Details of the Target

General Information of Target

Target ID LDTP07223
Target Name Zinc finger protein 318 (ZNF318)
Gene Name ZNF318
Gene ID 24149
Synonyms
Zinc finger protein 318; Endocrine regulatory protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYRSSARSSVSSHRPKDDGGGGPRSGRSSGSSSGPARRSSPPPPPSGSSSRTPARRPRSP
SGHRGRRASPSPPRGRRVSPSPPRARRGSPSPPRGRRLFPPGPAGFRGSSRGESRADYAR
DGRGDHPGDSGSRRRSPGLCSDSLEKSLRITVGNDHFCVSTPERRRLSDRLGSPVDNLED
MDRDDLTDDSVFTRSSQCSRGLERYISQEEGPLSPFLGQLDEDYRTKETFLHRSDYSPHI
SCHDELLRGTERNREKLKGYSIRSEERSREAKRPRYDDTVKINSMGGDHPSFTSGTRNYR
QRRRSPSPRFLDPEFRELDLARRKREEEEERSRSLSQELVGVDGGGTGCSIPGLSGVLTA
SEPGYSLHRPEEVSVMPKKSILKKRIEVDIMEPSMQLESFSSSTSSSQDHPLYSGHPSLP
LSGAIAAFASEIENKGTMVETALKEPQGNLYQWGPLPGIPKDNSPLREKFGSFLCHKDNL
DLKAEGPERHTDFLLPHERASQDGSGFSRILSMLADSTSTQEKRRRSFPDIEDEEKFLYG
DEEEDLKAESVPKPLGSSESEVMRQKASSLPSSAPAVKLESLEETNPEYAKIHDLLKTIG
LDIGVAEISQLAARTQERLHGKKPSLRSSADRRSSVDRYFSADHCSSVDHRFSADRCSSV
DHCFSADRRSSDPHRLESREAHHSNTHSPEVSHPHPPSPVDPYLLTKNSPPFLKSDHPVG
HISGPEVVGSGFQSSVAVRCMLPSAPSAPIRLPHTAALSQFHMPRASQFAAARIPPNYQG
PAIPPASFDAYRHYMAYAASRWPMYPTSQPSNHPVPEPHRIMPITKQATRSRPNLRVIPT
VTPDKPKQKESLRGSIPAAQVPVQVSIPSLIRYNPEKISDEKNRASQKQKVIEEREKLKN
DREARQKKMYYLRTELERLHKQQGEMLRKKRREKDGHKDPLLVEVSRLQDNIMKDIAELR
QEAEEAEKKQSELDKVAQILGINIFDKSQKSLSDSREPTEKPGKAEKSKSPEKVSSFSNS
SSNKESKVNNEKFRTKSPKPAESPQSATKQLDQPTAAYEYYDAGNHWCKDCNTICGTMFD
FFTHMHNKKHTQTLDPYNRPWASKTQSEAKQDAIKRTDKITVPAKGSEFLVPISGFYCQL
CEEFLGDPISGEQHVKGHQHNEKYKKYVDENPLYEERRNLDRQAGLAVVLETERRRQSEL
KRKLSEKPKEEKKEKKAKAVKEVKEDDKVSEKLEDQLSEGRNSPEKAENKRNTGIKLQLK
EEVKKESPTSSSFGKFSWKKPEKEEEKSSLVTPSISKEEILESSKDKEDGKTEAGKAKPI
KIKLSGKTVVAHTSPWMPVVTTSTQTKIRPNLPIPSTVLRKSCSATMSKPAPLNTFLSIK
SSGTTAKPLPVVKESSADLLLPPDIISKAFGGEEVILKGSPEEKVVLAEKSEPSHLPEQI
LPPPPPPPPPPPPPPPVIPHPAAPSAAQANAILAPVKSNPVVSQTLSPGFVGPNILNPVL
PVAIMASAQPAAIPSDETAPGVSESDRDQTLFSVLVRPPPPLSSVFSEQAKKLEKRNSCL
ATANAKDLYDIFYSSGGKGAPETKGAPETKLSGGPLANGENSNLSRTKSSDTSSTSPLNS
SASQEELHQDEGLVAAPIVSNSEKPIAKTLVALGKWSVVEHVGPKSTGSTYGFLQPLTRL
