Details of the Target

General Information of Target

Target ID LDTP00968
Target Name Acyl-CoA (8-3)-desaturase (FADS1)
Gene Name FADS1
Gene ID 3992
Synonyms
FADSD5; Acyl-CoA; 8-3)-desaturase; EC 1.14.19.44; Delta(5) fatty acid desaturase; D5D; Delta(5) desaturase; Delta-5 desaturase; Fatty acid desaturase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVIS
HYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVE
RMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHD
FGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFA
LGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMI
TFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQL
QATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLL
SAFADIIHSLKESGQLWLDAYLHQ
Target Bioclass
Enzyme
Family
Fatty acid desaturase type 1 family
Subcellular location
Endoplasmic reticulum membrane
Function
[Isoform 1]: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively. As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells. Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6).; [Isoform 2]: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.
Uniprot ID
O60427
Ensemble ID
ENST00000433932.5
HGNC ID
HGNC:3574
ChEMBL ID
CHEMBL5840

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.27  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		20.00  LDD0389  [2]
DA-P2
 Probe Info  		15.50  LDD0348  [3]
HRP
 Probe Info  		21.93  LDD0347  [3]
P11
 Probe Info  		20.00  LDD0201  [4]
Alkylaryl probe 3
 Probe Info  		5.08  LDD0282  [5]
DBIA
 Probe Info  		C407(3.33)  LDD3310  [6]
BTD
 Probe Info  		C407(1.16)  LDD2099  [7]
DA-P3
 Probe Info  		14.15  LDD0179  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Acrolein
 Probe Info  		C407(0.00); C31(0.00)  LDD0217  [10]
Crotonaldehyde
 Probe Info  		C31(0.00); C407(0.00)  LDD0219  [10]
Methacrolein
 Probe Info  		C31(0.00); C407(0.00)  LDD0218  [10]
AOyne
 Probe Info  		9.10  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0472  [13]
FFF probe15
 Probe Info  		20.00  LDD0478  [13]
STS-2
 Probe Info  		N.A.  LDD0139  [14]
OEA-DA
 Probe Info  		18.92  LDD0046  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0563  Abegg_cp(+)-11 HeLa C407(2.10)  LDD0314  [9]
 LDCM0215  AC10 PaTu 8988t C407(0.72)  LDD1094  [16]
 LDCM0226  AC11 PaTu 8988t C407(0.79)  LDD1105  [16]
 LDCM0237  AC12 PaTu 8988t C407(0.78)  LDD1116  [16]
 LDCM0259  AC14 PaTu 8988t C407(0.85)  LDD1138  [16]
 LDCM0263  AC143 PaTu 8988t C407(0.69)  LDD1142  [16]
 LDCM0264  AC144 PaTu 8988t C407(0.66)  LDD1143  [16]
 LDCM0265  AC145 PaTu 8988t C407(0.63)  LDD1144  [16]
 LDCM0266  AC146 PaTu 8988t C407(0.63)  LDD1145  [16]
 LDCM0267  AC147 PaTu 8988t C407(0.80)  LDD1146  [16]
 LDCM0268  AC148 PaTu 8988t C407(0.60)  LDD1147  [16]
 LDCM0269  AC149 PaTu 8988t C407(0.57)  LDD1148  [16]
 LDCM0270  AC15 PaTu 8988t C407(0.74)  LDD1149  [16]
 LDCM0271  AC150 PaTu 8988t C407(0.53)  LDD1150  [16]
 LDCM0272  AC151 PaTu 8988t C407(0.46)  LDD1151  [16]
 LDCM0273  AC152 PaTu 8988t C407(0.60)  LDD1152  [16]
 LDCM0274  AC153 PaTu 8988t C407(0.53)  LDD1153  [16]
 LDCM0621  AC154 PaTu 8988t C407(0.50)  LDD2166  [16]
 LDCM0622  AC155 PaTu 8988t C407(0.54)  LDD2167  [16]
 LDCM0623  AC156 PaTu 8988t C407(0.53)  LDD2168  [16]
