Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FBP2  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Adrenal
Disease Model Bone marrow neuroblastoma [ICD11: 2A00]
Model Name Human neuroblastoma cells (SH-SY5Y)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 24 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 42.6
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 26.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 19.3
 LDTP03945  Patatin-like phospholipase domain-containing protein 4 (PNPLA4) 15.0
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) 14.7
 LDTP11261  Monoacylglycerol lipase ABHD6 (ABHD6) 9.1
 LDTP02217  Procathepsin L (CTSL) 6.9
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 5.6
 LDTP09620  Soluble calcium-activated nucleotidase 1 (CANT1) 3.9
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 3.9
 LDTP03109  Amine oxidase [flavin-containing] A (MAOA) 3.6
 LDTP11284  Phosphatidylserine synthase 2 (PTDSS2) 3.2
 LDTP01616  CTD nuclear envelope phosphatase 1 (CTDNEP1) 3.1
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 3.0
 LDTP02198  Cathepsin D (CTSD) 2.7
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 2.7
 LDTP05905  Acid ceramidase (ASAH1) 2.6
 LDTP07362  Atlastin-3 (ATL3) 2.6
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 2.6
 LDTP07028  Long-chain fatty acid transport protein 3 (SLC27A3) 2.2
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 2.2
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 2.1
 LDTP12188  Arsenite methyltransferase (AS3MT) 2.1
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 2.0
Transporter and channel
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.2
 LDTP06633  Reticulon-1 (RTN1) 4.5
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 4.4
 LDTP06490  Vesicle-associated membrane protein 3 (VAMP3) 4.4
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 4.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 3.9
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 3.5
 LDTP01060  PRA1 family protein 2 (PRAF2) 3.4
 LDTP15948  Transmembrane protein 126A (TMEM126A) 3.1
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 2.7
 LDTP00970  Gasdermin-E (GSDME) 2.6
 LDTP14509  ATP synthase subunit d, mitochondrial (ATP5PD) 2.6
 LDTP02122  Integrin beta-1 (ITGB1) 2.5
 LDTP10754  Pannexin-1 (PANX1) 2.5
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) 2.2
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 2.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 2.2
 LDTP00546  Secretory carrier-associated membrane protein 1 (SCAMP1) 2.1
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05973  CD166 antigen (ALCAM) 3.3
 LDTP02666  Neural cell adhesion molecule 1 (NCAM1) 2.3
Other
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02443  Calmodulin-3 (CALM3) 12.3
 LDTP10357  RUS family member 1 (RUSF1) 10.9
 LDTP01250  Barrier-to-autointegration factor (BANF1) 7.0
 LDTP01522  Reticulon-3 (RTN3) 6.1
 LDTP12412  Reticulon-4 (RTN4) 6.0
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 5.7
 LDTP00759  Tumor protein D54 (TPD52L2) 4.2
 LDTP09967  Stathmin-2 (STMN2) 4.0
 LDTP11140  Peroxiredoxin-like 2A (PRXL2A) 3.8
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 3.8
 LDTP14747  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (GNG2) 3.7
 LDTP10924  Prohibitin-2 (PHB2) 3.4
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) 2.9
 LDTP02977  Cadherin-2 (CDH2) 2.6
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 2.6
 LDTP03503  Myristoylated alanine-rich C-kinase substrate (MARCKS) 2.4
 LDTP08389  Syntaxin-12 (STX12) 2.2
 LDTP01021  Perilipin-3 (PLIN3) 2.2

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580