CQSRPYETITPKTDTLAIWTSSSFQSDTSRDISPEKSELDLGEPGPPGVEPPPQLLDIQC
KESQKLVEIHLRESVNQDKESQELRKSEDCRESEIETNTELKERVKELSEGIVDEGVSTS
IGPHSIDDSNLNHGNRYMWEGEVKQPNLLMIDKEAEQSNKLMTGSETPSKVVIKLSPQAC
SFTKAKLDSFLSEARSLLNPQDTPVKISAPELLLHSPARSAMCLTGSPQEQGVSVVSEEG
LENSAPESASRTSRYRSLKLKRERSKDFQVKKIYELAVWDENKKRPETWESPEKPKTEAL
ELQDVHPELTVTIESKALEDFEATDLKVEELTALGNLGDMPVDFCTTRVSPAHRSPTVLC
QKVCEENSVSPIGCNSSDPADFEPIPSFSGFPLDSPKTLVLDFETEGERNSPNPRSVRIP
SPNILKTGLTENVDRGLGGLEGTHQALDLLAGGMMPEEVKESSQLDKQESLGLELKTINS
AGLGPSPCLPDLVDFVTRTSGVQKDKLCSPLSEPGDPSKCSSLELGPLQLEISNASTTEV
AILQVDDDSGDPLNLVKAPVSRSPPREQVIEDNMVPQGMPEQETTVGAIQDHTESSVHN
Target Bioclass
Other
Subcellular location
Nucleus
Function
[Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.; [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.
Uniprot ID
Q5VUA4
Ensemble ID
ENST00000361428.3
HGNC ID
HGNC:13578

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A770V DBIA    Probe Info 
CAL148 SNV: p.S374F DBIA    Probe Info 
CAL78 SNV: p.S568R DBIA    Probe Info 
CASKI SNV: p.R254Ter; p.E1774K DBIA    Probe Info 
COLO792 SNV: p.Q502Ter .
DU145 SNV: p.P1966T DBIA    Probe Info 
EFO27 SNV: p.P1445S DBIA    Probe Info 
FUOV1 SNV: p.K383R DBIA    Probe Info 
HCC1395 SNV: p.G1274R DBIA    Probe Info 
HCT116 Deletion: p.V1457LfsTer20 DBIA    Probe Info 
HEC1 SNV: p.P306T; p.P1520H DBIA    Probe Info 
HEC1B SNV: p.P306T .
HGC27 SNV: p.L354F DBIA    Probe Info 
HT115 SNV: p.S1289Ter; p.E1753Ter DBIA    Probe Info 
ICC9 SNV: p.F292C DBIA    Probe Info 
IGR1 SNV: p.P1461S
Substitution: p.P1132L		 DBIA    Probe Info 
IGROV1 SNV: p.P1541L DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.K1216RfsTer5 DBIA    Probe Info 
JHH7 SNV: p.R872I .
MDAMB231 SNV: p.E203K .
MFE319 SNV: p.S1754F DBIA    Probe Info 
MOLT4 SNV: p.S2160Y .
OE33 SNV: p.Q2248E DBIA    Probe Info 
ONS76 SNV: p.S1016L DBIA    Probe Info 
OVCAR8 Deletion: p.P1452_P1456del DBIA    Probe Info 
PEO1 SNV: p.G504S .
