General Information of Experiment

Probe Name Alkylaryl probe 3  Probe Info 
Probe concentration 1 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Phenelzine  Competitor Info 
Competitor Concentration 10 mM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 25 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 20.0
 LDTP03109  Amine oxidase [flavin-containing] A (MAOA) 20.0
 LDTP03384  Amine oxidase [flavin-containing] B (MAOB) 20.0
 LDTP15725  Secernin-2 (SCRN2) 20.0
 LDTP00344  Stearoyl-CoA desaturase (SCD) 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) 20.0
 LDTP00624  Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) 17.6
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 14.6
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 11.8
 LDTP02198  Cathepsin D (CTSD) 10.3
 LDTP07662  DBH-like monooxygenase protein 1 (MOXD1) 8.3
 LDTP04581  Holocytochrome c-type synthase (HCCS) 7.9
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) 7.5
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) 7.3
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 5.6
 LDTP00968  Acyl-CoA (8-3)-desaturase (FADS1) 5.1
 LDTP02824  Ribosyldihydronicotinamide dehydrogenase [quinone] (NQO2) 5.0
 LDTP12473  Sialic acid synthase (NANS) 4.6
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 4.4
 LDTP00957  Lysine-specific histone demethylase 1A (KDM1A) 3.9
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 3.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 3.3
 LDTP04622  Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) 3.2
 LDTP04030  Biotinidase (BTD) 3.1
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 3.1
Other
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06030  Cytochrome c oxidase copper chaperone (COX17) 3.1

References

1 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.