 LDCM0624  AC157 PaTu 8988t C407(0.51)  LDD2169  [16]
 LDCM0285  AC25 PaTu 8988t C407(1.06)  LDD1164  [16]
 LDCM0286  AC26 PaTu 8988t C407(0.92)  LDD1165  [16]
 LDCM0287  AC27 PaTu 8988t C407(0.99)  LDD1166  [16]
 LDCM0288  AC28 PaTu 8988t C407(0.87)  LDD1167  [16]
 LDCM0289  AC29 PaTu 8988t C407(0.98)  LDD1168  [16]
 LDCM0291  AC30 PaTu 8988t C407(1.14)  LDD1170  [16]
 LDCM0292  AC31 PaTu 8988t C407(1.10)  LDD1171  [16]
 LDCM0293  AC32 PaTu 8988t C407(1.07)  LDD1172  [16]
 LDCM0294  AC33 PaTu 8988t C407(0.82)  LDD1173  [16]
 LDCM0295  AC34 PaTu 8988t C407(0.95)  LDD1174  [16]
 LDCM0296  AC35 PaTu 8988t C364(0.73)  LDD1175  [16]
 LDCM0297  AC36 PaTu 8988t C364(0.57)  LDD1176  [16]
 LDCM0298  AC37 PaTu 8988t C364(0.64)  LDD1177  [16]
 LDCM0299  AC38 PaTu 8988t C364(0.65)  LDD1178  [16]
 LDCM0300  AC39 PaTu 8988t C364(0.67)  LDD1179  [16]
 LDCM0302  AC40 PaTu 8988t C364(0.54)  LDD1181  [16]
 LDCM0303  AC41 PaTu 8988t C364(0.63)  LDD1182  [16]
 LDCM0304  AC42 PaTu 8988t C364(0.76)  LDD1183  [16]
 LDCM0305  AC43 PaTu 8988t C364(0.70)  LDD1184  [16]
 LDCM0306  AC44 PaTu 8988t C364(0.55)  LDD1185  [16]
 LDCM0307  AC45 PaTu 8988t C364(0.57)  LDD1186  [16]
 LDCM0323  AC6 PaTu 8988t C407(0.90)  LDD1202  [16]
 LDCM0334  AC7 PaTu 8988t C407(1.04)  LDD1213  [16]
 LDCM0345  AC8 PaTu 8988t C407(1.00)  LDD1224  [16]
 LDCM0520  AKOS000195272 MDA-MB-231 C407(0.81)  LDD2113  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C407(0.68)  LDD1127  [16]
 LDCM0356  AKOS034007680 PaTu 8988t C407(0.86)  LDD1235  [16]
 LDCM0275  AKOS034007705 PaTu 8988t C407(0.75)  LDD1154  [16]
 LDCM0156  Aniline NCI-H1299 11.82  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [4]
 LDCM0108  Chloroacetamide HeLa C407(0.00); H410(0.00); H443(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C407(20.00)  LDD2227  [12]
 LDCM0367  CL1 PaTu 8988t C364(0.91); C407(0.83)  LDD1246  [16]
 LDCM0368  CL10 PaTu 8988t C364(0.68); C407(0.64)  LDD1247  [16]
 LDCM0370  CL101 PaTu 8988t C407(0.90)  LDD1249  [16]
 LDCM0371  CL102 PaTu 8988t C407(0.92)  LDD1250  [16]
 LDCM0372  CL103 PaTu 8988t C407(0.76)  LDD1251  [16]
 LDCM0373  CL104 PaTu 8988t C407(0.91)  LDD1252  [16]
 LDCM0379  CL11 PaTu 8988t C364(0.81); C407(0.82)  LDD1258  [16]
 LDCM0382  CL112 PaTu 8988t C407(1.04)  LDD1261  [16]
 LDCM0383  CL113 PaTu 8988t C407(1.01)  LDD1262  [16]
 LDCM0384  CL114 PaTu 8988t C407(0.93)  LDD1263  [16]
 LDCM0385  CL115 PaTu 8988t C407(1.00)  LDD1264  [16]
 LDCM0386  CL116 PaTu 8988t C407(0.95)  LDD1265  [16]
 LDCM0387  CL117 PaTu 8988t C364(0.65)  LDD1266  [16]
 LDCM0388  CL118 PaTu 8988t C364(0.88)  LDD1267  [16]
 LDCM0389  CL119 PaTu 8988t C364(0.71)  LDD1268  [16]
 LDCM0390  CL12 PaTu 8988t C364(0.78); C407(0.78)  LDD1269  [16]
 LDCM0391  CL120 PaTu 8988t C364(0.60)  LDD1270  [16]
 LDCM0400  CL13 PaTu 8988t C364(0.79); C407(0.64)  LDD1279  [16]
 LDCM0401  CL14 PaTu 8988t C364(0.69); C407(0.61)  LDD1280  [16]
 LDCM0402  CL15 PaTu 8988t C364(0.66); C407(0.66)  LDD1281  [16]
 LDCM0403  CL16 PaTu 8988t C364(1.46); C407(0.82)  LDD1282  [16]
 LDCM0404  CL17 PaTu 8988t C364(1.14); C407(0.70)  LDD1283  [16]
 LDCM0405  CL18 PaTu 8988t C364(1.12); C407(0.70)  LDD1284  [16]
 LDCM0406  CL19 PaTu 8988t C364(1.18); C407(0.67)  LDD1285  [16]
