Details of the Target

General Information of Target

Target ID LDTP04437
Target Name Aldehyde dehydrogenase family 3 member A2 (ALDH3A2)
Gene Name ALDH3A2
Gene ID 224
Synonyms
ALDH10; FALDH; Aldehyde dehydrogenase family 3 member A2; EC 1.2.1.3; EC 1.2.1.94; Aldehyde dehydrogenase 10; Fatty aldehyde dehydrogenase; Microsomal aldehyde dehydrogenase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY
Target Type
Successful
Target Bioclass
Enzyme
Family
Aldehyde dehydrogenase family
Subcellular location
Microsome membrane
Function
Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length . Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
TTD ID
T65291
Uniprot ID
P51648
DrugMap ID
TTB6UM0
Ensemble ID
ENST00000176643.11
HGNC ID
HGNC:403
ChEMBL ID
CHEMBL4295779

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.E28D DBIA    Probe Info 
A498 SNV: p.S14Y DBIA    Probe Info 
DU145 SNV: p.I291K DBIA    Probe Info 
HGC27 SNV: p.C226Ter DBIA    Probe Info 
HT1376 SNV: p.Q153Ter DBIA    Probe Info 
JURKAT SNV: p.I242V .
SNGM SNV: p.K452N DBIA    Probe Info 
SNU1 SNV: p.R355C DBIA    Probe Info 
WM793 SNV: p.P338L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.59  LDD0402  [1]
FBP2
 Probe Info  		2.01  LDD0317  [2]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K199(6.67)  LDD0277  [4]
AZ-9
 Probe Info  		E207(0.90)  LDD2208  [5]
Alkylaryl probe 3
 Probe Info  		3.68  LDD0282  [6]
DBIA
 Probe Info  		C50(1.17)  LDD3310  [7]
Backus_15
 Probe Info  		2.20  LDD0423  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
IPM
 Probe Info  		N.A.  LDD0005  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
1d-yne
 Probe Info  		N.A.  LDD0357  [17]
Acrolein
 Probe Info  		C50(0.00); C226(0.00)  LDD0217  [18]
W1
 Probe Info  		C220(0.00); C226(0.00)  LDD0236  [19]
AOyne
 Probe Info  		14.00  LDD0443  [20]
NAIA_5
 Probe Info  		C50(0.00); C425(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 137 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		5.08  LDD0398  [21]
C004
 Probe Info  		8.63  LDD1714  [22]
C007
 Probe Info  		5.39  LDD1716  [22]
C017
 Probe Info  		12.73  LDD1725  [22]
C022
 Probe Info  		18.13  LDD1728  [22]
C027
 Probe Info  		6.87  LDD1733  [22]
C040
 Probe Info  		31.12  LDD1740  [22]
C041
 Probe Info  		7.84  LDD1741  [22]
C049
 Probe Info  		11.24  LDD1747  [22]
C053
 Probe Info  		4.99  LDD1751  [22]
C055
 Probe Info  		29.24  LDD1752  [22]
C056
 Probe Info  		59.30  LDD1753  [22]
C063
 Probe Info  		19.16  LDD1760  [22]
C064
 Probe Info  		6.11  LDD1761  [22]
C070
 Probe Info  		20.11  LDD1766  [22]
C072
 Probe Info  		11.55  LDD1768  [22]
C082
 Probe Info  		6.50  LDD1774  [22]
C091
 Probe Info  		30.27  LDD1782  [22]
C092
 Probe Info  		53.45  LDD1783  [22]
C094
 Probe Info  		47.50  LDD1785  [22]
C095
 Probe Info  		7.06  LDD1786  [22]
C100
 Probe Info  		6.45  LDD1789  [22]
C106
 Probe Info  		58.08  LDD1793  [22]
C107
 Probe Info  		9.78  LDD1794  [22]
C108
 Probe Info  		15.35  LDD1795  [22]
C112
 Probe Info  		64.00  LDD1799  [22]
C129
 Probe Info  		6.92  LDD1811  [22]