SNU1 SNV: p.S1610L DBIA    Probe Info 
SUPT1 SNV: p.D503N DBIA    Probe Info 
SW1116 SNV: p.R960W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K1866(10.00)  LDD0277  [2]
Alkylaryl probe 2
 Probe Info  		3.00  LDD0390  [3]
AHL-Pu-1
 Probe Info  		C1770(4.32)  LDD0169  [4]
HPAP
 Probe Info  		8.15  LDD0062  [5]
HHS-475
 Probe Info  		Y1671(0.13)  LDD0267  [6]
DBIA
 Probe Info  		C1071(2.95); C1075(2.95); C1860(3.53); C475(2.37)  LDD0080  [7]
IA-alkyne
 Probe Info  		C645(0.00); C1559(0.00)  LDD0036  [8]
NAIA_4
 Probe Info  		C1681(0.00); C2168(0.00)  LDD2226  [9]
NAIA_5
 Probe Info  		C1681(0.00); C242(0.00); C2168(0.00); C645(0.00)  LDD2224  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
IPM
 Probe Info  		C158(0.00); C1860(0.00); C2040(0.00); C1559(0.00)  LDD0005  [11]
VSF
 Probe Info  		C1860(0.00); C2168(0.00); C2188(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C1740(0.00); C657(0.00); C1681(0.00); C645(0.00)  LDD0018  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
HHS-465
 Probe Info  		N.A.  LDD2240  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C2168(2.54); C1903(2.59)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1770(4.32)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C475(1.73)  LDD0812  [7]
 LDCM0215  AC10 HEK-293T C475(1.56)  LDD0813  [7]
 LDCM0216  AC100 HCT 116 C475(0.85)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C475(0.98)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C475(0.84)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C475(1.10)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C475(1.11)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C475(0.98)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C475(0.97)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C475(0.17)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C475(0.72)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C475(1.04)  LDD0542  [7]
 LDCM0226  AC11 HEK-293T C475(0.97)  LDD0824  [7]
 LDCM0227  AC110 HCT 116 C475(0.90)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C475(0.71)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C475(0.44)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C475(0.91)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C475(1.15)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C475(1.30)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C475(1.22)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C475(1.12)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C475(1.10)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C475(1.14)  LDD0553  [7]
 LDCM0237  AC12 HEK-293T C475(1.28)  LDD0835  [7]
 LDCM0238  AC120 HCT 116 C475(1.52)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C475(0.93)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C475(1.19)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C475(0.88)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C475(1.03)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C475(1.02)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C475(1.28)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C475(1.19)  LDD0562  [7]
 LDCM0246  AC128 PaTu 8988t C475(1.01)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C475(1.13)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C475(1.03)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C475(1.04)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C475(1.06)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C475(1.22)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C475(1.13)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C475(1.17)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C475(1.11)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C475(1.17)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C475(1.19)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C475(0.93)  LDD1137  [7]
 LDCM0259  AC14 HEK-293T C475(1.27)  LDD0857  [7]
 LDCM0260  AC140 PaTu 8988t C475(1.42)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C475(1.14)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C475(1.14)  LDD1141  [7]
 LDCM0263  AC143 HCT 116 C475(0.98)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C475(1.23)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C475(1.16)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C475(1.30)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C475(1.53)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C475(1.67)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C475(1.54)  LDD0586  [7]
 LDCM0270  AC15 HEK-293T C475(1.61)  LDD0868  [7]
 LDCM0271  AC150 HCT 116 C475(1.06)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C475(0.98)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C475(1.31)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C475(1.76)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C475(1.37)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C475(1.28)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C475(1.12)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C475(0.99)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C475(0.94)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C475(1.06)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C475(0.96)  LDD0595  [7]