 LDCM0407  CL2 PaTu 8988t C364(0.68); C407(0.75)  LDD1286  [16]
 LDCM0408  CL20 PaTu 8988t C364(0.95); C407(0.60)  LDD1287  [16]
 LDCM0409  CL21 PaTu 8988t C364(0.97); C407(0.59)  LDD1288  [16]
 LDCM0410  CL22 PaTu 8988t C364(1.09); C407(0.63)  LDD1289  [16]
 LDCM0411  CL23 PaTu 8988t C364(1.10); C407(0.58)  LDD1290  [16]
 LDCM0412  CL24 PaTu 8988t C364(1.55); C407(0.76)  LDD1291  [16]
 LDCM0413  CL25 PaTu 8988t C364(0.84); C407(0.81)  LDD1292  [16]
 LDCM0414  CL26 PaTu 8988t C364(1.09); C407(0.62)  LDD1293  [16]
 LDCM0415  CL27 PaTu 8988t C364(0.97); C407(0.75)  LDD1294  [16]
 LDCM0416  CL28 PaTu 8988t C364(0.87); C407(0.55)  LDD1295  [16]
 LDCM0417  CL29 PaTu 8988t C364(1.18); C407(0.58)  LDD1296  [16]
 LDCM0418  CL3 PaTu 8988t C364(0.84); C407(0.67)  LDD1297  [16]
 LDCM0419  CL30 PaTu 8988t C364(0.92); C407(0.73)  LDD1298  [16]
 LDCM0420  CL31 PaTu 8988t C364(1.08); C407(0.93)  LDD1299  [16]
 LDCM0421  CL32 PaTu 8988t C364(0.93); C407(1.10)  LDD1300  [16]
 LDCM0422  CL33 PaTu 8988t C364(0.87); C407(0.92)  LDD1301  [16]
 LDCM0423  CL34 PaTu 8988t C364(0.92); C407(1.23)  LDD1302  [16]
 LDCM0424  CL35 PaTu 8988t C407(1.07); C364(1.01)  LDD1303  [16]
 LDCM0425  CL36 PaTu 8988t C364(0.63); C407(1.16)  LDD1304  [16]
 LDCM0426  CL37 PaTu 8988t C364(0.99); C407(1.10)  LDD1305  [16]
 LDCM0428  CL39 PaTu 8988t C364(0.96); C407(1.05)  LDD1307  [16]
 LDCM0429  CL4 PaTu 8988t C364(0.96); C407(0.83)  LDD1308  [16]
 LDCM0430  CL40 PaTu 8988t C364(1.00); C407(0.91)  LDD1309  [16]
 LDCM0431  CL41 PaTu 8988t C364(0.92); C407(1.02)  LDD1310  [16]
 LDCM0432  CL42 PaTu 8988t C364(0.98); C407(1.15)  LDD1311  [16]
 LDCM0433  CL43 PaTu 8988t C364(0.94); C407(1.06)  LDD1312  [16]
 LDCM0434  CL44 PaTu 8988t C364(0.90); C407(1.08)  LDD1313  [16]
 LDCM0435  CL45 PaTu 8988t C364(1.00); C407(1.03)  LDD1314  [16]
 LDCM0440  CL5 PaTu 8988t C364(0.81); C407(0.65)  LDD1319  [16]
 LDCM0451  CL6 PaTu 8988t C364(0.81); C407(0.73)  LDD1330  [16]
 LDCM0453  CL61 PaTu 8988t C407(1.07)  LDD1332  [16]
 LDCM0454  CL62 PaTu 8988t C407(1.19)  LDD1333  [16]
 LDCM0455  CL63 PaTu 8988t C407(1.09)  LDD1334  [16]
 LDCM0456  CL64 PaTu 8988t C407(1.06)  LDD1335  [16]
 LDCM0457  CL65 PaTu 8988t C407(0.95)  LDD1336  [16]
 LDCM0458  CL66 PaTu 8988t C407(0.94)  LDD1337  [16]
 LDCM0459  CL67 PaTu 8988t C407(0.78)  LDD1338  [16]
 LDCM0460  CL68 PaTu 8988t C407(0.68)  LDD1339  [16]
 LDCM0461  CL69 PaTu 8988t C407(0.74)  LDD1340  [16]
 LDCM0462  CL7 PaTu 8988t C364(0.71); C407(0.73)  LDD1341  [16]
 LDCM0463  CL70 PaTu 8988t C407(0.73)  LDD1342  [16]
 LDCM0464  CL71 PaTu 8988t C407(1.11)  LDD1343  [16]
 LDCM0465  CL72 PaTu 8988t C407(1.52)  LDD1344  [16]
 LDCM0466  CL73 PaTu 8988t C407(0.76)  LDD1345  [16]
 LDCM0467  CL74 PaTu 8988t C407(1.24)  LDD1346  [16]
 LDCM0469  CL76 PaTu 8988t C364(1.09); C407(0.89)  LDD1348  [16]
 LDCM0470  CL77 PaTu 8988t C364(1.11); C407(1.00)  LDD1349  [16]
 LDCM0471  CL78 PaTu 8988t C364(0.79); C407(0.94)  LDD1350  [16]
 LDCM0472  CL79 PaTu 8988t C364(1.28); C407(1.02)  LDD1351  [16]
 LDCM0473  CL8 PaTu 8988t C364(0.74); C407(0.62)  LDD1352  [16]
 LDCM0474  CL80 PaTu 8988t C364(1.08); C407(1.00)  LDD1353  [16]
 LDCM0475  CL81 PaTu 8988t C364(0.80); C407(0.92)  LDD1354  [16]