C130
 Probe Info  		8.88  LDD1812  [22]
C134
 Probe Info  		56.49  LDD1816  [22]
C135
 Probe Info  		21.56  LDD1817  [22]
C139
 Probe Info  		13.09  LDD1821  [22]
C140
 Probe Info  		8.06  LDD1822  [22]
C141
 Probe Info  		15.45  LDD1823  [22]
C143
 Probe Info  		27.47  LDD1825  [22]
C153
 Probe Info  		37.79  LDD1834  [22]
C159
 Probe Info  		16.34  LDD1839  [22]
C160
 Probe Info  		11.79  LDD1840  [22]
C161
 Probe Info  		19.84  LDD1841  [22]
C163
 Probe Info  		10.63  LDD1843  [22]
C165
 Probe Info  		12.64  LDD1845  [22]
C166
 Probe Info  		7.01  LDD1846  [22]
C169
 Probe Info  		36.50  LDD1849  [22]
C178
 Probe Info  		34.30  LDD1857  [22]
C186
 Probe Info  		11.39  LDD1864  [22]
C187
 Probe Info  		25.11  LDD1865  [22]
C191
 Probe Info  		9.78  LDD1868  [22]
C194
 Probe Info  		13.45  LDD1870  [22]
C196
 Probe Info  		16.68  LDD1872  [22]
C198
 Probe Info  		21.41  LDD1874  [22]
C201
 Probe Info  		90.51  LDD1877  [22]
C206
 Probe Info  		41.36  LDD1881  [22]
C207
 Probe Info  		21.41  LDD1882  [22]
C210
 Probe Info  		75.58  LDD1884  [22]
C211
 Probe Info  		8.11  LDD1885  [22]
C213
 Probe Info  		17.39  LDD1887  [22]
C218
 Probe Info  		36.00  LDD1892  [22]
C219
 Probe Info  		6.87  LDD1893  [22]
C220
 Probe Info  		32.45  LDD1894  [22]
C225
 Probe Info  		6.45  LDD1898  [22]
C226
 Probe Info  		5.62  LDD1899  [22]
C228
 Probe Info  		41.93  LDD1901  [22]
C231
 Probe Info  		28.84  LDD1904  [22]
C233
 Probe Info  		11.16  LDD1906  [22]
C234
 Probe Info  		6.50  LDD1907  [22]
C235
 Probe Info  		43.41  LDD1908  [22]
C238
 Probe Info  		22.32  LDD1911  [22]
C240
 Probe Info  		9.06  LDD1913  [22]
C243
 Probe Info  		23.43  LDD1916  [22]
C244
 Probe Info  		18.64  LDD1917  [22]
C246
 Probe Info  		37.79  LDD1919  [22]
C249
 Probe Info  		19.43  LDD1922  [22]
C252
 Probe Info  		18.13  LDD1925  [22]
C264
 Probe Info  		47.18  LDD1935  [22]
C265
 Probe Info  		24.93  LDD1936  [22]
C270
 Probe Info  		11.24  LDD1940  [22]
C273
 Probe Info  		7.21  LDD1943  [22]
C277
 Probe Info  		18.64  LDD1947  [22]
C278
 Probe Info  		99.73  LDD1948  [22]
C280
 Probe Info  		10.93  LDD1950  [22]
C282
 Probe Info  		44.32  LDD1952  [22]
C284
 Probe Info  		60.97  LDD1954  [22]
C285
 Probe Info  		48.84  LDD1955  [22]
C287
 Probe Info  		21.26  LDD1957  [22]
C288
 Probe Info  		8.57  LDD1958  [22]
C289
 Probe Info  		75.58  LDD1959  [22]
C293
 Probe Info  		42.22  LDD1963  [22]
C296
 Probe Info  		23.92  LDD1966  [22]
C299
 Probe Info  		11.63  LDD1968  [22]
C305
 Probe Info  		16.80  LDD1974  [22]
C310
 Probe Info  		18.51  LDD1977  [22]
C314
 Probe Info  		17.15  LDD1981  [22]
C322
 Probe Info  		5.74  LDD1988  [22]
C326
 Probe Info  		9.06  LDD1990  [22]
C338
 Probe Info  		10.41  LDD2001  [22]
C339
 Probe Info  		11.63  LDD2002  [22]
C343
 Probe Info  		30.27  LDD2005  [22]
C348
 Probe Info  		13.36  LDD2009  [22]
C349
 Probe Info  		30.27  LDD2010  [22]
C350
 Probe Info  		65.80  LDD2011  [22]
C355
 Probe Info  		38.59  LDD2016  [22]
C356
 Probe Info  		12.13  LDD2017  [22]
C357
 Probe Info  		6.68  LDD2018  [22]
