Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Jackson_1  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Cisar_cp14  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14805  D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) 20.0
 LDTP03647  Guanylate-binding protein 2 (GBP2) 20.0
 LDTP11504  Histone-lysine N-methyltransferase SETD2 (SETD2) 20.0
 LDTP11819  STE20-like serine/threonine-protein kinase (SLK) 20.0
 LDTP14092  Protein phosphatase methylesterase 1 (PPME1) 15.6
 LDTP10441  E3 ubiquitin-protein ligase Itchy homolog (ITCH) 10.6
 LDTP05911  Serine/threonine-protein kinase PRP4 homolog (PRPF4B) 10.4
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) 10.3
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 7.6
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 6.0
 LDTP06612  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (DECR1) 5.6
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 4.9
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 4.9
 LDTP11852  Presenilin-associated rhomboid-like protein, mitochondrial (PARL) 3.7
 LDTP07028  Long-chain fatty acid transport protein 3 (SLC27A3) 3.6
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 3.0
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 2.4
 LDTP00543  1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) 2.3
Transporter and channel
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06177  Clathrin interactor 1 (CLINT1) 20.0
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 20.0
 LDTP09278  Multiple coagulation factor deficiency protein 2 (MCFD2) 12.5
 LDTP05293  Ankyrin-2 (ANK2) 10.3
 LDTP04578  Clathrin heavy chain 2 (CLTCL1) 2.5
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06204  Signal transducer and activator of transcription 4 (STAT4) 20.0
 LDTP02897  Nucleolar transcription factor 1 (UBTF) 2.4
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06148  Semaphorin-3A (SEMA3A) 20.0
Other
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08950  ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) 20.0
 LDTP05189  Chromobox protein homolog 1 (CBX1) 20.0
 LDTP13993  F-box only protein 7 (FBXO7) 20.0
 LDTP04500  Heterogeneous nuclear ribonucleoprotein M (HNRNPM) 20.0
 LDTP19976  Leucine-rich repeat-containing protein 40 (LRRC40) 20.0
 LDTP10400  MORF4 family-associated protein 1-like 1 (MRFAP1L1) 20.0
 LDTP00584  Neurosecretory protein VGF (VGF) 20.0
 LDTP08491  Protein AHNAK2 (AHNAK2) 20.0
 LDTP14085  Protein PRRC2C (PRRC2C) 20.0
 LDTP07147  RAB6-interacting golgin (GORAB) 20.0
 LDTP01853  Somatoliberin (GHRH) 20.0
 LDTP06557  Synaptophysin-like protein 1 (SYPL1) 20.0
 LDTP17719  TBC1 domain family member 19 (TBC1D19) 20.0
 LDTP05778  Chromobox protein homolog 3 (CBX3) 10.8
 LDTP01456  Pre-mRNA-processing factor 6 (PRPF6) 10.4
 LDTP13657  Melanoma-associated antigen D2 (MAGED2) 4.3

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.