 LDCM0279  AC2 HEK-293T C475(1.59)  LDD0877  [7]
 LDCM0280  AC20 HCT 116 C475(1.04)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C475(1.00)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C475(0.87)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C475(1.05)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C475(0.98)  LDD0601  [7]
 LDCM0285  AC25 HEK-293T C475(0.79)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C475(0.91)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C475(0.90)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C475(0.77)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C475(0.93)  LDD0887  [7]
 LDCM0290  AC3 HEK-293T C475(1.23)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C475(0.84)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C475(0.75)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C475(0.73)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C475(0.90)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C475(0.75)  LDD0893  [7]
 LDCM0296  AC35 HCT 116 C475(0.80)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C475(1.02)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C475(0.87)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C475(0.83)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C475(1.14)  LDD0617  [7]
 LDCM0301  AC4 HEK-293T C475(1.13)  LDD0899  [7]
 LDCM0302  AC40 HCT 116 C475(0.89)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C475(0.94)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C475(1.03)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C475(0.89)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C475(1.14)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C475(1.07)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C475(0.77)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C475(0.91)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C475(1.01)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C475(1.15)  LDD0628  [7]
 LDCM0312  AC5 HEK-293T C475(1.26)  LDD0910  [7]
 LDCM0313  AC50 HCT 116 C475(1.03)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C475(0.84)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C475(0.85)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C475(1.15)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C475(0.99)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C475(1.01)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C475(1.20)  LDD0636  [7]
 LDCM0320  AC57 PaTu 8988t C1071(0.95); C1075(0.95)  LDD1199  [7]
 LDCM0321  AC58 PaTu 8988t C1071(0.99); C1075(0.99)  LDD1200  [7]
 LDCM0322  AC59 PaTu 8988t C1071(0.89); C1075(0.89)  LDD1201  [7]
 LDCM0323  AC6 HEK-293T C475(0.84)  LDD0921  [7]
 LDCM0324  AC60 PaTu 8988t C1071(1.06); C1075(1.06)  LDD1203  [7]
 LDCM0325  AC61 PaTu 8988t C1071(1.04); C1075(1.04)  LDD1204  [7]
 LDCM0326  AC62 PaTu 8988t C1071(0.99); C1075(0.99)  LDD1205  [7]
 LDCM0327  AC63 PaTu 8988t C1071(0.95); C1075(0.95)  LDD1206  [7]
 LDCM0328  AC64 PaTu 8988t C1071(1.00); C1075(1.00)  LDD1207  [7]
 LDCM0329  AC65 PaTu 8988t C1071(0.86); C1075(0.86)  LDD1208  [7]
 LDCM0330  AC66 PaTu 8988t C1071(0.82); C1075(0.82)  LDD1209  [7]
 LDCM0331  AC67 PaTu 8988t C1071(1.17); C1075(1.17)  LDD1210  [7]
 LDCM0332  AC68 HCT 116 C475(1.22)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C475(1.26)  LDD0650  [7]
 LDCM0334  AC7 HEK-293T C475(1.32)  LDD0932  [7]
 LDCM0335  AC70 HCT 116 C475(1.25)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C475(1.15)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C475(1.24)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C475(1.64)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C475(1.43)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C475(1.40)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C475(1.29)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C475(1.21)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C475(1.17)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C475(1.24)  LDD0661  [7]
 LDCM0345  AC8 HEK-293T C475(1.15)  LDD0943  [7]
 LDCM0346  AC80 HCT 116 C475(1.15)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C475(0.97)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C475(1.57)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C475(1.60)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C475(1.46)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C475(1.27)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C475(1.02)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C475(0.99)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C475(1.17)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C475(1.21)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C475(0.72)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C475(1.50)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C475(1.34)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C475(1.11)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C475(1.40)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C475(0.96)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C475(1.24)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C475(1.41)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C475(1.45)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C475(0.82)  LDD0683  [7]