C362
 Probe Info  		99.73  LDD2023  [22]
C363
 Probe Info  		46.85  LDD2024  [22]
C364
 Probe Info  		56.49  LDD2025  [22]
C366
 Probe Info  		30.06  LDD2027  [22]
C367
 Probe Info  		13.27  LDD2028  [22]
C373
 Probe Info  		7.36  LDD2033  [22]
C376
 Probe Info  		13.18  LDD2036  [22]
C378
 Probe Info  		6.92  LDD2037  [22]
C382
 Probe Info  		18.25  LDD2041  [22]
C383
 Probe Info  		13.64  LDD2042  [22]
C386
 Probe Info  		7.84  LDD2045  [22]
C388
 Probe Info  		99.73  LDD2047  [22]
C390
 Probe Info  		99.73  LDD2049  [22]
C391
 Probe Info  		16.56  LDD2050  [22]
C396
 Probe Info  		5.54  LDD2055  [22]
C399
 Probe Info  		9.71  LDD2058  [22]
C403
 Probe Info  		30.27  LDD2061  [22]
C407
 Probe Info  		37.01  LDD2064  [22]
C409
 Probe Info  		4.96  LDD2066  [22]
C413
 Probe Info  		15.45  LDD2069  [22]
C424
 Probe Info  		11.47  LDD2079  [22]
C426
 Probe Info  		18.00  LDD2081  [22]
C429
 Probe Info  		17.51  LDD2084  [22]
C431
 Probe Info  		32.67  LDD2086  [22]
FFF probe11
 Probe Info  		20.00  LDD0471  [23]
FFF probe13
 Probe Info  		20.00  LDD0475  [23]
FFF probe14
 Probe Info  		20.00  LDD0477  [23]
FFF probe15
 Probe Info  		5.15  LDD0478  [23]
FFF probe2
 Probe Info  		20.00  LDD0463  [23]
FFF probe3
 Probe Info  		20.00  LDD0464  [23]
FFF probe4
 Probe Info  		19.61  LDD0466  [23]
JN0003
 Probe Info  		20.00  LDD0469  [23]
PARPYnD
 Probe Info  		1.55  LDD0376  [24]
A-DA
 Probe Info  		2.00  LDD0142  [25]
OEA-DA
 Probe Info  		20.00  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C50(0.90); C214(0.84); C425(1.10); C220(1.00)  LDD1507  [27]
 LDCM0215  AC10 HEK-293T C50(0.92); C214(0.90); C425(1.10); C241(1.12)  LDD1508  [27]
 LDCM0226  AC11 HEK-293T C50(0.91); C214(0.91); C241(1.00)  LDD1509  [27]
 LDCM0237  AC12 HEK-293T C50(0.90); C214(0.94); C425(0.88)  LDD1510  [27]
 LDCM0259  AC14 HEK-293T C50(0.95); C214(0.95); C425(1.05)  LDD1512  [27]
 LDCM0270  AC15 HEK-293T C50(1.01); C214(0.97); C425(0.97); C241(1.16)  LDD1513  [27]
 LDCM0276  AC17 HEK-293T C50(0.97); C214(0.89); C425(1.02); C220(1.00)  LDD1515  [27]
 LDCM0277  AC18 HEK-293T C50(0.94); C214(0.97); C425(1.04); C241(0.98)  LDD1516  [27]
 LDCM0278  AC19 HEK-293T C50(0.89); C214(0.90); C241(0.84)  LDD1517  [27]
 LDCM0279  AC2 HEK-293T C50(0.99); C214(1.00); C425(1.06); C241(0.70)  LDD1518  [27]
 LDCM0280  AC20 HEK-293T C50(0.93); C214(0.98); C425(1.05)  LDD1519  [27]
 LDCM0281  AC21 HEK-293T C50(0.95); C214(1.00); C425(1.04); C241(1.04)  LDD1520  [27]
 LDCM0282  AC22 HEK-293T C50(0.98); C214(0.91); C425(1.08)  LDD1521  [27]
 LDCM0283  AC23 HEK-293T C50(0.99); C214(0.93); C425(0.98); C241(0.98)  LDD1522  [27]
 LDCM0284  AC24 HEK-293T C50(0.97); C214(0.97); C425(1.00)  LDD1523  [27]
 LDCM0285  AC25 HEK-293T C50(0.92); C214(0.90); C425(1.05); C220(0.99)  LDD1524  [27]
 LDCM0286  AC26 HEK-293T C50(0.93); C214(0.94); C425(1.05); C241(0.74)  LDD1525  [27]
 LDCM0287  AC27 HEK-293T C50(0.89); C214(0.94); C241(0.97)  LDD1526  [27]
 LDCM0288  AC28 HEK-293T C50(1.01); C214(0.99); C425(1.02)  LDD1527  [27]
 LDCM0289  AC29 HEK-293T C50(0.91); C214(1.07); C425(0.95); C241(1.07)  LDD1528  [27]
