General Information of Experiment

Probe Name Alkylaryl probe 2  Probe Info 
Probe concentration 1 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Phenelzine  Competitor Info 
Competitor Concentration 10 mM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07457  DNA oxidative demethylase ALKBH2 (ALKBH2) 20.0
 LDTP17022  Secernin-3 (SCRN3) 16.0
 LDTP13703  Histone lysine demethylase PHF8 (PHF8) 15.0
 LDTP15725  Secernin-2 (SCRN2) 13.0
 LDTP08084  BRCA1-associated protein (BRAP) 11.0
 LDTP00344  Stearoyl-CoA desaturase (SCD) 9.0
 LDTP05967  Nucleic acid dioxygenase ALKBH1 (ALKBH1) 8.0
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 6.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 6.0
 LDTP01005  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) 6.0
 LDTP02918  S-adenosylmethionine decarboxylase proenzyme (AMD1) 6.0
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 5.0
 LDTP11595  Alpha-ketoglutarate-dependent dioxygenase FTO (FTO) 5.0
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) 5.0
 LDTP02386  Fructose-bisphosphate aldolase C (ALDOC) 5.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.0
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 5.0
 LDTP18414  5'-nucleotidase domain-containing protein 2 (NT5DC2) 4.0
 LDTP00968  Acyl-CoA (8-3)-desaturase (FADS1) 4.0
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 4.0
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 4.0
 LDTP00325  Pirin (PIR) 4.0
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) 4.0
 LDTP12420  Xaa-Pro aminopeptidase 3 (XPNPEP3) 4.0
 LDTP02888  Aspartate aminotransferase, cytoplasmic (GOT1) 3.0
 LDTP07492  Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6) 3.0
 LDTP10215  Carboxymethylenebutenolidase homolog (CMBL) 3.0
 LDTP07662  DBH-like monooxygenase protein 1 (MOXD1) 3.0
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 3.0
 LDTP12110  Elongator complex protein 3 (ELP3) 3.0
 LDTP07979  FAST kinase domain-containing protein 5, mitochondrial (FASTKD5) 3.0
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) 3.0
 LDTP10888  Legumain (LGMN) 3.0
 LDTP03939  Lysine-specific demethylase 5C (KDM5C) 3.0
 LDTP11440  Lysine-specific demethylase 5D (KDM5D) 3.0
 LDTP05793  Methanethiol oxidase (SELENBP1) 3.0
 LDTP07065  Phytanoyl-CoA dioxygenase domain-containing protein 1 (PHYHD1) 3.0
 LDTP07092  Probable arginine--tRNA ligase, mitochondrial (RARS2) 3.0
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) 3.0
 LDTP00285  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) 3.0
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 3.0
 LDTP00645  Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) 3.0
 LDTP04401  Ras-related protein Rab-13 (RAB13) 3.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 3.0
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 3.0
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 3.0
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 3.0
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 3.0
 LDTP01969  Transferrin receptor protein 1 (TFRC) 3.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 3.0
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12412  Reticulon-4 (RTN4) 11.0
 LDTP00510  Spectrin beta chain, non-erythrocytic 2 (SPTBN2) 3.0
 LDTP07223  Zinc finger protein 318 (ZNF318) 3.0

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.