Details of the Target

General Information of Target

Target ID LDTP07028
Target Name Long-chain fatty acid transport protein 3 (SLC27A3)
Gene Name SLC27A3
Gene ID 11000
Synonyms
ACSVL3; FATP3; Long-chain fatty acid transport protein 3; FATP-3; Fatty acid transport protein 3; Arachidonate--CoA ligase; EC 6.2.1.15; Long-chain-fatty-acid--CoA ligase; EC 6.2.1.3; Solute carrier family 27 member 3; Very long-chain acyl-CoA synthetase homolog 3; VLCS-3; EC 6.2.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALLLLPLLLLLPLLLLKLHLWPQLRWLPADLAFAVRALCCKRALRARALAAAAADPEG
PEGGCSLAWRLAELAQQRAAHTFLIHGSRRFSYSEAERESNRAARAFLRALGWDWGPDGG
DSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLLPAGPEF
LWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGL
HLWAAGPGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARI
SHLKILQCQGFYQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQF
WEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQ
VLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMAT
SPGEPGLLVAPVSQQSPFLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRF
HDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHAL
DLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQ
AVGAYLPLTTARYSALLAGNLRI
Target Bioclass
Enzyme
Family
ATP-dependent AMP-binding enzyme family
Subcellular location
Mitochondrion membrane
Function
Mainly functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates. Can mediate the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across membranes.
Uniprot ID
Q5K4L6
Ensemble ID
ENST00000623839.3
HGNC ID
HGNC:10997

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		2.23  LDD0317  [1]
STPyne
 Probe Info  		K43(1.79)  LDD0277  [2]
Jackson_1
 Probe Info  		2.07  LDD0120  [3]
AHL-Pu-1
 Probe Info  		C524(2.24)  LDD0170  [4]
DBIA
 Probe Info  		C112(0.95); C411(0.79)  LDD0532  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
IPM
 Probe Info  		C65(0.00); C532(0.00)  LDD2156  [8]
AOyne
 Probe Info  		12.80  LDD0443  [9]
NAIA_5
 Probe Info  		C209(0.00); C379(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C524(2.24)  LDD0170  [4]
 LDCM0214  AC1 HEK-293T C112(0.70)  LDD0812  [5]
 LDCM0215  AC10 HCT 116 C112(0.95); C411(0.79)  LDD0532  [5]
 LDCM0216  AC100 HEK-293T C112(0.91)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C112(0.97)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C112(0.87)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C112(0.87)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C112(0.75)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C112(1.07)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C112(1.38)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C112(0.85)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C112(1.10)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C112(1.03)  LDD0823  [5]
 LDCM0226  AC11 HCT 116 C112(0.86); C411(0.99)  LDD0543  [5]
 LDCM0227  AC110 HEK-293T C112(0.77)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C112(0.77)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C112(0.77)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C112(1.01); C411(1.02)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C112(0.98); C411(1.08)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C112(1.00); C411(1.13)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C112(0.96); C411(1.13)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C112(1.02); C411(1.34)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C112(1.11); C411(1.29)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C112(0.90); C411(1.17)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C112(1.01); C411(0.92)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C112(1.21); C411(0.97)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C112(1.01); C411(1.37)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C112(1.27); C411(1.10)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C112(0.86); C411(1.40)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C112(1.11); C411(1.21)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C112(1.32); C411(0.96)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C112(1.07); C411(1.25)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C112(1.15); C411(1.18)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C112(1.28)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C112(0.84)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C112(0.83)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C112(1.03)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C112(1.00)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C112(0.83)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C112(0.87)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C112(0.73)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C112(0.92)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C112(0.74)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C112(0.77)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C112(0.68)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C112(0.98); C411(1.01)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C112(0.82)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C112(0.79)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C112(0.78)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C112(0.73)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C112(0.76)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C112(0.84)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C112(0.78)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C112(0.82)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C112(0.89)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C112(1.00)  LDD0867  [5]
 LDCM0270  AC15 HCT 116 C411(0.86); C112(0.87)  LDD0587  [5]
 LDCM0271  AC150 HEK-293T C112(0.88)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C112(0.92)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C112(1.04)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C112(0.89)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C112(0.88)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C112(1.03)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C112(0.80)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C112(0.73)  LDD2165  [5]
 LDCM0276  AC17 HCT 116 C411(1.43)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C411(1.19)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C411(1.30)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C112(0.54)  LDD0877  [5]
 LDCM0280  AC20 HCT 116 C411(1.48)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C411(1.14)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C411(1.26)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C411(1.55)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C411(1.33)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C112(0.96)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C112(1.08)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C112(0.94)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C112(1.07)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C112(0.94)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C112(0.87)  LDD0888  [5]