 LDCM0290  AC3 HEK-293T C50(0.93); C214(0.87); C241(1.05)  LDD1529  [27]
 LDCM0291  AC30 HEK-293T C50(1.09); C214(0.97); C425(1.08)  LDD1530  [27]
 LDCM0292  AC31 HEK-293T C50(1.07); C214(0.98); C425(1.03); C241(1.33)  LDD1531  [27]
 LDCM0293  AC32 HEK-293T C50(1.03); C214(1.01); C425(1.01)  LDD1532  [27]
 LDCM0294  AC33 HEK-293T C50(0.82); C214(0.88); C425(1.08); C220(0.93)  LDD1533  [27]
 LDCM0295  AC34 HEK-293T C50(0.98); C214(0.95); C425(1.03); C241(0.69)  LDD1534  [27]
 LDCM0296  AC35 HEK-293T C50(0.92); C214(0.88); C241(1.19)  LDD1535  [27]
 LDCM0297  AC36 HEK-293T C50(0.87); C214(0.92); C425(1.06)  LDD1536  [27]
 LDCM0298  AC37 HEK-293T C50(0.94); C214(1.08); C425(1.09); C241(1.14)  LDD1537  [27]
 LDCM0299  AC38 HEK-293T C50(0.96); C214(0.97); C425(1.19)  LDD1538  [27]
 LDCM0300  AC39 HEK-293T C50(0.97); C214(0.97); C425(0.98); C241(1.03)  LDD1539  [27]
 LDCM0301  AC4 HEK-293T C50(0.94); C214(0.96); C425(0.99)  LDD1540  [27]
 LDCM0302  AC40 HEK-293T C50(0.95); C214(1.03); C425(1.03)  LDD1541  [27]
 LDCM0303  AC41 HEK-293T C50(0.95); C214(0.93); C425(1.00); C220(1.02)  LDD1542  [27]
 LDCM0304  AC42 HEK-293T C50(0.90); C214(0.89); C425(1.15); C241(0.77)  LDD1543  [27]
 LDCM0305  AC43 HEK-293T C50(0.96); C214(0.93); C241(0.95)  LDD1544  [27]
 LDCM0306  AC44 HEK-293T C50(0.92); C214(0.97); C425(1.01)  LDD1545  [27]
 LDCM0307  AC45 HEK-293T C50(0.89); C214(0.96); C425(1.08); C241(1.10)  LDD1546  [27]
 LDCM0308  AC46 HEK-293T C50(1.03); C214(0.91); C425(1.02)  LDD1547  [27]
 LDCM0309  AC47 HEK-293T C50(0.98); C214(1.01); C425(1.02); C241(1.06)  LDD1548  [27]
 LDCM0310  AC48 HEK-293T C50(1.05); C214(1.01); C425(0.99)  LDD1549  [27]
 LDCM0311  AC49 HEK-293T C50(0.87); C214(0.89); C425(1.01); C220(0.95)  LDD1550  [27]
 LDCM0312  AC5 HEK-293T C50(0.97); C214(1.09); C425(1.06); C241(1.06)  LDD1551  [27]
 LDCM0313  AC50 HEK-293T C50(0.96); C214(0.90); C425(1.08); C241(0.92)  LDD1552  [27]
 LDCM0314  AC51 HEK-293T C50(1.01); C214(0.97); C241(0.94)  LDD1553  [27]
 LDCM0315  AC52 HEK-293T C50(0.94); C214(0.99); C425(1.01)  LDD1554  [27]
 LDCM0316  AC53 HEK-293T C50(0.88); C214(0.99); C425(1.00); C241(0.92)  LDD1555  [27]
 LDCM0317  AC54 HEK-293T C50(0.97); C214(0.90); C425(1.12)  LDD1556  [27]
 LDCM0318  AC55 HEK-293T C50(0.84); C214(0.98); C425(0.97); C241(1.36)  LDD1557  [27]
 LDCM0319  AC56 HEK-293T C50(1.02); C214(0.97); C425(1.00)  LDD1558  [27]
 LDCM0320  AC57 HEK-293T C50(0.84); C214(0.89); C425(1.01); C220(1.05)  LDD1559  [27]
 LDCM0321  AC58 HEK-293T C50(0.96); C214(0.98); C425(1.06); C241(0.77)  LDD1560  [27]
 LDCM0322  AC59 HEK-293T C50(0.91); C214(0.89); C241(0.96)  LDD1561  [27]
 LDCM0323  AC6 HEK-293T C50(0.99); C214(1.00); C425(0.97)  LDD1562  [27]
 LDCM0324  AC60 HEK-293T C50(0.92); C214(0.98); C425(0.99)  LDD1563  [27]
 LDCM0325  AC61 HEK-293T C50(0.88); C214(1.01); C425(1.05); C241(1.01)  LDD1564  [27]
 LDCM0326  AC62 HEK-293T C50(0.98); C214(0.92); C425(1.03)  LDD1565  [27]
 LDCM0327  AC63 HEK-293T C50(0.97); C214(1.03); C425(1.01); C241(1.11)  LDD1566  [27]
