Details of the Target

General Information of Target

Target ID LDTP02443
Target Name Calmodulin-3 (CALM3)
Gene Name CALM3
Gene ID 801
Synonyms
CALML2; CAM3; CAMC; CAMIII; Calmodulin-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Target Bioclass
Other
Family
Calmodulin family
Subcellular location
Cytoplasm, cytoskeleton, spindle
Function
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.; (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity.
Uniprot ID
P0DP25
Ensemble ID
ENST00000291295.14
HGNC ID
HGNC:1449

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD0393  [1]
FBPP2
 Probe Info  		16.59  LDD0318  [2]
C-Sul
 Probe Info  		14.74  LDD0066  [3]
FBP2
 Probe Info  		12.28  LDD0317  [2]
AMP probe
 Probe Info  		K95(0.00); K22(0.00)  LDD0200  [4]
ATP probe
 Probe Info  		K95(0.00); K22(0.00); K78(0.00); K31(0.00)  LDD0199  [4]
CY-1
 Probe Info  		D134(0.00); E140(0.00); Y139(0.00); Q136(0.00)  LDD0246  [5]
NHS
 Probe Info  		N.A.  LDD0010  [6]
PAL-AfBPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.19  LDD1740  [7]
C053
 Probe Info  		8.57  LDD1751  [7]
C056
 Probe Info  		23.26  LDD1753  [7]
C063
 Probe Info  		16.80  LDD1760  [7]
C194
 Probe Info  		11.39  LDD1870  [7]
C196
 Probe Info  		13.83  LDD1872  [7]
C208
 Probe Info  		5.78  LDD1883  [7]
C210
 Probe Info  		85.04  LDD1884  [7]
C211
 Probe Info  		8.06  LDD1885  [7]
C212
 Probe Info  		6.19  LDD1886  [7]
C213
 Probe Info  		21.71  LDD1887  [7]
C214
 Probe Info  		5.90  LDD1888  [7]
C226
 Probe Info  		6.59  LDD1899  [7]
C228
 Probe Info  		15.03  LDD1901  [7]
C231
 Probe Info  		13.74  LDD1904  [7]
C238
 Probe Info  		12.04  LDD1911  [7]
C243
 Probe Info  		11.55  LDD1916  [7]
C293
 Probe Info  		38.59  LDD1963  [7]
C310
 Probe Info  		9.13  LDD1977  [7]
C355
 Probe Info  		22.47  LDD2016  [7]
C357
 Probe Info  		6.82  LDD2018  [7]
C362
 Probe Info  		27.47  LDD2023  [7]
C364
 Probe Info  		14.93  LDD2025  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587