  CL2 HCT 116 C215(1.03)  LDD0724  [4]
 LDCM0409  CL21 HEK-293T C215(1.18)  LDD1613  [12]
 LDCM0411  CL23 HEK-293T C224(1.45); C215(1.14)  LDD1615  [12]
 LDCM0413  CL25 HEK-293T C224(1.01)  LDD1617  [12]
 LDCM0415  CL27 HEK-293T C224(1.42)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C224(1.09)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C224(0.89)  LDD1621  [12]
 LDCM0418  CL3 HCT 116 C215(1.03)  LDD0735  [4]
 LDCM0420  CL31 HEK-293T C224(1.19)  LDD1624  [12]
 LDCM0422  CL33 HEK-293T C215(1.02)  LDD1626  [12]
 LDCM0424  CL35 HEK-293T C224(1.88); C215(0.99)  LDD1628  [12]
 LDCM0426  CL37 HEK-293T C224(1.31)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C224(1.19)  LDD1632  [12]
 LDCM0429  CL4 HCT 116 C215(1.01)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C224(1.07)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C224(0.99)  LDD1635  [12]
 LDCM0433  CL43 HEK-293T C224(1.00)  LDD1637  [12]
 LDCM0435  CL45 HEK-293T C215(1.01)  LDD1639  [12]
 LDCM0437  CL47 HEK-293T C224(1.48); C215(1.06)  LDD1641  [12]
 LDCM0439  CL49 HEK-293T C224(1.05)  LDD1643  [12]
 LDCM0440  CL5 HCT 116 C215(0.98)  LDD0757  [4]
 LDCM0443  CL52 HEK-293T C224(1.13)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C224(1.06)  LDD1647  [12]
 LDCM0446  CL55 HEK-293T C224(1.11)  LDD1649  [12]
 LDCM0448  CL57 HEK-293T C215(1.16)  LDD1651  [12]
 LDCM0450  CL59 HEK-293T C224(1.45); C215(1.15)  LDD1653  [12]
 LDCM0451  CL6 HCT 116 C215(1.14)  LDD0768  [4]
 LDCM0453  CL61 HCT 116 C115(1.11); C215(1.12)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C115(1.32); C215(1.03)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C115(1.06); C215(1.20)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C115(1.07); C215(1.26)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C115(1.13); C215(1.20)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C115(1.18); C215(1.19)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C115(1.40); C215(0.91)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C115(1.38); C215(0.81)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C115(1.32); C215(1.04)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C215(1.03)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C115(1.11); C215(1.03)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C115(1.06); C215(1.02)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C115(1.24); C215(0.99)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C115(1.18); C215(0.90)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C115(1.39); C215(1.08)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C224(1.09)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C224(0.94)  LDD1673  [12]
 LDCM0472  CL79 HEK-293T C224(0.92)  LDD1675  [12]
 LDCM0473  CL8 HCT 116 C215(0.91)  LDD0790  [4]
 LDCM0475  CL81 HEK-293T C215(1.06)  LDD1678  [12]
 LDCM0477  CL83 HEK-293T C224(1.08); C215(1.19)  LDD1680  [12]
 LDCM0479  CL85 HEK-293T C224(1.03)  LDD1682  [12]
 LDCM0481  CL87 HEK-293T C224(1.24)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C224(0.87)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C224(0.92)  LDD1686  [12]
 LDCM0484  CL9 HCT 116 C215(1.17)  LDD0801  [4]
 LDCM0486  CL91 HCT 116 C115(1.03); C215(0.92)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C115(0.91); C215(0.86)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C115(0.96); C215(0.77)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C115(0.89); C215(0.85)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C115(1.16); C215(1.10)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C115(1.35); C215(0.73)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C115(1.01); C215(0.74)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C115(1.03); C215(0.94)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C115(1.03); C215(0.97)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C224(0.99)  LDD1698  [12]
 LDCM0468  Fragment33 HCT 116 C115(1.37); C215(0.98)  LDD0785  [4]
 LDCM0022  KB02 HCT 116 C204(2.24); C224(2.55)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C204(1.48); C224(1.78)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C204(4.14); C224(2.22)  LDD0082  [4]
 LDCM0014  Panhematin HEK-293T 4.38  LDD0062  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402