 LDCM0328  AC64 HEK-293T C50(1.01); C214(0.96); C425(1.02)  LDD1567  [27]
 LDCM0334  AC7 HEK-293T C50(0.92); C214(0.99); C425(1.01); C241(1.44)  LDD1568  [27]
 LDCM0345  AC8 HEK-293T C50(0.96); C214(0.99); C425(1.10)  LDD1569  [27]
 LDCM0248  AKOS034007472 HEK-293T C50(0.97); C214(1.04); C425(0.99); C241(1.14)  LDD1511  [27]
 LDCM0356  AKOS034007680 HEK-293T C50(0.99); C214(0.89); C425(1.03); C220(1.04)  LDD1570  [27]
 LDCM0275  AKOS034007705 HEK-293T C50(1.02); C214(1.01); C425(0.99)  LDD1514  [27]
 LDCM0156  Aniline NCI-H1299 11.42  LDD0403  [1]
 LDCM0147  AZ0108 MDA-MB-468 1.55  LDD0376  [24]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C50(0.21)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C50(0.86); C214(1.06); C425(1.14)  LDD1571  [27]
 LDCM0368  CL10 HEK-293T C50(0.86); C214(1.14); C425(1.19)  LDD1572  [27]
 LDCM0369  CL100 HEK-293T C50(0.82); C214(0.95); C425(1.11); C241(1.14)  LDD1573  [27]
 LDCM0370  CL101 HEK-293T C50(0.96); C214(1.00); C425(1.03)  LDD1574  [27]
 LDCM0371  CL102 HEK-293T C50(0.96); C214(0.93); C425(1.25); C241(1.09)  LDD1575  [27]
 LDCM0372  CL103 HEK-293T C50(0.92); C214(0.89); C425(0.91); C241(1.06)  LDD1576  [27]
 LDCM0373  CL104 HEK-293T C50(0.99); C214(1.00); C425(1.08); C241(1.05)  LDD1577  [27]
 LDCM0374  CL105 HEK-293T C50(0.95); C214(1.12); C425(1.59)  LDD1578  [27]
 LDCM0375  CL106 HEK-293T C50(0.92); C214(0.85); C425(1.08); C241(0.91)  LDD1579  [27]
 LDCM0376  CL107 HEK-293T C50(0.95); C214(0.87); C425(0.93); C241(1.03)  LDD1580  [27]
 LDCM0377  CL108 HEK-293T C50(0.91); C214(0.94); C425(1.04); C241(0.88)  LDD1581  [27]
 LDCM0378  CL109 HEK-293T C50(1.08); C214(1.23); C425(1.83)  LDD1582  [27]
 LDCM0379  CL11 HEK-293T C50(0.87); C214(1.22); C425(1.00); C241(1.78)  LDD1583  [27]
 LDCM0380  CL110 HEK-293T C50(0.90); C214(1.07); C425(1.41); C241(1.54)  LDD1584  [27]
 LDCM0381  CL111 HEK-293T C50(0.90); C214(1.01); C425(1.07); C241(1.19)  LDD1585  [27]
 LDCM0382  CL112 HEK-293T C50(0.91); C214(0.91); C425(0.99); C241(0.97)  LDD1586  [27]
 LDCM0383  CL113 HEK-293T C50(0.93); C214(0.94); C425(1.01)  LDD1587  [27]
 LDCM0384  CL114 HEK-293T C50(0.95); C214(1.01); C425(1.20); C241(1.02)  LDD1588  [27]
 LDCM0385  CL115 HEK-293T C50(0.97); C214(0.92); C425(1.04); C241(0.91)  LDD1589  [27]
 LDCM0386  CL116 HEK-293T C50(0.89); C214(0.90); C425(1.01); C241(1.23)  LDD1590  [27]
 LDCM0387  CL117 HEK-293T C50(0.97); C214(0.98); C425(1.00)  LDD1591  [27]
 LDCM0388  CL118 HEK-293T C50(0.91); C214(0.80); C425(1.11); C241(1.09)  LDD1592  [27]
 LDCM0389  CL119 HEK-293T C50(0.93); C214(0.91); C425(0.89); C241(0.84)  LDD1593  [27]
 LDCM0390  CL12 HEK-293T C50(0.92); C214(1.14); C425(0.82)  LDD1594  [27]
 LDCM0391  CL120 HEK-293T C50(0.94); C214(0.94); C425(1.03); C241(1.02)  LDD1595  [27]
 LDCM0392  CL121 HEK-293T C50(0.95); C214(0.92); C425(1.03)  LDD1596  [27]
 LDCM0393  CL122 HEK-293T C50(0.97); C214(0.77); C425(1.16); C241(0.95)  LDD1597  [27]
 LDCM0394  CL123 HEK-293T C50(0.87); C214(0.89); C425(1.35); C241(1.12)  LDD1598  [27]
 LDCM0395  CL124 HEK-293T C50(0.86); C214(0.96); C425(1.10); C241(1.21)  LDD1599  [27]