 LDCM0248  AKOS034007472 HEK-293T C475(0.93)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C475(2.15)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C475(1.37)  LDD0873  [7]
 LDCM0156  Aniline NCI-H1299 11.75  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C1681(20.00); C242(1.39)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C475(1.06)  LDD0965  [7]
 LDCM0368  CL10 HEK-293T C475(1.29)  LDD0966  [7]
 LDCM0369  CL100 HEK-293T C475(1.35)  LDD0967  [7]
 LDCM0370  CL101 HEK-293T C475(1.07)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C475(1.37)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C475(1.31)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C475(1.09)  LDD0971  [7]
 LDCM0374  CL105 HCT 116 C475(1.13)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C475(1.19)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C475(1.16)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C475(1.26)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C475(1.20)  LDD0695  [7]
 LDCM0379  CL11 HEK-293T C475(1.25)  LDD0977  [7]
 LDCM0380  CL110 HCT 116 C475(1.34)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C475(1.10)  LDD0698  [7]
 LDCM0382  CL112 HEK-293T C475(0.99)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C475(0.73)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C475(0.75)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C475(0.79)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C475(0.63)  LDD0984  [7]
 LDCM0387  CL117 HCT 116 C475(1.24)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C475(1.18)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C475(0.94)  LDD0706  [7]
 LDCM0390  CL12 HEK-293T C475(1.01)  LDD0988  [7]
 LDCM0391  CL120 HCT 116 C475(0.93)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C475(0.78)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C475(0.97)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C475(1.16)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C475(1.14)  LDD0712  [7]
 LDCM0396  CL125 PaTu 8988t C1071(1.11); C1075(1.11)  LDD1275  [7]
 LDCM0397  CL126 PaTu 8988t C1071(0.99); C1075(0.99)  LDD1276  [7]
 LDCM0398  CL127 PaTu 8988t C1071(0.84); C1075(0.84)  LDD1277  [7]
 LDCM0399  CL128 PaTu 8988t C1071(0.91); C1075(0.91)  LDD1278  [7]
 LDCM0400  CL13 HEK-293T C475(1.07)  LDD0998  [7]
 LDCM0401  CL14 HEK-293T C475(1.14)  LDD0999  [7]
 LDCM0402  CL15 HEK-293T C475(1.24)  LDD1000  [7]
 LDCM0403  CL16 HEK-293T C475(1.00)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C475(1.19)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C475(0.92)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C475(1.12)  LDD1004  [7]
 LDCM0407  CL2 HEK-293T C475(1.11)  LDD1005  [7]
 LDCM0408  CL20 HEK-293T C475(1.17)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C475(1.08)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C475(1.14)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C475(0.77)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C475(0.68)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C475(0.86)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C475(0.78)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C475(0.61)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C475(0.88)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C475(0.85)  LDD1015  [7]
 LDCM0418  CL3 HEK-293T C475(1.03)  LDD1016  [7]
 LDCM0419  CL30 HEK-293T C475(0.85)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C1363(0.83); C1559(0.83); C475(0.77)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C1363(1.07); C1559(1.07); C475(0.99)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C1363(1.59); C1559(1.59); C475(0.92)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C1363(0.98); C1559(0.98); C475(0.89)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C1363(1.35); C1559(1.35); C475(1.15)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C1363(1.19); C1559(1.19); C475(1.07)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C1363(0.94); C1559(0.94); C475(0.98)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C1363(1.43); C1559(1.43); C475(1.54)  LDD1026  [7]
 LDCM0429  CL4 HEK-293T C475(1.07)  LDD1027  [7]
 LDCM0430  CL40 HEK-293T C1363(1.01); C1559(1.01); C475(0.98)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C1363(1.34); C1559(1.34); C475(1.33)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C1363(1.29); C1559(1.29); C475(1.51)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C1363(1.25); C1559(1.25); C475(1.72)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C1363(0.96); C1559(0.96); C475(0.99)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C1363(1.38); C1559(1.38); C475(1.22)  LDD1033  [7]
 LDCM0436  CL46 PaTu 8988t C1071(0.99); C1075(0.99)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C1071(1.09); C1075(1.09)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C1071(1.08); C1075(1.08)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C1071(1.07); C1075(1.07)  LDD1318  [7]