 LDCM0291  AC30 HCT 116 C112(1.04)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C112(1.00)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C112(0.91)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C112(1.00)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C112(1.00)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C112(1.33)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C112(0.97)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C112(0.85)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C112(0.79)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C112(1.10)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C112(1.02)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C112(0.89)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C112(1.10)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C112(1.14)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C112(0.77)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C112(0.96)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C112(0.88)  LDD0905  [5]
 LDCM0308  AC46 HCT 116 C112(1.10); C411(1.34)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C112(1.15); C411(1.35)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C411(1.28); C112(1.42)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C411(0.84); C112(1.06)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C112(0.58)  LDD0910  [5]
 LDCM0313  AC50 HCT 116 C411(0.79); C112(1.01)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C112(1.11); C411(1.44)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C112(0.92); C411(1.18)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C411(1.04); C112(1.12)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C411(0.96); C112(0.98)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C411(0.88); C112(0.98)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C411(0.87); C112(1.05)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C411(1.22)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C411(1.24)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C411(1.31)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C411(0.81); C112(0.96)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C411(1.32)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C411(1.25)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C411(1.20)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C411(1.24)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C411(1.28)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C411(1.51)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C411(1.69)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C411(1.25)  LDD0648  [5]
 LDCM0332  AC68 HEK-293T C112(0.92)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C112(0.83)  LDD0931  [5]
 LDCM0334  AC7 HCT 116 C112(0.99); C411(1.00)  LDD0651  [5]
 LDCM0335  AC70 HEK-293T C112(0.61)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C112(0.67)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C112(0.74)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C112(0.76)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C112(0.77)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C112(0.62)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C112(0.82)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C112(0.69)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C112(0.63)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C112(0.83)  LDD0942  [5]
 LDCM0345  AC8 HCT 116 C411(0.84); C112(0.91)  LDD0662  [5]
 LDCM0346  AC80 HEK-293T C112(0.49)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C112(0.68)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C112(0.40)  LDD0946  [5]
 LDCM0349  AC83 HCT 116 C411(0.77)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C411(0.73)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C411(0.83)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C411(0.97)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C411(0.92)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C411(0.79)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C411(0.77)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C411(1.15)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C411(0.72)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C411(0.70)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C411(0.79)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C411(1.06)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C411(1.02)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C411(0.81)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C411(0.66)  LDD0681  [5]
 LDCM0365  AC98 HEK-293T C112(1.10)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C112(0.97)  LDD0964  [5]
 LDCM0248  AKOS034007472 HCT 116 C112(1.17); C411(0.97)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C411(0.99); C112(1.05)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C411(0.89); C112(0.90)  LDD0592  [5]
 LDCM0071  Cisar_cp14 MDA-MB-231 3.60  LDD0121  [3]
 LDCM0070  Cisar_cp37 MDA-MB-231 2.07  LDD0120  [3]
 LDCM0367  CL1 HEK-293T C112(1.14)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C112(0.60)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C112(0.49)  LDD0967  [5]
 LDCM0370  CL101 HCT 116 C411(0.89); C112(0.99)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C411(0.94); C112(0.99)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C411(0.93); C112(1.03)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C411(0.73); C112(0.96)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C411(1.11)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C411(1.25)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C411(1.25)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C411(1.22)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C411(1.28)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C112(0.58)  LDD0977  [5]
 LDCM0380  CL110 HCT 116 C411(0.94)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C411(1.10)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C112(0.87)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C112(0.93)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C112(0.82)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C112(0.86)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C112(0.99)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C112(1.02)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C112(1.17)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C112(0.91)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C112(0.98)  LDD0988  [5]
 LDCM0391  CL120 HEK-293T C112(1.22)  LDD0989  [5]