 LDCM0396  CL125 HEK-293T C50(1.01); C214(0.90); C425(0.95)  LDD1600  [27]
 LDCM0397  CL126 HEK-293T C50(0.96); C214(1.02); C425(1.12); C241(1.00)  LDD1601  [27]
 LDCM0398  CL127 HEK-293T C50(0.93); C214(0.98); C425(1.04); C241(0.98)  LDD1602  [27]
 LDCM0399  CL128 HEK-293T C50(1.01); C214(0.89); C425(1.13); C241(1.08)  LDD1603  [27]
 LDCM0400  CL13 HEK-293T C50(0.94); C214(0.90); C425(1.03)  LDD1604  [27]
 LDCM0401  CL14 HEK-293T C50(0.92); C214(0.89); C425(1.11); C241(1.08)  LDD1605  [27]
 LDCM0402  CL15 HEK-293T C50(0.85); C214(0.96); C425(1.16); C241(0.88)  LDD1606  [27]
 LDCM0403  CL16 HEK-293T C50(0.88); C214(0.92); C425(1.01); C241(0.95)  LDD1607  [27]
 LDCM0404  CL17 HEK-293T C50(1.01); C214(1.09); C425(1.08); C220(1.04)  LDD1608  [27]
 LDCM0405  CL18 HEK-293T C50(0.91); C214(0.95); C425(0.91); C241(1.15)  LDD1609  [27]
 LDCM0406  CL19 HEK-293T C50(0.99); C214(1.08); C241(1.05)  LDD1610  [27]
 LDCM0407  CL2 HEK-293T C50(0.98); C214(1.03); C425(1.08); C241(1.00)  LDD1611  [27]
 LDCM0408  CL20 HEK-293T C50(0.99); C214(1.13); C425(0.85)  LDD1612  [27]
 LDCM0409  CL21 HEK-293T C50(0.81); C214(1.21); C425(0.92); C241(1.27)  LDD1613  [27]
 LDCM0410  CL22 HEK-293T C50(1.05); C214(1.11); C425(0.97)  LDD1614  [27]
 LDCM0411  CL23 HEK-293T C50(0.96); C214(1.17); C425(0.88); C241(1.59)  LDD1615  [27]
 LDCM0412  CL24 HEK-293T C50(1.16); C214(1.13); C425(0.84)  LDD1616  [27]
 LDCM0413  CL25 HEK-293T C50(0.97); C214(1.02); C425(1.10)  LDD1617  [27]
 LDCM0414  CL26 HEK-293T C50(0.96); C214(0.90); C425(1.05); C241(1.05)  LDD1618  [27]
 LDCM0415  CL27 HEK-293T C50(0.96); C214(0.94); C425(0.87); C241(0.97)  LDD1619  [27]
 LDCM0416  CL28 HEK-293T C50(1.09); C214(0.98); C425(1.03); C241(1.20)  LDD1620  [27]
 LDCM0417  CL29 HEK-293T C50(0.97); C214(0.95); C425(0.97); C220(0.93)  LDD1621  [27]
 LDCM0418  CL3 HEK-293T C50(0.86); C214(1.03); C425(1.03); C241(0.95)  LDD1622  [27]
 LDCM0419  CL30 HEK-293T C50(1.02); C214(1.03); C425(0.86); C241(1.02)  LDD1623  [27]
 LDCM0420  CL31 HEK-293T C50(0.89); C214(1.14); C241(0.97)  LDD1624  [27]
 LDCM0421  CL32 HEK-293T C50(0.95); C214(1.02); C425(0.95)  LDD1625  [27]
 LDCM0422  CL33 HEK-293T C50(0.86); C214(1.17); C425(1.10); C241(0.76)  LDD1626  [27]
 LDCM0423  CL34 HEK-293T C50(0.91); C214(1.19); C425(0.93)  LDD1627  [27]
 LDCM0424  CL35 HEK-293T C50(1.03); C214(1.12); C425(0.76); C241(0.96)  LDD1628  [27]
 LDCM0425  CL36 HEK-293T C50(0.95); C214(1.21); C425(0.92)  LDD1629  [27]
 LDCM0426  CL37 HEK-293T C50(0.96); C214(1.04); C425(1.09)  LDD1630  [27]
 LDCM0428  CL39 HEK-293T C50(0.84); C214(0.99); C425(1.19); C241(1.43)  LDD1632  [27]
 LDCM0429  CL4 HEK-293T C50(0.92); C214(0.99); C425(1.08); C241(1.11)  LDD1633  [27]
 LDCM0430  CL40 HEK-293T C50(0.93); C214(0.96); C425(0.96); C241(0.97)  LDD1634  [27]
 LDCM0431  CL41 HEK-293T C50(0.88); C214(1.04); C425(0.99); C220(1.06)  LDD1635  [27]
 LDCM0432  CL42 HEK-293T C50(1.01); C214(1.15); C425(1.02); C241(0.78)  LDD1636  [27]
 LDCM0433  CL43 HEK-293T C50(0.94); C214(1.17); C241(1.10)  LDD1637  [27]