 LDCM0476  CL82 PaTu 8988t C364(1.22); C407(0.99)  LDD1355  [16]
 LDCM0477  CL83 PaTu 8988t C364(1.09); C407(0.93)  LDD1356  [16]
 LDCM0478  CL84 PaTu 8988t C364(0.89); C407(1.02)  LDD1357  [16]
 LDCM0479  CL85 PaTu 8988t C364(0.83); C407(0.96)  LDD1358  [16]
 LDCM0480  CL86 PaTu 8988t C364(0.98); C407(0.99)  LDD1359  [16]
 LDCM0481  CL87 PaTu 8988t C364(0.96); C407(1.00)  LDD1360  [16]
 LDCM0482  CL88 PaTu 8988t C364(1.12); C407(0.99)  LDD1361  [16]
 LDCM0483  CL89 PaTu 8988t C364(0.80); C407(0.96)  LDD1362  [16]
 LDCM0484  CL9 PaTu 8988t C364(0.72); C407(0.67)  LDD1363  [16]
 LDCM0485  CL90 PaTu 8988t C364(0.87); C407(0.92)  LDD1364  [16]
 LDCM0027  Dopamine HEK-293T 14.15  LDD0179  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C407(7.77)  LDD1702  [7]
 LDCM0625  F8 Ramos C407(0.71)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C407(1.17)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C407(3.49)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C407(1.51)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C407(1.02)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C407(1.94)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C407(1.45)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C407(0.88)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C407(1.95)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C407(0.79)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C407(0.80)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C407(1.12)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C407(0.93)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C407(1.12)  LDD2201  [17]
 LDCM0468  Fragment33 PaTu 8988t C407(0.79)  LDD1347  [16]
 LDCM0596  Fragment38 Ramos C407(1.24)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C407(1.44)  LDD2184  [17]
 LDCM0427  Fragment51 PaTu 8988t C364(0.97); C407(1.08)  LDD1306  [16]
 LDCM0610  Fragment52 Ramos C407(1.37)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C407(1.34)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C407(0.93)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C407(1.74)  LDD2188  [17]
 LDCM0015  HNE MDA-MB-231 C407(0.95)  LDD0346  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C407(1.01); C364(0.94)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C407(1.08); C364(0.89)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C407(3.33)  LDD3310  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C407(1.16)  LDD2099  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C407(0.85)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C407(0.80)  LDD2109  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C407(0.87)  LDD2123  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C407(1.00)  LDD2127  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C407(1.46)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C407(0.93)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C407(0.69); C31(1.16)  LDD2140  [7]
 LDCM0099  Phenelzine HEK-293T 5.08  LDD0282  [5]
 LDCM0029  Quercetin HEK-293T 6.41  LDD0181  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-linolenic Acid Small molecular drug DB00132
Icosapent Small molecular drug DB00159

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD044402