 LDCM0392  CL121 HCT 116 C112(0.50); C411(0.72)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C112(0.97); C411(1.05)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C411(0.95); C112(1.15)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C112(0.83); C411(1.15)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C411(1.23)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C411(1.18)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C411(1.10)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C411(1.20)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C112(0.94)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C112(0.78)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C112(0.63)  LDD1000  [5]
 LDCM0403  CL16 HCT 116 C112(1.31)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C112(1.31)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C112(1.07)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C112(1.17)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C112(0.81)  LDD1005  [5]
 LDCM0408  CL20 HCT 116 C112(1.07)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C112(1.00)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C112(1.24)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C112(1.39)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C112(0.96)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C112(0.82)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C112(1.24)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C112(1.22)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C112(1.08)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C112(1.06)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C112(0.96)  LDD1016  [5]
 LDCM0419  CL30 HCT 116 C112(1.12)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C112(0.51)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C112(0.52)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C112(0.39)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C112(0.70)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C112(0.44)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C112(0.53)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C112(0.59)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C112(0.30)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C112(0.93)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C112(0.43)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C112(0.39)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C112(0.37)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C112(0.32)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C112(0.44)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C112(0.30)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C112(0.57)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C112(0.72)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C112(0.74)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C112(0.72)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C112(0.78)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C112(0.64)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C112(0.78)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C112(1.31)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C112(1.12)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C112(0.73)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C112(0.68)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C112(0.78)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C112(0.84)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C112(0.92)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C112(0.65)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C112(0.96)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C112(0.64)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C112(0.70)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C112(0.83)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C112(0.66)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C112(1.03)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C112(0.79)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C112(0.78)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C112(1.08)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C112(0.72)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C112(1.19)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C112(0.65)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C112(0.86)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C112(0.70)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C112(0.86)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C112(0.92)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C112(0.55)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C112(0.92)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C112(0.79)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C112(0.93)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C112(0.70)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C112(0.68)  LDD1071  [5]
 LDCM0474  CL80 HEK-293T C112(0.92)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C112(0.79)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C112(1.00)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C112(0.75)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C112(0.71)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C112(0.77)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C112(0.73)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C112(0.65)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C112(0.74)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C112(0.76)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C112(0.90)  LDD1082  [5]
 LDCM0485  CL90 HEK-293T C112(0.68)  LDD1083  [5]
 LDCM0486  CL91 HEK-293T C112(1.00)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C112(0.92)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C112(0.82)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C112(0.43)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C112(0.44)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C112(0.57)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C112(0.69)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C112(0.71)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C112(0.76)  LDD1092  [5]
 LDCM0582  Fragment23 Ramos C65(1.42)  LDD2196  [11]
 LDCM0586  Fragment28 Ramos C65(0.96)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C65(2.06)  LDD2199  [11]
 LDCM0468  Fragment33 HEK-293T C112(0.43)  LDD1066  [5]
 LDCM0596  Fragment38 Ramos C65(1.69)  LDD2203  [11]
 LDCM0427  Fragment51 HEK-293T C112(0.58)  LDD1025  [5]
 LDCM0571  Fragment9 Ramos C65(0.59)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C532(1.32)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C532(1.09)  LDD1497  [12]
 LDCM0024  KB05 IGR37 C364(2.01)  LDD3314  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C65(1.65)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C65(0.61)  LDD2207  [14]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.