 LDCM0434  CL44 HEK-293T C50(0.92); C214(1.10); C425(0.81)  LDD1638  [27]
 LDCM0435  CL45 HEK-293T C50(0.91); C214(1.17); C425(1.07); C241(1.35)  LDD1639  [27]
 LDCM0436  CL46 HEK-293T C50(0.84); C214(1.15); C425(0.88)  LDD1640  [27]
 LDCM0437  CL47 HEK-293T C50(1.12); C214(1.13); C425(0.85); C241(0.99)  LDD1641  [27]
 LDCM0438  CL48 HEK-293T C50(0.93); C214(1.15); C425(0.74)  LDD1642  [27]
 LDCM0439  CL49 HEK-293T C50(0.83); C214(1.01); C425(1.11)  LDD1643  [27]
 LDCM0440  CL5 HEK-293T C50(0.95); C214(1.05); C425(0.92); C220(1.01)  LDD1644  [27]
 LDCM0441  CL50 HEK-293T C50(0.93); C214(1.01); C425(1.14); C241(1.21)  LDD1645  [27]
 LDCM0443  CL52 HEK-293T C50(0.90); C214(0.95); C425(1.00); C241(1.25)  LDD1646  [27]
 LDCM0444  CL53 HEK-293T C50(0.87); C214(1.05); C425(1.10); C220(1.04)  LDD1647  [27]
 LDCM0445  CL54 HEK-293T C50(0.76); C214(0.94); C425(1.43); C241(2.12)  LDD1648  [27]
 LDCM0446  CL55 HEK-293T C50(0.93); C214(1.09); C241(0.98)  LDD1649  [27]
 LDCM0447  CL56 HEK-293T C50(1.01); C214(1.08); C425(0.83)  LDD1650  [27]
 LDCM0448  CL57 HEK-293T C50(0.85); C214(1.17); C425(1.06); C241(1.14)  LDD1651  [27]
 LDCM0449  CL58 HEK-293T C50(0.94); C214(1.02); C425(1.14)  LDD1652  [27]
 LDCM0450  CL59 HEK-293T C50(0.94); C214(1.13); C425(0.83); C241(1.32)  LDD1653  [27]
 LDCM0451  CL6 HEK-293T C50(0.75); C214(1.21); C425(1.07); C241(1.00)  LDD1654  [27]
 LDCM0452  CL60 HEK-293T C50(0.97); C214(1.24); C425(0.93)  LDD1655  [27]
 LDCM0453  CL61 HEK-293T C50(0.90); C214(0.91); C425(1.04)  LDD1656  [27]
 LDCM0454  CL62 HEK-293T C50(0.95); C214(0.94); C425(1.12); C241(1.02)  LDD1657  [27]
 LDCM0455  CL63 HEK-293T C50(0.89); C214(0.94); C425(1.09); C241(0.92)  LDD1658  [27]
 LDCM0456  CL64 HEK-293T C50(0.91); C214(1.22); C425(1.29); C241(2.40)  LDD1659  [27]
 LDCM0457  CL65 HEK-293T C50(0.89); C214(0.94); C425(1.04); C220(0.94)  LDD1660  [27]
 LDCM0458  CL66 HEK-293T C50(0.95); C214(1.08); C425(0.95); C241(0.83)  LDD1661  [27]
 LDCM0459  CL67 HEK-293T C50(0.99); C214(1.11); C241(0.95)  LDD1662  [27]
 LDCM0460  CL68 HEK-293T C50(0.95); C214(1.12); C425(0.95)  LDD1663  [27]
 LDCM0461  CL69 HEK-293T C50(0.87); C214(1.11); C425(0.95); C241(0.95)  LDD1664  [27]
 LDCM0462  CL7 HEK-293T C50(0.99); C214(1.16); C241(1.89)  LDD1665  [27]
 LDCM0463  CL70 HEK-293T C50(1.01); C214(1.16); C425(0.98)  LDD1666  [27]
 LDCM0464  CL71 HEK-293T C50(0.91); C214(1.22); C425(0.82); C241(1.32)  LDD1667  [27]
 LDCM0465  CL72 HEK-293T C50(0.97); C214(1.07); C425(0.85)  LDD1668  [27]
 LDCM0466  CL73 HEK-293T C50(1.01); C214(1.01); C425(1.20)  LDD1669  [27]
 LDCM0467  CL74 HEK-293T C50(1.03); C214(0.89); C425(1.10); C241(1.05)  LDD1670  [27]
 LDCM0469  CL76 HEK-293T C50(0.95); C214(0.95); C425(1.06); C241(1.04)  LDD1672  [27]
 LDCM0470  CL77 HEK-293T C50(0.78); C214(1.03); C425(1.22); C220(1.08)  LDD1673  [27]
 LDCM0471  CL78 HEK-293T C50(1.06); C214(0.97); C425(0.94); C241(1.09)  LDD1674  [27]
 LDCM0472  CL79 HEK-293T C50(0.96); C214(1.08); C241(1.20)  LDD1675  [27]
 LDCM0473  CL8 HEK-293T C50(0.74); C214(1.12); C425(1.06)  LDD1676  [27]
