Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C211  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 89 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 85.0
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 81.6
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 78.8
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 48.5
 LDTP03540  Heme oxygenase 2 (HMOX2) 41.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 38.1
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 35.5
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 32.7
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 32.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 31.1
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 25.6
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 24.9
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 22.0
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 21.9
 LDTP17633  Beta-galactosidase-1-like protein 2 (GLB1L2) 20.3
 LDTP05905  Acid ceramidase (ASAH1) 20.1
 LDTP12610  Obg-like ATPase 1 (OLA1) 19.7
 LDTP02505  Lysosomal protective protein (CTSA) 18.3
 LDTP07620  Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) 17.9
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 17.6
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 17.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 17.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 16.4
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 16.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 15.5
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 15.5
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 14.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 14.6
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 14.5
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 14.4
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 14.2
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 14.2
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 14.0
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 13.9
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 13.8
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 13.7
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 13.2
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 12.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 12.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 12.4
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 12.4
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 12.3
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 12.2
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 12.1
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 12.0
 LDTP08933  Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) 11.9
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 11.7
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 11.6
 LDTP00654  Synaptobrevin homolog YKT6 (YKT6) 11.2
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 10.8
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 10.5
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 10.4
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 10.3
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 10.2
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 10.1
 LDTP01518  NADH dehydrogenase 1 alpha subcomplex subunit 7 (NDUFA7) 10.1
 LDTP00697  Cytochrome b5 type B (CYB5B) 10.1
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 9.9
 LDTP00282  Beta-mannosidase (MANBA) 9.8
 LDTP00316  Ribonuclease T2 (RNASET2) 9.8
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 9.7
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 9.7
 LDTP02141  Alpha-galactosidase A (GLA) 9.6
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 9.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 9.4
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 9.4
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 9.3
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 9.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 9.1
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 9.1
 LDTP03671  Multidrug resistance-associated protein 1 (ABCC1) 9.1
 LDTP11708  ADP-ribosylation factor-like protein 6 (ARL6) 9.0
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 8.9
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 8.8
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 8.8
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 8.8
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 8.6
 LDTP03787  Choline kinase alpha (CHKA) 8.6
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 8.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 8.5
 LDTP02837  Beta-galactosidase (GLB1) 8.4
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 8.3
 LDTP04565  Methionine aminopeptidase 1 (METAP1) 8.3
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 8.1
 LDTP13751  Exonuclease 1 (EXO1) 8.1
 LDTP01514  NADH dehydrogenase 1 beta subcomplex subunit 4 (NDUFB4) 8.1
 LDTP13195  Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) 7.9
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 7.8
 LDTP13200  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (FTSJ1) 7.8
Transporter and channel
Click to Show/Hide to Show 50 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 98.4
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 67.2
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 54.9
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 43.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 37.3
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 36.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 35.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 33.1
 LDTP15948  Transmembrane protein 126A (TMEM126A) 27.7
 LDTP02215  Prosaposin (PSAP) 25.3
 LDTP20002  Transmembrane protein 160 (TMEM160) 23.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 23.1
 LDTP07236  Protein GPR107 (GPR107) 22.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 20.1
 LDTP16190  Protein FAM8A1 (FAM8A1) 18.9
 LDTP16813  Tetraspanin-3 (TSPAN3) 17.8
 LDTP11406  Transmembrane protein 59 (TMEM59) 16.9
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 16.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 15.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 15.2
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 14.6
 LDTP15481  Transmembrane protein 87A (TMEM87A) 13.9
 LDTP05236  Phosphatidylinositol transfer protein alpha isoform (PITPNA) 13.4
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 13.3
 LDTP01574  Importin-7 (IPO7) 13.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 13.0
 LDTP00310  Syntenin-1 (SDCBP) 12.7
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 11.6
 LDTP11607  Exportin-4 (XPO4) 11.5
 LDTP00592  Surfeit locus protein 4 (SURF4) 10.9
 LDTP13256  SUN domain-containing protein 2 (SUN2) 10.8
 LDTP02071  Amyloid-beta precursor protein (APP) 10.6
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 10.3
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 9.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 9.6
 LDTP09288  Vang-like protein 1 (VANGL1) 9.6
 LDTP10663  Importin-9 (IPO9) 9.5
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.4
 LDTP03546  Translocator protein (TSPO) 9.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 9.3
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 9.2
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 8.9
 LDTP05900  Metaxin-1 (MTX1) 8.8
 LDTP03380  Stomatin (STOM) 8.8
 LDTP12644  Mitochondrial potassium channel ATP-binding subunit (ABCB8) 8.2
 LDTP11213  Nucleoporin NDC1 (NDC1) 8.2
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 8.2
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 8.1
 LDTP12451  Integral membrane protein 2C (ITM2C) 8.0
 LDTP00630  Importin-8 (IPO8) 7.8
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05065  Y-box-binding protein 1 (YBX1) 8.2
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) 7.9
Other
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 80.4
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 50.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 39.1
 LDTP18883  Protein CEBPZOS (CEBPZOS) 37.5
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 36.8
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 27.7
 LDTP01075  Protein CutA (CUTA) 23.1
 LDTP00105  Protein unc-119 homolog B (UNC119B) 22.9
 LDTP11076  Apolipoprotein L2 (APOL2) 20.4
 LDTP07681  Bombesin receptor-activated protein C6orf89 (C6orf89) 20.4
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 20.3
 LDTP14458  Tetraspanin-6 (TSPAN6) 17.8
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 16.3
 LDTP05375  Nucleobindin-1 (NUCB1) 15.9
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 15.0
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 14.5
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 14.0
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 13.9
 LDTP02927  Ganglioside GM2 activator (GM2A) 13.8
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 12.7
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 12.6
 LDTP10056  Protein FAM162A (FAM162A) 11.8
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 11.5
 LDTP07574  Superkiller complex protein 3 (SKIC3) 11.2
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 11.0
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 10.6
 LDTP11327  RNA polymerase II-associated protein 1 (RPAP1) 10.6
 LDTP00887  Calumenin (CALU) 10.1
 LDTP08796  Protein SYS1 homolog (SYS1) 10.1
 LDTP05960  Trophoblast glycoprotein (TPBG) 9.9
 LDTP10281  Cytoplasmic dynein 2 intermediate chain 2 (DYNC2I2) 9.7
 LDTP05226  RNA-binding protein 3 (RBM3) 9.6
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 9.6
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 9.3
 LDTP04091  Adapter molecule crk (CRK) 9.2
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 9.2
 LDTP13170  COP9 signalosome complex subunit 7a (COPS7A) 9.1
 LDTP06134  Protocadherin Fat 1 (FAT1) 9.1
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 9.1
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 9.0
 LDTP19924  Protein PBDC1 (PBDC1) 9.0
 LDTP07132  Ubiquitin-associated protein 2 (UBAP2) 8.8
 LDTP04527  RNA-binding protein 5 (RBM5) 8.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 8.3
 LDTP13152  DnaJ homolog subfamily B member 11 (DNAJB11) 8.2
 LDTP02443  Calmodulin-3 (CALM3) 8.1
 LDTP09787  Nicastrin (NCSTN) 8.1
 LDTP01494  Protein YIF1A (YIF1A) 8.1
 LDTP01973  Ferritin light chain (FTL) 8.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 7.9
 LDTP11995  WD repeat and coiled-coil-containing protein (WDCP) 7.8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587