 LDCM0440  CL5 HEK-293T C475(1.17)  LDD1038  [7]
 LDCM0441  CL50 PaTu 8988t C1071(1.12); C1075(1.12)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C1071(0.91); C1075(0.91)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C1071(1.06); C1075(1.06)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C1071(1.18); C1075(1.18)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C1071(1.48); C1075(1.48)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C1071(1.20); C1075(1.20)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C1071(0.39); C1075(0.39)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C1071(1.22); C1075(1.22)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C1071(1.16); C1075(1.16)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C1071(1.55); C1075(1.55)  LDD1329  [7]
 LDCM0451  CL6 HEK-293T C475(1.10)  LDD1049  [7]
 LDCM0452  CL60 PaTu 8988t C1071(1.29); C1075(1.29)  LDD1331  [7]
 LDCM0453  CL61 HEK-293T C1363(0.91); C2040(0.96); C1681(1.23); C158(1.14)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C1363(0.97); C2040(1.10); C158(1.09); C1860(1.01)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C1363(1.00); C2040(0.95); C1681(0.89); C1860(0.86)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C1363(1.01); C2040(1.00); C1681(1.05); C1860(0.95)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C1363(0.93); C2040(1.04); C1681(0.89); C158(1.17)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C1363(1.07); C2040(0.99); C1681(0.89); C158(1.01)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C1363(0.94); C2040(1.04); C1681(0.67); C1860(0.84)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C1363(0.99); C2040(0.83); C1681(0.62); C1860(0.77)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C1363(1.02); C2040(0.99); C1681(0.60); C1860(0.78)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C475(1.25)  LDD1060  [7]
 LDCM0463  CL70 HEK-293T C1363(0.99); C2040(0.70); C1681(0.47); C1860(0.84)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C1363(1.00); C2040(0.66); C1681(0.46); C1860(0.85)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C1363(1.06); C2040(0.89); C1681(0.52); C158(1.11)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C1363(0.94); C2040(0.95); C1681(1.39); C158(1.20)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C1363(0.99); C2040(1.00); C158(1.06); C1860(1.00)  LDD1670  [16]
 LDCM0469  CL76 PaTu 8988t C1071(0.95); C1075(0.95); C475(1.03)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C1071(1.00); C1075(1.00); C475(1.22)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C1071(1.09); C1075(1.09); C475(1.42)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C1071(1.02); C1075(1.02); C475(1.61)  LDD1351  [7]
 LDCM0473  CL8 HEK-293T C475(1.34)  LDD1071  [7]
 LDCM0474  CL80 PaTu 8988t C1071(1.10); C1075(1.10); C475(1.30)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C1071(1.13); C1075(1.13); C475(1.39)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C1071(0.89); C1075(0.89); C475(1.41)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C1071(1.12); C1075(1.12); C475(1.66)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C1071(1.05); C1075(1.05); C475(1.10)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C1071(1.10); C1075(1.10); C475(1.28)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C1071(1.06); C1075(1.06); C475(1.31)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C1071(1.35); C1075(1.35); C475(1.51)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C1071(1.23); C1075(1.23); C475(1.81)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C1071(1.13); C1075(1.13); C475(1.24)  LDD1362  [7]
 LDCM0484  CL9 HEK-293T C475(1.34)  LDD1082  [7]
 LDCM0485  CL90 PaTu 8988t C1071(1.10); C1075(1.10); C475(1.66)  LDD1364  [7]
 LDCM0486  CL91 HEK-293T C475(0.88)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C475(1.06)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C475(1.10)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C475(1.18)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C475(1.40)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C475(1.01)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C475(1.00)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C475(1.24)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C475(1.05)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C1363(1.03); C2040(0.95); C1681(0.96); C1860(1.04)  LDD1698  [16]
 LDCM0468  Fragment33 HEK-293T C1363(0.94); C2040(0.91); C1681(0.95); C1860(1.06)  LDD1671  [16]
 LDCM0427  Fragment51 HEK-293T C1363(1.18); C1559(1.18); C475(1.07)  LDD1025  [7]
 LDCM0119  HHS-0401 DM93 Y1671(0.13)  LDD0267  [6]
 LDCM0022  KB02 HCT 116 C1071(2.95); C1075(2.95); C1860(3.53); C475(2.37)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C1071(3.85); C1075(3.85); C1860(1.88); C475(1.76)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C1071(3.48); C1075(3.48); C1860(3.23); C475(2.84)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0014  Panhematin HEK-293T 8.15  LDD0062  [5]
 LDCM0099  Phenelzine HEK-293T 3.00  LDD0390  [3]

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402