 LDCM0474  CL80 HEK-293T C50(1.00); C214(1.07); C425(0.87)  LDD1677  [27]
 LDCM0475  CL81 HEK-293T C50(1.01); C214(1.08); C425(0.86); C241(1.18)  LDD1678  [27]
 LDCM0476  CL82 HEK-293T C50(0.97); C214(1.07); C425(0.94)  LDD1679  [27]
 LDCM0477  CL83 HEK-293T C50(0.93); C214(1.17); C425(0.90); C241(1.25)  LDD1680  [27]
 LDCM0478  CL84 HEK-293T C50(0.94); C214(1.36); C425(1.22)  LDD1681  [27]
 LDCM0479  CL85 HEK-293T C50(1.01); C214(0.99); C425(1.09)  LDD1682  [27]
 LDCM0480  CL86 HEK-293T C50(0.92); C214(1.04); C425(1.19); C241(1.04)  LDD1683  [27]
 LDCM0481  CL87 HEK-293T C50(0.95); C214(0.95); C425(0.94); C241(1.03)  LDD1684  [27]
 LDCM0482  CL88 HEK-293T C50(0.99); C214(0.91); C425(1.18); C241(1.36)  LDD1685  [27]
 LDCM0483  CL89 HEK-293T C50(0.86); C214(0.88); C425(1.05); C220(0.88)  LDD1686  [27]
 LDCM0484  CL9 HEK-293T C50(0.82); C214(1.25); C425(0.89); C241(1.37)  LDD1687  [27]
 LDCM0485  CL90 HEK-293T C50(0.59); C214(1.11); C425(1.36); C241(1.14)  LDD1688  [27]
 LDCM0486  CL91 HEK-293T C50(0.93); C214(1.03); C241(1.16)  LDD1689  [27]
 LDCM0487  CL92 HEK-293T C50(0.25); C214(0.99); C425(1.08)  LDD1690  [27]
 LDCM0488  CL93 HEK-293T C50(0.81); C214(1.11); C425(0.97); C241(1.34)  LDD1691  [27]
 LDCM0489  CL94 HEK-293T C50(0.92); C214(1.19); C425(0.99)  LDD1692  [27]
 LDCM0490  CL95 HEK-293T C50(0.72); C214(1.20); C425(0.96); C241(1.03)  LDD1693  [27]
 LDCM0491  CL96 HEK-293T C50(0.89); C214(1.19); C425(0.94)  LDD1694  [27]
 LDCM0492  CL97 HEK-293T C50(1.05); C214(1.27); C425(1.75)  LDD1695  [27]
 LDCM0493  CL98 HEK-293T C50(0.96); C214(1.04); C425(1.14); C241(1.19)  LDD1696  [27]
 LDCM0494  CL99 HEK-293T C50(0.94); C214(1.07); C425(1.07); C241(0.94)  LDD1697  [27]
 LDCM0495  E2913 HEK-293T C50(0.84); C214(0.98); C425(1.23); C241(1.04)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C50(2.11)  LDD1702  [28]
 LDCM0082  FK866 A-549 2.00  LDD0142  [25]
 LDCM0468  Fragment33 HEK-293T C50(0.88); C214(0.93); C425(1.18); C241(1.19)  LDD1671  [27]
 LDCM0427  Fragment51 HEK-293T C50(1.05); C214(1.00); C425(1.06); C241(0.95)  LDD1631  [27]
 LDCM0167  HOIPIN 11a HEK-293T 2.20  LDD0423  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C214(0.83); C425(0.89); C50(1.03); C226(0.70)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C214(0.94); C425(0.85); C50(1.00); C226(1.11)  LDD1497  [27]
 LDCM0024  KB05 COLO792 C50(1.17)  LDD3310  [7]
 LDCM0109  NEM HeLa N.A.  LDD0227  [18]
 LDCM0099  Phenelzine HEK-293T 3.68  LDD0282  [6]
 LDCM0084  Ro 48-8071 A-549 2.48  LDD0145  [25]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Disulfiram Small molecular drug D0X5SD
Nadh Small molecular drug DB00157
Ozanimod . DB12612
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aloe-emodin Small molecular drug D09BUG
Nsc-527035 Small molecular drug D04DKX
S-methyl 4-methyl-4-morpholinopent-2-ynethioate Small molecular drug D0M0YO
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nps 1776 Small molecular drug D00DBH

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
25 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761